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🍽️ methacholine chloride,(prescription)

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  1. Diagnostic Tool: Methacholine chloride is used in bronchial provocation testing to assess airway responsiveness. It is administered via inhalation to induce bronchoconstriction in individuals suspected of having asthma or other respiratory conditions characterized by airway hyperresponsiveness.

  2. Asthma Diagnosis: Bronchial provocation testing with methacholine chloride can help healthcare providers diagnose asthma by evaluating the degree of airway narrowing or bronchoconstriction in response to the inhalation of the medication. This test is especially useful when other diagnostic methods, such as spirometry or peak flow measurements, are inconclusive.

  3. Procedure: During bronchial provocation testing, methacholine chloride is delivered via a nebulizer or inhalation device. The concentration of methacholine chloride is gradually increased in a stepwise fashion, and lung function is monitored using spirometry or other pulmonary function tests after each inhalation. The test is stopped when a certain level of bronchoconstriction is reached or when predetermined criteria are met.

  4. Safety Considerations: Methacholine chloride provocation testing should be performed under the supervision of healthcare professionals experienced in the procedure, as it can induce bronchoconstriction and respiratory symptoms in susceptible individuals. Close monitoring of lung function and vital signs is essential during the test to ensure patient safety.

  5. Contraindications: Methacholine chloride provocation testing is contraindicated in individuals with severe or uncontrolled asthma, as well as those with certain cardiovascular conditions or other contraindications to bronchoconstrictor challenge testing. The procedure should be avoided in pregnant women and individuals with acute respiratory infections or other acute respiratory conditions.

  6. Adverse Reactions: Common adverse reactions to methacholine chloride provocation testing may include coughing, chest tightness, wheezing, shortness of breath, and bronchospasm. These symptoms typically resolve once the test is discontinued and bronchodilator medication is administered to reverse bronchoconstriction.

  7. Interpretation of Results: The results of methacholine chloride provocation testing are interpreted based on the degree of bronchoconstriction observed and the concentration of methacholine chloride required to induce a specified level of airway narrowing. A positive test result, indicating airway hyperresponsiveness, supports a diagnosis of asthma or other respiratory conditions.

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Data Contradictions — Limits of Certainity

Impacted of methacholine chloride,(prescription) On Probiotics

Rank Probiotic Impact
genus Bifidobacterium Reduces
species Akkermansia muciniphila Reduces
species Bacteroides uniformis Reduces
species Bifidobacterium adolescentis Reduces
species Bifidobacterium longum Reduces
species Escherichia coli Reduces
species Parabacteroides distasonis Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by methacholine chloride,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Akkermansiaceae family Decreases
0 1 Escherichia genus Decreases
0 1 Dorea genus Decreases
0 1 Roseburia genus Decreases
0 1 Parabacteroides genus Decreases
0 1 Ruminococcus genus Decreases
0 1 Bacteroides genus Decreases
0 1 Bifidobacterium genus Decreases
0 1 Clostridioides genus Decreases
0 1 Collinsella genus Decreases
0 1 Coprococcus genus Decreases
0 1 Eggerthella genus Decreases
0 1 Fusobacterium genus Decreases
0 1 Mediterraneibacter genus Decreases
0 1 Odoribacter genus Decreases
0 1 Phocaeicola genus Decreases
0 1 Streptococcus genus Decreases
0 1 Veillonella genus Decreases
1 0 Akkermansia genus Decreases
0 1 Clostridium genus Decreases
0 1 Enterocloster genus Decreases
0 1 Blautia genus Decreases
0 1 Escherichia coli O25:H16 no rank Decreases
0 1 Clostridium perfringens A no rank Decreases
0 1 Clostridium perfringens C no rank Decreases
0 1 Clostridium perfringens CPE no rank Decreases
0 1 environmental samples no rank Decreases
0 1 Escherichia coli O145:H34 no rank Decreases
0 1 Escherichia coli O16:H48 no rank Decreases
0 1 unclassified Akkermansia no rank Decreases
0 1 Clostridium perfringens D no rank Decreases
0 1 Escherichia coli O141:H4 no rank Decreases
0 1 Clostridium perfringens B no rank Decreases
0 1 Escherichia coli O139:H1 no rank Decreases
0 1 Clostridium perfringens E no rank Decreases
0 1 Escherichia coli O80:H26 no rank Decreases
0 1 Escherichia coli O158:H23 no rank Decreases
0 1 Escherichia coli O84:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H4 no rank Decreases
0 1 Escherichia coli O2:K1:H7 no rank Decreases
0 1 Escherichia coli O78:H51 no rank Decreases
0 1 Escherichia coli O18ac:H14 no rank Decreases
0 1 Escherichia coli O85:H1 no rank Decreases
0 1 Escherichia coli O7:H15 no rank Decreases
0 1 Escherichia coli O68:H12 no rank Decreases
0 1 Escherichia coli O55:H7 no rank Decreases
0 1 Escherichia coli O1:K1:H7 no rank Decreases
0 1 Escherichia coli O15:H12 no rank Decreases
0 1 Escherichia coli O170:H18 no rank Decreases
0 1 Escherichia coli O155:H21 no rank Decreases
0 1 Escherichia coli O19:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H5 no rank Decreases
0 1 Escherichia coli O20:H12 no rank Decreases
0 1 Escherichia coli O111 serogroup Decreases
0 1 Escherichia coli O121 serogroup Decreases
0 1 Escherichia coli O155 serogroup Decreases
0 1 Escherichia coli O177 serogroup Decreases
0 1 Escherichia coli O26 serogroup Decreases
0 1 Escherichia coli O3 serogroup Decreases
0 1 Escherichia coli O5 serogroup Decreases
0 1 Escherichia coli O86 serogroup Decreases
0 1 Escherichia coli O91 serogroup Decreases
0 1 Escherichia coli O103 serogroup Decreases
0 1 Escherichia coli O78 serogroup Decreases
0 1 Escherichia coli O43 serogroup Decreases
0 1 Escherichia coli O119 serogroup Decreases
0 1 Escherichia coli O157 serogroup Decreases
0 1 Escherichia coli O145 serogroup Decreases
0 1 Escherichia coli O1:HNT serotype Decreases
0 1 Escherichia coli O10:K5(L):H4 serotype Decreases
0 1 Escherichia coli O103:H11 serotype Decreases
0 1 Escherichia coli O103:H25 serotype Decreases
0 1 Escherichia coli O104:H21 serotype Decreases
0 1 Escherichia coli O111:H11 serotype Decreases
0 1 Escherichia coli O111:H8 serotype Decreases
0 1 Escherichia coli O112ac:H19 serotype Decreases
0 1 Escherichia coli O114:H49 serotype Decreases
0 1 Escherichia coli O118:H16 serotype Decreases
0 1 Escherichia coli O121:H7 serotype Decreases
0 1 Escherichia coli O123:H11 serotype Decreases
0 1 Escherichia coli O127:H27 serotype Decreases
0 1 Escherichia coli O127:H6 serotype Decreases
0 1 Escherichia coli O128:H2 serotype Decreases
0 1 Escherichia coli O128ac:H12 serotype Decreases
0 1 Escherichia coli O145:H25 serotype Decreases
0 1 Escherichia coli O145:NM serotype Decreases
0 1 Escherichia coli O146:H21 serotype Decreases
0 1 Escherichia coli O153:H2 serotype Decreases
0 1 Escherichia coli O156:H25 serotype Decreases
0 1 Escherichia coli O157:H43 serotype Decreases
0 1 Escherichia coli O157:NM serotype Decreases
0 1 Escherichia coli O165:H25 serotype Decreases
0 1 Escherichia coli O174:H2 serotype Decreases
0 1 Escherichia coli O174:H21 serotype Decreases
0 1 Escherichia coli O174:H8 serotype Decreases
0 1 Escherichia coli O176:H45 serotype Decreases
0 1 Escherichia coli O177:NM serotype Decreases
0 1 Escherichia coli O26:H1 serotype Decreases
0 1 Escherichia coli O28ac:NM serotype Decreases
0 1 Escherichia coli O29:H4 serotype Decreases
0 1 Escherichia coli O32:H37 serotype Decreases
0 1 Escherichia coli O6:H16:CFA/II serotype Decreases
0 1 Escherichia coli O69:H11 serotype Decreases
0 1 Escherichia coli O78:H12 serotype Decreases
0 1 Escherichia coli O79:H7 serotype Decreases
0 1 Escherichia coli O81:NM serotype Decreases
0 1 Escherichia coli O86:H34 serotype Decreases
0 1 Escherichia coli O91:H14 serotype Decreases
0 1 Escherichia coli O91:NM serotype Decreases
0 1 Escherichia coli ONT:H33 serotype Decreases
0 1 Escherichia coli O100:H21 serotype Decreases
0 1 Escherichia coli O121:H19 serotype Decreases
0 1 Escherichia coli O157:H7 serotype Decreases
0 1 Escherichia coli O16:H6 serotype Decreases
0 1 Escherichia coli O89m:H9 serotype Decreases
0 1 Escherichia coli O111:H- serotype Decreases
0 1 Escherichia coli O113:H21 serotype Decreases
0 1 Escherichia coli H20 serotype Decreases
0 1 Escherichia coli O150:H6 serotype Decreases
0 1 Escherichia coli O111:NM serotype Decreases
0 1 Escherichia coli O112ab:H8 serotype Decreases
0 1 Escherichia coli O99:H6 serotype Decreases
0 1 Escherichia coli O26:H11 serotype Decreases
0 1 Escherichia coli O145:H28 serotype Decreases
0 1 Escherichia coli O126:H45 serotype Decreases
0 1 Escherichia coli O2:H6 serotype Decreases
0 1 Escherichia coli O7:H4 serotype Decreases
0 1 Escherichia coli O1:H42 serotype Decreases
0 1 Escherichia coli O25:NM serotype Decreases
0 1 Escherichia coli O25:H1 serotype Decreases
0 1 Escherichia coli O7:K1 serotype Decreases
0 1 Escherichia coli O125ac:K+:H10 serotype Decreases
0 1 Escherichia coli O6:K2:H1 serotype Decreases
0 1 Escherichia coli O152:H23 serotype Decreases
0 1 Escherichia coli O15:H18 serotype Decreases
0 1 Escherichia coli O39:NM serotype Decreases
0 1 Escherichia coli O44:H18 serotype Decreases
0 1 Escherichia coli O2:K2:H1 serotype Decreases
0 1 Escherichia coli O8:H8 serotype Decreases
0 1 Escherichia coli O89m:H10 serotype Decreases
0 1 Escherichia coli O10:H32 serotype Decreases
0 1 Escherichia coli O6:H16 serotype Decreases
0 1 Escherichia coli O157:H- serotype Decreases
0 1 Escherichia coli O45:H2 serotype Decreases
0 1 Escherichia coli O103:H2 serotype Decreases
0 1 Escherichia coli O167:H26 serotype Decreases
0 1 Escherichia coli O104:H4 serotype Decreases
0 1 Escherichia coli O83:H1 serotype Decreases
0 1 Escherichia coli O9:H10 serotype Decreases
0 1 Escherichia coli O78:H4 serotype Decreases
0 1 Escherichia coli O139:H28 serotype Decreases
1 0 Roseburia hominis species Decreases
1 0 Collinsella aerofaciens species Decreases
1 0 Veillonella parvula species Decreases
1 0 Escherichia coli species Decreases
1 0 Dorea formicigenerans species Decreases
1 0 Bacteroides xylanisolvens species Decreases
1 0 Bifidobacterium longum species Decreases
1 0 Blautia obeum species Decreases
1 0 Bacteroides ovatus species Decreases
1 0 Akkermansia muciniphila species Decreases
1 0 Fusobacterium nucleatum species Decreases
1 0 Clostridioides difficile species Decreases
1 0 Mediterraneibacter gnavus species Decreases
1 0 Clostridium perfringens species Decreases
1 0 Coprococcus comes species Decreases
1 0 Bifidobacterium adolescentis species Decreases
1 0 Bacteroides caccae species Decreases
0 1 Akkermansia massiliensis species Decreases
0 1 Candidatus Akkermansia intestinavium species Decreases
1 0 Enterocloster bolteae species Decreases
1 0 [Ruminococcus] torques species Decreases
1 0 Eggerthella lenta species Decreases
1 0 Odoribacter splanchnicus species Decreases
1 0 Parabacteroides distasonis species Decreases
1 0 Bacteroides uniformis species Decreases
1 0 Ruminococcus bromii species Decreases
1 0 Phocaeicola vulgatus species Decreases
1 0 Streptococcus salivarius species Decreases
1 0 Bacteroides fragilis species Decreases
0 1 Akkermansia glycaniphila species Decreases
0 1 Bifidobacterium longum subsp. longum subspecies Decreases
0 1 Bifidobacterium longum subsp. infantis subspecies Decreases
0 1 Bifidobacterium longum subsp. suis subspecies Decreases
0 1 Fusobacterium nucleatum subsp. nucleatum subspecies Decreases
0 1 Bifidobacterium longum subsp. suillum subspecies Decreases

Impact of methacholine chloride,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Acne 0.6 0.5 0.2
ADHD 4 0.9 3.44
Age-Related Macular Degeneration and Glaucoma 1.1 0.4 1.75
Allergic Rhinitis (Hay Fever) 3.2 2.1 0.52
Allergies 7.1 3.8 0.87
Allergy to milk products 2.4 1.6 0.5
Alopecia (Hair Loss) 1.1 1.1
Alzheimer's disease 6.4 4.7 0.36
Amyotrophic lateral sclerosis (ALS) Motor Neuron 2.7 1.3 1.08
Ankylosing spondylitis 3.7 1.2 2.08
Anorexia Nervosa 1.6 2.1 -0.31
Antiphospholipid syndrome (APS) 0.9 0.9
Asthma 4.5 2.6 0.73
Atherosclerosis 2.1 1.5 0.4
Atrial fibrillation 2.9 1.6 0.81
Autism 8.3 7 0.19
Autoimmune Disease 1.2 1 0.2
Barrett esophagus cancer 0.6 0.3 1
benign prostatic hyperplasia 0.6 0.3 1
Biofilm 1.9 1.9
Bipolar Disorder 2.1 1.7 0.24
Brain Trauma 0.9 1.4 -0.56
Breast Cancer 1.6 0.3 4.33
Cancer (General) 0.9 1.7 -0.89
Carcinoma 4.7 2.6 0.81
Celiac Disease 1.9 3.3 -0.74
Cerebral Palsy 1.6 1.3 0.23
Chronic Fatigue Syndrome 4.4 4 0.1
Chronic Kidney Disease 4 1.6 1.5
Chronic Lyme 0.4 0.8 -1
Chronic Obstructive Pulmonary Disease (COPD) 1.8 1.7 0.06
Chronic Urticaria (Hives) 2 0.4 4
Coagulation / Micro clot triggering bacteria 1.9 1.3 0.46
Cognitive Function 3.5 1.6 1.19
Colorectal Cancer 7.8 3 1.6
Constipation 1.3 1.3 0
Coronary artery disease 2.4 1.9 0.26
COVID-19 7.9 7 0.13
Crohn's Disease 7.3 4.4 0.66
Cushing's Syndrome (hypercortisolism) 0.4 -0.4
cystic fibrosis 1.2 1.6 -0.33
d-lactic acidosis (one form of brain fog) 0.6 0.6
deep vein thrombosis 3.1 1.4 1.21
Denture Wearers Oral Shifts 1.4 1.4
Depression 8.4 7.8 0.08
Dermatomyositis 0.3 0.3 0
Eczema 2 1.7 0.18
Endometriosis 3.5 2.3 0.52
Eosinophilic Esophagitis 0.3 0.6 -1
Epilepsy 3.3 1.8 0.83
erectile dysfunction 1.7 0.3 4.67
Fibromyalgia 2.5 1.8 0.39
Functional constipation / chronic idiopathic constipation 4.6 3.1 0.48
gallstone disease (gsd) 3.5 1.3 1.69
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 1.1 0.7 0.57
Generalized anxiety disorder 3.3 2.6 0.27
giant cell arteritis 0.2 -0.2
Glioblastoma 0.3 -0.3
Gout 2.2 1.3 0.69
Graves' disease 1.9 3.3 -0.74
Gulf War Syndrome 0.9 0.9 0
Halitosis 1.5 0.3 4
Hashimoto's thyroiditis 3.2 1 2.2
Heart Failure 4.1 1.6 1.56
hemorrhagic stroke 1.3 1.3
Hidradenitis Suppurativa 0.9 0.3 2
High Histamine/low DAO 1.7 0.6 1.83
hypercholesterolemia (High Cholesterol) 1.1 0.4 1.75
hyperglycemia 2.5 1.8 0.39
Hyperlipidemia (High Blood Fats) 0.8 0.3 1.67
hypersomnia 0.4 -0.4
hypertension (High Blood Pressure 4.1 4.1 0
Hypothyroidism 0.2 1 -4
Hypoxia 3.5 0.3 10.67
IgA nephropathy (IgAN) 1.9 2.8 -0.47
Inflammatory Bowel Disease 6.9 6.5 0.06
Insomnia 2.2 2.5 -0.14
Intelligence 1.5 1.5
Intracranial aneurysms 1.4 0.9 0.56
Irritable Bowel Syndrome 7.3 4.5 0.62
ischemic stroke 3.3 1.4 1.36
Liver Cirrhosis 7.2 5.2 0.38
Long COVID 5 5.8 -0.16
Low bone mineral density 0.8 -0.8
Lung Cancer 0.9 1.4 -0.56
Lymphoma 0.6 0.6
Mast Cell Issues / mastitis 1.3 0.9 0.44
ME/CFS with IBS 0.8 1.9 -1.37
ME/CFS without IBS 1.3 1.8 -0.38
membranous nephropathy 0.3 0.3
Menopause 1.5 0.8 0.88
Metabolic Syndrome 7.2 6.8 0.06
Mood Disorders 8.5 6.2 0.37
multiple chemical sensitivity [MCS] 0.8 0.1 7
Multiple Sclerosis 5.7 3.8 0.5
Multiple system atrophy (MSA) 1.3 0.7 0.86
myasthenia gravis 0.9 0.7 0.29
neuropathic pain 0.3 2.7 -8
Neuropathy (all types) 0.9 2.4 -1.67
neuropsychiatric disorders (PANDAS, PANS) 1.2 1.2
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 4.8 4 0.2
NonCeliac Gluten Sensitivity 1.7 0.6 1.83
Obesity 10 7.4 0.35
obsessive-compulsive disorder 4 3.2 0.25
Osteoarthritis 2 1.4 0.43
Osteoporosis 2.5 2 0.25
pancreatic cancer 2.1 0.6 2.5
Parkinson's Disease 7.5 4.1 0.83
Polycystic ovary syndrome 4.8 2.6 0.85
Postural orthostatic tachycardia syndrome 0.2 0.6 -2
Premenstrual dysphoric disorder 0.7 0.4 0.75
primary biliary cholangitis 1.2 1.2 0
Primary sclerosing cholangitis 2.4 2.3 0.04
Psoriasis 3.5 2.1 0.67
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 7 3.5 1
Rosacea 0.8 1 -0.25
Schizophrenia 6.5 3 1.17
scoliosis 0.9 0.3 2
Sjögren syndrome 2.6 2.2 0.18
Sleep Apnea 1.9 1.8 0.06
Slow gastric motility / Gastroparesis 1.5 0.3 4
Small Intestinal Bacterial Overgrowth (SIBO) 2.2 0.5 3.4
Stress / posttraumatic stress disorder 3.4 2.7 0.26
Systemic Lupus Erythematosus 3.7 1.6 1.31
Tic Disorder 1 1.2 -0.2
Tourette syndrome 1.1 0.3 2.67
Type 1 Diabetes 4 3.1 0.29
Type 2 Diabetes 7.6 6.7 0.13
Ulcerative colitis 5.1 4.9 0.04
Unhealthy Ageing 4.1 2 1.05
Vitiligo 1.6 1.4 0.14

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