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🍽️ glycopyrrolate,(prescription) [Can cause cognitive issues]

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  1. Reduced Saliva Production: Glycopyrrolate is commonly prescribed to reduce saliva production, particularly in conditions where excessive saliva production is a problem, such as in patients with certain neurological disorders or those undergoing surgery.

  2. Treatment of Excessive Sweating: Glycopyrrolate may also be used to treat hyperhidrosis, a condition characterized by excessive sweating beyond what is necessary to regulate body temperature. It works by reducing sweat gland activity.

  3. Management of Gastrointestinal Disorders: Glycopyrrolate can be used to treat gastrointestinal conditions such as peptic ulcers and irritable bowel syndrome (IBS) by reducing gastrointestinal secretions and motility.

  4. Control of Respiratory Secretions: In palliative care and end-of-life situations, glycopyrrolate may be administered to control excessive respiratory secretions, which can cause discomfort and difficulty breathing.

  5. Preoperative Medication: Glycopyrrolate may be used as preoperative medication to reduce saliva and respiratory secretions, minimize the risk of aspiration during surgery, and facilitate intubation.

  6. Muscarinic Antagonist: Glycopyrrolate is a muscarinic antagonist that blocks the action of acetylcholine at muscarinic receptors, leading to reduced glandular secretions and smooth muscle contractions.

  7. Side Effects: Common side effects of glycopyrrolate include dry mouth, blurred vision, constipation, urinary retention, and cognitive issues such as confusion or memory impairment. These side effects are related to its anticholinergic activity.

  8. Contraindications: Glycopyrrolate is contraindicated in individuals with certain medical conditions such as narrow-angle glaucoma, obstructive urinary disorders, severe ulcerative colitis, and myasthenia gravis.

  9. Drug Interactions: Glycopyrrolate may interact with other medications, particularly those with anticholinergic effects or drugs that affect heart rate or rhythm. It's essential for patients to inform their healthcare provider about all medications they are taking to avoid potential interactions.

  10. Dosage and Administration: The dosage of glycopyrrolate depends on the condition being treated, the patient's age, weight, and medical history. It is available in various formulations, including oral tablets, oral solution, and injectable solution.

  11. Patient Monitoring: Patients receiving glycopyrrolate should be monitored regularly for side effects and therapeutic efficacy. Adjustments to the dosage may be necessary based on the patient's response to treatment and any adverse reactions experienced.

  12. Patient Education: Patients should be educated about the proper use of glycopyrrolate, including its potential side effects and precautions. They should also be advised to report any new or worsening symptoms to their healthcare provider.

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βš—οΈ Compensation for antibiotic usage

Data Contradictions β€” Limits of Certainity

Impacted of glycopyrrolate,(prescription) [Can cause cognitive issues] On Probiotics

Rank Probiotic Impact
genus Bifidobacterium Reduces
species Anaerobutyricum hallii Reduces
species Bifidobacterium adolescentis Reduces
species Blautia wexlerae Reduces
species Christensenella minuta Reduces
species Lactococcus cremoris Reduces

Bacteria Impacted by glycopyrrolate,(prescription) [Can cause cognitive issues]

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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πŸ““ Direct Citations πŸ‘ͺπŸ‘Ά Indirect Citations Taxonomy Rank Effect
0 1 Enterocloster genus Decreases
0 1 Coprococcus genus Decreases
0 1 Mediterraneibacter genus Decreases
0 1 Flavonifractor genus Decreases
0 1 Hungatella genus Decreases
0 1 Bacteroides genus Decreases
0 1 Bifidobacterium genus Decreases
0 1 Collinsella genus Decreases
0 1 Eggerthella genus Decreases
0 1 Clostridium genus Decreases
0 1 Agathobacter genus Decreases
0 1 Clostridium perfringens A no rank Decreases
0 1 Clostridium perfringens B no rank Decreases
0 1 Clostridium perfringens C no rank Decreases
0 1 Clostridium perfringens CPE no rank Decreases
0 1 Clostridium perfringens D no rank Decreases
0 1 Clostridium perfringens E no rank Decreases
1 0 Enterocloster bolteae species Decreases
1 0 [Ruminococcus] torques species Decreases
1 0 Coprococcus comes species Decreases
0 1 Coprococcus catus species Decreases
0 1 Dorea longicatena species Decreases
0 1 Dorea formicigenerans species Decreases
1 0 Bacteroides caccae species Decreases
0 1 Blautia obeum species Decreases
0 1 Anaerobutyricum hallii species Decreases
0 1 Blautia sp. SC05B48 species Decreases
0 1 Wansuia hejianensis species Decreases
0 1 Ligilactobacillus ruminis species Decreases
0 1 Enterocloster clostridioformis species Decreases
0 1 Subdoligranulum variabile species Decreases
0 1 Komagataeibacter oboediens species Decreases
0 1 [Ruminococcus] lactaris species Decreases
0 1 Eubacterium ventriosum species Decreases
0 1 Coprococcus eutactus species Decreases
0 1 Lacrimispora saccharolytica species Decreases
0 1 Butyrivibrio crossotus species Decreases
0 1 Flavonifractor plautii species Decreases
0 1 Hungatella hathewayi species Decreases
0 1 Blautia liquoris species Decreases
0 1 Lachnoanaerobaculum gingivalis species Decreases
0 1 Clostridium sp. SY8519 species Decreases
0 1 Clostridium sp. M62/1 species Decreases
0 1 Eubacterium sp. MSJ-33 species Decreases
0 1 Faecalibacillus intestinalis species Decreases
0 1 Christensenella minuta species Decreases
0 1 Faecalitalea cylindroides species Decreases
0 1 Massilistercora timonensis species Decreases
0 1 Coprococcus sp. ART55/1 species Decreases
0 1 Faecalibacterium duncaniae species Decreases
0 1 Catenibacterium mitsuokai species Decreases
0 1 Novisyntrophococcus fermenticellae species Decreases
0 1 Catenibacterium sp. co_0103 species Decreases
0 1 Vescimonas fastidiosa species Decreases
0 1 Qiania dongpingensis species Decreases
0 1 Bacillus paralicheniformis species Decreases
0 1 Faecalibacterium sp. I4-1-79 species Decreases
0 1 Intestinibaculum porci species Decreases
0 1 Anaerostipes hadrus species Decreases
0 1 Treponema peruense species Decreases
0 1 Faecalibacterium sp. IP-3-29 species Decreases
0 1 Maliibacterium massiliense species Decreases
0 1 Faecalibacterium sp. I2-3-92 species Decreases
0 1 Roseburia hominis species Decreases
0 1 Ruminococcus champanellensis species Decreases
0 1 Faecalibacterium sp. HTF-F species Decreases
0 1 [Clostridium] hylemonae species Decreases
0 1 Pseudobutyrivibrio xylanivorans species Decreases
0 1 Longicatena caecimuris species Decreases
0 1 Wujia chipingensis species Decreases
0 1 Faecalibacterium sp. I3-3-89 species Decreases
0 1 Marvinbryantia formatexigens species Decreases
0 1 Clostridium cadaveris species Decreases
0 1 Lactococcus cremoris species Decreases
0 1 Lachnoclostridium phocaeense species Decreases
1 0 Bifidobacterium adolescentis species Decreases
0 1 Roseburia rectibacter species Decreases
0 1 Faecalibacterium sp. IP-1-18 species Decreases
0 1 Ruminococcus bicirculans (ex Wegman et al. 2014) species Decreases
0 1 Mageeibacillus indolicus species Decreases
0 1 Vescimonas coprocola species Decreases
0 1 Fannyhessea vaginae species Decreases
0 1 Streptococcus suis species Decreases
0 1 Adlercreutzia equolifaciens species Decreases
0 1 Faecalibacterium sp. I3-3-33 species Decreases
0 1 Roseburia intestinalis species Decreases
0 1 Ruminococcus gauvreauii species Decreases
0 1 Lawsonibacter asaccharolyticus species Decreases
0 1 Blautia wexlerae species Decreases
0 1 Solibaculum mannosilyticum species Decreases
0 1 Faecalibacterium sp. I4-3-84 species Decreases
0 1 Monoglobus pectinilyticus species Decreases
0 1 Oscillibacter hominis species Decreases
1 0 Collinsella aerofaciens species Decreases
1 0 Eggerthella lenta species Decreases
1 0 Clostridium perfringens species Decreases
1 0 Mediterraneibacter gnavus species Decreases
1 0 Bacteroides fragilis species Decreases
1 0 Agathobacter rectalis species Decreases

Impact of glycopyrrolate,(prescription) [Can cause cognitive issues] on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Acne 0.1 -0.1
ADHD 0.2 0.6 -2
Age-Related Macular Degeneration and Glaucoma 0.2 0.2
Allergic Rhinitis (Hay Fever) 0.3 0.3 0
Allergies 1 0.3 2.33
Allergy to milk products 0.4 0.4 0
Alopecia (Hair Loss) 0.1 0.1 0
Alzheimer's disease 0.7 1.6 -1.29
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0.3 0.3
Ankylosing spondylitis 0.3 0.1 2
Anorexia Nervosa 0.1 0.1 0
Antiphospholipid syndrome (APS) 0.1 0.1
Asthma 0.3 0.2 0.5
Atherosclerosis 0.2 0.1 1
Atrial fibrillation 0.4 0.2 1
Autism 2.2 0.8 1.75
Autoimmune Disease 0.1 0.1 0
benign prostatic hyperplasia 0.1 -0.1
Biofilm 0 0
Bipolar Disorder 0.3 0.3 0
Brain Trauma 0.2 0.1 1
Breast Cancer 0.1 0.1
Cancer (General) 0.4 -0.4
Carcinoma 0.2 0.2 0
Celiac Disease 0.2 0.1 1
Cerebral Palsy 0.2 0.1 1
Chronic Fatigue Syndrome 1.2 2 -0.67
Chronic Kidney Disease 1.3 1.1 0.18
Chronic Lyme 0.1 -0.1
Chronic Obstructive Pulmonary Disease (COPD) 0.3 0.2 0.5
Chronic Urticaria (Hives) 0 0 0
Cognitive Function 0.2 0.1 1
Colorectal Cancer 0.5 0.4 0.25
Constipation 0.1 0.1
Coronary artery disease 0.3 0.6 -1
COVID-19 1.3 2.7 -1.08
Crohn's Disease 0.8 0.8 0
Cushing's Syndrome (hypercortisolism) 0.1 -0.1
cystic fibrosis 0.2 -0.2
deep vein thrombosis 0.3 0.1 2
Depression 2.1 1.5 0.4
Dermatomyositis 0.1 -0.1
Eczema 0.1 0.2 -1
Endometriosis 0.3 0.2 0.5
Epilepsy 0.5 0.1 4
erectile dysfunction 0.1 0.1 0
Fibromyalgia 0.5 0.6 -0.2
Functional constipation / chronic idiopathic constipation 0.5 1.1 -1.2
gallstone disease (gsd) 0.1 0.1 0
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0 0.7 0
Generalized anxiety disorder 0.4 0.4 0
giant cell arteritis 0 0
Gout 0.3 0.3 0
Graves' disease 0.2 0.3 -0.5
Gulf War Syndrome 0.3 0.1 2
Halitosis 0.1 0.1
Hashimoto's thyroiditis 0.9 0.6 0.5
Heart Failure 0.5 0.3 0.67
hemorrhagic stroke 0.1 0.1
Hidradenitis Suppurativa 0.1 0.1
High Histamine/low DAO 0.1 0.1 0
hypercholesterolemia (High Cholesterol) 0 0
hyperglycemia 0.1 -0.1
Hyperlipidemia (High Blood Fats) 0.1 0.1 0
hypersomnia 0.1 0.2 -1
hypertension (High Blood Pressure 0.7 0.6 0.17
Hypothyroidism 0.2 0.3 -0.5
Hypoxia 0.2 0.2
IgA nephropathy (IgAN) 0.2 0.5 -1.5
Inflammatory Bowel Disease 0.9 1.6 -0.78
Insomnia 0.5 0.2 1.5
Intelligence 0.3 0.3
Intracranial aneurysms 0.1 0.4 -3
Irritable Bowel Syndrome 1 0.4 1.5
ischemic stroke 0.1 0.1 0
Liver Cirrhosis 0.6 0.5 0.2
Long COVID 2.4 1.2 1
Low bone mineral density 0.5 -0.5
Lung Cancer 0.3 0.2 0.5
Mast Cell Issues / mastitis 0.3 -0.3
ME/CFS with IBS 0.6 1.7 -1.83
ME/CFS without IBS 0.4 0.6 -0.5
Menopause 0.3 0.3
Metabolic Syndrome 1.2 0.9 0.33
Mood Disorders 2.4 1 1.4
Multiple Sclerosis 0.5 1 -1
Multiple system atrophy (MSA) 0.1 0.1 0
myasthenia gravis 0 0
neuropathic pain 0 0.2 0
Neuropathy (all types) 0 0
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 0.3 0.9 -2
NonCeliac Gluten Sensitivity 0.2 0.1 1
Obesity 2.3 1.2 0.92
obsessive-compulsive disorder 0.8 0.9 -0.13
Osteoarthritis 0.5 0.3 0.67
Osteoporosis 0.1 0.1 0
Parkinson's Disease 1.9 1.3 0.46
Polycystic ovary syndrome 0.7 0.2 2.5
Postural orthostatic tachycardia syndrome 0 0.3 0
Premenstrual dysphoric disorder 0.1 0.1
primary biliary cholangitis 0.1 -0.1
Primary sclerosing cholangitis 0.1 0.9 -8
Psoriasis 0.5 0.3 0.67
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 0.8 0.5 0.6
Rosacea 0.7 0 0
Schizophrenia 1 0.4 1.5
scoliosis 0.4 0.4
sensorineural hearing loss 0.3 0.3
Sjögren syndrome 0.3 -0.3
Sleep Apnea 0.3 0.3 0
Slow gastric motility / Gastroparesis 0.1 0.1 0
Small Intestinal Bacterial Overgrowth (SIBO) 0.3 0.3
Stress / posttraumatic stress disorder 0.2 0.5 -1.5
Systemic Lupus Erythematosus 0.6 0.2 2
Tic Disorder 0.4 -0.4
Tourette syndrome 0.1 -0.1
Type 1 Diabetes 0.4 0.5 -0.25
Type 2 Diabetes 1.9 0.5 2.8
Ulcerative colitis 0.4 0.8 -1
Unhealthy Ageing 1.6 0.3 4.33
Vitiligo 0.2 0.5 -1.5

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