AI Engines For more Details: Perplexity Kagi Labs You
Headache: Headache is a common side effect of isosorbide mononitrate therapy, especially when initiating treatment or increasing the dosage. It is usually transient and may improve over time.
Hypotension: Isosorbide mononitrate can cause low blood pressure, leading to symptoms such as dizziness, lightheadedness, and fainting, particularly when standing up quickly from a sitting or lying position.
Tolerance: Prolonged use of isosorbide mononitrate may lead to the development of tolerance, necessitating dose adjustments or medication rotation to maintain its effectiveness in preventing angina.
Reflex Tachycardia: Isosorbide mononitrate-induced vasodilation can trigger reflex tachycardia (rapid heart rate) as the body attempts to compensate for decreased blood pressure. This effect may be more pronounced in individuals with preexisting cardiovascular conditions.
Interaction with Phosphodiesterase-5 Inhibitors: Concurrent use of isosorbide mononitrate with phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil) or riociguat can potentiate the hypotensive effects and increase the risk of adverse cardiovascular events.
Nitrate Tolerance: Long-term use of nitrates, including isosorbide mononitrate, may lead to the development of nitrate tolerance, requiring intermittent drug-free periods or dose adjustments to maintain efficacy.
Contraindications: Isosorbide mononitrate is contraindicated in individuals with severe hypotension, severe anemia, increased intracranial pressure, or those who have recently taken phosphodiesterase-5 inhibitors or riociguat due to the risk of severe hypotension and cardiovascular collapse.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Lacticaseibacillus paracasei | Reduces |
| species | Parabacteroides distasonis | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
| 📓 Direct Citations | 👪👶 Indirect Citations | Taxonomy | Rank | Effect |
|---|---|---|---|---|
| 0 | 1 | Ruminococcus | genus | Decreases |
| 0 | 1 | Lacrimispora | genus | Decreases |
| 0 | 1 | Parabacteroides | genus | Decreases |
| 0 | 1 | Lacticaseibacillus | genus | Decreases |
| 0 | 1 | Enterocloster | genus | Decreases |
| 0 | 1 | Streptococcus | genus | Decreases |
| 0 | 1 | Roseburia | genus | Decreases |
| 0 | 1 | Bilophila | genus | Decreases |
| 1 | 0 | Ruminococcus bromii | species | Decreases |
| 1 | 0 | Lacrimispora saccharolytica | species | Decreases |
| 1 | 0 | Parabacteroides distasonis | species | Decreases |
| 1 | 0 | Lacticaseibacillus paracasei | species | Decreases |
| 1 | 0 | Enterocloster bolteae | species | Decreases |
| 1 | 0 | Streptococcus parasanguinis | species | Decreases |
| 1 | 0 | Roseburia hominis | species | Decreases |
| 1 | 0 | Bilophila wadsworthia | species | Decreases |
| 0 | 1 | Lacticaseibacillus paracasei subsp. paracasei | subspecies | Decreases |
| 0 | 1 | Lacticaseibacillus paracasei subsp. tolerans | subspecies | Decreases |
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Abdominal Aortic Aneurysm | 0 | 0 | |
| ADHD | 0.7 | 0.7 | |
| Age-Related Macular Degeneration and Glaucoma | 0 | 0.1 | 0 |
| Allergic Rhinitis (Hay Fever) | 0.2 | 0.2 | 0 |
| Allergies | 0.6 | 1.1 | -0.83 |
| Allergy to milk products | 0.5 | 0.1 | 4 |
| Alopecia (Hair Loss) | 0.3 | 0.3 | |
| Alzheimer's disease | 0.7 | 0.7 | 0 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 0.5 | -0.5 | |
| Ankylosing spondylitis | 0.4 | 0.5 | -0.25 |
| Anorexia Nervosa | 0.7 | 0.6 | 0.17 |
| Antiphospholipid syndrome (APS) | 0.1 | 0 | 0 |
| Asthma | 0.1 | 0.1 | 0 |
| Atherosclerosis | 0.5 | 0 | 0 |
| Atrial fibrillation | 0.7 | 0.2 | 2.5 |
| Autism | 0.9 | 1.1 | -0.22 |
| Autoimmune Disease | 0.1 | 0 | 0 |
| Barrett esophagus cancer | 0.1 | -0.1 | |
| Biofilm | 0.2 | 0.2 | |
| Bipolar Disorder | 0.7 | 0.5 | 0.4 |
| Brain Trauma | 0.1 | 0.5 | -4 |
| Cancer (General) | 0.3 | -0.3 | |
| Carcinoma | 0.7 | 0.6 | 0.17 |
| Celiac Disease | 0.1 | 0.7 | -6 |
| Cerebral Palsy | 0.1 | 0.5 | -4 |
| Chronic Fatigue Syndrome | 1.5 | 0.9 | 0.67 |
| Chronic Kidney Disease | 0.1 | 0.1 | 0 |
| Chronic Lyme | 0 | 0 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 0.2 | 0.1 | 1 |
| Chronic Urticaria (Hives) | 0.1 | 0.1 | |
| Coagulation / Micro clot triggering bacteria | 0.2 | 0.6 | -2 |
| Cognitive Function | 0.7 | 0.1 | 6 |
| Colorectal Cancer | 0.9 | 0 | 0 |
| Constipation | 0.5 | 0 | 0 |
| Coronary artery disease | 0.6 | 0 | 0 |
| COVID-19 | 0.7 | 1.2 | -0.71 |
| Crohn's Disease | 1.1 | 0.7 | 0.57 |
| cystic fibrosis | 0 | 0 | |
| deep vein thrombosis | 0.6 | -0.6 | |
| Denture Wearers Oral Shifts | 0.1 | 0.1 | |
| Depression | 1.6 | 1.1 | 0.45 |
| Dermatomyositis | 0.1 | 0.1 | |
| Eczema | 0.1 | 0.1 | 0 |
| Endometriosis | 0.2 | 0.5 | -1.5 |
| Eosinophilic Esophagitis | 0.1 | -0.1 | |
| Epilepsy | 0.1 | 0.1 | 0 |
| Fibromyalgia | 0.2 | 0.2 | |
| Functional constipation / chronic idiopathic constipation | 0.7 | 0.7 | 0 |
| gallstone disease (gsd) | 0.6 | 0 | 0 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.1 | -0.1 | |
| Generalized anxiety disorder | 0.1 | 0.1 | 0 |
| Glioblastoma | 0.1 | -0.1 | |
| Gout | 0.6 | 0.6 | |
| Graves' disease | 0.6 | 0.6 | 0 |
| Gulf War Syndrome | 0.1 | 0.1 | |
| Halitosis | 0.1 | 0.1 | 0 |
| Hashimoto's thyroiditis | 0.5 | 0 | 0 |
| Heart Failure | 0.7 | 0.5 | 0.4 |
| hemorrhagic stroke | 0.1 | 0.1 | |
| Hidradenitis Suppurativa | 0.1 | 0.1 | |
| High Histamine/low DAO | 0 | 0.5 | 0 |
| hyperglycemia | 0.1 | -0.1 | |
| Hyperlipidemia (High Blood Fats) | 0 | 0 | |
| hypersomnia | 0 | 0 | |
| hypertension (High Blood Pressure | 0.7 | 0.7 | 0 |
| Hypoxia | 0.1 | 0.1 | |
| IgA nephropathy (IgAN) | 0.7 | 0 | 0 |
| Inflammatory Bowel Disease | 0.3 | 1.6 | -4.33 |
| Insomnia | 0.1 | 0.6 | -5 |
| Intracranial aneurysms | 0.6 | 0.6 | |
| Irritable Bowel Syndrome | 0.6 | 0.7 | -0.17 |
| ischemic stroke | 0.7 | 0 | 0 |
| Liver Cirrhosis | 0.9 | 0.6 | 0.5 |
| Long COVID | 0.4 | 1.3 | -2.25 |
| Low bone mineral density | 0 | 0 | |
| Lung Cancer | 0 | 0.5 | 0 |
| Mast Cell Issues / mastitis | 0.1 | 0.5 | -4 |
| ME/CFS with IBS | 0.2 | 0.2 | |
| ME/CFS without IBS | 0.1 | 0.3 | -2 |
| membranous nephropathy | 0.1 | 0.1 | |
| Menopause | 0.1 | 0 | 0 |
| Metabolic Syndrome | 0.8 | 0.9 | -0.13 |
| Mood Disorders | 1.6 | 1 | 0.6 |
| multiple chemical sensitivity [MCS] | 0.1 | 0.1 | |
| Multiple Sclerosis | 0.9 | 1 | -0.11 |
| Multiple system atrophy (MSA) | 0.2 | 0.5 | -1.5 |
| myasthenia gravis | 0.1 | 0 | 0 |
| neuropathic pain | 0.3 | -0.3 | |
| Neuropathy (all types) | 0.1 | 0.2 | -1 |
| neuropsychiatric disorders (PANDAS, PANS) | 0.1 | 0.1 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 0.6 | 0.5 | 0.2 |
| Obesity | 0.9 | 1 | -0.11 |
| obsessive-compulsive disorder | 0.8 | 0.1 | 7 |
| Osteoarthritis | 0.1 | 0.6 | -5 |
| Osteoporosis | 0.5 | 0.1 | 4 |
| pancreatic cancer | 0.1 | 0.1 | 0 |
| Parkinson's Disease | 0.9 | 1.2 | -0.33 |
| Polycystic ovary syndrome | 1.6 | 1.2 | 0.33 |
| Premenstrual dysphoric disorder | 0.1 | -0.1 | |
| primary biliary cholangitis | 0.1 | 0.1 | 0 |
| Primary sclerosing cholangitis | 0.3 | 0.9 | -2 |
| Psoriasis | 0.6 | 0.5 | 0.2 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 1.4 | 0 | 0 |
| Rosacea | 0.5 | 0 | 0 |
| Schizophrenia | 0.7 | 0.7 | 0 |
| scoliosis | 0.5 | -0.5 | |
| Sjögren syndrome | 0.2 | 0.1 | 1 |
| Sleep Apnea | 0.5 | 0 | 0 |
| Slow gastric motility / Gastroparesis | 0.5 | 0.5 | |
| Small Intestinal Bacterial Overgrowth (SIBO) | 0.1 | 0.1 | |
| Stress / posttraumatic stress disorder | 0.2 | 0.2 | 0 |
| Systemic Lupus Erythematosus | 0.2 | 1.1 | -4.5 |
| Tic Disorder | 0.6 | 0.6 | |
| Tourette syndrome | 0.1 | 0.1 | |
| Type 1 Diabetes | 0.6 | 0.6 | 0 |
| Type 2 Diabetes | 0.9 | 0.9 | 0 |
| Ulcerative colitis | 0.3 | 0.8 | -1.67 |
| Unhealthy Ageing | 0.3 | 0.2 | 0.5 |
| Vitiligo | 0.7 | 0.1 | 6 |
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