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🍽️ clonidine hydrochloride,(prescription)

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  1. Hypertension: Clonidine hydrochloride is commonly prescribed to lower blood pressure in individuals with hypertension. It works by stimulating alpha-2 adrenergic receptors in the brainstem, which leads to decreased sympathetic outflow from the central nervous system. This results in reduced peripheral vascular resistance, heart rate, and blood pressure. Clonidine hydrochloride may be used alone or in combination with other antihypertensive medications to achieve target blood pressure levels.

  2. Attention Deficit Hyperactivity Disorder (ADHD): Clonidine hydrochloride is sometimes used off-label to treat ADHD, particularly in children who cannot tolerate or do not respond adequately to stimulant medications. It can help improve symptoms such as hyperactivity, impulsivity, and inattention by modulating certain neurotransmitter systems in the brain. Clonidine hydrochloride may be used as monotherapy or as an adjunct to other ADHD medications.

  3. Opioid Withdrawal: Clonidine hydrochloride is also used off-label to manage symptoms of opioid withdrawal in individuals undergoing detoxification or maintenance therapy for opioid addiction. It can help alleviate symptoms such as anxiety, agitation, sweating, diarrhea, and drug cravings by reducing sympathetic nervous system activity. Clonidine hydrochloride may be used as part of a comprehensive opioid withdrawal management program, along with other medications and supportive therapies.

  4. Anxiety Disorders: Clonidine hydrochloride may have anxiolytic (anti-anxiety) effects in certain individuals and may be used off-label to manage symptoms of anxiety disorders such as generalized anxiety disorder (GAD) or panic disorder. It works by reducing sympathetic nervous system activity and modulating the release of certain neurotransmitters involved in the stress response. Clonidine hydrochloride may be used alone or in combination with other anxiolytic medications or psychotherapy.

  5. Tourette Syndrome: Clonidine hydrochloride is sometimes used off-label to manage symptoms of Tourette syndrome, a neurological disorder characterized by involuntary motor and vocal tics. It may help reduce the frequency and severity of tics by modulating neurotransmitter activity in the brain. Clonidine hydrochloride may be used as adjunctive therapy to other medications or behavioral interventions for Tourette syndrome.

  6. Menopausal Symptoms: Clonidine hydrochloride may be used off-label to alleviate certain symptoms of menopause, such as hot flashes and night sweats. It may help regulate body temperature and reduce the frequency and severity of vasomotor symptoms associated with hormonal fluctuations during menopause. Clonidine hydrochloride may be used as an alternative to hormone replacement therapy (HRT) in women who cannot or prefer not to use estrogen-based treatments.

  7. Sleep Disorders: Clonidine hydrochloride may be used off-label to improve sleep quality and duration in individuals with certain sleep disorders, such as insomnia or sleep disturbances associated with ADHD or opioid withdrawal. It may help promote sleep by reducing arousal and increasing relaxation through its effects on the central nervous system. Clonidine hydrochloride may be used as adjunctive therapy to other sleep medications or behavioral interventions.

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⚗️ Compensation for antibiotic usage

Data Contradictions — Limits of Certainity

Impacted of clonidine hydrochloride,(prescription) On Probiotics

Rank Probiotic Impact
species Akkermansia muciniphila Reduces
species Escherichia coli Reduces
species Streptococcus thermophilus Reduces

Bacteria Impacted by clonidine hydrochloride,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Akkermansiaceae family Decreases
0 1 Streptococcus genus Decreases
0 1 Escherichia genus Decreases
0 1 Ruminococcus genus Decreases
0 1 Shigella genus Decreases
0 1 Collinsella genus Decreases
0 1 Phocaeicola genus Decreases
0 1 Bilophila genus Decreases
0 1 Coprococcus genus Decreases
1 0 Akkermansia genus Decreases
0 1 Roseburia genus Decreases
0 1 Escherichia coli O1:K1:H7 no rank Decreases
0 1 Escherichia coli O139:H1 no rank Decreases
0 1 Escherichia coli O141:H4 no rank Decreases
0 1 Escherichia coli O145:H34 no rank Decreases
0 1 Escherichia coli O15:H12 no rank Decreases
0 1 Escherichia coli O155:H21 no rank Decreases
0 1 Escherichia coli O158:H23 no rank Decreases
0 1 Escherichia coli O16:H48 no rank Decreases
0 1 Escherichia coli O170:H18 no rank Decreases
0 1 Escherichia coli O18ac:H14 no rank Decreases
0 1 Escherichia coli O19:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H4 no rank Decreases
0 1 Escherichia coli O2:K1:H5 no rank Decreases
0 1 Escherichia coli O2:K1:H7 no rank Decreases
0 1 Escherichia coli O20:H12 no rank Decreases
0 1 Escherichia coli O25:H16 no rank Decreases
0 1 Escherichia coli O55:H7 no rank Decreases
0 1 Escherichia coli O68:H12 no rank Decreases
0 1 Escherichia coli O7:H15 no rank Decreases
0 1 Escherichia coli O78:H51 no rank Decreases
0 1 Escherichia coli O80:H26 no rank Decreases
0 1 Escherichia coli O84:H7 no rank Decreases
0 1 Escherichia coli O85:H1 no rank Decreases
0 1 environmental samples no rank Decreases
0 1 unclassified Akkermansia no rank Decreases
0 1 Escherichia coli O103 serogroup Decreases
0 1 Escherichia coli O111 serogroup Decreases
0 1 Escherichia coli O119 serogroup Decreases
0 1 Escherichia coli O121 serogroup Decreases
0 1 Escherichia coli O145 serogroup Decreases
0 1 Escherichia coli O155 serogroup Decreases
0 1 Escherichia coli O157 serogroup Decreases
0 1 Escherichia coli O177 serogroup Decreases
0 1 Escherichia coli O26 serogroup Decreases
0 1 Escherichia coli O3 serogroup Decreases
0 1 Escherichia coli O43 serogroup Decreases
0 1 Escherichia coli O5 serogroup Decreases
0 1 Escherichia coli O78 serogroup Decreases
0 1 Escherichia coli O86 serogroup Decreases
0 1 Escherichia coli O91 serogroup Decreases
0 1 Escherichia coli H20 serotype Decreases
0 1 Escherichia coli O1:H42 serotype Decreases
0 1 Escherichia coli O1:HNT serotype Decreases
0 1 Escherichia coli O10:H32 serotype Decreases
0 1 Escherichia coli O10:K5(L):H4 serotype Decreases
0 1 Escherichia coli O100:H21 serotype Decreases
0 1 Escherichia coli O103:H11 serotype Decreases
0 1 Escherichia coli O103:H2 serotype Decreases
0 1 Escherichia coli O103:H25 serotype Decreases
0 1 Escherichia coli O104:H21 serotype Decreases
0 1 Escherichia coli O104:H4 serotype Decreases
0 1 Escherichia coli O111:H- serotype Decreases
0 1 Escherichia coli O111:H11 serotype Decreases
0 1 Escherichia coli O111:H8 serotype Decreases
0 1 Escherichia coli O111:NM serotype Decreases
0 1 Escherichia coli O112ab:H8 serotype Decreases
0 1 Escherichia coli O112ac:H19 serotype Decreases
0 1 Escherichia coli O113:H21 serotype Decreases
0 1 Escherichia coli O114:H49 serotype Decreases
0 1 Escherichia coli O118:H16 serotype Decreases
0 1 Escherichia coli O121:H19 serotype Decreases
0 1 Escherichia coli O121:H7 serotype Decreases
0 1 Escherichia coli O123:H11 serotype Decreases
0 1 Escherichia coli O125ac:K+:H10 serotype Decreases
0 1 Escherichia coli O126:H45 serotype Decreases
0 1 Escherichia coli O127:H27 serotype Decreases
0 1 Escherichia coli O127:H6 serotype Decreases
0 1 Escherichia coli O128:H2 serotype Decreases
0 1 Escherichia coli O128ac:H12 serotype Decreases
0 1 Escherichia coli O139:H28 serotype Decreases
0 1 Escherichia coli O145:H25 serotype Decreases
0 1 Escherichia coli O145:H28 serotype Decreases
0 1 Escherichia coli O145:NM serotype Decreases
0 1 Escherichia coli O146:H21 serotype Decreases
0 1 Escherichia coli O15:H18 serotype Decreases
0 1 Escherichia coli O150:H6 serotype Decreases
0 1 Escherichia coli O152:H23 serotype Decreases
0 1 Escherichia coli O153:H2 serotype Decreases
0 1 Escherichia coli O156:H25 serotype Decreases
0 1 Escherichia coli O157:H- serotype Decreases
0 1 Escherichia coli O157:H43 serotype Decreases
0 1 Escherichia coli O157:H7 serotype Decreases
0 1 Escherichia coli O157:NM serotype Decreases
0 1 Escherichia coli O16:H6 serotype Decreases
0 1 Escherichia coli O165:H25 serotype Decreases
0 1 Escherichia coli O167:H26 serotype Decreases
0 1 Escherichia coli O174:H2 serotype Decreases
0 1 Escherichia coli O174:H21 serotype Decreases
0 1 Escherichia coli O174:H8 serotype Decreases
0 1 Escherichia coli O176:H45 serotype Decreases
0 1 Escherichia coli O177:NM serotype Decreases
0 1 Escherichia coli O2:H6 serotype Decreases
0 1 Escherichia coli O2:K2:H1 serotype Decreases
0 1 Escherichia coli O25:H1 serotype Decreases
0 1 Escherichia coli O25:NM serotype Decreases
0 1 Escherichia coli O26:H1 serotype Decreases
0 1 Escherichia coli O26:H11 serotype Decreases
0 1 Escherichia coli O28ac:NM serotype Decreases
0 1 Escherichia coli O29:H4 serotype Decreases
0 1 Escherichia coli O32:H37 serotype Decreases
0 1 Escherichia coli O39:NM serotype Decreases
0 1 Escherichia coli O44:H18 serotype Decreases
0 1 Escherichia coli O45:H2 serotype Decreases
0 1 Escherichia coli O6:H16 serotype Decreases
0 1 Escherichia coli O6:H16:CFA/II serotype Decreases
0 1 Escherichia coli O6:K2:H1 serotype Decreases
0 1 Escherichia coli O69:H11 serotype Decreases
0 1 Escherichia coli O7:H4 serotype Decreases
0 1 Escherichia coli O7:K1 serotype Decreases
0 1 Escherichia coli O78:H12 serotype Decreases
0 1 Escherichia coli O78:H4 serotype Decreases
0 1 Escherichia coli O79:H7 serotype Decreases
0 1 Escherichia coli O8:H8 serotype Decreases
0 1 Escherichia coli O81:NM serotype Decreases
0 1 Escherichia coli O83:H1 serotype Decreases
0 1 Escherichia coli O86:H34 serotype Decreases
0 1 Escherichia coli O89m:H10 serotype Decreases
0 1 Escherichia coli O89m:H9 serotype Decreases
0 1 Escherichia coli O9:H10 serotype Decreases
0 1 Escherichia coli O91:H14 serotype Decreases
0 1 Escherichia coli O91:NM serotype Decreases
0 1 Escherichia coli O99:H6 serotype Decreases
0 1 Escherichia coli ONT:H33 serotype Decreases
1 0 Streptococcus salivarius species Decreases
0 1 Streptococcus sp. FDAARGOS_192 species Decreases
1 0 Escherichia coli species Decreases
1 0 Ruminococcus bromii species Decreases
0 1 Streptococcus vestibularis species Decreases
1 0 Collinsella aerofaciens species Decreases
0 1 Streptococcus parasanguinis species Decreases
0 1 Streptococcus sp. LPB0220 species Decreases
0 1 Streptococcus sp. HSISM1 species Decreases
1 0 Phocaeicola vulgatus species Decreases
0 1 Shigella dysenteriae species Decreases
0 1 Shigella flexneri species Decreases
0 1 Escherichia albertii species Decreases
0 1 Streptococcus gordonii species Decreases
0 1 Escherichia fergusonii species Decreases
0 1 Streptococcus sp. oral taxon 061 species Decreases
0 1 Streptococcus australis species Decreases
0 1 Streptococcus lactarius species Decreases
0 1 Shigella boydii species Decreases
0 1 Streptococcus oralis species Decreases
0 1 Streptococcus sp. Marseille-Q6470 species Decreases
0 1 Streptococcus sp. oral taxon 431 species Decreases
0 1 Streptococcus infantis species Decreases
1 0 Bilophila wadsworthia species Decreases
0 1 Parolsenella catena species Decreases
0 1 Streptococcus ilei species Decreases
0 1 Streptococcus thermophilus species Decreases
0 1 Streptococcus sp. A12 species Decreases
1 0 Coprococcus comes species Decreases
1 0 Akkermansia muciniphila species Decreases
1 0 Roseburia intestinalis species Decreases
0 1 Akkermansia glycaniphila species Decreases
0 1 Akkermansia massiliensis species Decreases
0 1 Candidatus Akkermansia intestinavium species Decreases

Impact of clonidine hydrochloride,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.1 0.1
ADHD 0.5 0.1 4
Age-Related Macular Degeneration and Glaucoma 0 0
Allergic Rhinitis (Hay Fever) 0.5 0.9 -0.8
Allergies 1.1 0.5 1.2
Allergy to milk products 0.7 0.2 2.5
Alopecia (Hair Loss) 0.1 0.1
Alzheimer's disease 0.7 1 -0.43
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0.4 0.6 -0.5
Ankylosing spondylitis 1.2 0.1 11
Anorexia Nervosa 0.5 0.5 0
Antiphospholipid syndrome (APS) 0.7 0.1 6
Asthma 1.4 0.4 2.5
Atherosclerosis 0.7 0 0
Atrial fibrillation 0.5 0.4 0.25
Autism 1.2 1.5 -0.25
Autoimmune Disease 0.6 0 0
Barrett esophagus cancer 0.3 -0.3
benign prostatic hyperplasia 0.3 0.3
Biofilm 0.9 0.9
Bipolar Disorder 0.5 0.2 1.5
Brain Trauma 0.4 0.2 1
Breast Cancer 0.4 0.4
Cancer (General) 0.1 -0.1
Carcinoma 0.8 0.3 1.67
Celiac Disease 0.9 0.2 3.5
Cerebral Palsy 0.3 0.2 0.5
Chronic Fatigue Syndrome 1.1 0.9 0.22
Chronic Kidney Disease 0.4 0.2 1
Chronic Lyme 0 0
Chronic Obstructive Pulmonary Disease (COPD) 1.9 0.4 3.75
Chronic Urticaria (Hives) 0.9 0 0
Coagulation / Micro clot triggering bacteria 1 0.5 1
Cognitive Function 0.6 0.3 1
Colorectal Cancer 2.6 0.6 3.33
Constipation 0.7 0 0
Coronary artery disease 1.3 0.1 12
COVID-19 2 1.8 0.11
Crohn's Disease 1.8 0.4 3.5
Cushing's Syndrome (hypercortisolism) 0.2 -0.2
cystic fibrosis 0.6 0 0
d-lactic acidosis (one form of brain fog) 0.4 0.4
deep vein thrombosis 0.8 0.5 0.6
Denture Wearers Oral Shifts 1 1
Depression 1.9 1.3 0.46
Dermatomyositis 0.3 0.3
Eczema 0.6 1 -0.67
Endometriosis 1.1 0.6 0.83
Eosinophilic Esophagitis 0.3 -0.3
Epilepsy 1.2 0 0
erectile dysfunction 0.3 0.3
Fibromyalgia 0 0.1 0
Functional constipation / chronic idiopathic constipation 1.4 0.2 6
gallstone disease (gsd) 0.7 0 0
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.2 0.3 -0.5
Generalized anxiety disorder 1.1 0.4 1.75
Glioblastoma 0.3 -0.3
Gout 0.5 0.2 1.5
Graves' disease 0.3 0.6 -1
Gulf War Syndrome 0.4 0 0
Halitosis 0.3 0.3 0
Hashimoto's thyroiditis 0.2 0.1 1
Heart Failure 1.2 0.2 5
Hidradenitis Suppurativa 0.4 0.4
High Histamine/low DAO 0.4 0.1 3
hypercholesterolemia (High Cholesterol) 0.4 0 0
hyperglycemia 1.5 0 0
Hyperlipidemia (High Blood Fats) 0.2 0.1 1
hypersomnia 0.2 -0.2
hypertension (High Blood Pressure 0.9 0.6 0.5
Hypothyroidism 0 0.1 0
Hypoxia 0 0
IgA nephropathy (IgAN) 0.5 0 0
Inflammatory Bowel Disease 2.2 1.7 0.29
Insomnia 1 0.5 1
Intelligence 0.5 0.5
Intracranial aneurysms 0.1 0.2 -1
Irritable Bowel Syndrome 1.4 0.9 0.56
ischemic stroke 0.9 0.3 2
Liver Cirrhosis 1.8 1 0.8
Long COVID 0.9 0.9 0
Low bone mineral density 0.1 -0.1
Lung Cancer 0.4 0.2 1
Lymphoma 0.3 0.3
Mast Cell Issues / mastitis 0.6 0.2 2
ME/CFS with IBS 0.3 0.1 2
ME/CFS without IBS 0.3 0.3
membranous nephropathy 0.3 0.3
Menopause 0.3 0 0
Metabolic Syndrome 1.8 0.8 1.25
Mood Disorders 1.5 1.3 0.15
multiple chemical sensitivity [MCS] 1.1 1.1
Multiple Sclerosis 2.3 0.5 3.6
Multiple system atrophy (MSA) 0.3 0.1 2
myasthenia gravis 0.6 0 0
neuropathic pain 0 0
Neuropathy (all types) 0.3 0.2 0.5
neuropsychiatric disorders (PANDAS, PANS) 0.7 0.7
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 1.3 0.2 5.5
NonCeliac Gluten Sensitivity 0.1 0.1
Obesity 1.7 1.3 0.31
obsessive-compulsive disorder 1.4 0.4 2.5
Osteoarthritis 0.5 0.5 0
Osteoporosis 0.5 0.3 0.67
pancreatic cancer 0.3 0.3 0
Parkinson's Disease 2.6 0.8 2.25
Polycystic ovary syndrome 1.3 0.8 0.63
Postural orthostatic tachycardia syndrome 0.1 -0.1
Premenstrual dysphoric disorder 0.1 0.1
primary biliary cholangitis 0.3 0.4 -0.33
Primary sclerosing cholangitis 0.5 0.2 1.5
Psoriasis 1.1 0.1 10
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 1.6 0.2 7
Rosacea 0.1 0 0
Schizophrenia 1 0.2 4
scoliosis 0.4 0.2 1
Sjögren syndrome 0.6 0.6
Sleep Apnea 0.3 0.1 2
Slow gastric motility / Gastroparesis 0.5 0.5
Small Intestinal Bacterial Overgrowth (SIBO) 0.8 0.8
Stress / posttraumatic stress disorder 0.5 0.2 1.5
Systemic Lupus Erythematosus 0.7 0.2 2.5
Tic Disorder 0.7 0.1 6
Tourette syndrome 0.3 0.3
Type 1 Diabetes 1.1 0.7 0.57
Type 2 Diabetes 2 1.1 0.82
Ulcerative colitis 1.2 0.5 1.4
Unhealthy Ageing 0.6 0.1 5
Vitiligo 0.5 0.1 4

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