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Coronary Artery Disease (CAD): Dilazep dihydrochloride is used in the management of coronary artery disease, a condition characterized by the narrowing or blockage of the coronary arteries that supply blood to the heart muscle. Dilazep acts as a coronary vasodilator, meaning it dilates the coronary arteries, which improves blood flow to the heart muscle and reduces myocardial ischemia (lack of oxygen).
Angina Pectoris: Angina pectoris is chest pain or discomfort caused by reduced blood flow to the heart muscle. Dilazep dihydrochloride can help alleviate angina symptoms by dilating the coronary arteries, improving blood flow, and reducing the workload on the heart. It is often used as an adjunctive therapy in individuals with stable angina who are not adequately controlled with other medications such as beta-blockers or calcium channel blockers.
Peripheral Arterial Disease (PAD): Dilazep dihydrochloride may also be used in the treatment of peripheral arterial disease, a condition characterized by narrowed or blocked arteries in the legs, arms, or other parts of the body. By dilating the peripheral arteries, dilazep improves blood flow to the affected limbs, reducing symptoms such as leg pain or cramping during physical activity (intermittent claudication).
Antiplatelet Effect: In addition to its vasodilator effects, dilazep dihydrochloride also has antiplatelet properties, meaning it inhibits the aggregation of platelets, which are blood cells involved in clot formation. This antiplatelet effect helps reduce the risk of thrombosis (blood clot formation) in the coronary and peripheral arteries, which can lead to myocardial infarction (heart attack) or ischemic stroke.
Side Effects: Common side effects of dilazep dihydrochloride may include headache, dizziness, flushing, palpitations, and gastrointestinal symptoms such as nausea or abdominal discomfort. These side effects are usually mild and transient and may diminish with continued use or dosage adjustments. However, more serious side effects, such as hypotension (low blood pressure), bradycardia (slow heart rate), or allergic reactions, may occur rarely and require medical attention.
Contraindications: Dilazep dihydrochloride is contraindicated in individuals with known hypersensitivity or allergy to the medication or any of its components. It should be used with caution in individuals with hypotension, bradycardia, heart block, or severe hepatic impairment.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Bacteroides uniformis | Reduces |
| species | Escherichia coli | Reduces |
| species | Lacticaseibacillus paracasei | Reduces |
| species | Parabacteroides distasonis | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
| 📓 Direct Citations | 👪👶 Indirect Citations | Taxonomy | Rank | Effect |
|---|---|---|---|---|
| 0 | 1 | Escherichia | genus | Decreases |
| 0 | 1 | Parabacteroides | genus | Decreases |
| 0 | 1 | Agathobacter | genus | Decreases |
| 0 | 1 | Bacteroides | genus | Decreases |
| 0 | 1 | Bilophila | genus | Decreases |
| 0 | 1 | Mediterraneibacter | genus | Decreases |
| 0 | 1 | Streptococcus | genus | Decreases |
| 0 | 1 | Lacticaseibacillus | genus | Decreases |
| 0 | 1 | Escherichia coli O25:H16 | no rank | Decreases |
| 0 | 1 | Escherichia coli O145:H34 | no rank | Decreases |
| 0 | 1 | Escherichia coli O16:H48 | no rank | Decreases |
| 0 | 1 | Escherichia coli O141:H4 | no rank | Decreases |
| 0 | 1 | Escherichia coli O139:H1 | no rank | Decreases |
| 0 | 1 | Escherichia coli O80:H26 | no rank | Decreases |
| 0 | 1 | Escherichia coli O158:H23 | no rank | Decreases |
| 0 | 1 | Escherichia coli O84:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O2:K1:H4 | no rank | Decreases |
| 0 | 1 | Escherichia coli O2:K1:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O78:H51 | no rank | Decreases |
| 0 | 1 | Escherichia coli O18ac:H14 | no rank | Decreases |
| 0 | 1 | Escherichia coli O85:H1 | no rank | Decreases |
| 0 | 1 | Escherichia coli O7:H15 | no rank | Decreases |
| 0 | 1 | Escherichia coli O68:H12 | no rank | Decreases |
| 0 | 1 | Escherichia coli O55:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O1:K1:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O15:H12 | no rank | Decreases |
| 0 | 1 | Escherichia coli O170:H18 | no rank | Decreases |
| 0 | 1 | Escherichia coli O155:H21 | no rank | Decreases |
| 0 | 1 | Escherichia coli O19:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O2:K1:H5 | no rank | Decreases |
| 0 | 1 | Escherichia coli O20:H12 | no rank | Decreases |
| 0 | 1 | Escherichia coli O111 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O121 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O155 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O177 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O26 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O3 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O5 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O86 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O91 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O103 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O78 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O43 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O119 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O157 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O145 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O1:HNT | serotype | Decreases |
| 0 | 1 | Escherichia coli O10:K5(L):H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O103:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O103:H25 | serotype | Decreases |
| 0 | 1 | Escherichia coli O104:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli O111:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O111:H8 | serotype | Decreases |
| 0 | 1 | Escherichia coli O112ac:H19 | serotype | Decreases |
| 0 | 1 | Escherichia coli O114:H49 | serotype | Decreases |
| 0 | 1 | Escherichia coli O118:H16 | serotype | Decreases |
| 0 | 1 | Escherichia coli O121:H7 | serotype | Decreases |
| 0 | 1 | Escherichia coli O123:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O127:H27 | serotype | Decreases |
| 0 | 1 | Escherichia coli O127:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O128:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O128ac:H12 | serotype | Decreases |
| 0 | 1 | Escherichia coli O145:H25 | serotype | Decreases |
| 0 | 1 | Escherichia coli O145:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O146:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli O153:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O156:H25 | serotype | Decreases |
| 0 | 1 | Escherichia coli O157:H43 | serotype | Decreases |
| 0 | 1 | Escherichia coli O157:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O165:H25 | serotype | Decreases |
| 0 | 1 | Escherichia coli O174:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O174:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli O174:H8 | serotype | Decreases |
| 0 | 1 | Escherichia coli O176:H45 | serotype | Decreases |
| 0 | 1 | Escherichia coli O177:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O26:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O28ac:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O29:H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O32:H37 | serotype | Decreases |
| 0 | 1 | Escherichia coli O6:H16:CFA/II | serotype | Decreases |
| 0 | 1 | Escherichia coli O69:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O78:H12 | serotype | Decreases |
| 0 | 1 | Escherichia coli O79:H7 | serotype | Decreases |
| 0 | 1 | Escherichia coli O81:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O86:H34 | serotype | Decreases |
| 0 | 1 | Escherichia coli O91:H14 | serotype | Decreases |
| 0 | 1 | Escherichia coli O91:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli ONT:H33 | serotype | Decreases |
| 0 | 1 | Escherichia coli O100:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli O121:H19 | serotype | Decreases |
| 0 | 1 | Escherichia coli O157:H7 | serotype | Decreases |
| 0 | 1 | Escherichia coli O16:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O89m:H9 | serotype | Decreases |
| 0 | 1 | Escherichia coli O111:H- | serotype | Decreases |
| 0 | 1 | Escherichia coli O113:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli H20 | serotype | Decreases |
| 0 | 1 | Escherichia coli O150:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O111:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O112ab:H8 | serotype | Decreases |
| 0 | 1 | Escherichia coli O99:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O26:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O145:H28 | serotype | Decreases |
| 0 | 1 | Escherichia coli O126:H45 | serotype | Decreases |
| 0 | 1 | Escherichia coli O2:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O7:H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O1:H42 | serotype | Decreases |
| 0 | 1 | Escherichia coli O25:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O25:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O7:K1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O125ac:K+:H10 | serotype | Decreases |
| 0 | 1 | Escherichia coli O6:K2:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O152:H23 | serotype | Decreases |
| 0 | 1 | Escherichia coli O15:H18 | serotype | Decreases |
| 0 | 1 | Escherichia coli O39:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O44:H18 | serotype | Decreases |
| 0 | 1 | Escherichia coli O2:K2:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O8:H8 | serotype | Decreases |
| 0 | 1 | Escherichia coli O89m:H10 | serotype | Decreases |
| 0 | 1 | Escherichia coli O10:H32 | serotype | Decreases |
| 0 | 1 | Escherichia coli O6:H16 | serotype | Decreases |
| 0 | 1 | Escherichia coli O157:H- | serotype | Decreases |
| 0 | 1 | Escherichia coli O45:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O103:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O167:H26 | serotype | Decreases |
| 0 | 1 | Escherichia coli O104:H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O83:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O9:H10 | serotype | Decreases |
| 0 | 1 | Escherichia coli O78:H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O139:H28 | serotype | Decreases |
| 1 | 0 | Lacticaseibacillus paracasei | species | Decreases |
| 1 | 0 | Parabacteroides distasonis | species | Decreases |
| 1 | 0 | Parabacteroides merdae | species | Decreases |
| 1 | 0 | Streptococcus salivarius | species | Decreases |
| 1 | 0 | Bilophila wadsworthia | species | Decreases |
| 1 | 0 | Bacteroides xylanisolvens | species | Decreases |
| 1 | 0 | Agathobacter rectalis | species | Decreases |
| 1 | 0 | Escherichia coli | species | Decreases |
| 1 | 0 | Mediterraneibacter gnavus | species | Decreases |
| 1 | 0 | Bacteroides ovatus | species | Decreases |
| 1 | 0 | Bacteroides uniformis | species | Decreases |
| 1 | 0 | Bacteroides fragilis | species | Decreases |
| 0 | 1 | Lacticaseibacillus paracasei subsp. paracasei | subspecies | Decreases |
| 0 | 1 | Lacticaseibacillus paracasei subsp. tolerans | subspecies | Decreases |
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Abdominal Aortic Aneurysm | 0.3 | 0.3 | |
| Acne | 0.3 | 0.3 | |
| ADHD | 1.3 | 1.3 | |
| Age-Related Macular Degeneration and Glaucoma | 0.4 | -0.4 | |
| Allergic Rhinitis (Hay Fever) | 1.8 | 0.6 | 2 |
| Allergies | 1.7 | 0.3 | 4.67 |
| Allergy to milk products | 0.6 | 1.3 | -1.17 |
| Alopecia (Hair Loss) | 0.6 | 0.6 | |
| Alzheimer's disease | 2 | 2.5 | -0.25 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 0.7 | 0.3 | 1.33 |
| Ankylosing spondylitis | 2.1 | 0.5 | 3.2 |
| Anorexia Nervosa | 0.7 | 1 | -0.43 |
| Antiphospholipid syndrome (APS) | 0.6 | 0.3 | 1 |
| Asthma | 1.6 | 0.6 | 1.67 |
| Atherosclerosis | 0.7 | 0.7 | |
| Atrial fibrillation | 1.4 | 1.9 | -0.36 |
| Autism | 1.9 | 3.3 | -0.74 |
| Autoimmune Disease | 0.9 | 0.9 | |
| Barrett esophagus cancer | 0.3 | -0.3 | |
| benign prostatic hyperplasia | 0.6 | 0.3 | 1 |
| Biofilm | 0.8 | 0.8 | |
| Bipolar Disorder | 1.6 | 1.6 | |
| Brain Trauma | 0.3 | 0.3 | 0 |
| Breast Cancer | 0.3 | 0.3 | |
| Cancer (General) | 0.6 | -0.6 | |
| Carcinoma | 1.9 | 0.7 | 1.71 |
| Celiac Disease | 1 | 1 | 0 |
| Cerebral Palsy | 0.6 | 0.3 | 1 |
| Chronic Fatigue Syndrome | 1.4 | 2.7 | -0.93 |
| Chronic Kidney Disease | 1.5 | 0.6 | 1.5 |
| Chronic Lyme | 0.3 | -0.3 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 1.2 | 0.3 | 3 |
| Chronic Urticaria (Hives) | 1.2 | 0.1 | 11 |
| Coagulation / Micro clot triggering bacteria | 1.6 | 0.3 | 4.33 |
| Cognitive Function | 1 | 0.3 | 2.33 |
| Colorectal Cancer | 2.9 | 0.9 | 2.22 |
| Constipation | 0.9 | 0.9 | |
| Coronary artery disease | 1.7 | 0.8 | 1.13 |
| COVID-19 | 2.8 | 2.3 | 0.22 |
| Crohn's Disease | 3.3 | 1.2 | 1.75 |
| Cushing's Syndrome (hypercortisolism) | 0.3 | -0.3 | |
| cystic fibrosis | 0.9 | 0.3 | 2 |
| d-lactic acidosis (one form of brain fog) | 0.3 | 0.3 | |
| deep vein thrombosis | 1 | 0.6 | 0.67 |
| Denture Wearers Oral Shifts | 0.9 | 0.9 | |
| Depression | 3.7 | 3.4 | 0.09 |
| Dermatomyositis | 0.3 | 0.3 | |
| Eczema | 1.1 | 1 | 0.1 |
| Endometriosis | 1.9 | 0.3 | 5.33 |
| Eosinophilic Esophagitis | 0.3 | -0.3 | |
| Epilepsy | 1.6 | 1.3 | 0.23 |
| erectile dysfunction | 1.1 | 1.1 | |
| Fibromyalgia | 1 | 0.4 | 1.5 |
| Functional constipation / chronic idiopathic constipation | 2.2 | 0.8 | 1.75 |
| gallstone disease (gsd) | 1.7 | 1.7 | |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.1 | 0.3 | -2 |
| Generalized anxiety disorder | 1.7 | 0.6 | 1.83 |
| Glioblastoma | 0.3 | -0.3 | |
| Gout | 1 | 1 | |
| Graves' disease | 0.7 | 0.6 | 0.17 |
| Gulf War Syndrome | 0.3 | 0.1 | 2 |
| Halitosis | 0.6 | 0.3 | 1 |
| Hashimoto's thyroiditis | 0.4 | 0.6 | -0.5 |
| Heart Failure | 2.1 | 0.3 | 6 |
| hemorrhagic stroke | 0.4 | 0.4 | |
| Hidradenitis Suppurativa | 0.9 | 0.9 | |
| High Histamine/low DAO | 0.3 | 0.3 | |
| hypercholesterolemia (High Cholesterol) | 0.3 | 0.3 | |
| hyperglycemia | 1.5 | 0.7 | 1.14 |
| Hyperlipidemia (High Blood Fats) | 0.3 | 0.3 | |
| hypersomnia | 0.3 | -0.3 | |
| hypertension (High Blood Pressure | 2.2 | 1 | 1.2 |
| Hypoxia | 1.6 | 1.6 | |
| IgA nephropathy (IgAN) | 1 | 0.5 | 1 |
| Inflammatory Bowel Disease | 3 | 2.8 | 0.07 |
| Insomnia | 1.2 | 0.9 | 0.33 |
| Intelligence | 0.7 | 0.7 | |
| Intracranial aneurysms | 0.7 | 0.7 | |
| Irritable Bowel Syndrome | 1.8 | 1.3 | 0.38 |
| ischemic stroke | 1.3 | 1.2 | 0.08 |
| Liver Cirrhosis | 3.2 | 1.2 | 1.67 |
| Long COVID | 2.1 | 1.3 | 0.62 |
| Lung Cancer | 0.9 | 0.9 | |
| Lymphoma | 0.6 | 0.6 | |
| Mast Cell Issues / mastitis | 0.9 | 0.9 | |
| ME/CFS with IBS | 0.3 | 0.3 | 0 |
| ME/CFS without IBS | 0.5 | 0.9 | -0.8 |
| membranous nephropathy | 0.3 | 0.3 | |
| Menopause | 0.5 | 0.5 | |
| Metabolic Syndrome | 3.1 | 1.6 | 0.94 |
| Mood Disorders | 3.4 | 3.4 | 0 |
| multiple chemical sensitivity [MCS] | 0.9 | 0.9 | |
| Multiple Sclerosis | 2.2 | 2.1 | 0.05 |
| myasthenia gravis | 0.9 | 0.9 | |
| neuropathic pain | 0.7 | -0.7 | |
| Neuropathy (all types) | 0.3 | 1 | -2.33 |
| neuropsychiatric disorders (PANDAS, PANS) | 0.6 | 0.6 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 1.7 | 0.6 | 1.83 |
| NonCeliac Gluten Sensitivity | 0.3 | 0.3 | 0 |
| Obesity | 2.4 | 2.6 | -0.08 |
| obsessive-compulsive disorder | 2.4 | 1.1 | 1.18 |
| Osteoarthritis | 1.5 | 0.6 | 1.5 |
| Osteoporosis | 0.9 | 0.6 | 0.5 |
| pancreatic cancer | 0.3 | 0.3 | 0 |
| Parkinson's Disease | 2.9 | 1.9 | 0.53 |
| Polycystic ovary syndrome | 3.1 | 0.9 | 2.44 |
| Premenstrual dysphoric disorder | 0.4 | -0.4 | |
| primary biliary cholangitis | 0.3 | 0.4 | -0.33 |
| Primary sclerosing cholangitis | 1 | 1.2 | -0.2 |
| Psoriasis | 0.7 | 1.7 | -1.43 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 2.1 | 0.8 | 1.63 |
| Schizophrenia | 1.4 | 0.7 | 1 |
| scoliosis | 0.3 | 0.3 | 0 |
| Sjögren syndrome | 1.3 | 1.1 | 0.18 |
| Sleep Apnea | 0.3 | -0.3 | |
| Slow gastric motility / Gastroparesis | 0.6 | 0.6 | |
| Small Intestinal Bacterial Overgrowth (SIBO) | 0.9 | 0.9 | |
| Stress / posttraumatic stress disorder | 1 | 0.7 | 0.43 |
| Systemic Lupus Erythematosus | 2.2 | 2.2 | |
| Tic Disorder | 0.3 | 0.3 | |
| Tourette syndrome | 0.3 | 0.3 | 0 |
| Type 1 Diabetes | 1.8 | 0.6 | 2 |
| Type 2 Diabetes | 2.8 | 1.6 | 0.75 |
| Ulcerative colitis | 2.1 | 1.5 | 0.4 |
| Unhealthy Ageing | 1.2 | 0.8 | 0.5 |
| Vitiligo | 1.1 | 0.4 | 1.75 |
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