🍽️ glimepiride,(prescription)

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Blood Glucose Control: Glimepiride helps lower blood sugar levels by increasing insulin secretion from the pancreas and improving insulin sensitivity in the body's cells. It is effective in managing hyperglycemia (high blood sugar) in patients with type 2 diabetes mellitus.
Insulin Secretagogue: As a sulfonylurea, glimepiride acts as an insulin secretagogue, promoting the release of insulin from the beta cells of the pancreas. This mechanism helps reduce blood glucose levels by increasing insulin availability.
Hypoglycemia: One of the common side effects of glimepiride is hypoglycemia, or low blood sugar levels. This can occur if the dose of glimepiride is too high relative to the individual's insulin needs or if meals are skipped or delayed.
Weight Gain: Some individuals may experience weight gain while taking glimepiride. This can be attributed to the medication's effect of increasing insulin levels, which can promote fat storage.
Gastrointestinal Effects: Glimepiride may cause gastrointestinal side effects such as nausea, vomiting, diarrhea, or abdominal discomfort in some patients. These effects are usually mild and transient.
Skin Reactions: Rarely, glimepiride may cause skin reactions such as rash or itching. If these symptoms occur, patients should consult their healthcare provider.
Liver Function: Glimepiride can affect liver function, although significant liver toxicity is rare. Liver function tests may be monitored periodically in patients taking glimepiride, especially those with pre-existing liver conditions.
Allergic Reactions: Some individuals may experience allergic reactions to glimepiride, although these are rare. Symptoms of an allergic reaction may include rash, itching, swelling, dizziness, or difficulty breathing. Immediate medical attention is necessary if an allergic reaction occurs.
Drug Interactions: Glimepiride may interact with other medications, including other antidiabetic drugs, leading to changes in blood sugar levels or an increased risk of hypoglycemia or other adverse effects. It's important for patients to inform their healthcare providers about all medications they are taking.
Cardiovascular Effects: While glimepiride itself does not directly affect the cardiovascular system, maintaining good blood sugar control with medications like glimepiride can reduce the risk of long-term cardiovascular complications associated with diabetes, such as heart disease and stroke.

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Check for interactions on Supp.AI | 📚 PubMed Citations

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Data Contradictions — Limits of Certainity

Impacted of glimepiride,(prescription) On Probiotics

Rank	Probiotic	Impact
species	Escherichia coli	Reduces
species	Parabacteroides distasonis	Reduces

Bacteria Impacted by glimepiride,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations	👪👶 Indirect Citations	Taxonomy	Rank	Effect
0	1	Cryptococcaceae	family	Decreases
1	0	Cryptococcus	genus	Decreases
0	1	Parabacteroides	genus	Decreases
0	1	Bacteroides	genus	Decreases
0	1	Streptococcus	genus	Decreases
0	1	Coprococcus	genus	Decreases
0	1	Mediterraneibacter	genus	Decreases
0	1	Segatella	genus	Decreases
0	1	Escherichia	genus	Decreases
0	1	unclassified Cryptococcus (in: basidiomycete fungi)	no rank	Decreases
0	1	Escherichia coli O1:K1:H7	no rank	Decreases
0	1	Escherichia coli O139:H1	no rank	Decreases
0	1	Escherichia coli O141:H4	no rank	Decreases
0	1	Escherichia coli O145:H34	no rank	Decreases
0	1	Escherichia coli O15:H12	no rank	Decreases
0	1	Escherichia coli O155:H21	no rank	Decreases
0	1	Escherichia coli O158:H23	no rank	Decreases
0	1	Escherichia coli O16:H48	no rank	Decreases
0	1	Escherichia coli O170:H18	no rank	Decreases
0	1	Escherichia coli O18ac:H14	no rank	Decreases
0	1	Escherichia coli O19:H7	no rank	Decreases
0	1	Escherichia coli O2:K1:H4	no rank	Decreases
0	1	Escherichia coli O2:K1:H5	no rank	Decreases
0	1	Escherichia coli O2:K1:H7	no rank	Decreases
0	1	Escherichia coli O20:H12	no rank	Decreases
0	1	Escherichia coli O25:H16	no rank	Decreases
0	1	Escherichia coli O55:H7	no rank	Decreases
0	1	Escherichia coli O68:H12	no rank	Decreases
0	1	Escherichia coli O7:H15	no rank	Decreases
0	1	Escherichia coli O78:H51	no rank	Decreases
0	1	Escherichia coli O80:H26	no rank	Decreases
0	1	Escherichia coli O84:H7	no rank	Decreases
0	1	Escherichia coli O85:H1	no rank	Decreases
0	1	Escherichia coli O103	serogroup	Decreases
0	1	Escherichia coli O111	serogroup	Decreases
0	1	Escherichia coli O119	serogroup	Decreases
0	1	Escherichia coli O121	serogroup	Decreases
0	1	Escherichia coli O145	serogroup	Decreases
0	1	Escherichia coli O155	serogroup	Decreases
0	1	Escherichia coli O157	serogroup	Decreases
0	1	Escherichia coli O177	serogroup	Decreases
0	1	Escherichia coli O26	serogroup	Decreases
0	1	Escherichia coli O3	serogroup	Decreases
0	1	Escherichia coli O43	serogroup	Decreases
0	1	Escherichia coli O5	serogroup	Decreases
0	1	Escherichia coli O78	serogroup	Decreases
0	1	Escherichia coli O86	serogroup	Decreases
0	1	Escherichia coli O91	serogroup	Decreases
0	1	Escherichia coli H20	serotype	Decreases
0	1	Escherichia coli O1:H42	serotype	Decreases
0	1	Escherichia coli O1:HNT	serotype	Decreases
0	1	Escherichia coli O10:H32	serotype	Decreases
0	1	Escherichia coli O10:K5(L):H4	serotype	Decreases
0	1	Escherichia coli O100:H21	serotype	Decreases
0	1	Escherichia coli O103:H11	serotype	Decreases
0	1	Escherichia coli O103:H2	serotype	Decreases
0	1	Escherichia coli O103:H25	serotype	Decreases
0	1	Escherichia coli O104:H21	serotype	Decreases
0	1	Escherichia coli O104:H4	serotype	Decreases
0	1	Escherichia coli O111:H-	serotype	Decreases
0	1	Escherichia coli O111:H11	serotype	Decreases
0	1	Escherichia coli O111:H8	serotype	Decreases
0	1	Escherichia coli O111:NM	serotype	Decreases
0	1	Escherichia coli O112ab:H8	serotype	Decreases
0	1	Escherichia coli O112ac:H19	serotype	Decreases
0	1	Escherichia coli O113:H21	serotype	Decreases
0	1	Escherichia coli O114:H49	serotype	Decreases
0	1	Escherichia coli O118:H16	serotype	Decreases
0	1	Escherichia coli O121:H19	serotype	Decreases
0	1	Escherichia coli O121:H7	serotype	Decreases
0	1	Escherichia coli O123:H11	serotype	Decreases
0	1	Escherichia coli O125ac:K+:H10	serotype	Decreases
0	1	Escherichia coli O126:H45	serotype	Decreases
0	1	Escherichia coli O127:H27	serotype	Decreases
0	1	Escherichia coli O127:H6	serotype	Decreases
0	1	Escherichia coli O128:H2	serotype	Decreases
0	1	Escherichia coli O128ac:H12	serotype	Decreases
0	1	Escherichia coli O139:H28	serotype	Decreases
0	1	Escherichia coli O145:H25	serotype	Decreases
0	1	Escherichia coli O145:H28	serotype	Decreases
0	1	Escherichia coli O145:NM	serotype	Decreases
0	1	Escherichia coli O146:H21	serotype	Decreases
0	1	Escherichia coli O15:H18	serotype	Decreases
0	1	Escherichia coli O150:H6	serotype	Decreases
0	1	Escherichia coli O152:H23	serotype	Decreases
0	1	Escherichia coli O153:H2	serotype	Decreases
0	1	Escherichia coli O156:H25	serotype	Decreases
0	1	Escherichia coli O157:H-	serotype	Decreases
0	1	Escherichia coli O157:H43	serotype	Decreases
0	1	Escherichia coli O157:H7	serotype	Decreases
0	1	Escherichia coli O157:NM	serotype	Decreases
0	1	Escherichia coli O16:H6	serotype	Decreases
0	1	Escherichia coli O165:H25	serotype	Decreases
0	1	Escherichia coli O167:H26	serotype	Decreases
0	1	Escherichia coli O174:H2	serotype	Decreases
0	1	Escherichia coli O174:H21	serotype	Decreases
0	1	Escherichia coli O174:H8	serotype	Decreases
0	1	Escherichia coli O176:H45	serotype	Decreases
0	1	Escherichia coli O177:NM	serotype	Decreases
0	1	Escherichia coli O2:H6	serotype	Decreases
0	1	Escherichia coli O2:K2:H1	serotype	Decreases
0	1	Escherichia coli O25:H1	serotype	Decreases
0	1	Escherichia coli O25:NM	serotype	Decreases
0	1	Escherichia coli O26:H1	serotype	Decreases
0	1	Escherichia coli O26:H11	serotype	Decreases
0	1	Escherichia coli O28ac:NM	serotype	Decreases
0	1	Escherichia coli O29:H4	serotype	Decreases
0	1	Escherichia coli O32:H37	serotype	Decreases
0	1	Escherichia coli O39:NM	serotype	Decreases
0	1	Escherichia coli O44:H18	serotype	Decreases
0	1	Escherichia coli O45:H2	serotype	Decreases
0	1	Escherichia coli O6:H16	serotype	Decreases
0	1	Escherichia coli O6:H16:CFA/II	serotype	Decreases
0	1	Escherichia coli O6:K2:H1	serotype	Decreases
0	1	Escherichia coli O69:H11	serotype	Decreases
0	1	Escherichia coli O7:H4	serotype	Decreases
0	1	Escherichia coli O7:K1	serotype	Decreases
0	1	Escherichia coli O78:H12	serotype	Decreases
0	1	Escherichia coli O78:H4	serotype	Decreases
0	1	Escherichia coli O79:H7	serotype	Decreases
0	1	Escherichia coli O8:H8	serotype	Decreases
0	1	Escherichia coli O81:NM	serotype	Decreases
0	1	Escherichia coli O83:H1	serotype	Decreases
0	1	Escherichia coli O86:H34	serotype	Decreases
0	1	Escherichia coli O89m:H10	serotype	Decreases
0	1	Escherichia coli O89m:H9	serotype	Decreases
0	1	Escherichia coli O9:H10	serotype	Decreases
0	1	Escherichia coli O91:H14	serotype	Decreases
0	1	Escherichia coli O91:NM	serotype	Decreases
0	1	Escherichia coli O99:H6	serotype	Decreases
0	1	Escherichia coli ONT:H33	serotype	Decreases
1	0	Parabacteroides distasonis	species	Decreases
1	0	Bacteroides fragilis	species	Decreases
1	0	Streptococcus salivarius	species	Decreases
0	1	Streptococcus sp. FDAARGOS_192	species	Decreases
1	0	Coprococcus comes	species	Decreases
1	0	Mediterraneibacter gnavus	species	Decreases
1	0	Segatella copri	species	Decreases
1	0	Escherichia coli	species	Decreases
0	1	Cryptococcus neoformans species complex	species group	Decreases

Impact of glimepiride,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition	Positive Impact	Negative Impact	Benefit Ratio Impact
ADHD	0.6	0.1	5
Age-Related Macular Degeneration and Glaucoma		0.4	-0.4
Allergic Rhinitis (Hay Fever)	0.8	0.2	3
Allergies	0.8	0.2	3
Allergy to milk products	0.3	0.6	-1
Alopecia (Hair Loss)	0.6		0.6
Alzheimer's disease	0.8	0.6	0.33
Amyotrophic lateral sclerosis (ALS) Motor Neuron	0.8	0.1	7
Ankylosing spondylitis	1.1	0.2	4.5
Anorexia Nervosa	0.6	0.5	0.2
Antiphospholipid syndrome (APS)	0.2		0.2
Asthma	0.8	0.2	3
Atherosclerosis	0.4		0.4
Atrial fibrillation	1	0.7	0.43
Autism	1.2	1.8	-0.5
Autoimmune Disease	0.2		0.2
Barrett esophagus cancer		0.1	-0.1
benign prostatic hyperplasia	0	0.1	0
Biofilm	0.3		0.3
Bipolar Disorder	0.6	0.1	5
Brain Trauma	0.1	0.1	0
Breast Cancer	0.1		0.1
Carcinoma	0.7	0.6	0.17
Celiac Disease	0.5	0.6	-0.2
Cerebral Palsy	0.2	0.1	1
Chronic Fatigue Syndrome	0.4	1	-1.5
Chronic Kidney Disease	0.7	0.1	6
Chronic Lyme		0.1	-0.1
Chronic Obstructive Pulmonary Disease (COPD)	0.5	0.2	1.5
Chronic Urticaria (Hives)	0.2	0.3	-0.5
Coagulation / Micro clot triggering bacteria	0.7	0.1	6
Cognitive Function	0.7	0.1	6
Colorectal Cancer	1.3	0.2	5.5
Constipation	0.2		0.2
Coronary artery disease	0.4	0.4	0
COVID-19	0.8	0.7	0.14
Crohn's Disease	1.8	0.9	1
Cushing's Syndrome (hypercortisolism)		0.1	-0.1
cystic fibrosis	0.1	0.1	0
d-lactic acidosis (one form of brain fog)	0.1		0.1
deep vein thrombosis	0.4	0.2	1
Denture Wearers Oral Shifts	0.3		0.3
Depression	1.7	0.9	0.89
Dermatomyositis	0.1		0.1
Eczema	0.3	0.6	-1
Endometriosis	0.9	0.2	3.5
Eosinophilic Esophagitis		0.1	-0.1
Epilepsy	0.6	0.6	0
erectile dysfunction	0.2		0.2
Fibromyalgia	0.4	0.4	0
Functional constipation / chronic idiopathic constipation	1.1	1	0.1
gallstone disease (gsd)	0.9		0.9
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	0.2	0.1	1
Generalized anxiety disorder	0.6	0.3	1
Glioblastoma		0.1	-0.1
Gout	0.2	0.1	1
Graves' disease	0.6	0.2	2
Gulf War Syndrome	0.2	0.2	0
Halitosis	0.2	0.1	1
Hashimoto's thyroiditis	0.3	0.1	2
Heart Failure	1		1
hemorrhagic stroke	0.4		0.4
Hidradenitis Suppurativa	0.2		0.2
High Histamine/low DAO	0.1		0.1
hypercholesterolemia (High Cholesterol)	0.1		0.1
hyperglycemia	0.4	0.6	-0.5
hypertension (High Blood Pressure	0.7	0.5	0.4
Hypothyroidism	0.5	0.1	4
Hypoxia	0.6		0.6
IgA nephropathy (IgAN)	0.7	0.2	2.5
Inflammatory Bowel Disease	1.4	1.3	0.08
Insomnia	0.5	0.2	1.5
Intelligence	0.3	0.1	2
Intracranial aneurysms	0.6	0.1	5
Irritable Bowel Syndrome	0.6	0.7	-0.17
ischemic stroke	0.8	0.2	3
Liver Cirrhosis	1.3	0.4	2.25
Long COVID	1	0.6	0.67
Low bone mineral density		0.1	-0.1
Lung Cancer	0		0
Lymphoma	0		0
Mast Cell Issues / mastitis	0.2	0.1	1
ME/CFS with IBS	0.1	0.3	-2
ME/CFS without IBS	0.2	0.7	-2.5
membranous nephropathy	0.1		0.1
Menopause	0.1		0.1
Metabolic Syndrome	1.2	1	0.2
Mood Disorders	1.6	0.9	0.78
multiple chemical sensitivity [MCS]	0.3		0.3
Multiple Sclerosis	1.3	1.7	-0.31
myasthenia gravis	0.2		0.2
neuropathic pain		0.6	-0.6
Neuropathy (all types)	0.1	0.5	-4
neuropsychiatric disorders (PANDAS, PANS)	0.2		0.2
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	0.5	0.2	1.5
NonCeliac Gluten Sensitivity	0.1	0.1	0
Obesity	1.1	1.3	-0.18
obsessive-compulsive disorder	1	0.5	1
Osteoarthritis	0.4	0.2	1
Osteoporosis	0.2	0.2	0
pancreatic cancer	0.1	0.1	0
Parkinson's Disease	1.3	0.7	0.86
Polycystic ovary syndrome	1.7	0.2	7.5
Postural orthostatic tachycardia syndrome		0.1	-0.1
Premenstrual dysphoric disorder		0.4	-0.4
primary biliary cholangitis	0.1	0.1	0
Primary sclerosing cholangitis	0.7	1.2	-0.71
Psoriasis	0.4	1.3	-2.25
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	1	0.4	1.5
Schizophrenia	0.7	0.6	0.17
scoliosis	0.2		0.2
Sjögren syndrome	0.7	0.6	0.17
Sleep Apnea	0.1	0.2	-1
Slow gastric motility / Gastroparesis	0.2		0.2
Small Intestinal Bacterial Overgrowth (SIBO)	0.4		0.4
Stress / posttraumatic stress disorder	0.7	0.6	0.17
Systemic Lupus Erythematosus	1.6		1.6
Tic Disorder	0.1	0.1	0
Tourette syndrome	0.1	0.1	0
Type 1 Diabetes	0.6	0.2	2
Type 2 Diabetes	1.2	1.1	0.09
Ulcerative colitis	1	1	0
Unhealthy Ageing	0.7	0.5	0.4
Vitiligo	0.9	0.6	0.5

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