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Gastrointestinal Effects: Indomethacin can cause gastrointestinal side effects, such as:
Stomach pain
Heartburn
Nausea
Vomiting
Diarrhea
Gastric ulcers
Gastrointestinal bleeding
Cardiovascular Risks: Like other NSAIDs, indomethacin is associated with an increased risk of cardiovascular events, including heart attack and stroke, especially when used at high doses or for long durations.
Renal Effects: Indomethacin can cause adverse effects on kidney function, including:
Decreased kidney function
Fluid retention
Edema
High blood pressure (hypertension)
Kidney damage in some cases
Central Nervous System Effects: Indomethacin may cause central nervous system (CNS) side effects, such as:
Headache
Dizziness
Drowsiness
Confusion
Depression
Anxiety
Hematologic Effects: Indomethacin may affect blood clotting and platelet function, leading to:
Increased bleeding tendency
Anemia
Thrombocytopenia
Hepatotoxicity: Rare cases of liver damage and liver failure have been reported with NSAID use, including indomethacin.
Allergic Reactions: Some individuals may experience allergic reactions to indomethacin, ranging from mild skin rash to severe hypersensitivity reactions such as anaphylaxis.
Gastrointestinal Perforation: In rare cases, NSAIDs like indomethacin can lead to gastrointestinal perforation, a serious condition that requires immediate medical attention.
Other Adverse Effects: Additional adverse effects associated with indomethacin use may include tinnitus (ringing in the ears), blurred vision, photosensitivity, and exacerbation of asthma in susceptible individuals.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
Impact of indomethacin,(prescription) on Conditions from US National Library of Medicine
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups.
We just tally: X|reduces + Y|Increase = Positive β X|increases + Y|decrease = Negative.
Benefit Ratio: Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
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