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Sleep Aid: Doxylamine succinate is primarily used to promote sleep and relieve occasional insomnia. It works by blocking the action of histamine, a neurotransmitter involved in wakefulness, thereby inducing drowsiness and facilitating sleep initiation.
Allergy Relief: It may be used to alleviate symptoms of allergic rhinitis, hay fever, and other allergic reactions, such as sneezing, itching, watery eyes, and runny nose, by blocking the effects of histamine.
Nausea and Vomiting: Doxylamine succinate is sometimes used to relieve nausea and vomiting associated with motion sickness or morning sickness during pregnancy. It exerts antiemetic effects by acting on the vomiting center in the brain.
Cough and Cold: It may be included in over-the-counter cold and cough medications to help relieve symptoms such as nasal congestion, coughing, and sneezing, as well as to promote sleep in individuals with cold or flu symptoms.
Motion Sickness: Doxylamine succinate may be used to prevent and alleviate symptoms of motion sickness, such as nausea and vomiting, by exerting its sedative and antiemetic effects.
Morning Sickness: In pregnant women experiencing morning sickness, doxylamine succinate, often combined with pyridoxine (vitamin B6), is sometimes used to alleviate nausea and vomiting during pregnancy.
| Rank | Probiotic | Impact |
|---|---|---|
| genus | Bifidobacterium | Reduces |
| species | Akkermansia muciniphila | Reduces |
| species | Bifidobacterium adolescentis | Reduces |
| species | Bifidobacterium longum | Reduces |
| subspecies | Bifidobacterium longum subsp. infantis | Reduces |
| subspecies | Bifidobacterium longum subsp. longum | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
| 📓 Direct Citations | 👪👶 Indirect Citations | Taxonomy | Rank | Effect |
|---|---|---|---|---|
| 0 | 1 | Akkermansiaceae | family | Decreases |
| 0 | 1 | Dorea | genus | Decreases |
| 0 | 1 | Roseburia | genus | Decreases |
| 0 | 1 | Parabacteroides | genus | Decreases |
| 0 | 1 | Agathobacter | genus | Decreases |
| 0 | 1 | Bacteroides | genus | Decreases |
| 0 | 1 | Bifidobacterium | genus | Decreases |
| 0 | 1 | Bilophila | genus | Decreases |
| 0 | 1 | Clostridioides | genus | Decreases |
| 0 | 1 | Collinsella | genus | Decreases |
| 0 | 1 | Coprococcus | genus | Decreases |
| 0 | 1 | Eggerthella | genus | Decreases |
| 0 | 1 | Mediterraneibacter | genus | Decreases |
| 0 | 1 | Odoribacter | genus | Decreases |
| 0 | 1 | Phocaeicola | genus | Decreases |
| 0 | 1 | Streptococcus | genus | Decreases |
| 0 | 1 | Veillonella | genus | Decreases |
| 0 | 1 | Enterocloster | genus | Decreases |
| 0 | 1 | Blautia | genus | Decreases |
| 1 | 0 | Akkermansia | genus | Decreases |
| 0 | 1 | environmental samples | no rank | Decreases |
| 0 | 1 | unclassified Akkermansia | no rank | Decreases |
| 1 | 0 | Bifidobacterium longum | species | Decreases |
| 1 | 0 | [Ruminococcus] torques | species | Decreases |
| 1 | 0 | Agathobacter rectalis | species | Decreases |
| 1 | 0 | Bacteroides caccae | species | Decreases |
| 1 | 0 | Dorea formicigenerans | species | Decreases |
| 1 | 0 | Bifidobacterium adolescentis | species | Decreases |
| 1 | 0 | Collinsella aerofaciens | species | Decreases |
| 1 | 0 | Bacteroides xylanisolvens | species | Decreases |
| 0 | 1 | Akkermansia massiliensis | species | Decreases |
| 0 | 1 | Candidatus Akkermansia intestinavium | species | Decreases |
| 1 | 0 | Enterocloster bolteae | species | Decreases |
| 1 | 0 | Blautia obeum | species | Decreases |
| 1 | 0 | Odoribacter splanchnicus | species | Decreases |
| 1 | 0 | Eggerthella lenta | species | Decreases |
| 1 | 0 | Mediterraneibacter gnavus | species | Decreases |
| 1 | 0 | Roseburia hominis | species | Decreases |
| 1 | 0 | Veillonella parvula | species | Decreases |
| 1 | 0 | Bilophila wadsworthia | species | Decreases |
| 1 | 0 | Bacteroides ovatus | species | Decreases |
| 1 | 0 | Coprococcus comes | species | Decreases |
| 1 | 0 | Akkermansia muciniphila | species | Decreases |
| 1 | 0 | Streptococcus parasanguinis | species | Decreases |
| 1 | 0 | Parabacteroides merdae | species | Decreases |
| 1 | 0 | Phocaeicola vulgatus | species | Decreases |
| 1 | 0 | Clostridioides difficile | species | Decreases |
| 0 | 1 | Akkermansia glycaniphila | species | Decreases |
| 0 | 1 | Bifidobacterium longum subsp. longum | subspecies | Decreases |
| 0 | 1 | Bifidobacterium longum subsp. infantis | subspecies | Decreases |
| 0 | 1 | Bifidobacterium longum subsp. suis | subspecies | Decreases |
| 0 | 1 | Bifidobacterium longum subsp. suillum | subspecies | Decreases |
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Abdominal Aortic Aneurysm | 0.3 | 0.3 | |
| Acne | 0.6 | 0.9 | -0.5 |
| ADHD | 3.6 | 0.9 | 3 |
| Age-Related Macular Degeneration and Glaucoma | 1.1 | 0.4 | 1.75 |
| Allergic Rhinitis (Hay Fever) | 2.2 | 1.8 | 0.22 |
| Allergies | 3.7 | 2.8 | 0.32 |
| Allergy to milk products | 1 | 1 | 0 |
| Alopecia (Hair Loss) | 1 | 1 | |
| Alzheimer's disease | 3.9 | 4.6 | -0.18 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 1.9 | 0.7 | 1.71 |
| Ankylosing spondylitis | 2.2 | 0.5 | 3.4 |
| Anorexia Nervosa | 1.1 | 1.8 | -0.64 |
| Antiphospholipid syndrome (APS) | 0.3 | 0.3 | 0 |
| Asthma | 3.6 | 2.2 | 0.64 |
| Atherosclerosis | 0.9 | 1.2 | -0.33 |
| Atrial fibrillation | 2.9 | 1.8 | 0.61 |
| Autism | 5.9 | 5.5 | 0.07 |
| Autoimmune Disease | 0.6 | 0.8 | -0.33 |
| Barrett esophagus cancer | 0.3 | 0.3 | 0 |
| benign prostatic hyperplasia | 0.3 | -0.3 | |
| Biofilm | 0.9 | 0.9 | |
| Bipolar Disorder | 1.3 | 1.4 | -0.08 |
| Brain Trauma | 0.9 | 1.1 | -0.22 |
| Breast Cancer | 0.6 | 0.6 | |
| Cancer (General) | 0.6 | 1.8 | -2 |
| Carcinoma | 3.4 | 2.3 | 0.48 |
| Celiac Disease | 1.2 | 3.3 | -1.75 |
| Cerebral Palsy | 1.2 | 1 | 0.2 |
| Chronic Fatigue Syndrome | 2.5 | 3.8 | -0.52 |
| Chronic Kidney Disease | 3.5 | 2.7 | 0.3 |
| Chronic Lyme | 0 | 0.8 | 0 |
| Chronic Obstructive Pulmonary Disease (COPD) | 1 | 1.4 | -0.4 |
| Chronic Urticaria (Hives) | 0.6 | 0.1 | 5 |
| Coagulation / Micro clot triggering bacteria | 0.7 | 1 | -0.43 |
| Cognitive Function | 3.2 | 1.5 | 1.13 |
| Colorectal Cancer | 5 | 2.2 | 1.27 |
| Constipation | 0.3 | 1.3 | -3.33 |
| Coronary artery disease | 1.1 | 2.4 | -1.18 |
| COVID-19 | 5 | 6.1 | -0.22 |
| Crohn's Disease | 4.6 | 3.8 | 0.21 |
| Cushing's Syndrome (hypercortisolism) | 0.3 | -0.3 | |
| cystic fibrosis | 1.6 | -1.6 | |
| deep vein thrombosis | 1 | 1.1 | -0.1 |
| Denture Wearers Oral Shifts | 0.5 | 0.5 | |
| Depression | 6.8 | 6.4 | 0.06 |
| Dermatomyositis | 0.3 | 0.3 | 0 |
| Eczema | 0.8 | 1.5 | -0.88 |
| Endometriosis | 2.3 | 1.4 | 0.64 |
| Eosinophilic Esophagitis | 0.6 | -0.6 | |
| Epilepsy | 1.3 | 1.3 | 0 |
| erectile dysfunction | 0.5 | 0.3 | 0.67 |
| Fibromyalgia | 2.3 | 1.7 | 0.35 |
| Functional constipation / chronic idiopathic constipation | 2.7 | 3 | -0.11 |
| gallstone disease (gsd) | 1.6 | 0.9 | 0.78 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 0.3 | 0.6 | -1 |
| Generalized anxiety disorder | 1.6 | 2.4 | -0.5 |
| Glioblastoma | 0.3 | -0.3 | |
| Gout | 1.7 | 0.9 | 0.89 |
| Graves' disease | 1.6 | 3 | -0.88 |
| Gulf War Syndrome | 0.7 | 0.5 | 0.4 |
| Halitosis | 0.9 | 0.3 | 2 |
| Hashimoto's thyroiditis | 2.8 | 1.6 | 0.75 |
| Heart Failure | 1.5 | 1.6 | -0.07 |
| hemorrhagic stroke | 1 | 1 | |
| Hidradenitis Suppurativa | 0.9 | 0.3 | 2 |
| High Histamine/low DAO | 0.5 | 0.3 | 0.67 |
| hypercholesterolemia (High Cholesterol) | 0.3 | 0.1 | 2 |
| hyperglycemia | 0.8 | 1.3 | -0.63 |
| Hyperlipidemia (High Blood Fats) | 0.9 | 0.3 | 2 |
| hypersomnia | 0.7 | -0.7 | |
| hypertension (High Blood Pressure | 3.2 | 3.7 | -0.16 |
| Hypothyroidism | 0.3 | 1 | -2.33 |
| Hypoxia | 1.6 | 0.3 | 4.33 |
| IgA nephropathy (IgAN) | 1.3 | 1.7 | -0.31 |
| Inflammatory Bowel Disease | 3 | 5.3 | -0.77 |
| Insomnia | 1.9 | 2 | -0.05 |
| Intelligence | 0.8 | 0.8 | |
| Intracranial aneurysms | 0.9 | 0.9 | 0 |
| Irritable Bowel Syndrome | 4.4 | 3 | 0.47 |
| ischemic stroke | 2.5 | 1.1 | 1.27 |
| Liver Cirrhosis | 4.7 | 3.6 | 0.31 |
| Long COVID | 4 | 5.5 | -0.38 |
| Low bone mineral density | 0.8 | -0.8 | |
| Lung Cancer | 0.7 | 0.8 | -0.14 |
| Lymphoma | 0.3 | 0.3 | |
| Mast Cell Issues / mastitis | 0.3 | 0.6 | -1 |
| ME/CFS with IBS | 0.6 | 1.4 | -1.33 |
| ME/CFS without IBS | 1 | 1.6 | -0.6 |
| membranous nephropathy | 0.3 | 0.3 | |
| Menopause | 1.5 | 0.6 | 1.5 |
| Metabolic Syndrome | 5.2 | 5.5 | -0.06 |
| Mood Disorders | 6.5 | 5.3 | 0.23 |
| multiple chemical sensitivity [MCS] | 0.6 | 0.1 | 5 |
| Multiple Sclerosis | 3.9 | 3.2 | 0.22 |
| Multiple system atrophy (MSA) | 0.5 | 0.4 | 0.25 |
| myasthenia gravis | 0.3 | 0.5 | -0.67 |
| neuropathic pain | 0.3 | 2.1 | -6 |
| Neuropathy (all types) | 0.8 | 1.9 | -1.37 |
| neuropsychiatric disorders (PANDAS, PANS) | 0.6 | 0.6 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 2.5 | 3.9 | -0.56 |
| NonCeliac Gluten Sensitivity | 1.4 | 0.6 | 1.33 |
| Obesity | 7.3 | 5.6 | 0.3 |
| obsessive-compulsive disorder | 1.8 | 3.4 | -0.89 |
| Osteoarthritis | 0.9 | 0.9 | 0 |
| Osteoporosis | 1.4 | 1.7 | -0.21 |
| pancreatic cancer | 0.9 | 0.6 | 0.5 |
| Parkinson's Disease | 6 | 4.1 | 0.46 |
| Polycystic ovary syndrome | 2.8 | 2.2 | 0.27 |
| Postural orthostatic tachycardia syndrome | 0.6 | -0.6 | |
| Premenstrual dysphoric disorder | 0.7 | 0.4 | 0.75 |
| primary biliary cholangitis | 1.2 | 0.6 | 1 |
| Primary sclerosing cholangitis | 1.6 | 1.4 | 0.14 |
| Psoriasis | 1.8 | 2.2 | -0.22 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 5.4 | 3.5 | 0.54 |
| Rosacea | 0.9 | 0.8 | 0.13 |
| Schizophrenia | 4.5 | 2.3 | 0.96 |
| scoliosis | 0.3 | 0.3 | 0 |
| Sjögren syndrome | 1.6 | 2.4 | -0.5 |
| Sleep Apnea | 1.3 | 1.5 | -0.15 |
| Slow gastric motility / Gastroparesis | 0.6 | 0.3 | 1 |
| Small Intestinal Bacterial Overgrowth (SIBO) | 1.2 | 0.7 | 0.71 |
| Stress / posttraumatic stress disorder | 2.2 | 2.5 | -0.14 |
| Systemic Lupus Erythematosus | 2.8 | 1.3 | 1.15 |
| Tic Disorder | 0.6 | 1.2 | -1 |
| Tourette syndrome | 0.9 | 0.3 | 2 |
| Type 1 Diabetes | 2.4 | 2.9 | -0.21 |
| Type 2 Diabetes | 5.9 | 4.4 | 0.34 |
| Ulcerative colitis | 2.5 | 3.6 | -0.44 |
| Unhealthy Ageing | 3.5 | 2.4 | 0.46 |
| Vitiligo | 1.3 | 0.9 | 0.44 |
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