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Partial list of Citations used for Recommendations or Conditions

Recent additions may not be included but will usually appear in 24 hrs or less.

Rational Source
Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats. ✅ Go to Publication ✅
Scientific reports (Sci Rep ) Vol: 5 Issue Pages: 14405
Pub: 2015 Sep 23 Epub: 2015 Sep 23 Authors Zhang X , Zhao Y , Xu J , Xue Z , Zhang M , Pang X , Zhang X , Zhao L ,
Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats. ✅ Go to Publication ✅
Scientific reports (Sci Rep ) Vol: 5 Issue Pages: 14405
Pub: 2015 Sep 23 Epub: 2015 Sep 23 Authors Zhang X , Zhao Y , Xu J , Xue Z , Zhang M , Pang X , Zhang X , Zhao L ,
Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats. ✅ Go to Publication ✅
Scientific reports (Sci Rep ) Vol: 5 Issue Pages: 14405
Pub: 2015 Sep 23 Epub: 2015 Sep 23 Authors Zhang X , Zhao Y , Xu J , Xue Z , Zhang M , Pang X , Zhang X , Zhao L ,
Curated database of commensal, symbiotic and pathogenic microbiota ✅
Generative Bioinformatics (Center of Excellence in Generative Medicine ) Vol: Issue Pages:
Pub: 2014 Jun Epub: Authors D'Adamo Peter ,
Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. ✅ Go to Publication ✅
Molecular medicine reports (Mol Med Rep ) Vol: 15 Issue 5 Pages: 2765-2787
Pub: 2017 May Epub: 2017 Mar 14 Authors Xu JH , Liu XZ , Pan W , Zou DJ ,
Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. ✅ Go to Publication ✅
Molecular medicine reports (Mol Med Rep ) Vol: 15 Issue 5 Pages: 2765-2787
Pub: 2017 May Epub: 2017 Mar 14 Authors Xu JH , Liu XZ , Pan W , Zou DJ ,
Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. ✅ Go to Publication ✅
Molecular medicine reports (Mol Med Rep ) Vol: 15 Issue 5 Pages: 2765-2787
Pub: 2017 May Epub: 2017 Mar 14 Authors Xu JH , Liu XZ , Pan W , Zou DJ ,
Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. ✅ Go to Publication ✅
Molecular medicine reports (Mol Med Rep ) Vol: 15 Issue 5 Pages: 2765-2787
Pub: 2017 May Epub: 2017 Mar 14 Authors Xu JH , Liu XZ , Pan W , Zou DJ ,
Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. ✅ Go to Publication ✅
Molecular medicine reports (Mol Med Rep ) Vol: 15 Issue 5 Pages: 2765-2787
Pub: 2017 May Epub: 2017 Mar 14 Authors Xu JH , Liu XZ , Pan W , Zou DJ ,
Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats. ✅ Go to Publication ✅
PloS one (PLoS One ) Vol: 7 Issue 8 Pages: e42529
Pub: 2012 Epub: 2012 Aug 3 Authors Zhang X , Zhao Y , Zhang M , Pang X , Xu J , Kang C , Li M , Zhang C , Zhang Z , Zhang Y , Li X , Ning G , Zhao L ,
Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats. ✅ Go to Publication ✅
PloS one (PLoS One ) Vol: 7 Issue 8 Pages: e42529
Pub: 2012 Epub: 2012 Aug 3 Authors Zhang X , Zhao Y , Zhang M , Pang X , Xu J , Kang C , Li M , Zhang C , Zhang Z , Zhang Y , Li X , Ning G , Zhao L ,
Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats. ✅ Go to Publication ✅
PloS one (PLoS One ) Vol: 7 Issue 8 Pages: e42529
Pub: 2012 Epub: 2012 Aug 3 Authors Zhang X , Zhao Y , Zhang M , Pang X , Xu J , Kang C , Li M , Zhang C , Zhang Z , Zhang Y , Li X , Ning G , Zhao L ,
The Effects of Berberine on the Gut Microbiota in Apc <sup>min/+</sup> Mice Fed with a High Fat Diet. ✅
Molecules (Basel, Switzerland) (Molecules ) Vol: 23 Issue 9 Pages:
Pub: 2018 Sep 8 Epub: 2018 Sep 8 Authors Wang H , Guan L , Li J , Lai M , Wen X ,
Effect of Berberine on Atherosclerosis and Gut Microbiota Modulation and Their Correlation in High-Fat Diet-Fed ApoE-/- Mice. ✅ Go to Publication ✅
Frontiers in pharmacology (Front Pharmacol ) Vol: 11 Issue Pages: 223
Pub: 2020 Epub: 2020 Mar 13 Authors Wu M , Yang S , Wang S , Cao Y , Zhao R , Li X , Xing Y , Liu L ,
Effect of Berberine on Atherosclerosis and Gut Microbiota Modulation and Their Correlation in High-Fat Diet-Fed ApoE-/- Mice. ✅ Go to Publication ✅
Frontiers in pharmacology (Front Pharmacol ) Vol: 11 Issue Pages: 223
Pub: 2020 Epub: 2020 Mar 13 Authors Wu M , Yang S , Wang S , Cao Y , Zhao R , Li X , Xing Y , Liu L ,
Modulation of gut microbiota mediates berberine-induced expansion of immuno-suppressive cells to against alcoholic liver disease. ✅ Go to Publication ✅
Clinical and translational medicine (Clin Transl Med ) Vol: 10 Issue 4 Pages: e112
Pub: 2020 Aug Epub: 2020 Aug 13 Authors Li S , Wang N , Tan HY , Chueng F , Zhang ZJ , Yuen MF , Feng Y ,
Modulation of gut microbiota mediates berberine-induced expansion of immuno-suppressive cells to against alcoholic liver disease. ✅ Go to Publication ✅
Clinical and translational medicine (Clin Transl Med ) Vol: 10 Issue 4 Pages: e112
Pub: 2020 Aug Epub: 2020 Aug 13 Authors Li S , Wang N , Tan HY , Chueng F , Zhang ZJ , Yuen MF , Feng Y ,
Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome. ✅ Go to Publication ✅
NPJ biofilms and microbiomes (NPJ Biofilms Microbiomes ) Vol: 7 Issue 1 Pages: 36
Pub: 2021 Apr 16 Epub: 2021 Apr 16 Authors Li X , Su C , Jiang Z , Yang Y , Zhang Y , Yang M , Zhang X , Du Y , Zhang J , Wang L , Jiang J , Hong B ,
Effect of berberine on spleen transcriptome and gut microbiota composition in experimental autoimmune uveitis. ✅ Go to Publication ✅
International immunopharmacology (Int Immunopharmacol ) Vol: 81 Issue Pages: 106270
Pub: 2020 Apr Epub: 2020 Feb 7 Authors Du Z , Wang Q , Huang X , Yi S , Mei S , Yuan G , Su G , Cao Q , Zhou C , Wang Y , Kijlstra A , Yang P ,
Berberine ameliorates aGVHD by gut microbiota remodelling, TLR4 signalling suppression and colonic barrier repairment for NLRP3 inflammasome inhibition. ✅ Go to Publication ✅
Journal of cellular and molecular medicine (J Cell Mol Med ) Vol: 26 Issue 4 Pages: 1060-1070
Pub: 2022 Feb Epub: 2022 Jan 5 Authors Zhao Y , Huang J , Li T , Zhang S , Wen C , Wang L ,
Berberine ameliorates aGVHD by gut microbiota remodelling, TLR4 signalling suppression and colonic barrier repairment for NLRP3 inflammasome inhibition. ✅ Go to Publication ✅
Journal of cellular and molecular medicine (J Cell Mol Med ) Vol: 26 Issue 4 Pages: 1060-1070
Pub: 2022 Feb Epub: 2022 Jan 5 Authors Zhao Y , Huang J , Li T , Zhang S , Wen C , Wang L ,
Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study. ✅ Go to Publication ✅
Genome medicine (Genome Med ) Vol: 13 Issue 1 Pages: 125
Pub: 2021 Aug 9 Epub: 2021 Aug 9 Authors Ming J , Yu X , Xu X , Wang L , Ding C , Wang Z , Xie X , Li S , Yang W , Luo S , He Q , Du Y , Tian Z , Gao X , Ma K , Fang Y , Li C , Zhao J , Wang X , Ji Q ,
Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study. ✅ Go to Publication ✅
Genome medicine (Genome Med ) Vol: 13 Issue 1 Pages: 125
Pub: 2021 Aug 9 Epub: 2021 Aug 9 Authors Ming J , Yu X , Xu X , Wang L , Ding C , Wang Z , Xie X , Li S , Yang W , Luo S , He Q , Du Y , Tian Z , Gao X , Ma K , Fang Y , Li C , Zhao J , Wang X , Ji Q ,
Preventive effects of a nutraceutical mixture of berberine, citrus and apple extracts on metabolic disturbances in Zucker fatty rats. ✅ Go to Publication ✅
PloS one (PLoS One ) Vol: 19 Issue 7 Pages: e0306783
Pub: 2024 Epub: 2024 Jul 26 Authors Siliman Misha M , Destrumelle S , Le Jan D , Mansour NM , Fizanne L , Ouguerram K , Desfontis JC , Mallem MY ,
Berberine. ✅
Alternative medicine review : a journal of clinical therapeutic (Altern Med Rev ) Vol: 5 Issue 2 Pages: 175-7
Pub: 2000 Apr Epub: Authors
Berberine alleviates ETEC-induced intestinal inflammation and oxidative stress damage by optimizing intestinal microbial composition in a weaned piglet model. ✅ Go to Publication ✅
Frontiers in immunology (Front Immunol ) Vol: 15 Issue Pages: 1460127
Pub: 2024 Epub: 2024 Sep 16 Authors Wang Y , Zhang Z , Du M , Ji X , Liu X , Zhao C , Pang X , Jin E , Wen A , Li S , Zhang F ,
Berberine alleviates ETEC-induced intestinal inflammation and oxidative stress damage by optimizing intestinal microbial composition in a weaned piglet model. ✅ Go to Publication ✅
Frontiers in immunology (Front Immunol ) Vol: 15 Issue Pages: 1460127
Pub: 2024 Epub: 2024 Sep 16 Authors Wang Y , Zhang Z , Du M , Ji X , Liu X , Zhao C , Pang X , Jin E , Wen A , Li S , Zhang F ,
Berberine alleviates ETEC-induced intestinal inflammation and oxidative stress damage by optimizing intestinal microbial composition in a weaned piglet model. ✅ Go to Publication ✅
Frontiers in immunology (Front Immunol ) Vol: 15 Issue Pages: 1460127
Pub: 2024 Epub: 2024 Sep 16 Authors Wang Y , Zhang Z , Du M , Ji X , Liu X , Zhao C , Pang X , Jin E , Wen A , Li S , Zhang F ,
Berberine alleviates ischemia reperfusion injury induced AKI by regulation of intestinal microbiota and reducing intestinal inflammation. ✅ Go to Publication ✅
BMC complementary medicine and therapies (BMC Complement Med Ther ) Vol: 24 Issue 1 Pages: 66
Pub: 2024 Jan 30 Epub: 2024 Jan 30 Authors Huo A , Wang F ,
Berberine alleviates ischemia reperfusion injury induced AKI by regulation of intestinal microbiota and reducing intestinal inflammation. ✅ Go to Publication ✅
BMC complementary medicine and therapies (BMC Complement Med Ther ) Vol: 24 Issue 1 Pages: 66
Pub: 2024 Jan 30 Epub: 2024 Jan 30 Authors Huo A , Wang F ,
Berberine alleviates ischemia reperfusion injury induced AKI by regulation of intestinal microbiota and reducing intestinal inflammation. ✅ Go to Publication ✅
BMC complementary medicine and therapies (BMC Complement Med Ther ) Vol: 24 Issue 1 Pages: 66
Pub: 2024 Jan 30 Epub: 2024 Jan 30 Authors Huo A , Wang F ,
Berberine alleviates ischemia reperfusion injury induced AKI by regulation of intestinal microbiota and reducing intestinal inflammation. ✅ Go to Publication ✅
BMC complementary medicine and therapies (BMC Complement Med Ther ) Vol: 24 Issue 1 Pages: 66
Pub: 2024 Jan 30 Epub: 2024 Jan 30 Authors Huo A , Wang F ,
Berberine-microbiota interplay: orchestrating gut health through modulation of the gut microbiota and metabolic transformation into bioactive metabolites. ✅ Go to Publication ✅
Frontiers in pharmacology (Front Pharmacol ) Vol: 14 Issue Pages: 1281090
Pub: 2023 Epub: 2023 Dec 7 Authors Dehau T , Cherlet M , Croubels S , Van De Vliet M , Goossens E , Van Immerseel F ,
Berberine-microbiota interplay: orchestrating gut health through modulation of the gut microbiota and metabolic transformation into bioactive metabolites. ✅ Go to Publication ✅
Frontiers in pharmacology (Front Pharmacol ) Vol: 14 Issue Pages: 1281090
Pub: 2023 Epub: 2023 Dec 7 Authors Dehau T , Cherlet M , Croubels S , Van De Vliet M , Goossens E , Van Immerseel F ,
Berberine-microbiota interplay: orchestrating gut health through modulation of the gut microbiota and metabolic transformation into bioactive metabolites. ✅ Go to Publication ✅
Frontiers in pharmacology (Front Pharmacol ) Vol: 14 Issue Pages: 1281090
Pub: 2023 Epub: 2023 Dec 7 Authors Dehau T , Cherlet M , Croubels S , Van De Vliet M , Goossens E , Van Immerseel F ,
A High Dose of Dietary Berberine Improves Gut Wall Morphology, Despite an Expansion of Enterobacteriaceae and a Reduction in Beneficial Microbiota in Broiler Chickens. ✅ Go to Publication ✅
mSystems (mSystems ) Vol: 8 Issue 1 Pages: e0123922
Pub: 2023 Feb 23 Epub: 2023 Jan 31 Authors Dehau T , Cherlet M , Croubels S , van Immerseel F , Goossens E ,
A High Dose of Dietary Berberine Improves Gut Wall Morphology, Despite an Expansion of Enterobacteriaceae and a Reduction in Beneficial Microbiota in Broiler Chickens. ✅ Go to Publication ✅
mSystems (mSystems ) Vol: 8 Issue 1 Pages: e0123922
Pub: 2023 Feb 23 Epub: 2023 Jan 31 Authors Dehau T , Cherlet M , Croubels S , van Immerseel F , Goossens E ,
A High Dose of Dietary Berberine Improves Gut Wall Morphology, Despite an Expansion of Enterobacteriaceae and a Reduction in Beneficial Microbiota in Broiler Chickens. ✅ Go to Publication ✅
mSystems (mSystems ) Vol: 8 Issue 1 Pages: e0123922
Pub: 2023 Feb 23 Epub: 2023 Jan 31 Authors Dehau T , Cherlet M , Croubels S , van Immerseel F , Goossens E ,
Berberine inhibits Chlamydia pneumoniae infection-induced vascular smooth muscle cell migration through downregulating MMP3 and MMP9 via PI3K. ✅ Go to Publication ✅
European journal of pharmacology (Eur J Pharmacol ) Vol: 755 Issue Pages: 102-9
Pub: 2015 May 15 Epub: 2015 Mar 3 Authors Ma L , Zhang L , Wang B , Wei J , Liu J , Zhang L ,
The efficacy and underlying mechanisms of berberine in the treatment of recurrent Clostridioides difficile infection. ✅ Go to Publication ✅
International journal of antimicrobial agents (Int J Antimicrob Agents ) Vol: 65 Issue 5 Pages: 107468
Pub: 2025 Feb 20 Epub: 2025 Feb 20 Authors Wang L , Xu T , Wu S , Zhao C , Huang H ,

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