🍽️ tibolone,(prescription)

Menopausal Symptoms Relief: Tibolone is used to alleviate menopausal symptoms such as hot flashes, night sweats, vaginal dryness, and mood swings. It acts as an estrogenic, progestogenic, and androgenic agent, providing relief from these symptoms.

Prevention of Osteoporosis: Tibolone helps prevent bone loss and osteoporosis in postmenopausal women by exerting estrogen-like effects on bone density and metabolism. It can help reduce the risk of fractures associated with osteoporosis.

Improvement of Sexual Function: Tibolone may improve sexual function and libido in postmenopausal women by increasing vaginal lubrication and reducing discomfort during intercourse.

Cardiovascular Health: Tibolone has been shown to have neutral or beneficial effects on cardiovascular risk factors, such as lipid profiles and markers of inflammation, in postmenopausal women. However, its overall impact on cardiovascular health is still debated.

Endometrial Protection: Unlike estrogen-alone therapy, tibolone does not increase the risk of endometrial hyperplasia or cancer because of its progestogenic activity, which protects the endometrium.

Breast Health: Tibolone may have a neutral or slightly protective effect on breast tissue, reducing the risk of breast cancer compared to estrogen-alone therapy. However, its long-term effects on breast health require further investigation.

Liver Function: Tibolone is associated with a low risk of hepatotoxicity, but liver function should be monitored periodically during treatment, especially in women with pre-existing liver conditions.

Metabolic Effects: Tibolone may influence metabolic parameters such as insulin sensitivity and lipid metabolism. It may have variable effects on glucose tolerance and body weight in different individuals.

Mood and Cognition: Tibolone may have positive effects on mood, cognitive function, and quality of life in postmenopausal women. It may alleviate symptoms of depression and anxiety associated with menopause.

Thromboembolic Risk: Like other forms of hormone therapy, tibolone may increase the risk of thromboembolic events such as deep vein thrombosis (DVT) and pulmonary embolism, particularly in women with additional risk factors.

Uterine Bleeding: Irregular uterine bleeding or spotting may occur during the initial months of tibolone therapy, but it usually resolves with continued treatment.

Contraindications: Tibolone is contraindicated in women with a history of breast cancer, endometrial cancer, or thromboembolic disorders. It should be used with caution in women with liver dysfunction or cardiovascular risk factors.