This site may require a log-in in the near future. We are constantly being swamped by AI agents. If they continue to take down the site, we will be changing to requiring logins to access any item.

🍽️ guanethidine sulfate,(prescription)

AI Engines For more Details: Perplexity  Kagi Labs  You 

  1. Mechanism of Action: Guanethidine sulfate belongs to a class of medications known as sympatholytics or adrenergic neuron blockers. It works by inhibiting the release of norepinephrine from nerve endings, which reduces sympathetic nervous system activity. This leads to vasodilation (widening of blood vessels) and a subsequent decrease in blood pressure.

  2. Treatment of Hypertension: Guanethidine sulfate was historically used as an antihypertensive medication to lower blood pressure in patients with essential hypertension (high blood pressure without an identifiable cause). It was particularly useful in patients who did not respond adequately to other antihypertensive agents.

  3. Limited Use: Despite its efficacy in lowering blood pressure, guanethidine sulfate is rarely used today due to several limitations and side effects associated with its use. These include the need for frequent dosing, slow onset of action, and a high incidence of adverse effects.

  4. Adverse Effects: Guanethidine sulfate can cause a range of side effects, some of which can be severe. Common side effects include orthostatic hypotension (a sudden drop in blood pressure upon standing), dizziness, lightheadedness, weakness, fatigue, gastrointestinal disturbances (such as nausea and diarrhea), and sexual dysfunction.

  5. Orthostatic Hypotension: Orthostatic hypotension is one of the most significant side effects of guanethidine sulfate. It occurs due to the medication's ability to reduce sympathetic tone, leading to inadequate compensation for changes in body position. Patients may experience symptoms such as dizziness, lightheadedness, or fainting when transitioning from lying down to standing up.

  6. Central Nervous System Effects: Guanethidine sulfate can cross the blood-brain barrier and exert effects on the central nervous system. This may result in side effects such as sedation, confusion, depression, and cognitive impairment.

  7. Cardiovascular Effects: In addition to lowering blood pressure, guanethidine sulfate may also affect heart rate and rhythm. It can cause bradycardia (slow heart rate) and may exacerbate conduction abnormalities in patients with pre-existing cardiac conditions.

  8. Withdrawal Rebound Hypertension: Abrupt discontinuation of guanethidine sulfate can lead to rebound hypertension, characterized by a sudden and significant increase in blood pressure. Therefore, the medication should be tapered off gradually under medical supervision when discontinuing treatment.

  9. Contraindications and Precautions: Guanethidine sulfate is contraindicated in patients with hypersensitivity to the medication, severe bradycardia, heart block, or pheochromocytoma (a rare adrenal gland tumor). It should be used with caution in patients with pre-existing cardiovascular disease, renal impairment, or hepatic impairment.

  10. Interactions with Other Medications: Guanethidine sulfate may interact with other medications that affect blood pressure or sympathetic nervous system activity. Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking before starting guanethidine sulfate.

;

Check for interactions on Supp.AI   |   📚 PubMed Citations

⚗️ Compensation for antibiotic usage

Data Contradictions — Limits of Certainity

Impacted of guanethidine sulfate,(prescription) On Probiotics

Rank Probiotic Impact
species Escherichia coli Reduces
species Lacticaseibacillus paracasei Reduces

Bacteria Impacted by guanethidine sulfate,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

🧙?

📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Clostridium genus Decreases
0 1 Lacticaseibacillus genus Decreases
0 1 Roseburia genus Decreases
0 1 Streptococcus genus Decreases
0 1 Bacteroides genus Decreases
0 1 Parabacteroides genus Decreases
0 1 Fusobacterium genus Decreases
0 1 Escherichia genus Decreases
0 1 Clostridium perfringens A no rank Decreases
0 1 Clostridium perfringens B no rank Decreases
0 1 Clostridium perfringens C no rank Decreases
0 1 Clostridium perfringens CPE no rank Decreases
0 1 Clostridium perfringens D no rank Decreases
0 1 Clostridium perfringens E no rank Decreases
0 1 Escherichia coli O1:K1:H7 no rank Decreases
0 1 Escherichia coli O139:H1 no rank Decreases
0 1 Escherichia coli O141:H4 no rank Decreases
0 1 Escherichia coli O145:H34 no rank Decreases
0 1 Escherichia coli O15:H12 no rank Decreases
0 1 Escherichia coli O155:H21 no rank Decreases
0 1 Escherichia coli O158:H23 no rank Decreases
0 1 Escherichia coli O16:H48 no rank Decreases
0 1 Escherichia coli O170:H18 no rank Decreases
0 1 Escherichia coli O18ac:H14 no rank Decreases
0 1 Escherichia coli O19:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H4 no rank Decreases
0 1 Escherichia coli O2:K1:H5 no rank Decreases
0 1 Escherichia coli O2:K1:H7 no rank Decreases
0 1 Escherichia coli O20:H12 no rank Decreases
0 1 Escherichia coli O25:H16 no rank Decreases
0 1 Escherichia coli O55:H7 no rank Decreases
0 1 Escherichia coli O68:H12 no rank Decreases
0 1 Escherichia coli O7:H15 no rank Decreases
0 1 Escherichia coli O78:H51 no rank Decreases
0 1 Escherichia coli O80:H26 no rank Decreases
0 1 Escherichia coli O84:H7 no rank Decreases
0 1 Escherichia coli O85:H1 no rank Decreases
0 1 Escherichia coli O103 serogroup Decreases
0 1 Escherichia coli O111 serogroup Decreases
0 1 Escherichia coli O119 serogroup Decreases
0 1 Escherichia coli O121 serogroup Decreases
0 1 Escherichia coli O145 serogroup Decreases
0 1 Escherichia coli O155 serogroup Decreases
0 1 Escherichia coli O157 serogroup Decreases
0 1 Escherichia coli O177 serogroup Decreases
0 1 Escherichia coli O26 serogroup Decreases
0 1 Escherichia coli O3 serogroup Decreases
0 1 Escherichia coli O43 serogroup Decreases
0 1 Escherichia coli O5 serogroup Decreases
0 1 Escherichia coli O78 serogroup Decreases
0 1 Escherichia coli O86 serogroup Decreases
0 1 Escherichia coli O91 serogroup Decreases
0 1 Escherichia coli H20 serotype Decreases
0 1 Escherichia coli O1:H42 serotype Decreases
0 1 Escherichia coli O1:HNT serotype Decreases
0 1 Escherichia coli O10:H32 serotype Decreases
0 1 Escherichia coli O10:K5(L):H4 serotype Decreases
0 1 Escherichia coli O100:H21 serotype Decreases
0 1 Escherichia coli O103:H11 serotype Decreases
0 1 Escherichia coli O103:H2 serotype Decreases
0 1 Escherichia coli O103:H25 serotype Decreases
0 1 Escherichia coli O104:H21 serotype Decreases
0 1 Escherichia coli O104:H4 serotype Decreases
0 1 Escherichia coli O111:H- serotype Decreases
0 1 Escherichia coli O111:H11 serotype Decreases
0 1 Escherichia coli O111:H8 serotype Decreases
0 1 Escherichia coli O111:NM serotype Decreases
0 1 Escherichia coli O112ab:H8 serotype Decreases
0 1 Escherichia coli O112ac:H19 serotype Decreases
0 1 Escherichia coli O113:H21 serotype Decreases
0 1 Escherichia coli O114:H49 serotype Decreases
0 1 Escherichia coli O118:H16 serotype Decreases
0 1 Escherichia coli O121:H19 serotype Decreases
0 1 Escherichia coli O121:H7 serotype Decreases
0 1 Escherichia coli O123:H11 serotype Decreases
0 1 Escherichia coli O125ac:K+:H10 serotype Decreases
0 1 Escherichia coli O126:H45 serotype Decreases
0 1 Escherichia coli O127:H27 serotype Decreases
0 1 Escherichia coli O127:H6 serotype Decreases
0 1 Escherichia coli O128:H2 serotype Decreases
0 1 Escherichia coli O128ac:H12 serotype Decreases
0 1 Escherichia coli O139:H28 serotype Decreases
0 1 Escherichia coli O145:H25 serotype Decreases
0 1 Escherichia coli O145:H28 serotype Decreases
0 1 Escherichia coli O145:NM serotype Decreases
0 1 Escherichia coli O146:H21 serotype Decreases
0 1 Escherichia coli O15:H18 serotype Decreases
0 1 Escherichia coli O150:H6 serotype Decreases
0 1 Escherichia coli O152:H23 serotype Decreases
0 1 Escherichia coli O153:H2 serotype Decreases
0 1 Escherichia coli O156:H25 serotype Decreases
0 1 Escherichia coli O157:H- serotype Decreases
0 1 Escherichia coli O157:H43 serotype Decreases
0 1 Escherichia coli O157:H7 serotype Decreases
0 1 Escherichia coli O157:NM serotype Decreases
0 1 Escherichia coli O16:H6 serotype Decreases
0 1 Escherichia coli O165:H25 serotype Decreases
0 1 Escherichia coli O167:H26 serotype Decreases
0 1 Escherichia coli O174:H2 serotype Decreases
0 1 Escherichia coli O174:H21 serotype Decreases
0 1 Escherichia coli O174:H8 serotype Decreases
0 1 Escherichia coli O176:H45 serotype Decreases
0 1 Escherichia coli O177:NM serotype Decreases
0 1 Escherichia coli O2:H6 serotype Decreases
0 1 Escherichia coli O2:K2:H1 serotype Decreases
0 1 Escherichia coli O25:H1 serotype Decreases
0 1 Escherichia coli O25:NM serotype Decreases
0 1 Escherichia coli O26:H1 serotype Decreases
0 1 Escherichia coli O26:H11 serotype Decreases
0 1 Escherichia coli O28ac:NM serotype Decreases
0 1 Escherichia coli O29:H4 serotype Decreases
0 1 Escherichia coli O32:H37 serotype Decreases
0 1 Escherichia coli O39:NM serotype Decreases
0 1 Escherichia coli O44:H18 serotype Decreases
0 1 Escherichia coli O45:H2 serotype Decreases
0 1 Escherichia coli O6:H16 serotype Decreases
0 1 Escherichia coli O6:H16:CFA/II serotype Decreases
0 1 Escherichia coli O6:K2:H1 serotype Decreases
0 1 Escherichia coli O69:H11 serotype Decreases
0 1 Escherichia coli O7:H4 serotype Decreases
0 1 Escherichia coli O7:K1 serotype Decreases
0 1 Escherichia coli O78:H12 serotype Decreases
0 1 Escherichia coli O78:H4 serotype Decreases
0 1 Escherichia coli O79:H7 serotype Decreases
0 1 Escherichia coli O8:H8 serotype Decreases
0 1 Escherichia coli O81:NM serotype Decreases
0 1 Escherichia coli O83:H1 serotype Decreases
0 1 Escherichia coli O86:H34 serotype Decreases
0 1 Escherichia coli O89m:H10 serotype Decreases
0 1 Escherichia coli O89m:H9 serotype Decreases
0 1 Escherichia coli O9:H10 serotype Decreases
0 1 Escherichia coli O91:H14 serotype Decreases
0 1 Escherichia coli O91:NM serotype Decreases
0 1 Escherichia coli O99:H6 serotype Decreases
0 1 Escherichia coli ONT:H33 serotype Decreases
1 0 Clostridium perfringens species Decreases
1 0 Lacticaseibacillus paracasei species Decreases
1 0 Roseburia hominis species Decreases
1 0 Streptococcus salivarius species Decreases
1 0 Bacteroides fragilis species Decreases
0 1 Butyrivibrio crossotus species Decreases
0 1 Subdoligranulum variabile species Decreases
0 1 Vescimonas fastidiosa species Decreases
0 1 Eubacterium sp. MSJ-33 species Decreases
0 1 Streptococcus sp. FDAARGOS_192 species Decreases
0 1 Simiaoa sunii species Decreases
0 1 Coprococcus eutactus species Decreases
0 1 Clostridium sp. SY8519 species Decreases
0 1 Clostridium sp. M62/1 species Decreases
0 1 Wujia chipingensis species Decreases
0 1 Ruminococcus champanellensis species Decreases
0 1 Faecalibacterium sp. I4-1-79 species Decreases
0 1 Coprococcus sp. ART55/1 species Decreases
0 1 Ligilactobacillus ruminis species Decreases
0 1 Coprococcus catus species Decreases
0 1 Faecalibacterium duncaniae species Decreases
0 1 Eubacterium ventriosum species Decreases
0 1 Faecalibacterium sp. HTF-F species Decreases
0 1 Wansuia hejianensis species Decreases
0 1 Coprococcus comes species Decreases
0 1 Faecalibacterium sp. IP-1-18 species Decreases
0 1 Lacrimispora saccharolytica species Decreases
0 1 Vescimonas coprocola species Decreases
1 0 Streptococcus parasanguinis species Decreases
0 1 Ruminococcus bicirculans (ex Wegman et al. 2014) species Decreases
0 1 Faecalibacterium sp. I3-3-33 species Decreases
0 1 Faecalibacterium sp. I4-3-84 species Decreases
0 1 Roseburia rectibacter species Decreases
0 1 Lachnospira eligens species Decreases
0 1 Oscillibacter hominis species Decreases
0 1 Roseburia intestinalis species Decreases
0 1 Faecalibacterium sp. I2-3-92 species Decreases
0 1 Qiania dongpingensis species Decreases
0 1 Intestinimonas butyriciproducens species Decreases
1 0 Parabacteroides merdae species Decreases
0 1 Pusillibacter faecalis species Decreases
0 1 Blautia obeum species Decreases
0 1 Pseudobutyrivibrio xylanivorans species Decreases
0 1 Massilistercora timonensis species Decreases
0 1 [Ruminococcus] lactaris species Decreases
0 1 Faecalibacterium sp. I3-3-89 species Decreases
0 1 Faecalibacterium sp. IP-3-29 species Decreases
0 1 [Clostridium] hylemonae species Decreases
0 1 Flintibacter sp. KGMB00164 species Decreases
0 1 Catenibacterium mitsuokai species Decreases
0 1 Maliibacterium massiliense species Decreases
0 1 Intestinibaculum porci species Decreases
0 1 Dorea formicigenerans species Decreases
0 1 Treponema peruense species Decreases
1 0 Fusobacterium nucleatum species Decreases
1 0 Escherichia coli species Decreases
0 1 Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases
0 1 Lacticaseibacillus paracasei subsp. tolerans subspecies Decreases
0 1 Fusobacterium nucleatum subsp. nucleatum subspecies Decreases

Impact of guanethidine sulfate,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
ADHD 0.4 0.1 3
Age-Related Macular Degeneration and Glaucoma 0.3 0.1 2
Allergic Rhinitis (Hay Fever) 0.7 0.5 0.4
Allergies 1 0.5 1
Allergy to milk products 0.5 0.3 0.67
Alopecia (Hair Loss) 0.1 -0.1
Alzheimer's disease 0.9 1.5 -0.67
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0.3 0.1 2
Ankylosing spondylitis 0.3 0.1 2
Anorexia Nervosa 0.5 0.9 -0.8
Antiphospholipid syndrome (APS) 0.3 0.3
Asthma 1.3 0.4 2.25
Atherosclerosis 0.4 0.6 -0.5
Atrial fibrillation 0.5 0.2 1.5
Autism 1.6 1.3 0.23
Autoimmune Disease 0.1 0.5 -4
Barrett esophagus cancer 0 0.1 0
benign prostatic hyperplasia 0 0.1 0
Biofilm 0.4 0.4
Bipolar Disorder 0.5 0.2 1.5
Brain Trauma 0.1 0.3 -2
Breast Cancer 0.1 0.1
Cancer (General) 0 1 0
Carcinoma 0.4 0.2 1
Celiac Disease 0.6 0.2 2
Cerebral Palsy 0.5 0.3 0.67
Chronic Fatigue Syndrome 0.8 0.8 0
Chronic Kidney Disease 0.3 0.5 -0.67
Chronic Lyme 0.3 -0.3
Chronic Obstructive Pulmonary Disease (COPD) 0.6 0.3 1
Chronic Urticaria (Hives) 0.5 0.2 1.5
Coagulation / Micro clot triggering bacteria 0.3 0.3 0
Cognitive Function 0.3 0.6 -1
Colorectal Cancer 1.6 0.8 1
Constipation 0.1 0.2 -1
Coronary artery disease 0.2 0.5 -1.5
COVID-19 1 1.4 -0.4
Crohn's Disease 1.2 0.7 0.71
Cushing's Syndrome (hypercortisolism) 0.1 -0.1
cystic fibrosis 0.1 0.3 -2
d-lactic acidosis (one form of brain fog) 0.1 0.1
deep vein thrombosis 0.4 0.4 0
Denture Wearers Oral Shifts 0.5 0.5
Depression 1.8 2 -0.11
Dermatomyositis 0.1 0.1
Eczema 0.5 0.9 -0.8
Endometriosis 0.4 0.2 1
Eosinophilic Esophagitis 0 0.1 0
Epilepsy 1.2 0.3 3
erectile dysfunction 0.5 0.5
Fibromyalgia 0.8 0.5 0.6
Functional constipation / chronic idiopathic constipation 1 0.8 0.25
gallstone disease (gsd) 0.7 0.2 2.5
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.3 0.2 0.5
Generalized anxiety disorder 0.3 0.5 -0.67
giant cell arteritis 0.3 -0.3
Glioblastoma 0.1 -0.1
Gout 0.2 0.3 -0.5
Graves' disease 0.2 0.4 -1
Gulf War Syndrome 0.4 0.2 1
Halitosis 0.3 0.1 2
Hashimoto's thyroiditis 0.5 0.1 4
Heart Failure 0.9 0.2 3.5
hemorrhagic stroke 0.1 0.1
Hidradenitis Suppurativa 0.2 0.2
High Histamine/low DAO 1.2 1.2
hypercholesterolemia (High Cholesterol) 0.4 0.4
hyperglycemia 0.4 0.2 1
hypertension (High Blood Pressure 0.4 1 -1.5
Hypoxia 1.1 1.1
IgA nephropathy (IgAN) 0.3 0.7 -1.33
Inflammatory Bowel Disease 2.4 1.3 0.85
Insomnia 0.5 0.4 0.25
Intelligence 0.5 0.5
Intracranial aneurysms 0.2 0.2
Irritable Bowel Syndrome 1.1 0.7 0.57
ischemic stroke 0.3 0.3 0
Liver Cirrhosis 1.7 0.8 1.13
Long COVID 0.6 0.7 -0.17
Low bone mineral density 0.3 -0.3
Lung Cancer 0 0
Lymphoma 0 0
Mast Cell Issues / mastitis 0.2 0.2
ME/CFS with IBS 0.4 0.6 -0.5
ME/CFS without IBS 0.4 0.3 0.33
membranous nephropathy 0.1 0.1
Menopause 0.2 0.2 0
Metabolic Syndrome 1.2 1.3 -0.08
Mood Disorders 2.3 1.4 0.64
multiple chemical sensitivity [MCS] 0.4 0.4
Multiple Sclerosis 1.6 1.8 -0.13
Multiple system atrophy (MSA) 0.5 0.5
myasthenia gravis 0.1 0.5 -4
neuropathic pain 0.7 -0.7
Neuropathy (all types) 0.1 0.3 -2
neuropsychiatric disorders (PANDAS, PANS) 0.2 0.2
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 0.9 0.4 1.25
NonCeliac Gluten Sensitivity 0.1 0.1 0
Obesity 1.4 2 -0.43
obsessive-compulsive disorder 0.9 0.2 3.5
Osteoarthritis 0.5 0.3 0.67
Osteoporosis 0.6 0.2 2
pancreatic cancer 0.2 0.1 1
Parkinson's Disease 1.4 1.3 0.08
Polycystic ovary syndrome 1.2 0.7 0.71
Postural orthostatic tachycardia syndrome 0.3 0.3
Premenstrual dysphoric disorder 0.1 -0.1
primary biliary cholangitis 0.1 0.5 -4
Primary sclerosing cholangitis 0.7 0.6 0.17
Psoriasis 0.8 0.3 1.67
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 0.7 0.8 -0.14
Rosacea 0.5 -0.5
Schizophrenia 1.2 0.6 1
scoliosis 0.2 0.1 1
Sjögren syndrome 0.2 0.2 0
Sleep Apnea 0 0.3 0
Slow gastric motility / Gastroparesis 0.2 0.2
Small Intestinal Bacterial Overgrowth (SIBO) 0.6 0.6
Stress / posttraumatic stress disorder 0.7 0.3 1.33
Systemic Lupus Erythematosus 1 0.3 2.33
Tic Disorder 0.1 0.3 -2
Tourette syndrome 0.1 0.1 0
Type 1 Diabetes 0.7 0.7 0
Type 2 Diabetes 1.1 1.3 -0.18
Ulcerative colitis 1.8 1.3 0.38
Unhealthy Ageing 0.5 0.2 1.5
Vitiligo 0.5 0.5 0

Explanations /Info /Descriptions are influenced by Large Language Models and may not be accurate and include some hallucinations.Please report any to us for correction.

Copyright 2016 - 2025 Lassesen Consulting, LLC[2007], DBA, Microbiome Prescription All rights served.   Permission to data scrap or reverse engineer is explicitly denied to all users.U.S.Code Title 18 PART I CHAPTER 47 § 1030, CETS No.185, CFAA   Use of data on this site is prohibited except under written license.There is no charge for individual personal use.Use for any commercial applications or research requires a written license.   Caveat emptor: Analysis and suggestions are based on modelling(and thus infererence ) based on studies.The data sources are usually given for those that wish to consider alternative inferences.theories and models.   Inventions /Methodologies on this site are Patent Pending.

Microbiome Prescription do not make any representations that data or analyses available on this site is suitable for human diagnostic purposes, for informing treatment decisions, or for any other purposes and accept no responsibility or liability whatsoever for such use.
This site is not in strict compliance with Personal Health Information Laws. [216.73.216 ]