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Epilepsy: Levetiracetam is primarily used to manage seizures in individuals with epilepsy. It is effective in controlling partial-onset seizures (also known as focal seizures), generalized tonic-clonic seizures, myoclonic seizures, and absence seizures.
Partial-Onset Seizures: Levetiracetam has been shown to reduce the frequency and severity of partial-onset seizures, which involve abnormal electrical activity in a specific area of the brain. It may be used as monotherapy or in combination with other antiepileptic drugs (AEDs) for better seizure control.
Generalized Seizures: Levetiracetam is also effective in controlling generalized tonic-clonic seizures, which affect both sides of the brain and typically involve loss of consciousness and convulsions. It can help prevent the occurrence of these seizures and improve overall seizure management.
Myoclonic Seizures: Myoclonic seizures are characterized by sudden, brief muscle jerks or twitches. Levetiracetam has shown efficacy in reducing the frequency and severity of myoclonic seizures, particularly in individuals with juvenile myoclonic epilepsy.
Absence Seizures: Levetiracetam may also be effective in managing absence seizures, which involve brief episodes of impaired consciousness and staring spells. It can help prevent the occurrence of these seizures and improve seizure control in individuals with certain types of epilepsy syndromes.
Safety and Tolerability: Levetiracetam is generally well-tolerated, with a favorable safety profile compared to some other AEDs. Common side effects may include drowsiness, dizziness, fatigue, irritability, and behavioral changes. These side effects are usually mild and transient, but they may require dose adjustment or discontinuation of the medication in some cases.
Long-Term Treatment: Levetiracetam is suitable for long-term use in the management of epilepsy. It is often prescribed as a maintenance therapy to prevent seizure recurrence and improve quality of life in individuals with epilepsy.
Dosage Adjustment: The dosage of levetiracetam may need to be adjusted based on individual response, seizure control, and tolerability. Healthcare providers typically start with a low dose and gradually increase it to achieve optimal seizure management while minimizing side effects.
Monitoring and Follow-Up: Regular monitoring of seizure frequency, medication adherence, and potential adverse effects is important for optimizing treatment outcomes with levetiracetam. Healthcare providers may adjust the treatment plan as needed to ensure effective seizure control and minimize side effects.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Escherichia coli | Reduces |
| species | Parabacteroides distasonis | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
| π Direct Citations | πͺπΆ Indirect Citations | Taxonomy | Rank | Effect |
|---|---|---|---|---|
| 0 | 1 | Escherichia | genus | Decreases |
| 0 | 1 | Parabacteroides | genus | Decreases |
| 0 | 1 | Bacteroides | genus | Decreases |
| 0 | 1 | Fusobacterium | genus | Decreases |
| 0 | 1 | Lacrimispora | genus | Decreases |
| 0 | 1 | Mediterraneibacter | genus | Decreases |
| 0 | 1 | Streptococcus | genus | Decreases |
| 0 | 1 | Enterocloster | genus | Decreases |
| 0 | 1 | Escherichia coli O25:H16 | no rank | Decreases |
| 0 | 1 | Escherichia coli O145:H34 | no rank | Decreases |
| 0 | 1 | Escherichia coli O16:H48 | no rank | Decreases |
| 0 | 1 | Escherichia coli O141:H4 | no rank | Decreases |
| 0 | 1 | Escherichia coli O139:H1 | no rank | Decreases |
| 0 | 1 | Escherichia coli O80:H26 | no rank | Decreases |
| 0 | 1 | Escherichia coli O158:H23 | no rank | Decreases |
| 0 | 1 | Escherichia coli O84:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O2:K1:H4 | no rank | Decreases |
| 0 | 1 | Escherichia coli O2:K1:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O78:H51 | no rank | Decreases |
| 0 | 1 | Escherichia coli O18ac:H14 | no rank | Decreases |
| 0 | 1 | Escherichia coli O85:H1 | no rank | Decreases |
| 0 | 1 | Escherichia coli O7:H15 | no rank | Decreases |
| 0 | 1 | Escherichia coli O68:H12 | no rank | Decreases |
| 0 | 1 | Escherichia coli O55:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O1:K1:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O15:H12 | no rank | Decreases |
| 0 | 1 | Escherichia coli O170:H18 | no rank | Decreases |
| 0 | 1 | Escherichia coli O155:H21 | no rank | Decreases |
| 0 | 1 | Escherichia coli O19:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O2:K1:H5 | no rank | Decreases |
| 0 | 1 | Escherichia coli O20:H12 | no rank | Decreases |
| 0 | 1 | Escherichia coli O111 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O121 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O155 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O177 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O26 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O3 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O5 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O86 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O91 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O103 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O78 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O43 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O119 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O157 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O145 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O1:HNT | serotype | Decreases |
| 0 | 1 | Escherichia coli O10:K5(L):H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O103:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O103:H25 | serotype | Decreases |
| 0 | 1 | Escherichia coli O104:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli O111:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O111:H8 | serotype | Decreases |
| 0 | 1 | Escherichia coli O112ac:H19 | serotype | Decreases |
| 0 | 1 | Escherichia coli O114:H49 | serotype | Decreases |
| 0 | 1 | Escherichia coli O118:H16 | serotype | Decreases |
| 0 | 1 | Escherichia coli O121:H7 | serotype | Decreases |
| 0 | 1 | Escherichia coli O123:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O127:H27 | serotype | Decreases |
| 0 | 1 | Escherichia coli O127:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O128:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O128ac:H12 | serotype | Decreases |
| 0 | 1 | Escherichia coli O145:H25 | serotype | Decreases |
| 0 | 1 | Escherichia coli O145:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O146:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli O153:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O156:H25 | serotype | Decreases |
| 0 | 1 | Escherichia coli O157:H43 | serotype | Decreases |
| 0 | 1 | Escherichia coli O157:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O165:H25 | serotype | Decreases |
| 0 | 1 | Escherichia coli O174:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O174:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli O174:H8 | serotype | Decreases |
| 0 | 1 | Escherichia coli O176:H45 | serotype | Decreases |
| 0 | 1 | Escherichia coli O177:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O26:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O28ac:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O29:H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O32:H37 | serotype | Decreases |
| 0 | 1 | Escherichia coli O6:H16:CFA/II | serotype | Decreases |
| 0 | 1 | Escherichia coli O69:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O78:H12 | serotype | Decreases |
| 0 | 1 | Escherichia coli O79:H7 | serotype | Decreases |
| 0 | 1 | Escherichia coli O81:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O86:H34 | serotype | Decreases |
| 0 | 1 | Escherichia coli O91:H14 | serotype | Decreases |
| 0 | 1 | Escherichia coli O91:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli ONT:H33 | serotype | Decreases |
| 0 | 1 | Escherichia coli O100:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli O121:H19 | serotype | Decreases |
| 0 | 1 | Escherichia coli O157:H7 | serotype | Decreases |
| 0 | 1 | Escherichia coli O16:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O89m:H9 | serotype | Decreases |
| 0 | 1 | Escherichia coli O111:H- | serotype | Decreases |
| 0 | 1 | Escherichia coli O113:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli H20 | serotype | Decreases |
| 0 | 1 | Escherichia coli O150:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O111:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O112ab:H8 | serotype | Decreases |
| 0 | 1 | Escherichia coli O99:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O26:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O145:H28 | serotype | Decreases |
| 0 | 1 | Escherichia coli O126:H45 | serotype | Decreases |
| 0 | 1 | Escherichia coli O2:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O7:H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O1:H42 | serotype | Decreases |
| 0 | 1 | Escherichia coli O25:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O25:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O7:K1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O125ac:K+:H10 | serotype | Decreases |
| 0 | 1 | Escherichia coli O6:K2:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O152:H23 | serotype | Decreases |
| 0 | 1 | Escherichia coli O15:H18 | serotype | Decreases |
| 0 | 1 | Escherichia coli O39:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O44:H18 | serotype | Decreases |
| 0 | 1 | Escherichia coli O2:K2:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O8:H8 | serotype | Decreases |
| 0 | 1 | Escherichia coli O89m:H10 | serotype | Decreases |
| 0 | 1 | Escherichia coli O10:H32 | serotype | Decreases |
| 0 | 1 | Escherichia coli O6:H16 | serotype | Decreases |
| 0 | 1 | Escherichia coli O157:H- | serotype | Decreases |
| 0 | 1 | Escherichia coli O45:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O103:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O167:H26 | serotype | Decreases |
| 0 | 1 | Escherichia coli O104:H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O83:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O9:H10 | serotype | Decreases |
| 0 | 1 | Escherichia coli O78:H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O139:H28 | serotype | Decreases |
| 1 | 0 | Parabacteroides merdae | species | Decreases |
| 1 | 0 | Streptococcus salivarius | species | Decreases |
| 1 | 0 | Mediterraneibacter gnavus | species | Decreases |
| 1 | 0 | Bacteroides fragilis | species | Decreases |
| 1 | 0 | Streptococcus parasanguinis | species | Decreases |
| 1 | 0 | Escherichia coli | species | Decreases |
| 1 | 0 | Lacrimispora saccharolytica | species | Decreases |
| 1 | 0 | Parabacteroides distasonis | species | Decreases |
| 1 | 0 | Fusobacterium nucleatum | species | Decreases |
| 1 | 0 | Enterocloster bolteae | species | Decreases |
| 0 | 1 | Fusobacterium nucleatum subsp. nucleatum | subspecies | Decreases |
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Acne | 0.3 | 0.3 | |
| ADHD | 1 | 1 | |
| Age-Related Macular Degeneration and Glaucoma | 0.4 | -0.4 | |
| Allergic Rhinitis (Hay Fever) | 2.1 | 0.6 | 2.5 |
| Allergies | 2.2 | 0.6 | 2.67 |
| Allergy to milk products | 0.4 | 1.3 | -2.25 |
| Alopecia (Hair Loss) | 0.1 | 0.1 | |
| Alzheimer's disease | 2.3 | 1.4 | 0.64 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 1.2 | 0.1 | 11 |
| Ankylosing spondylitis | 1.4 | 1 | 0.4 |
| Anorexia Nervosa | 0.7 | 0.8 | -0.14 |
| Antiphospholipid syndrome (APS) | 0.4 | 0.4 | |
| Asthma | 1.7 | 0.6 | 1.83 |
| Atherosclerosis | 0.9 | 0.3 | 2 |
| Atrial fibrillation | 1.2 | 1.3 | -0.08 |
| Autism | 2.6 | 2.3 | 0.13 |
| Autoimmune Disease | 0.9 | 0.9 | |
| Barrett esophagus cancer | 0.3 | 0.3 | 0 |
| benign prostatic hyperplasia | 0.6 | 0.3 | 1 |
| Biofilm | 1.1 | 1.1 | |
| Bipolar Disorder | 1.3 | 1.3 | |
| Brain Trauma | 0.3 | 0.3 | 0 |
| Breast Cancer | 0.2 | 0.2 | |
| Cancer (General) | 0.3 | 0.3 | |
| Carcinoma | 1.9 | 0.7 | 1.71 |
| Celiac Disease | 0.9 | 0.7 | 0.29 |
| Cerebral Palsy | 0.6 | 0.3 | 1 |
| Chronic Fatigue Syndrome | 1.5 | 1.3 | 0.15 |
| Chronic Kidney Disease | 1.8 | 1.8 | |
| Chronic Lyme | 0.3 | -0.3 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 1.4 | 0.6 | 1.33 |
| Chronic Urticaria (Hives) | 1 | 0.2 | 4 |
| Coagulation / Micro clot triggering bacteria | 1.5 | 0.3 | 4 |
| Cognitive Function | 1 | 0.3 | 2.33 |
| Colorectal Cancer | 3.2 | 0.4 | 7 |
| Constipation | 1 | 1 | |
| Coronary artery disease | 1.5 | 0.5 | 2 |
| COVID-19 | 2.6 | 1.5 | 0.73 |
| Crohn's Disease | 2.8 | 1.2 | 1.33 |
| Cushing's Syndrome (hypercortisolism) | 0.3 | -0.3 | |
| cystic fibrosis | 0.7 | 0.3 | 1.33 |
| d-lactic acidosis (one form of brain fog) | 0.1 | 0.1 | |
| deep vein thrombosis | 1 | 0.6 | 0.67 |
| Denture Wearers Oral Shifts | 0.8 | 0.8 | |
| Depression | 2.5 | 2.2 | 0.14 |
| Dermatomyositis | 0.3 | 0.3 | |
| Eczema | 1.6 | 1 | 0.6 |
| Endometriosis | 1.7 | 0.1 | 16 |
| Eosinophilic Esophagitis | 0.3 | 0.3 | 0 |
| Epilepsy | 1.8 | 1.3 | 0.38 |
| erectile dysfunction | 1.6 | 1.6 | |
| Fibromyalgia | 1 | 0.7 | 0.43 |
| Functional constipation / chronic idiopathic constipation | 2 | 0.9 | 1.22 |
| gallstone disease (gsd) | 1.8 | 0.3 | 5 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.6 | 0.3 | 1 |
| Generalized anxiety disorder | 2.1 | 0.6 | 2.5 |
| Glioblastoma | 0.3 | -0.3 | |
| Gout | 0.9 | 0.9 | |
| Graves' disease | 0.7 | 0.6 | 0.17 |
| Gulf War Syndrome | 0.3 | 0.2 | 0.5 |
| Halitosis | 0.9 | 0.3 | 2 |
| Hashimoto's thyroiditis | 0.8 | 0.3 | 1.67 |
| Heart Failure | 2.2 | 2.2 | |
| hemorrhagic stroke | 0.7 | 0.7 | |
| Hidradenitis Suppurativa | 0.9 | 0.9 | |
| High Histamine/low DAO | 0.1 | 0.1 | |
| hypercholesterolemia (High Cholesterol) | 0.1 | 0.1 | |
| hyperglycemia | 1.2 | 0.7 | 0.71 |
| hypertension (High Blood Pressure | 2.2 | 0.8 | 1.75 |
| Hypoxia | 1.5 | 1.5 | |
| IgA nephropathy (IgAN) | 1.3 | 0.4 | 2.25 |
| Inflammatory Bowel Disease | 3.2 | 1.3 | 1.46 |
| Insomnia | 1.1 | 0.6 | 0.83 |
| Intelligence | 0.4 | 0.4 | |
| Intracranial aneurysms | 1 | 1 | |
| Irritable Bowel Syndrome | 2 | 1 | 1 |
| ischemic stroke | 1.2 | 0.9 | 0.33 |
| Liver Cirrhosis | 2.7 | 1 | 1.7 |
| Long COVID | 2.4 | 1 | 1.4 |
| Lung Cancer | 0.6 | 0.6 | |
| Lymphoma | 0.6 | 0.6 | |
| Mast Cell Issues / mastitis | 0.9 | 0.9 | |
| ME/CFS with IBS | 0.3 | 0.3 | 0 |
| ME/CFS without IBS | 0.7 | 0.4 | 0.75 |
| membranous nephropathy | 0.3 | 0.3 | |
| Menopause | 0.3 | 0.3 | |
| Metabolic Syndrome | 2.7 | 1.5 | 0.8 |
| Mood Disorders | 2.4 | 2.2 | 0.09 |
| multiple chemical sensitivity [MCS] | 0.8 | 0.8 | |
| Multiple Sclerosis | 2.3 | 1.3 | 0.77 |
| Multiple system atrophy (MSA) | 0.2 | 0.2 | |
| myasthenia gravis | 0.9 | 0.9 | |
| neuropathic pain | 0.7 | -0.7 | |
| Neuropathy (all types) | 0.3 | 1 | -2.33 |
| neuropsychiatric disorders (PANDAS, PANS) | 0.4 | 0.4 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 1.6 | 0.3 | 4.33 |
| NonCeliac Gluten Sensitivity | 0.3 | 0.3 | 0 |
| Obesity | 2.6 | 2.5 | 0.04 |
| obsessive-compulsive disorder | 2 | 1 | 1 |
| Osteoarthritis | 1.6 | 0.6 | 1.67 |
| Osteoporosis | 0.9 | 0.6 | 0.5 |
| pancreatic cancer | 1.2 | 0.6 | 1 |
| Parkinson's Disease | 2.5 | 2.3 | 0.09 |
| Polycystic ovary syndrome | 3.2 | 0.6 | 4.33 |
| Premenstrual dysphoric disorder | 0.4 | -0.4 | |
| primary biliary cholangitis | 0.3 | 0.6 | -1 |
| Primary sclerosing cholangitis | 1.5 | 1 | 0.5 |
| Psoriasis | 0.7 | 0.8 | -0.14 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 2.1 | 0.8 | 1.63 |
| Schizophrenia | 1.9 | 0.7 | 1.71 |
| scoliosis | 0.1 | 0.1 | |
| Sjögren syndrome | 1.3 | 0.7 | 0.86 |
| Sleep Apnea | 0.3 | 0.3 | 0 |
| Slow gastric motility / Gastroparesis | 0.4 | 0.4 | |
| Small Intestinal Bacterial Overgrowth (SIBO) | 1 | 1 | |
| Stress / posttraumatic stress disorder | 1.2 | 0.7 | 0.71 |
| Systemic Lupus Erythematosus | 2.6 | 0.1 | 25 |
| Tic Disorder | 0.3 | 0.3 | |
| Tourette syndrome | 0.3 | 0.3 | 0 |
| Type 1 Diabetes | 1.5 | 0.6 | 1.5 |
| Type 2 Diabetes | 2.7 | 1.7 | 0.59 |
| Ulcerative colitis | 2 | 0.9 | 1.22 |
| Unhealthy Ageing | 1.6 | 0.4 | 3 |
| Vitiligo | 1.2 | 0.4 | 2 |
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