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Skin Health: Nicotinamide is commonly used topically to treat various skin conditions due to its anti-inflammatory and anti-microbial properties. It is used in the treatment of acne vulgaris, where it helps reduce inflammation and the production of sebum, leading to fewer acne lesions. Nicotinamide is also used to treat other skin conditions like rosacea, eczema, and dermatitis.
Skin Aging: Nicotinamide has been shown to improve the appearance of aging skin by reducing fine lines, wrinkles, and hyperpigmentation. It helps enhance the skin's barrier function, increases collagen production, and reduces the degradation of elastin, leading to smoother and more youthful-looking skin.
Skin Cancer Prevention: Some studies suggest that nicotinamide may help reduce the risk of certain types of skin cancer, particularly non-melanoma skin cancers like basal cell carcinoma and squamous cell carcinoma. It is believed to exert its protective effects by repairing DNA damage caused by UV radiation and enhancing the repair mechanisms within skin cells.
Hyperphosphatemia: Nicotinamide has been investigated for its potential to lower phosphate levels in individuals with chronic kidney disease (CKD) who have hyperphosphatemia. By inhibiting the absorption of phosphate in the intestines, nicotinamide may help reduce serum phosphate levels and mitigate the risk of complications associated with CKD, such as cardiovascular disease and mineral bone disorders.
Diabetes: Nicotinamide has been studied for its role in improving beta-cell function and insulin sensitivity in individuals with type 1 and type 2 diabetes. It may help preserve beta-cell mass and function, leading to better glycemic control and reduced risk of diabetic complications. However, more research is needed to establish its efficacy and safety for diabetes management.
Neurological Disorders: Nicotinamide plays a crucial role in cellular energy metabolism and has been investigated for its potential neuroprotective effects in conditions like Alzheimer's disease, Parkinson's disease, and multiple sclerosis. It may help protect neurons from oxidative stress, inflammation, and mitochondrial dysfunction, although further research is needed to confirm its therapeutic benefits.
Other Conditions: Nicotinamide supplementation may also have benefits for other conditions, including pellagra (a niacin deficiency disease), osteoarthritis, inflammatory bowel disease, and prevention of migraine headaches. However, more research is needed to fully understand its effects in these areas.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Escherichia coli | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Acne | 0.5 | 0.5 | 0 |
| ADHD | 0.8 | 0.8 | |
| Allergic Rhinitis (Hay Fever) | 0.4 | 1.1 | -1.75 |
| Allergies | 1.7 | 0.4 | 3.25 |
| Allergy to milk products | 0.7 | 0.2 | 2.5 |
| Alzheimer's disease | 1.3 | 0.9 | 0.44 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 0.3 | 0.6 | -1 |
| Ankylosing spondylitis | 1.6 | 0.1 | 15 |
| Anorexia Nervosa | 0.6 | 0.1 | 5 |
| Antiphospholipid syndrome (APS) | 0.6 | 0.1 | 5 |
| Asthma | 1.1 | 0.5 | 1.2 |
| Atherosclerosis | 1.1 | 1.1 | |
| Atrial fibrillation | 0.1 | 0.5 | -4 |
| Autism | 1.3 | 1.5 | -0.15 |
| Autoimmune Disease | 0.8 | 0.8 | |
| benign prostatic hyperplasia | 0.5 | 0.5 | |
| Biofilm | 1.1 | 1.1 | |
| Bipolar Disorder | 1.1 | 0.1 | 10 |
| Brain Trauma | 0.3 | -0.3 | |
| Breast Cancer | 0.4 | 0.4 | |
| Cancer (General) | 0.2 | -0.2 | |
| Carcinoma | 0.3 | 0.1 | 2 |
| Celiac Disease | 1.1 | 0.7 | 0.57 |
| Cerebral Palsy | 0.1 | -0.1 | |
| Chronic Fatigue Syndrome | 0.7 | 0.1 | 6 |
| Chronic Kidney Disease | 0.4 | 0.4 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 1.4 | 1.4 | |
| Chronic Urticaria (Hives) | 1.3 | 0.1 | 12 |
| Coagulation / Micro clot triggering bacteria | 0.8 | 0.1 | 7 |
| Cognitive Function | 0.1 | 0.1 | |
| Colorectal Cancer | 1.1 | 0.6 | 0.83 |
| Constipation | 0.4 | 0.2 | 1 |
| Coronary artery disease | 1 | 1 | |
| COVID-19 | 2.4 | 0.9 | 1.67 |
| Crohn's Disease | 1.8 | 0.1 | 17 |
| cystic fibrosis | 1.1 | 1.1 | |
| d-lactic acidosis (one form of brain fog) | 0.4 | 0.4 | |
| deep vein thrombosis | 0.8 | 0.1 | 7 |
| Depression | 1.6 | 1.2 | 0.33 |
| Eczema | 0.5 | 0.5 | |
| Endometriosis | 1.3 | 0.5 | 1.6 |
| Epilepsy | 1.3 | 0.5 | 1.6 |
| erectile dysfunction | 0.3 | 0.3 | |
| Fibromyalgia | 0.1 | -0.1 | |
| Functional constipation / chronic idiopathic constipation | 0.9 | 0.5 | 0.8 |
| gallstone disease (gsd) | 0.7 | 0.7 | |
| Generalized anxiety disorder | 0.8 | 0.8 | |
| Gout | 0.1 | 0.1 | 0 |
| Graves' disease | 0.9 | 0.1 | 8 |
| Gulf War Syndrome | 0.5 | 0.5 | |
| Hashimoto's thyroiditis | 0.6 | 0.6 | |
| Heart Failure | 1.4 | 0.2 | 6 |
| hemorrhagic stroke | 0.5 | -0.5 | |
| Hidradenitis Suppurativa | 0.2 | 0.2 | |
| High Histamine/low DAO | 0.6 | 0.1 | 5 |
| hypercholesterolemia (High Cholesterol) | 0.4 | 0.4 | |
| hyperglycemia | 0.9 | 0.9 | |
| Hyperlipidemia (High Blood Fats) | 0.5 | 0.5 | |
| hypersomnia | 0.2 | -0.2 | |
| hypertension (High Blood Pressure | 1.3 | 0.3 | 3.33 |
| Hypothyroidism | 0.5 | -0.5 | |
| IgA nephropathy (IgAN) | 0.4 | 0.1 | 3 |
| Inflammatory Bowel Disease | 1.8 | 1.4 | 0.29 |
| Insomnia | 0.8 | 0.1 | 7 |
| Intelligence | 0.4 | 0.1 | 3 |
| Intracranial aneurysms | 0.1 | 0.1 | |
| Irritable Bowel Syndrome | 1.4 | 0.6 | 1.33 |
| ischemic stroke | 1 | 0.3 | 2.33 |
| Juvenile idiopathic arthritis | 0.5 | 0.5 | |
| Liver Cirrhosis | 1.4 | 1.3 | 0.08 |
| Long COVID | 1.3 | 0.4 | 2.25 |
| Lung Cancer | 0.3 | 0.1 | 2 |
| Lymphoma | 0.3 | 0.3 | |
| Mast Cell Issues / mastitis | 0.5 | 0.6 | -0.2 |
| Metabolic Syndrome | 1.8 | 0.3 | 5 |
| Mood Disorders | 1.1 | 1.2 | -0.09 |
| Multiple Sclerosis | 1.4 | 0.7 | 1 |
| Multiple system atrophy (MSA) | 0.2 | -0.2 | |
| myasthenia gravis | 0.3 | 0.3 | |
| neuropathic pain | 0.1 | 0.1 | |
| Neuropathy (all types) | 0.2 | -0.2 | |
| neuropsychiatric disorders (PANDAS, PANS) | 0.4 | 0.4 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 1.5 | 0.1 | 14 |
| NonCeliac Gluten Sensitivity | 0.5 | 0.5 | |
| Obesity | 1.8 | 0.9 | 1 |
| obsessive-compulsive disorder | 1 | 0.1 | 9 |
| Osteoarthritis | 0.2 | 0.6 | -2 |
| Osteoporosis | 0.4 | 0.4 | |
| pancreatic cancer | 0.2 | 0.2 | |
| Parkinson's Disease | 1.7 | 1.1 | 0.55 |
| Polycystic ovary syndrome | 1.1 | 0.3 | 2.67 |
| primary biliary cholangitis | 0.2 | 0.2 | |
| Primary sclerosing cholangitis | 0.1 | -0.1 | |
| Psoriasis | 1.3 | 0.1 | 12 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 1.6 | 1.6 | |
| Rosacea | 1.4 | 1.4 | |
| Schizophrenia | 0.9 | 0.8 | 0.13 |
| scoliosis | 0.5 | 0.1 | 4 |
| Sjögren syndrome | 0.5 | 0.7 | -0.4 |
| Sleep Apnea | 0.2 | 0.7 | -2.5 |
| Slow gastric motility / Gastroparesis | 0.5 | 0.5 | |
| Small Intestinal Bacterial Overgrowth (SIBO) | 0.6 | 0.6 | |
| Stress / posttraumatic stress disorder | 0.7 | 0.7 | 0 |
| Systemic Lupus Erythematosus | 0.8 | 0.8 | 0 |
| Tic Disorder | 0.1 | 0.1 | 0 |
| Type 1 Diabetes | 0.9 | 0.3 | 2 |
| Type 2 Diabetes | 1.7 | 1.3 | 0.31 |
| Ulcerative colitis | 1.7 | 0.4 | 3.25 |
| Vitiligo | 0.1 | 0.1 |
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