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Partial list of Citations used for Recommendations or Conditions

Recent additions may not be included but will usually appear in 24 hrs or less.

Rational Source
Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats. ✅ Go to Publication ✅
Scientific reports (Sci Rep ) Vol: 5 Issue Pages: 14405
Pub: 2015 Sep 23 Epub: 2015 Sep 23 Authors Zhang X , Zhao Y , Xu J , Xue Z , Zhang M , Pang X , Zhang X , Zhao L ,
Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats. ✅ Go to Publication ✅
Scientific reports (Sci Rep ) Vol: 5 Issue Pages: 14405
Pub: 2015 Sep 23 Epub: 2015 Sep 23 Authors Zhang X , Zhao Y , Xu J , Xue Z , Zhang M , Pang X , Zhang X , Zhao L ,
Antibacterial in vitro effects of preparations from Anthroposophical Medicine. ✅
BMC complementary and alternative medicine (BMC Complement Altern Med ) Vol: 16 Issue 1 Pages: 372
Pub: 2016 Sep 22 Epub: 2016 Sep 22 Authors Roser E , Gründemann C , Engels I , Huber R ,
Breaking the resistance of Escherichia coli: Antimicrobial activity of Berberis lycium Royle. ✅ Go to Publication ✅
Microbial pathogenesis (Microb Pathog ) Vol: 102 Issue Pages: 12-20
Pub: 2017 Jan Epub: 2016 Nov 23 Authors Malik TA , Kamili AN , Chishti MZ , Ahad S , Tantry MA , Hussain PR , Johri RK ,
Curated database of commensal, symbiotic and pathogenic microbiota ✅
Generative Bioinformatics (Center of Excellence in Generative Medicine ) Vol: Issue Pages:
Pub: 2014 Jun Epub: Authors D'Adamo Peter ,
Curated database of commensal, symbiotic and pathogenic microbiota ✅
Generative Bioinformatics (Center of Excellence in Generative Medicine ) Vol: Issue Pages:
Pub: 2014 Jun Epub: Authors D'Adamo Peter ,
Curated database of commensal, symbiotic and pathogenic microbiota ✅
Generative Bioinformatics (Center of Excellence in Generative Medicine ) Vol: Issue Pages:
Pub: 2014 Jun Epub: Authors D'Adamo Peter ,
Curated database of commensal, symbiotic and pathogenic microbiota ✅
Generative Bioinformatics (Center of Excellence in Generative Medicine ) Vol: Issue Pages:
Pub: 2014 Jun Epub: Authors D'Adamo Peter ,
Curated database of commensal, symbiotic and pathogenic microbiota ✅
Generative Bioinformatics (Center of Excellence in Generative Medicine ) Vol: Issue Pages:
Pub: 2014 Jun Epub: Authors D'Adamo Peter ,
Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. ✅ Go to Publication ✅
Molecular medicine reports (Mol Med Rep ) Vol: 15 Issue 5 Pages: 2765-2787
Pub: 2017 May Epub: 2017 Mar 14 Authors Xu JH , Liu XZ , Pan W , Zou DJ ,
Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. ✅ Go to Publication ✅
Molecular medicine reports (Mol Med Rep ) Vol: 15 Issue 5 Pages: 2765-2787
Pub: 2017 May Epub: 2017 Mar 14 Authors Xu JH , Liu XZ , Pan W , Zou DJ ,
Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. ✅ Go to Publication ✅
Molecular medicine reports (Mol Med Rep ) Vol: 15 Issue 5 Pages: 2765-2787
Pub: 2017 May Epub: 2017 Mar 14 Authors Xu JH , Liu XZ , Pan W , Zou DJ ,
Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. ✅ Go to Publication ✅
Molecular medicine reports (Mol Med Rep ) Vol: 15 Issue 5 Pages: 2765-2787
Pub: 2017 May Epub: 2017 Mar 14 Authors Xu JH , Liu XZ , Pan W , Zou DJ ,
Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. ✅ Go to Publication ✅
Molecular medicine reports (Mol Med Rep ) Vol: 15 Issue 5 Pages: 2765-2787
Pub: 2017 May Epub: 2017 Mar 14 Authors Xu JH , Liu XZ , Pan W , Zou DJ ,
Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. ✅ Go to Publication ✅
Molecular medicine reports (Mol Med Rep ) Vol: 15 Issue 5 Pages: 2765-2787
Pub: 2017 May Epub: 2017 Mar 14 Authors Xu JH , Liu XZ , Pan W , Zou DJ ,
Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. ✅ Go to Publication ✅
Molecular medicine reports (Mol Med Rep ) Vol: 15 Issue 5 Pages: 2765-2787
Pub: 2017 May Epub: 2017 Mar 14 Authors Xu JH , Liu XZ , Pan W , Zou DJ ,
Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. ✅ Go to Publication ✅
Molecular medicine reports (Mol Med Rep ) Vol: 15 Issue 5 Pages: 2765-2787
Pub: 2017 May Epub: 2017 Mar 14 Authors Xu JH , Liu XZ , Pan W , Zou DJ ,
Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats. ✅ Go to Publication ✅
PloS one (PLoS One ) Vol: 7 Issue 8 Pages: e42529
Pub: 2012 Epub: 2012 Aug 3 Authors Zhang X , Zhao Y , Zhang M , Pang X , Xu J , Kang C , Li M , Zhang C , Zhang Z , Zhang Y , Li X , Ning G , Zhao L ,
Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats. ✅ Go to Publication ✅
PloS one (PLoS One ) Vol: 7 Issue 8 Pages: e42529
Pub: 2012 Epub: 2012 Aug 3 Authors Zhang X , Zhao Y , Zhang M , Pang X , Xu J , Kang C , Li M , Zhang C , Zhang Z , Zhang Y , Li X , Ning G , Zhao L ,
Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats. ✅ Go to Publication ✅
PloS one (PLoS One ) Vol: 7 Issue 8 Pages: e42529
Pub: 2012 Epub: 2012 Aug 3 Authors Zhang X , Zhao Y , Zhang M , Pang X , Xu J , Kang C , Li M , Zhang C , Zhang Z , Zhang Y , Li X , Ning G , Zhao L ,
The Effects of Berberine on the Gut Microbiota in Apc <sup>min/+</sup> Mice Fed with a High Fat Diet. ✅
Molecules (Basel, Switzerland) (Molecules ) Vol: 23 Issue 9 Pages:
Pub: 2018 Sep 8 Epub: 2018 Sep 8 Authors Wang H , Guan L , Li J , Lai M , Wen X ,
Significant pharmacokinetic differences of berberine are attributable to variations in gut microbiota between Africans and Chinese. ✅ Go to Publication ✅
Scientific reports (Sci Rep ) Vol: 6 Issue Pages: 27671
Pub: 2016 Jun 10 Epub: 2016 Jun 10 Authors Alolga RN , Fan Y , Chen Z , Liu LW , Zhao YJ , Li J , Chen Y , Lai MD , Li P , Qi LW ,
Dietary prophage inducers and antimicrobials: toward landscaping the human gut microbiome. ✅ Go to Publication ✅
Gut microbes (Gut Microbes ) Vol: Issue Pages: 1-14
Pub: 2020 Jan 13 Epub: 2020 Jan 13 Authors Boling L , Cuevas DA , Grasis JA , Kang HS , Knowles B , Levi K , Maughan H , McNair K , Rojas MI , Sanchez SE , Smurthwaite C , Rohwer F ,
Berberine alters gut microbial function through modulation of bile acids. ✅ Go to Publication ✅
BMC microbiology (BMC Microbiol ) Vol: 21 Issue 1 Pages: 24
Pub: 2021 Jan 11 Epub: 2021 Jan 11 Authors Wolf PG , Devendran S , Doden HL , Ly LK , Moore T , Takei H , Nittono H , Murai T , Kurosawa T , Chlipala GE , Green SJ , Kakiyama G , Kashyap P , McCracken VJ , Gaskins HR , Gillevet PM , Ridlon JM ,
Effect of Berberine on Atherosclerosis and Gut Microbiota Modulation and Their Correlation in High-Fat Diet-Fed ApoE-/- Mice. ✅ Go to Publication ✅
Frontiers in pharmacology (Front Pharmacol ) Vol: 11 Issue Pages: 223
Pub: 2020 Epub: 2020 Mar 13 Authors Wu M , Yang S , Wang S , Cao Y , Zhao R , Li X , Xing Y , Liu L ,
Comparing the Influences of Metformin and Berberine on the Intestinal Microbiota of Rats With Nonalcoholic Steatohepatitis. ✅ Go to Publication ✅
In vivo (Athens, Greece) (In Vivo ) Vol: 37 Issue 5 Pages: 2105-2127
Pub: 2023 Sep-Oct Epub: Authors Chen D , Xiong J , Chen G , Zhang Z , Liu Y , Xu J , Xu H ,
Modulation of gut microbiota mediates berberine-induced expansion of immuno-suppressive cells to against alcoholic liver disease. ✅ Go to Publication ✅
Clinical and translational medicine (Clin Transl Med ) Vol: 10 Issue 4 Pages: e112
Pub: 2020 Aug Epub: 2020 Aug 13 Authors Li S , Wang N , Tan HY , Chueng F , Zhang ZJ , Yuen MF , Feng Y ,
Modulation of gut microbiota mediates berberine-induced expansion of immuno-suppressive cells to against alcoholic liver disease. ✅ Go to Publication ✅
Clinical and translational medicine (Clin Transl Med ) Vol: 10 Issue 4 Pages: e112
Pub: 2020 Aug Epub: 2020 Aug 13 Authors Li S , Wang N , Tan HY , Chueng F , Zhang ZJ , Yuen MF , Feng Y ,
Modulation of gut microbiota mediates berberine-induced expansion of immuno-suppressive cells to against alcoholic liver disease. ✅ Go to Publication ✅
Clinical and translational medicine (Clin Transl Med ) Vol: 10 Issue 4 Pages: e112
Pub: 2020 Aug Epub: 2020 Aug 13 Authors Li S , Wang N , Tan HY , Chueng F , Zhang ZJ , Yuen MF , Feng Y ,
Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome. ✅ Go to Publication ✅
NPJ biofilms and microbiomes (NPJ Biofilms Microbiomes ) Vol: 7 Issue 1 Pages: 36
Pub: 2021 Apr 16 Epub: 2021 Apr 16 Authors Li X , Su C , Jiang Z , Yang Y , Zhang Y , Yang M , Zhang X , Du Y , Zhang J , Wang L , Jiang J , Hong B ,
Effect of berberine on spleen transcriptome and gut microbiota composition in experimental autoimmune uveitis. ✅ Go to Publication ✅
International immunopharmacology (Int Immunopharmacol ) Vol: 81 Issue Pages: 106270
Pub: 2020 Apr Epub: 2020 Feb 7 Authors Du Z , Wang Q , Huang X , Yi S , Mei S , Yuan G , Su G , Cao Q , Zhou C , Wang Y , Kijlstra A , Yang P ,
Berberine ameliorates aGVHD by gut microbiota remodelling, TLR4 signalling suppression and colonic barrier repairment for NLRP3 inflammasome inhibition. ✅ Go to Publication ✅
Journal of cellular and molecular medicine (J Cell Mol Med ) Vol: 26 Issue 4 Pages: 1060-1070
Pub: 2022 Feb Epub: 2022 Jan 5 Authors Zhao Y , Huang J , Li T , Zhang S , Wen C , Wang L ,
Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study. ✅ Go to Publication ✅
Genome medicine (Genome Med ) Vol: 13 Issue 1 Pages: 125
Pub: 2021 Aug 9 Epub: 2021 Aug 9 Authors Ming J , Yu X , Xu X , Wang L , Ding C , Wang Z , Xie X , Li S , Yang W , Luo S , He Q , Du Y , Tian Z , Gao X , Ma K , Fang Y , Li C , Zhao J , Wang X , Ji Q ,
Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis). ✅ Go to Publication ✅
Journal of natural products (J Nat Prod ) Vol: 74 Issue 7 Pages: 1621-9
Pub: 2011 Jul 22 Epub: 2011 Jun 10 Authors Junio HA , Sy-Cordero AA , Ettefagh KA , Burns JT , Micko KT , Graf TN , Richter SJ , Cannon RE , Oberlies NH , Cech NB ,
Toxicology and carcinogenesis studies of goldenseal root powder (Hydrastis Canadensis) in F344/N rats and B6C3F1 mice (feed studies). ✅
National Toxicology Program technical report series (Natl Toxicol Program Tech Rep Ser ) Vol: Issue 562 Pages: 1-188
Pub: 2010 Aug Epub: Authors National Toxicology Program ,
Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition. ✅ Go to Publication ✅
Planta medica (Planta Med ) Vol: 77 Issue 8 Pages: 835-40
Pub: 2011 May Epub: 2010 Dec 14 Authors Ettefagh KA , Burns JT , Junio HA , Kaatz GW , Cech NB ,
Antibacterial activity of Hydrastis canadensis extract and its major isolated alkaloids. ✅
Planta medica (Planta Med ) Vol: 67 Issue 6 Pages: 561-4
Pub: 2001 Aug Epub: Authors Scazzocchio F , Cometa MF , Tomassini L , Palmery M ,
Antibacterial activity of Hydrastis canadensis extract and its major isolated alkaloids. ✅
Planta medica (Planta Med ) Vol: 67 Issue 6 Pages: 561-4
Pub: 2001 Aug Epub: Authors Scazzocchio F , Cometa MF , Tomassini L , Palmery M ,
Secondary Metabolites from the Leaves of the Medicinal Plant Goldenseal (Hydrastis canadensis). ✅ Go to Publication ✅
Phytochemistry letters (Phytochem Lett ) Vol: 20 Issue Pages: 54-60
Pub: 2017 Jun Epub: 2017 Apr 15 Authors Leyte-Lugo M , Britton ER , Foil DH , Brown AR , Todd DA , Rivera-Chávez J , Oberlies NH , Cech NB ,
Biochemometrics to Identify Synergists and Additives from Botanical Medicines: A Case Study with Hydrastis canadensis (Goldenseal). ✅ Go to Publication ✅
Journal of natural products (J Nat Prod ) Vol: 81 Issue 3 Pages: 484-493
Pub: 2018 Mar 23 Epub: 2017 Nov 1 Authors Britton ER , Kellogg JJ , Kvalheim OM , Cech NB ,

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