🍽️ spironolactone,(prescription)

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Edema: Spironolactone is often prescribed to treat edema associated with conditions such as congestive heart failure, liver cirrhosis, and nephrotic syndrome. It works by reducing fluid accumulation in the body through its diuretic effect.
Hypertension: Spironolactone can help lower blood pressure by promoting the excretion of excess sodium and water while conserving potassium. It is sometimes used alone or in combination with other antihypertensive medications to manage hypertension.
Heart Failure: Spironolactone is used as an adjunctive treatment for heart failure to reduce symptoms and improve survival rates. It may be particularly beneficial in patients with severe heart failure or those who cannot tolerate angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs).
Hormonal Disorders: Spironolactone has antiandrogenic properties, meaning it blocks the effects of male hormones like testosterone. It is used off-label to treat hormonal disorders such as polycystic ovary syndrome (PCOS) and hirsutism (excessive hair growth) in women by reducing androgen levels.
Acne: Due to its antiandrogenic effects, spironolactone is sometimes prescribed off-label to treat acne in women, especially when hormonal factors contribute to the development of acne lesions.
Female Pattern Hair Loss: Spironolactone may also be used off-label to treat female pattern hair loss (androgenetic alopecia) by reducing the activity of androgens that contribute to hair thinning and loss.
Primary Aldosteronism: Spironolactone is effective in treating primary aldosteronism, a condition characterized by excessive production of aldosterone hormone by the adrenal glands. It helps reduce aldosterone levels and correct associated fluid and electrolyte imbalances.
Polycystic Kidney Disease: In some cases, spironolactone may be used to manage fluid retention associated with polycystic kidney disease (PKD), a genetic disorder characterized by the growth of fluid-filled cysts in the kidneys.
Electrolyte Imbalance: Spironolactone helps maintain electrolyte balance by sparing potassium while promoting the excretion of sodium and water. However, excessive potassium retention can occur in some individuals, especially those with kidney dysfunction or concurrent use of other potassium-sparing drugs.
Side Effects: Common side effects of spironolactone may include increased urination, dizziness, headache, gastrointestinal upset, breast tenderness or enlargement (gynecomastia) in men, irregular menstrual periods, and electrolyte imbalances. Rare but serious side effects may include hyperkalemia (high potassium levels), allergic reactions, and kidney dysfunction.

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Data Contradictions — Limits of Certainity

Impacted of spironolactone,(prescription) On Probiotics

Rank	Probiotic	Impact
genus	Bifidobacterium	Reduces
species	Bacteroides uniformis	Reduces
species	Bifidobacterium adolescentis	Reduces
species	Bifidobacterium longum	Reduces
species	Escherichia coli	Reduces
species	Parabacteroides distasonis	Reduces
subspecies	Bifidobacterium longum subsp. infantis	Reduces
subspecies	Bifidobacterium longum subsp. longum	Reduces

Bacteria Impacted by spironolactone,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations	👪👶 Indirect Citations	Taxonomy	Rank	Effect
0	1	Escherichia	genus	Decreases
0	1	Dorea	genus	Decreases
0	1	Roseburia	genus	Decreases
0	1	Parabacteroides	genus	Decreases
0	1	Bacteroides	genus	Decreases
0	1	Bifidobacterium	genus	Decreases
0	1	Bilophila	genus	Decreases
0	1	Clostridioides	genus	Decreases
0	1	Collinsella	genus	Decreases
0	1	Eggerthella	genus	Decreases
0	1	Fusobacterium	genus	Decreases
0	1	Lachnospira	genus	Decreases
0	1	Lacrimispora	genus	Decreases
0	1	Mediterraneibacter	genus	Decreases
0	1	Odoribacter	genus	Decreases
0	1	Phocaeicola	genus	Decreases
0	1	Streptococcus	genus	Decreases
0	1	Veillonella	genus	Decreases
0	1	Clostridium	genus	Decreases
0	1	Enterocloster	genus	Decreases
0	1	Blautia	genus	Decreases
0	1	Thomasclavelia	genus	Decreases
0	1	Escherichia coli O25:H16	no rank	Decreases
0	1	Clostridium perfringens A	no rank	Decreases
0	1	Clostridium perfringens C	no rank	Decreases
0	1	Clostridium perfringens CPE	no rank	Decreases
0	1	Escherichia coli O145:H34	no rank	Decreases
0	1	Escherichia coli O16:H48	no rank	Decreases
0	1	Clostridium perfringens D	no rank	Decreases
0	1	Escherichia coli O141:H4	no rank	Decreases
0	1	Clostridium perfringens B	no rank	Decreases
0	1	Escherichia coli O139:H1	no rank	Decreases
0	1	Clostridium perfringens E	no rank	Decreases
0	1	Escherichia coli O80:H26	no rank	Decreases
0	1	Escherichia coli O158:H23	no rank	Decreases
0	1	Escherichia coli O84:H7	no rank	Decreases
0	1	Escherichia coli O2:K1:H4	no rank	Decreases
0	1	Escherichia coli O2:K1:H7	no rank	Decreases
0	1	Escherichia coli O78:H51	no rank	Decreases
0	1	Escherichia coli O18ac:H14	no rank	Decreases
0	1	Escherichia coli O85:H1	no rank	Decreases
0	1	Escherichia coli O7:H15	no rank	Decreases
0	1	Escherichia coli O68:H12	no rank	Decreases
0	1	Escherichia coli O55:H7	no rank	Decreases
0	1	Escherichia coli O1:K1:H7	no rank	Decreases
0	1	Escherichia coli O15:H12	no rank	Decreases
0	1	Escherichia coli O170:H18	no rank	Decreases
0	1	Escherichia coli O155:H21	no rank	Decreases
0	1	Escherichia coli O19:H7	no rank	Decreases
0	1	Escherichia coli O2:K1:H5	no rank	Decreases
0	1	Escherichia coli O20:H12	no rank	Decreases
0	1	Escherichia coli O111	serogroup	Decreases
0	1	Escherichia coli O121	serogroup	Decreases
0	1	Escherichia coli O155	serogroup	Decreases
0	1	Escherichia coli O177	serogroup	Decreases
0	1	Escherichia coli O26	serogroup	Decreases
0	1	Escherichia coli O3	serogroup	Decreases
0	1	Escherichia coli O5	serogroup	Decreases
0	1	Escherichia coli O86	serogroup	Decreases
0	1	Escherichia coli O91	serogroup	Decreases
0	1	Escherichia coli O103	serogroup	Decreases
0	1	Escherichia coli O78	serogroup	Decreases
0	1	Escherichia coli O43	serogroup	Decreases
0	1	Escherichia coli O119	serogroup	Decreases
0	1	Escherichia coli O157	serogroup	Decreases
0	1	Escherichia coli O145	serogroup	Decreases
0	1	Escherichia coli O1:HNT	serotype	Decreases
0	1	Escherichia coli O10:K5(L):H4	serotype	Decreases
0	1	Escherichia coli O103:H11	serotype	Decreases
0	1	Escherichia coli O103:H25	serotype	Decreases
0	1	Escherichia coli O104:H21	serotype	Decreases
0	1	Escherichia coli O111:H11	serotype	Decreases
0	1	Escherichia coli O111:H8	serotype	Decreases
0	1	Escherichia coli O112ac:H19	serotype	Decreases
0	1	Escherichia coli O114:H49	serotype	Decreases
0	1	Escherichia coli O118:H16	serotype	Decreases
0	1	Escherichia coli O121:H7	serotype	Decreases
0	1	Escherichia coli O123:H11	serotype	Decreases
0	1	Escherichia coli O127:H27	serotype	Decreases
0	1	Escherichia coli O127:H6	serotype	Decreases
0	1	Escherichia coli O128:H2	serotype	Decreases
0	1	Escherichia coli O128ac:H12	serotype	Decreases
0	1	Escherichia coli O145:H25	serotype	Decreases
0	1	Escherichia coli O145:NM	serotype	Decreases
0	1	Escherichia coli O146:H21	serotype	Decreases
0	1	Escherichia coli O153:H2	serotype	Decreases
0	1	Escherichia coli O156:H25	serotype	Decreases
0	1	Escherichia coli O157:H43	serotype	Decreases
0	1	Escherichia coli O157:NM	serotype	Decreases
0	1	Escherichia coli O165:H25	serotype	Decreases
0	1	Escherichia coli O174:H2	serotype	Decreases
0	1	Escherichia coli O174:H21	serotype	Decreases
0	1	Escherichia coli O174:H8	serotype	Decreases
0	1	Escherichia coli O176:H45	serotype	Decreases
0	1	Escherichia coli O177:NM	serotype	Decreases
0	1	Escherichia coli O26:H1	serotype	Decreases
0	1	Escherichia coli O28ac:NM	serotype	Decreases
0	1	Escherichia coli O29:H4	serotype	Decreases
0	1	Escherichia coli O32:H37	serotype	Decreases
0	1	Escherichia coli O6:H16:CFA/II	serotype	Decreases
0	1	Escherichia coli O69:H11	serotype	Decreases
0	1	Escherichia coli O78:H12	serotype	Decreases
0	1	Escherichia coli O79:H7	serotype	Decreases
0	1	Escherichia coli O81:NM	serotype	Decreases
0	1	Escherichia coli O86:H34	serotype	Decreases
0	1	Escherichia coli O91:H14	serotype	Decreases
0	1	Escherichia coli O91:NM	serotype	Decreases
0	1	Escherichia coli ONT:H33	serotype	Decreases
0	1	Escherichia coli O100:H21	serotype	Decreases
0	1	Escherichia coli O121:H19	serotype	Decreases
0	1	Escherichia coli O157:H7	serotype	Decreases
0	1	Escherichia coli O16:H6	serotype	Decreases
0	1	Escherichia coli O89m:H9	serotype	Decreases
0	1	Escherichia coli O111:H-	serotype	Decreases
0	1	Escherichia coli O113:H21	serotype	Decreases
0	1	Escherichia coli H20	serotype	Decreases
0	1	Escherichia coli O150:H6	serotype	Decreases
0	1	Escherichia coli O111:NM	serotype	Decreases
0	1	Escherichia coli O112ab:H8	serotype	Decreases
0	1	Escherichia coli O99:H6	serotype	Decreases
0	1	Escherichia coli O26:H11	serotype	Decreases
0	1	Escherichia coli O145:H28	serotype	Decreases
0	1	Escherichia coli O126:H45	serotype	Decreases
0	1	Escherichia coli O2:H6	serotype	Decreases
0	1	Escherichia coli O7:H4	serotype	Decreases
0	1	Escherichia coli O1:H42	serotype	Decreases
0	1	Escherichia coli O25:NM	serotype	Decreases
0	1	Escherichia coli O25:H1	serotype	Decreases
0	1	Escherichia coli O7:K1	serotype	Decreases
0	1	Escherichia coli O125ac:K+:H10	serotype	Decreases
0	1	Escherichia coli O6:K2:H1	serotype	Decreases
0	1	Escherichia coli O152:H23	serotype	Decreases
0	1	Escherichia coli O15:H18	serotype	Decreases
0	1	Escherichia coli O39:NM	serotype	Decreases
0	1	Escherichia coli O44:H18	serotype	Decreases
0	1	Escherichia coli O2:K2:H1	serotype	Decreases
0	1	Escherichia coli O8:H8	serotype	Decreases
0	1	Escherichia coli O89m:H10	serotype	Decreases
0	1	Escherichia coli O10:H32	serotype	Decreases
0	1	Escherichia coli O6:H16	serotype	Decreases
0	1	Escherichia coli O157:H-	serotype	Decreases
0	1	Escherichia coli O45:H2	serotype	Decreases
0	1	Escherichia coli O103:H2	serotype	Decreases
0	1	Escherichia coli O167:H26	serotype	Decreases
0	1	Escherichia coli O104:H4	serotype	Decreases
0	1	Escherichia coli O83:H1	serotype	Decreases
0	1	Escherichia coli O9:H10	serotype	Decreases
0	1	Escherichia coli O78:H4	serotype	Decreases
0	1	Escherichia coli O139:H28	serotype	Decreases
1	0	Clostridium perfringens	species	Decreases
1	0	Bacteroides thetaiotaomicron	species	Decreases
1	0	Bifidobacterium adolescentis	species	Decreases
1	0	Blautia obeum	species	Decreases
1	0	Clostridioides difficile	species	Decreases
1	0	Fusobacterium nucleatum	species	Decreases
1	0	Roseburia intestinalis	species	Decreases
1	0	Streptococcus parasanguinis	species	Decreases
1	0	Thomasclavelia ramosa	species	Decreases
1	0	Streptococcus salivarius	species	Decreases
1	0	Bacteroides ovatus	species	Decreases
1	0	Escherichia coli	species	Decreases
1	0	Odoribacter splanchnicus	species	Decreases
1	0	Dorea formicigenerans	species	Decreases
1	0	Bifidobacterium longum	species	Decreases
1	0	Enterocloster bolteae	species	Decreases
1	0	Veillonella parvula	species	Decreases
1	0	Roseburia hominis	species	Decreases
1	0	Parabacteroides distasonis	species	Decreases
1	0	Collinsella aerofaciens	species	Decreases
1	0	Parabacteroides merdae	species	Decreases
1	0	Phocaeicola vulgatus	species	Decreases
1	0	Bacteroides uniformis	species	Decreases
1	0	Mediterraneibacter gnavus	species	Decreases
1	0	Bacteroides fragilis	species	Decreases
1	0	[Ruminococcus] torques	species	Decreases
1	0	Bacteroides caccae	species	Decreases
1	0	Bacteroides xylanisolvens	species	Decreases
1	0	Bilophila wadsworthia	species	Decreases
1	0	Lacrimispora saccharolytica	species	Decreases
1	0	Eggerthella lenta	species	Decreases
1	0	Lachnospira eligens	species	Decreases
0	1	Bifidobacterium longum subsp. longum	subspecies	Decreases
0	1	Bifidobacterium longum subsp. infantis	subspecies	Decreases
0	1	Bifidobacterium longum subsp. suis	subspecies	Decreases
0	1	Fusobacterium nucleatum subsp. nucleatum	subspecies	Decreases
0	1	Bifidobacterium longum subsp. suillum	subspecies	Decreases

Impact of spironolactone,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition	Positive Impact	Negative Impact	Benefit Ratio Impact
Abdominal Aortic Aneurysm	0.9		0.9
Acne		0.3	-0.3
ADHD	4.1	0.3	12.67
Age-Related Macular Degeneration and Glaucoma	1.1	0.4	1.75
Allergic Rhinitis (Hay Fever)	3	2.8	0.07
Allergies	5.9	1.7	2.47
Allergy to milk products	1.3	1.6	-0.23
Alopecia (Hair Loss)	1.5		1.5
Alzheimer's disease	5.4	5.1	0.06
Amyotrophic lateral sclerosis (ALS) Motor Neuron	2	0.6	2.33
Ankylosing spondylitis	4	1.1	2.64
Anorexia Nervosa	1.3	2.3	-0.77
Antiphospholipid syndrome (APS)	2.1	0.3	6
Asthma	5.4	2.3	1.35
Atherosclerosis	1.9	1.9	0
Atrial fibrillation	2.8	1.9	0.47
Autism	7.6	7.5	0.01
Autoimmune Disease	1.2	1	0.2
Barrett esophagus cancer	0.6	0.3	1
benign prostatic hyperplasia	0.6	0.3	1
Biofilm	2.6		2.6
Bipolar Disorder	2.1	1.1	0.91
Brain Trauma	0.9	1.1	-0.22
Breast Cancer	1.2		1.2
Cancer (General)	0.9	2.3	-1.56
Carcinoma	4.6	2.3	1
Celiac Disease	2.9	3.4	-0.17
Cerebral Palsy	1.4	1	0.4
Chronic Fatigue Syndrome	4.3	4.7	-0.09
Chronic Kidney Disease	4	1.6	1.5
Chronic Lyme	0.6	0.8	-0.33
Chronic Obstructive Pulmonary Disease (COPD)	2.6	1.7	0.53
Chronic Urticaria (Hives)	1.9	0.2	8.5
Coagulation / Micro clot triggering bacteria	1.9	1	0.9
Cognitive Function	2.2	1.6	0.38
Colorectal Cancer	6.8	2.5	1.72
Constipation	1.5	0.7	1.14
Coronary artery disease	2	1.8	0.11
COVID-19	9.4	9	0.04
Crohn's Disease	7.8	3.7	1.11
Cushing's Syndrome (hypercortisolism)		0.6	-0.6
cystic fibrosis	1.1	1.9	-0.73
d-lactic acidosis (one form of brain fog)	0.6		0.6
deep vein thrombosis	2	1.1	0.82
Denture Wearers Oral Shifts	2		2
Depression	9.5	6.6	0.44
Dermatomyositis	0.3	0.3	0
Eczema	1.9	2.2	-0.16
Endometriosis	3.2	2	0.6
Eosinophilic Esophagitis	0.3	0.6	-1
Epilepsy	3.6	1.5	1.4
erectile dysfunction	1.4	0.3	3.67
Fibromyalgia	3.4	1.1	2.09
Functional constipation / chronic idiopathic constipation	5.4	2.5	1.16
gallstone disease (gsd)	3.2	1.1	1.91
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	1.7	1.2	0.42
Generalized anxiety disorder	2.7	1.6	0.69
giant cell arteritis		0.2	-0.2
Glioblastoma		0.3	-0.3
Gout	0.9	0.2	3.5
Graves' disease	1.6	2.7	-0.69
Gulf War Syndrome	0.6	1.1	-0.83
Halitosis	1.8	0.3	5
Hashimoto's thyroiditis	2.9	1.4	1.07
Heart Failure	3.8	1	2.8
hemorrhagic stroke	1.3		1.3
Hidradenitis Suppurativa	1.4	0.3	3.67
High Histamine/low DAO	2	0.3	5.67
hypercholesterolemia (High Cholesterol)	1		1
hyperglycemia	2.2	1.1	1
Hyperlipidemia (High Blood Fats)	0.9	0.3	2
hypersomnia		0.7	-0.7
hypertension (High Blood Pressure	3.8	4.6	-0.21
Hypothyroidism		0.7	-0.7
Hypoxia	3.6	0.3	11
IgA nephropathy (IgAN)	1.6	3.6	-1.25
Inflammatory Bowel Disease	8.7	7	0.24
Insomnia	2.1	1.8	0.17
Intelligence	1.4		1.4
Intracranial aneurysms	1.1	0.3	2.67
Irritable Bowel Syndrome	6.8	4.1	0.66
ischemic stroke	2.8	1.4	1
Liver Cirrhosis	7.1	3.6	0.97
Long COVID	6.2	6.5	-0.05
Low bone mineral density		0.8	-0.8
Lung Cancer	1.1	0.7	0.57
Lymphoma	0.6		0.6
Mast Cell Issues / mastitis	1.5	0.3	4
ME/CFS with IBS	1	1.7	-0.7
ME/CFS without IBS	1	2.1	-1.1
membranous nephropathy	0.3		0.3
Menopause	1.9	0.5	2.8
Metabolic Syndrome	6.6	6.7	-0.02
Mood Disorders	9.1	5.2	0.75
multiple chemical sensitivity [MCS]	1.1	0.1	10
Multiple Sclerosis	6.5	4.1	0.59
Multiple system atrophy (MSA)	1.1	0.4	1.75
myasthenia gravis	0.9	0.7	0.29
neuropathic pain	0.3	2.9	-8.67
Neuropathy (all types)	0.7	2.1	-2
neuropsychiatric disorders (PANDAS, PANS)	1.1		1.1
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	5.5	3.5	0.57
NonCeliac Gluten Sensitivity	1.3	0.6	1.17
Obesity	8.3	6.9	0.2
obsessive-compulsive disorder	5.4	2.3	1.35
Osteoarthritis	2.7	0.9	2
Osteoporosis	2.2	1.3	0.69
pancreatic cancer	1.2	0.3	3
Parkinson's Disease	7	5.3	0.32
Polycystic ovary syndrome	5.3	2.3	1.3
Postural orthostatic tachycardia syndrome	0.2	0.3	-0.5
Premenstrual dysphoric disorder	0.7	0.4	0.75
primary biliary cholangitis	1.2	1.4	-0.17
Primary sclerosing cholangitis	2.9	2.1	0.38
Psoriasis	2.9	1.7	0.71
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	6.6	3.4	0.94
Rosacea	0.5	0.7	-0.4
Schizophrenia	6.2	2.5	1.48
scoliosis	0.6	0.3	1
Sjögren syndrome	2.5	2.6	-0.04
Sleep Apnea	1.6	1.3	0.23
Slow gastric motility / Gastroparesis	1.1	0.3	2.67
Small Intestinal Bacterial Overgrowth (SIBO)	1.9	0.5	2.8
Stress / posttraumatic stress disorder	3.2	1.9	0.68
Systemic Lupus Erythematosus	3.8	1.6	1.37
Tic Disorder	0.9	1.2	-0.33
Tourette syndrome	0.9	0.3	2
Type 1 Diabetes	3.2	3.7	-0.16
Type 2 Diabetes	7.4	6.4	0.16
Ulcerative colitis	6.4	5.5	0.16
Unhealthy Ageing	5	1.6	2.13
Vitiligo	1.8	0.9	1

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