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🍽️ phenylbutazone,(prescription)

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  1. Anti-inflammatory: Phenylbutazone exerts its therapeutic effects by inhibiting the production of prostaglandins, which are substances involved in inflammation and pain. It helps reduce pain, swelling, and inflammation associated with various musculoskeletal disorders.

  2. Analgesic: Phenylbutazone has analgesic properties, providing relief from pain associated with inflammatory conditions such as arthritis and gout.

  3. Antipyretic: Like other NSAIDs, phenylbutazone can help reduce fever by inhibiting prostaglandin synthesis in the brain's hypothalamus, which regulates body temperature.

  4. Musculoskeletal Disorders: Phenylbutazone has been used to treat conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and gout. It helps alleviate pain, stiffness, and swelling associated with these disorders.

  5. Equine Use: Phenylbutazone has been widely used in horses for the treatment of musculoskeletal injuries and lameness. It is often administered orally or intravenously in equine medicine.

  6. Adverse Gastrointestinal Effects: Like other NSAIDs, phenylbutazone can cause gastrointestinal adverse effects, including stomach ulcers, gastritis, gastrointestinal bleeding, and perforation. These effects can be severe and may lead to complications such as gastrointestinal hemorrhage or perforation.

  7. Cardiovascular Effects: Phenylbutazone may increase the risk of cardiovascular events, including heart attack and stroke, particularly with long-term use or in individuals with pre-existing cardiovascular disease.

  8. Renal Effects: Phenylbutazone can impair kidney function and may cause kidney damage, particularly in individuals with pre-existing kidney disease or those at risk of renal impairment.

  9. Hematological Effects: Phenylbutazone can suppress bone marrow function, leading to decreased production of blood cells (anemia, leukopenia, and thrombocytopenia).

  10. Hypersensitivity Reactions: Some individuals may experience allergic reactions to phenylbutazone, ranging from mild skin rash to severe anaphylaxis.

  11. Hepatic Effects: Phenylbutazone has been associated with liver toxicity and may cause liver damage, particularly with long-term use or in individuals with pre-existing liver disease.

  12. Skin Reactions: Phenylbutazone can cause adverse skin reactions, including rash, itching, photosensitivity, and Stevens-Johnson syndrome (a severe skin reaction).

  13. Central Nervous System Effects: Phenylbutazone may cause central nervous system side effects such as headache, dizziness, drowsiness, and confusion.

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⚗️ Compensation for antibiotic usage

Data Contradictions — Limits of Certainity

Impacted of phenylbutazone,(prescription) On Probiotics

Rank Probiotic Impact
genus Bifidobacterium Reduces
species Bifidobacterium adolescentis Reduces
species Escherichia coli Reduces
species Lacticaseibacillus paracasei Reduces
species Parabacteroides distasonis Reduces

Bacteria Impacted by phenylbutazone,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Chromobacteriaceae family Decreases
0 1 Escherichia genus Decreases
0 1 Roseburia genus Decreases
1 0 Chromobacterium genus Decreases
0 1 Parabacteroides genus Decreases
0 1 Agathobacter genus Decreases
0 1 Bacteroides genus Decreases
0 1 Bifidobacterium genus Decreases
0 1 Collinsella genus Decreases
0 1 Eggerthella genus Decreases
0 1 Streptococcus genus Decreases
0 1 Clostridium genus Decreases
0 1 Segatella genus Decreases
0 1 Enterocloster genus Decreases
0 1 Lacticaseibacillus genus Decreases
0 1 Escherichia coli O25:H16 no rank Decreases
0 1 Clostridium perfringens A no rank Decreases
0 1 Clostridium perfringens C no rank Decreases
0 1 Clostridium perfringens CPE no rank Decreases
0 1 Escherichia coli O145:H34 no rank Decreases
0 1 Escherichia coli O16:H48 no rank Decreases
0 1 unclassified Chromobacterium no rank Decreases
0 1 Clostridium perfringens D no rank Decreases
0 1 Escherichia coli O141:H4 no rank Decreases
0 1 Clostridium perfringens B no rank Decreases
0 1 Escherichia coli O139:H1 no rank Decreases
0 1 Clostridium perfringens E no rank Decreases
0 1 Escherichia coli O80:H26 no rank Decreases
0 1 Escherichia coli O158:H23 no rank Decreases
0 1 Escherichia coli O84:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H4 no rank Decreases
0 1 Escherichia coli O2:K1:H7 no rank Decreases
0 1 Escherichia coli O78:H51 no rank Decreases
0 1 Escherichia coli O18ac:H14 no rank Decreases
0 1 Escherichia coli O85:H1 no rank Decreases
0 1 Escherichia coli O7:H15 no rank Decreases
0 1 Escherichia coli O68:H12 no rank Decreases
0 1 Escherichia coli O55:H7 no rank Decreases
0 1 Escherichia coli O1:K1:H7 no rank Decreases
0 1 Escherichia coli O15:H12 no rank Decreases
0 1 Escherichia coli O170:H18 no rank Decreases
0 1 Escherichia coli O155:H21 no rank Decreases
0 1 Escherichia coli O19:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H5 no rank Decreases
0 1 Escherichia coli O20:H12 no rank Decreases
0 1 Escherichia coli O111 serogroup Decreases
0 1 Escherichia coli O121 serogroup Decreases
0 1 Escherichia coli O155 serogroup Decreases
0 1 Escherichia coli O177 serogroup Decreases
0 1 Escherichia coli O26 serogroup Decreases
0 1 Escherichia coli O3 serogroup Decreases
0 1 Escherichia coli O5 serogroup Decreases
0 1 Escherichia coli O86 serogroup Decreases
0 1 Escherichia coli O91 serogroup Decreases
0 1 Escherichia coli O103 serogroup Decreases
0 1 Escherichia coli O78 serogroup Decreases
0 1 Escherichia coli O43 serogroup Decreases
0 1 Escherichia coli O119 serogroup Decreases
0 1 Escherichia coli O157 serogroup Decreases
0 1 Escherichia coli O145 serogroup Decreases
0 1 Escherichia coli O1:HNT serotype Decreases
0 1 Escherichia coli O10:K5(L):H4 serotype Decreases
0 1 Escherichia coli O103:H11 serotype Decreases
0 1 Escherichia coli O103:H25 serotype Decreases
0 1 Escherichia coli O104:H21 serotype Decreases
0 1 Escherichia coli O111:H11 serotype Decreases
0 1 Escherichia coli O111:H8 serotype Decreases
0 1 Escherichia coli O112ac:H19 serotype Decreases
0 1 Escherichia coli O114:H49 serotype Decreases
0 1 Escherichia coli O118:H16 serotype Decreases
0 1 Escherichia coli O121:H7 serotype Decreases
0 1 Escherichia coli O123:H11 serotype Decreases
0 1 Escherichia coli O127:H27 serotype Decreases
0 1 Escherichia coli O127:H6 serotype Decreases
0 1 Escherichia coli O128:H2 serotype Decreases
0 1 Escherichia coli O128ac:H12 serotype Decreases
0 1 Escherichia coli O145:H25 serotype Decreases
0 1 Escherichia coli O145:NM serotype Decreases
0 1 Escherichia coli O146:H21 serotype Decreases
0 1 Escherichia coli O153:H2 serotype Decreases
0 1 Escherichia coli O156:H25 serotype Decreases
0 1 Escherichia coli O157:H43 serotype Decreases
0 1 Escherichia coli O157:NM serotype Decreases
0 1 Escherichia coli O165:H25 serotype Decreases
0 1 Escherichia coli O174:H2 serotype Decreases
0 1 Escherichia coli O174:H21 serotype Decreases
0 1 Escherichia coli O174:H8 serotype Decreases
0 1 Escherichia coli O176:H45 serotype Decreases
0 1 Escherichia coli O177:NM serotype Decreases
0 1 Escherichia coli O26:H1 serotype Decreases
0 1 Escherichia coli O28ac:NM serotype Decreases
0 1 Escherichia coli O29:H4 serotype Decreases
0 1 Escherichia coli O32:H37 serotype Decreases
0 1 Escherichia coli O6:H16:CFA/II serotype Decreases
0 1 Escherichia coli O69:H11 serotype Decreases
0 1 Escherichia coli O78:H12 serotype Decreases
0 1 Escherichia coli O79:H7 serotype Decreases
0 1 Escherichia coli O81:NM serotype Decreases
0 1 Escherichia coli O86:H34 serotype Decreases
0 1 Escherichia coli O91:H14 serotype Decreases
0 1 Escherichia coli O91:NM serotype Decreases
0 1 Escherichia coli ONT:H33 serotype Decreases
0 1 Escherichia coli O100:H21 serotype Decreases
0 1 Escherichia coli O121:H19 serotype Decreases
0 1 Escherichia coli O157:H7 serotype Decreases
0 1 Escherichia coli O16:H6 serotype Decreases
0 1 Escherichia coli O89m:H9 serotype Decreases
0 1 Escherichia coli O111:H- serotype Decreases
0 1 Escherichia coli O113:H21 serotype Decreases
0 1 Escherichia coli H20 serotype Decreases
0 1 Escherichia coli O150:H6 serotype Decreases
0 1 Escherichia coli O111:NM serotype Decreases
0 1 Escherichia coli O112ab:H8 serotype Decreases
0 1 Escherichia coli O99:H6 serotype Decreases
0 1 Escherichia coli O26:H11 serotype Decreases
0 1 Escherichia coli O145:H28 serotype Decreases
0 1 Escherichia coli O126:H45 serotype Decreases
0 1 Escherichia coli O2:H6 serotype Decreases
0 1 Escherichia coli O7:H4 serotype Decreases
0 1 Escherichia coli O1:H42 serotype Decreases
0 1 Escherichia coli O25:NM serotype Decreases
0 1 Escherichia coli O25:H1 serotype Decreases
0 1 Escherichia coli O7:K1 serotype Decreases
0 1 Escherichia coli O125ac:K+:H10 serotype Decreases
0 1 Escherichia coli O6:K2:H1 serotype Decreases
0 1 Escherichia coli O152:H23 serotype Decreases
0 1 Escherichia coli O15:H18 serotype Decreases
0 1 Escherichia coli O39:NM serotype Decreases
0 1 Escherichia coli O44:H18 serotype Decreases
0 1 Escherichia coli O2:K2:H1 serotype Decreases
0 1 Escherichia coli O8:H8 serotype Decreases
0 1 Escherichia coli O89m:H10 serotype Decreases
0 1 Escherichia coli O10:H32 serotype Decreases
0 1 Escherichia coli O6:H16 serotype Decreases
0 1 Escherichia coli O157:H- serotype Decreases
0 1 Escherichia coli O45:H2 serotype Decreases
0 1 Escherichia coli O103:H2 serotype Decreases
0 1 Escherichia coli O167:H26 serotype Decreases
0 1 Escherichia coli O104:H4 serotype Decreases
0 1 Escherichia coli O83:H1 serotype Decreases
0 1 Escherichia coli O9:H10 serotype Decreases
0 1 Escherichia coli O78:H4 serotype Decreases
0 1 Escherichia coli O139:H28 serotype Decreases
1 0 Bacteroides caccae species Decreases
1 0 Eggerthella lenta species Decreases
1 0 Clostridium perfringens species Decreases
1 0 Collinsella aerofaciens species Decreases
1 0 Enterocloster bolteae species Decreases
1 0 Streptococcus salivarius species Decreases
1 0 Parabacteroides distasonis species Decreases
1 0 Parabacteroides merdae species Decreases
1 0 Segatella copri species Decreases
0 1 Chromobacterium haemolyticum species Decreases
0 1 Chromobacterium paludis species Decreases
0 1 Chromobacterium phragmitis species Decreases
0 1 Chromobacterium piscinae species Decreases
0 1 Chromobacterium rhizoryzae species Decreases
0 1 Chromobacterium subtsugae species Decreases
0 1 Chromobacterium vaccinii species Decreases
0 1 Chromobacterium violaceum species Decreases
1 0 Bacteroides xylanisolvens species Decreases
1 0 Escherichia coli species Decreases
1 0 Roseburia hominis species Decreases
1 0 Bifidobacterium adolescentis species Decreases
1 0 Streptococcus parasanguinis species Decreases
1 0 Lacticaseibacillus paracasei species Decreases
1 0 Bacteroides ovatus species Decreases
1 0 Agathobacter rectalis species Decreases
0 1 Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases
0 1 Lacticaseibacillus paracasei subsp. tolerans subspecies Decreases

Impact of phenylbutazone,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Acne 0.3 0.3 0
ADHD 2 0.6 2.33
Age-Related Macular Degeneration and Glaucoma 0.5 0.4 0.25
Allergic Rhinitis (Hay Fever) 2.1 0.9 1.33
Allergies 3.4 1.5 1.27
Allergy to milk products 0.9 1.6 -0.78
Alopecia (Hair Loss) 0.8 0.8
Alzheimer's disease 3 3.4 -0.13
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0.9 0.1 8
Ankylosing spondylitis 2.7 0.3 8
Anorexia Nervosa 1.2 1.6 -0.33
Antiphospholipid syndrome (APS) 0.4 0.4
Asthma 3 1.5 1
Atherosclerosis 1 1 0
Atrial fibrillation 1.6 1.9 -0.19
Autism 5.4 3.7 0.46
Autoimmune Disease 1.2 1 0.2
Barrett esophagus cancer 0.3 -0.3
benign prostatic hyperplasia 0.6 0.3 1
Biofilm 0.5 0.5
Bipolar Disorder 1.8 0.8 1.25
Brain Trauma 0.9 1.1 -0.22
Breast Cancer 0.4 0.4 0
Cancer (General) 1.5 -1.5
Carcinoma 2.5 1.3 0.92
Celiac Disease 0.7 1 -0.43
Cerebral Palsy 1.1 0.8 0.38
Chronic Fatigue Syndrome 2.9 1.8 0.61
Chronic Kidney Disease 2.6 0.9 1.89
Chronic Lyme 0.8 -0.8
Chronic Obstructive Pulmonary Disease (COPD) 1.1 0.8 0.38
Chronic Urticaria (Hives) 1.2 0.3 3
Coagulation / Micro clot triggering bacteria 1.4 0.8 0.75
Cognitive Function 2.1 1.3 0.62
Colorectal Cancer 3.7 2 0.85
Constipation 0.9 1.2 -0.33
Coronary artery disease 1.6 0.9 0.78
COVID-19 4.3 4.3 0
Crohn's Disease 3.8 1.9 1
Cushing's Syndrome (hypercortisolism) 0.3 -0.3
cystic fibrosis 0.7 1.2 -0.71
d-lactic acidosis (one form of brain fog) 0.1 0.1
deep vein thrombosis 1.3 1.1 0.18
Denture Wearers Oral Shifts 0.9 0.9
Depression 6.1 4.4 0.39
Dermatomyositis 0.3 0.3 0
Eczema 1.1 1.5 -0.36
Endometriosis 2 0.7 1.86
Eosinophilic Esophagitis 0.3 -0.3
Epilepsy 2.5 1.4 0.79
erectile dysfunction 1.1 0.3 2.67
Fibromyalgia 2.1 1.6 0.31
Functional constipation / chronic idiopathic constipation 2.3 2.7 -0.17
gallstone disease (gsd) 1.3 0.8 0.63
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.3 -0.3
Generalized anxiety disorder 1.6 1.6 0
giant cell arteritis 0.2 -0.2
Glioblastoma 0.3 -0.3
Gout 1.4 0.5 1.8
Graves' disease 1.3 1.7 -0.31
Gulf War Syndrome 0.5 0.3 0.67
Halitosis 0.6 0.3 1
Hashimoto's thyroiditis 1.1 0.6 0.83
Heart Failure 1.9 0.9 1.11
hemorrhagic stroke 0.4 0.4
Hidradenitis Suppurativa 0.6 0.6
High Histamine/low DAO 1.5 0.3 4
hypercholesterolemia (High Cholesterol) 0.3 0.3
hyperglycemia 1.3 1 0.3
Hyperlipidemia (High Blood Fats) 0.6 0.3 1
hypersomnia 0.3 -0.3
hypertension (High Blood Pressure 2.5 1.6 0.56
Hypothyroidism 0.6 -0.6
Hypoxia 2.6 0.6 3.33
IgA nephropathy (IgAN) 1.3 1.4 -0.08
Inflammatory Bowel Disease 4.9 3.6 0.36
Insomnia 1.2 1.4 -0.17
Intelligence 0.6 0.3 1
Intracranial aneurysms 0.7 0.6 0.17
Irritable Bowel Syndrome 3.6 2.4 0.5
ischemic stroke 1.4 1.7 -0.21
Liver Cirrhosis 4.1 1.7 1.41
Long COVID 4 2.9 0.38
Low bone mineral density 0.5 -0.5
Lung Cancer 1.3 1.3
Lymphoma 0.6 0.6
Mast Cell Issues / mastitis 0.9 0.3 2
ME/CFS with IBS 1.1 0.6 0.83
ME/CFS without IBS 1.5 1.1 0.36
membranous nephropathy 0.3 0.3
Menopause 0.5 0.5 0
Metabolic Syndrome 4.6 2.3 1
Mood Disorders 6.6 4.6 0.43
multiple chemical sensitivity [MCS] 0.9 0.9
Multiple Sclerosis 4.7 3.5 0.34
Multiple system atrophy (MSA) 0.2 0.3 -0.5
myasthenia gravis 0.9 0.7 0.29
neuropathic pain 0.3 1.4 -3.67
Neuropathy (all types) 0.6 2.2 -2.67
neuropsychiatric disorders (PANDAS, PANS) 0.4 0.4
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 2.7 1.3 1.08
NonCeliac Gluten Sensitivity 1.2 0.6 1
Obesity 5.3 3.4 0.56
obsessive-compulsive disorder 1.8 1.4 0.29
Osteoarthritis 1.4 0.9 0.56
Osteoporosis 1.9 0.9 1.11
pancreatic cancer 0.9 0.6 0.5
Parkinson's Disease 4.6 2.8 0.64
Polycystic ovary syndrome 3.5 1.6 1.19
Postural orthostatic tachycardia syndrome 0.2 0.3 -0.5
Premenstrual dysphoric disorder 0.6 0.4 0.5
primary biliary cholangitis 0.3 0.8 -1.67
Primary sclerosing cholangitis 1.3 1.1 0.18
Psoriasis 1.5 2.1 -0.4
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 3.9 1.7 1.29
Rosacea 0.3 1 -2.33
Schizophrenia 3.4 1.8 0.89
scoliosis 0.1 0.1
Sjögren syndrome 1.6 1.4 0.14
Sleep Apnea 0.3 1.1 -2.67
Slow gastric motility / Gastroparesis 0.4 0.3 0.33
Small Intestinal Bacterial Overgrowth (SIBO) 0.9 0.9
Stress / posttraumatic stress disorder 1.9 2.5 -0.32
Systemic Lupus Erythematosus 2.1 0.8 1.63
Tic Disorder 0.3 0.9 -2
Tourette syndrome 0.3 0.3 0
Type 1 Diabetes 2 1.7 0.18
Type 2 Diabetes 5.3 2.9 0.83
Ulcerative colitis 2.9 2.3 0.26
Unhealthy Ageing 1.5 1.3 0.15
Vitiligo 1.3 0.9 0.44

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