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Regulation of Menstrual Cycle: Progesterone is involved in regulating the menstrual cycle. During the menstrual cycle, progesterone levels rise after ovulation to prepare the uterus for implantation of a fertilized egg. If pregnancy does not occur, progesterone levels decrease, leading to menstruation.
Supporting Pregnancy: Progesterone is essential for maintaining pregnancy. It helps prepare the uterine lining for implantation of the fertilized egg and supports the growth and development of the embryo and fetus. Progesterone levels remain high throughout pregnancy, helping to prevent contractions of the uterine muscles and maintain the uterine lining.
Treatment of Menstrual Irregularities: Progesterone therapy may be used to regulate menstrual cycles in women with irregular periods or abnormal uterine bleeding. It can help induce regular menstrual cycles and restore hormonal balance.
Fertility Treatments: Progesterone may be prescribed as part of fertility treatments, such as in vitro fertilization (IVF) or ovulation induction. Supplementation with progesterone can support embryo implantation and early pregnancy in women undergoing fertility treatments.
Hormone Replacement Therapy (HRT): Progesterone is often used in combination with estrogen as part of hormone replacement therapy for menopausal women. It helps protect the uterus from the potential adverse effects of estrogen therapy, such as endometrial hyperplasia and cancer.
Management of Menopausal Symptoms: Progesterone therapy may help alleviate menopausal symptoms such as hot flashes, night sweats, and mood swings when used as part of HRT. It can also support bone health and reduce the risk of osteoporosis in menopausal women.
Prevention of Preterm Birth: In pregnant women at risk of preterm birth, progesterone supplementation may be prescribed to help reduce the risk of premature delivery. Progesterone therapy can help prevent preterm labor and prolong pregnancy in some cases.
Side Effects: Common side effects of progesterone therapy may include bloating, breast tenderness, mood changes, headache, dizziness, and fatigue. These side effects are usually mild and temporary but should be monitored by a healthcare provider.
Contraindications: Progesterone therapy may not be suitable for individuals with certain medical conditions, such as a history of hormone-sensitive cancers, liver disease, or blood clots. It is important to discuss any existing medical conditions and medications with a healthcare provider before starting progesterone therapy.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Bacteroides uniformis | Reduces |
| species | Escherichia coli | Reduces |
| species | Lacticaseibacillus paracasei | Reduces |
| species | Parabacteroides distasonis | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
| 📓 Direct Citations | 👪👶 Indirect Citations | Taxonomy | Rank | Effect |
|---|---|---|---|---|
| 0 | 1 | Escherichia | genus | Decreases |
| 0 | 1 | Parabacteroides | genus | Decreases |
| 0 | 1 | Ruminococcus | genus | Decreases |
| 0 | 1 | Bacteroides | genus | Decreases |
| 0 | 1 | Bilophila | genus | Decreases |
| 0 | 1 | Fusobacterium | genus | Decreases |
| 0 | 1 | Lacrimispora | genus | Decreases |
| 0 | 1 | Mediterraneibacter | genus | Decreases |
| 0 | 1 | Phocaeicola | genus | Decreases |
| 0 | 1 | Streptococcus | genus | Decreases |
| 0 | 1 | Segatella | genus | Decreases |
| 0 | 1 | Lacticaseibacillus | genus | Decreases |
| 0 | 1 | Escherichia coli O25:H16 | no rank | Decreases |
| 0 | 1 | Escherichia coli O145:H34 | no rank | Decreases |
| 0 | 1 | Escherichia coli O16:H48 | no rank | Decreases |
| 0 | 1 | Escherichia coli O141:H4 | no rank | Decreases |
| 0 | 1 | Escherichia coli O139:H1 | no rank | Decreases |
| 0 | 1 | Escherichia coli O80:H26 | no rank | Decreases |
| 0 | 1 | Escherichia coli O158:H23 | no rank | Decreases |
| 0 | 1 | Escherichia coli O84:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O2:K1:H4 | no rank | Decreases |
| 0 | 1 | Escherichia coli O2:K1:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O78:H51 | no rank | Decreases |
| 0 | 1 | Escherichia coli O18ac:H14 | no rank | Decreases |
| 0 | 1 | Escherichia coli O85:H1 | no rank | Decreases |
| 0 | 1 | Escherichia coli O7:H15 | no rank | Decreases |
| 0 | 1 | Escherichia coli O68:H12 | no rank | Decreases |
| 0 | 1 | Escherichia coli O55:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O1:K1:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O15:H12 | no rank | Decreases |
| 0 | 1 | Escherichia coli O170:H18 | no rank | Decreases |
| 0 | 1 | Escherichia coli O155:H21 | no rank | Decreases |
| 0 | 1 | Escherichia coli O19:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O2:K1:H5 | no rank | Decreases |
| 0 | 1 | Escherichia coli O20:H12 | no rank | Decreases |
| 0 | 1 | Escherichia coli O111 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O121 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O155 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O177 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O26 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O3 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O5 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O86 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O91 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O103 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O78 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O43 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O119 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O157 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O145 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O1:HNT | serotype | Decreases |
| 0 | 1 | Escherichia coli O10:K5(L):H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O103:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O103:H25 | serotype | Decreases |
| 0 | 1 | Escherichia coli O104:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli O111:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O111:H8 | serotype | Decreases |
| 0 | 1 | Escherichia coli O112ac:H19 | serotype | Decreases |
| 0 | 1 | Escherichia coli O114:H49 | serotype | Decreases |
| 0 | 1 | Escherichia coli O118:H16 | serotype | Decreases |
| 0 | 1 | Escherichia coli O121:H7 | serotype | Decreases |
| 0 | 1 | Escherichia coli O123:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O127:H27 | serotype | Decreases |
| 0 | 1 | Escherichia coli O127:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O128:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O128ac:H12 | serotype | Decreases |
| 0 | 1 | Escherichia coli O145:H25 | serotype | Decreases |
| 0 | 1 | Escherichia coli O145:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O146:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli O153:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O156:H25 | serotype | Decreases |
| 0 | 1 | Escherichia coli O157:H43 | serotype | Decreases |
| 0 | 1 | Escherichia coli O157:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O165:H25 | serotype | Decreases |
| 0 | 1 | Escherichia coli O174:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O174:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli O174:H8 | serotype | Decreases |
| 0 | 1 | Escherichia coli O176:H45 | serotype | Decreases |
| 0 | 1 | Escherichia coli O177:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O26:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O28ac:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O29:H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O32:H37 | serotype | Decreases |
| 0 | 1 | Escherichia coli O6:H16:CFA/II | serotype | Decreases |
| 0 | 1 | Escherichia coli O69:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O78:H12 | serotype | Decreases |
| 0 | 1 | Escherichia coli O79:H7 | serotype | Decreases |
| 0 | 1 | Escherichia coli O81:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O86:H34 | serotype | Decreases |
| 0 | 1 | Escherichia coli O91:H14 | serotype | Decreases |
| 0 | 1 | Escherichia coli O91:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli ONT:H33 | serotype | Decreases |
| 0 | 1 | Escherichia coli O100:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli O121:H19 | serotype | Decreases |
| 0 | 1 | Escherichia coli O157:H7 | serotype | Decreases |
| 0 | 1 | Escherichia coli O16:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O89m:H9 | serotype | Decreases |
| 0 | 1 | Escherichia coli O111:H- | serotype | Decreases |
| 0 | 1 | Escherichia coli O113:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli H20 | serotype | Decreases |
| 0 | 1 | Escherichia coli O150:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O111:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O112ab:H8 | serotype | Decreases |
| 0 | 1 | Escherichia coli O99:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O26:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O145:H28 | serotype | Decreases |
| 0 | 1 | Escherichia coli O126:H45 | serotype | Decreases |
| 0 | 1 | Escherichia coli O2:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O7:H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O1:H42 | serotype | Decreases |
| 0 | 1 | Escherichia coli O25:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O25:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O7:K1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O125ac:K+:H10 | serotype | Decreases |
| 0 | 1 | Escherichia coli O6:K2:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O152:H23 | serotype | Decreases |
| 0 | 1 | Escherichia coli O15:H18 | serotype | Decreases |
| 0 | 1 | Escherichia coli O39:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O44:H18 | serotype | Decreases |
| 0 | 1 | Escherichia coli O2:K2:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O8:H8 | serotype | Decreases |
| 0 | 1 | Escherichia coli O89m:H10 | serotype | Decreases |
| 0 | 1 | Escherichia coli O10:H32 | serotype | Decreases |
| 0 | 1 | Escherichia coli O6:H16 | serotype | Decreases |
| 0 | 1 | Escherichia coli O157:H- | serotype | Decreases |
| 0 | 1 | Escherichia coli O45:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O103:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O167:H26 | serotype | Decreases |
| 0 | 1 | Escherichia coli O104:H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O83:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O9:H10 | serotype | Decreases |
| 0 | 1 | Escherichia coli O78:H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O139:H28 | serotype | Decreases |
| 1 | 0 | Streptococcus salivarius | species | Decreases |
| 1 | 0 | Bacteroides caccae | species | Decreases |
| 1 | 0 | Fusobacterium nucleatum | species | Decreases |
| 1 | 0 | Parabacteroides distasonis | species | Decreases |
| 1 | 0 | Parabacteroides merdae | species | Decreases |
| 1 | 0 | Bacteroides uniformis | species | Decreases |
| 1 | 0 | Escherichia coli | species | Decreases |
| 1 | 0 | Lacticaseibacillus paracasei | species | Decreases |
| 1 | 0 | Streptococcus parasanguinis | species | Decreases |
| 1 | 0 | Bacteroides fragilis | species | Decreases |
| 1 | 0 | Ruminococcus bromii | species | Decreases |
| 1 | 0 | Bacteroides thetaiotaomicron | species | Decreases |
| 1 | 0 | Lacrimispora saccharolytica | species | Decreases |
| 1 | 0 | Bilophila wadsworthia | species | Decreases |
| 1 | 0 | Segatella copri | species | Decreases |
| 1 | 0 | Mediterraneibacter gnavus | species | Decreases |
| 1 | 0 | Phocaeicola vulgatus | species | Decreases |
| 0 | 1 | Lacticaseibacillus paracasei subsp. paracasei | subspecies | Decreases |
| 0 | 1 | Fusobacterium nucleatum subsp. nucleatum | subspecies | Decreases |
| 0 | 1 | Lacticaseibacillus paracasei subsp. tolerans | subspecies | Decreases |
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Abdominal Aortic Aneurysm | 0.4 | 0.4 | |
| Acne | 0.3 | 0.3 | |
| ADHD | 1.8 | 1.8 | |
| Age-Related Macular Degeneration and Glaucoma | 0.4 | -0.4 | |
| Allergic Rhinitis (Hay Fever) | 1.7 | 0.9 | 0.89 |
| Allergies | 2.2 | 1.1 | 1 |
| Allergy to milk products | 0.9 | 1.3 | -0.44 |
| Alopecia (Hair Loss) | 0.6 | 0.6 | |
| Alzheimer's disease | 3.5 | 2.4 | 0.46 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 0.8 | 0.6 | 0.33 |
| Ankylosing spondylitis | 2.2 | 1 | 1.2 |
| Anorexia Nervosa | 1 | 1.1 | -0.1 |
| Antiphospholipid syndrome (APS) | 0.7 | 0.3 | 1.33 |
| Asthma | 2.1 | 0.6 | 2.5 |
| Atherosclerosis | 1.4 | 0 | 0 |
| Atrial fibrillation | 1.5 | 1.7 | -0.13 |
| Autism | 2.6 | 3.7 | -0.42 |
| Autoimmune Disease | 0.9 | 0.9 | |
| Barrett esophagus cancer | 0.3 | 0.3 | 0 |
| benign prostatic hyperplasia | 0.6 | 0.3 | 1 |
| Biofilm | 1.6 | 1.6 | |
| Bipolar Disorder | 1.9 | 0.3 | 5.33 |
| Brain Trauma | 0.3 | 0.6 | -1 |
| Breast Cancer | 0.9 | 0.3 | 2 |
| Cancer (General) | 0.3 | 0.9 | -2 |
| Carcinoma | 3.1 | 1 | 2.1 |
| Celiac Disease | 1.2 | 1.3 | -0.08 |
| Cerebral Palsy | 0.6 | 0.6 | 0 |
| Chronic Fatigue Syndrome | 2.2 | 2.2 | 0 |
| Chronic Kidney Disease | 2 | 0.3 | 5.67 |
| Chronic Lyme | 0.3 | -0.3 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 1.9 | 0.6 | 2.17 |
| Chronic Urticaria (Hives) | 1.2 | 0.3 | 3 |
| Coagulation / Micro clot triggering bacteria | 1.6 | 0.6 | 1.67 |
| Cognitive Function | 1.3 | 0.3 | 3.33 |
| Colorectal Cancer | 4.9 | 0.9 | 4.44 |
| Constipation | 1.2 | 1.2 | |
| Coronary artery disease | 1.6 | 0.5 | 2.2 |
| COVID-19 | 3.7 | 3 | 0.23 |
| Crohn's Disease | 4.8 | 1.5 | 2.2 |
| Cushing's Syndrome (hypercortisolism) | 0.3 | -0.3 | |
| cystic fibrosis | 0.9 | 0.3 | 2 |
| d-lactic acidosis (one form of brain fog) | 0.3 | 0.3 | |
| deep vein thrombosis | 2.1 | 0.9 | 1.33 |
| Denture Wearers Oral Shifts | 1.6 | 1.6 | |
| Depression | 5.4 | 2.8 | 0.93 |
| Dermatomyositis | 0.3 | 0.3 | |
| Eczema | 1.2 | 1.2 | 0 |
| Endometriosis | 1.9 | 0.6 | 2.17 |
| Eosinophilic Esophagitis | 0.3 | 0.3 | 0 |
| Epilepsy | 2 | 1.3 | 0.54 |
| erectile dysfunction | 1.2 | 1.2 | |
| Fibromyalgia | 1 | 0.8 | 0.25 |
| Functional constipation / chronic idiopathic constipation | 2.5 | 1.9 | 0.32 |
| gallstone disease (gsd) | 2 | 0.3 | 5.67 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 1.1 | 0.3 | 2.67 |
| Generalized anxiety disorder | 1.9 | 0.6 | 2.17 |
| Glioblastoma | 0.3 | -0.3 | |
| Gout | 1.5 | 0.3 | 4 |
| Graves' disease | 1 | 0.9 | 0.11 |
| Gulf War Syndrome | 0.3 | 0.3 | 0 |
| Halitosis | 1.5 | 0.3 | 4 |
| Hashimoto's thyroiditis | 1.1 | 0.6 | 0.83 |
| Heart Failure | 2.9 | 0.3 | 8.67 |
| hemorrhagic stroke | 0.7 | 0.7 | |
| Hidradenitis Suppurativa | 1.2 | 1.2 | |
| High Histamine/low DAO | 0.3 | 0.3 | 0 |
| hypercholesterolemia (High Cholesterol) | 0.3 | 0.3 | |
| hyperglycemia | 1.6 | 0.7 | 1.29 |
| Hyperlipidemia (High Blood Fats) | 0.3 | 0.3 | |
| hypersomnia | 0.3 | -0.3 | |
| hypertension (High Blood Pressure | 2.5 | 1.5 | 0.67 |
| Hypoxia | 1.6 | 0.1 | 15 |
| IgA nephropathy (IgAN) | 1.6 | 0.7 | 1.29 |
| Inflammatory Bowel Disease | 3.9 | 2.6 | 0.5 |
| Insomnia | 1.3 | 0.9 | 0.44 |
| Intelligence | 1.1 | 0.1 | 10 |
| Intracranial aneurysms | 1.3 | 1.3 | |
| Irritable Bowel Syndrome | 3.4 | 1.8 | 0.89 |
| ischemic stroke | 1.6 | 0.9 | 0.78 |
| Liver Cirrhosis | 3.7 | 1.8 | 1.06 |
| Long COVID | 2.7 | 1.8 | 0.5 |
| Lung Cancer | 1.5 | 0.3 | 4 |
| Lymphoma | 0.6 | 0.6 | |
| Mast Cell Issues / mastitis | 1.5 | 0.3 | 4 |
| ME/CFS with IBS | 0.3 | 0.3 | 0 |
| ME/CFS without IBS | 0.4 | 0.9 | -1.25 |
| membranous nephropathy | 0.3 | 0.3 | |
| Menopause | 0.3 | 0.3 | |
| Metabolic Syndrome | 3.8 | 2.6 | 0.46 |
| Mood Disorders | 5 | 2.8 | 0.79 |
| multiple chemical sensitivity [MCS] | 1 | 1 | |
| Multiple Sclerosis | 3.2 | 2.2 | 0.45 |
| Multiple system atrophy (MSA) | 0.3 | 0.3 | 0 |
| myasthenia gravis | 0.9 | 0.9 | |
| neuropathic pain | 0.7 | -0.7 | |
| Neuropathy (all types) | 0.3 | 1 | -2.33 |
| neuropsychiatric disorders (PANDAS, PANS) | 0.6 | 0.6 | |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 2.2 | 0.6 | 2.67 |
| NonCeliac Gluten Sensitivity | 0.3 | 0.3 | 0 |
| Obesity | 4.2 | 3.5 | 0.2 |
| obsessive-compulsive disorder | 2.8 | 0.7 | 3 |
| Osteoarthritis | 1.7 | 0.9 | 0.89 |
| Osteoporosis | 1.2 | 0.6 | 1 |
| pancreatic cancer | 0.9 | 0.3 | 2 |
| Parkinson's Disease | 3.2 | 2.2 | 0.45 |
| Polycystic ovary syndrome | 3.8 | 1.3 | 1.92 |
| Premenstrual dysphoric disorder | 0.4 | -0.4 | |
| primary biliary cholangitis | 0.3 | 1 | -2.33 |
| Primary sclerosing cholangitis | 1.6 | 1.4 | 0.14 |
| Psoriasis | 1.1 | 1.4 | -0.27 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 3.1 | 0.8 | 2.88 |
| Rosacea | 0.3 | 0.3 | |
| Schizophrenia | 2.3 | 1 | 1.3 |
| scoliosis | 0.3 | 0.6 | -1 |
| Sjögren syndrome | 1.4 | 1.2 | 0.17 |
| Sleep Apnea | 0.6 | 0.6 | 0 |
| Slow gastric motility / Gastroparesis | 0.9 | 0.9 | |
| Small Intestinal Bacterial Overgrowth (SIBO) | 1.2 | 1.2 | |
| Stress / posttraumatic stress disorder | 1.3 | 0.7 | 0.86 |
| Systemic Lupus Erythematosus | 2.5 | 0.4 | 5.25 |
| Tic Disorder | 0.6 | 0.1 | 5 |
| Tourette syndrome | 0.3 | 0.3 | 0 |
| Type 1 Diabetes | 2 | 0.9 | 1.22 |
| Type 2 Diabetes | 4 | 2.8 | 0.43 |
| Ulcerative colitis | 2.8 | 2.2 | 0.27 |
| Unhealthy Ageing | 2.1 | 0.4 | 4.25 |
| Vitiligo | 1.5 | 0.4 | 2.75 |
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