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🍽️ norgestrel-(-)-d,(prescription)

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  1. Contraception: Norgestrel, when combined with estrogen, is commonly used in oral contraceptive pills (OCPs) to prevent pregnancy. It works primarily by inhibiting ovulation (the release of an egg from the ovary) and thickening the cervical mucus, making it more difficult for sperm to reach the egg. Additionally, it may alter the uterine lining to prevent implantation of a fertilized egg.

  2. Hormone Replacement Therapy (HRT): Norgestrel, along with estrogen, is used in HRT for women who are experiencing menopausal symptoms such as hot flashes, vaginal dryness, and mood changes. HRT helps to alleviate these symptoms by replacing the hormones that the body no longer produces in adequate amounts after menopause. Norgestrel can help protect the uterus from the potential adverse effects of estrogen therapy, such as endometrial hyperplasia (overgrowth of the uterine lining), when used in combination with estrogen.

  3. Menstrual Disorders: In some cases, norgestrel may be prescribed to regulate menstrual cycles and treat certain menstrual disorders, such as irregular or heavy menstrual bleeding (menorrhagia). It can help stabilize the hormonal fluctuations that contribute to these issues and promote more regular and lighter menstrual periods.

  4. Endometriosis: Norgestrel-containing contraceptive pills may be used off-label to manage symptoms of endometriosis, a condition in which the tissue that normally lines the inside of the uterus grows outside the uterus, leading to pelvic pain and infertility. By suppressing ovulation and reducing menstrual flow, norgestrel can help alleviate pain and inflammation associated with endometriosis.

  5. Polycystic Ovary Syndrome (PCOS): Norgestrel-containing contraceptive pills may also be used off-label to manage symptoms of PCOS, a hormonal disorder characterized by irregular menstrual periods, excessive hair growth, acne, and infertility. By regulating menstrual cycles and reducing androgen levels, norgestrel can help improve symptoms of PCOS, although it is not specifically approved for this indication.

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⚗️ Compensation for antibiotic usage

Data Contradictions — Limits of Certainity

Impacted of norgestrel-(-)-d,(prescription) On Probiotics

Rank Probiotic Impact
genus Bifidobacterium Reduces
species Akkermansia muciniphila Reduces
species Bacteroides uniformis Reduces
species Bifidobacterium adolescentis Reduces
species Bifidobacterium longum Reduces
species Escherichia coli Reduces
species Lacticaseibacillus paracasei Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by norgestrel-(-)-d,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Akkermansiaceae family Decreases
0 1 Escherichia genus Decreases
0 1 Dorea genus Decreases
0 1 Roseburia genus Decreases
0 1 Parabacteroides genus Decreases
1 0 Akkermansia genus Decreases
0 1 Ruminococcus genus Decreases
0 1 Bacteroides genus Decreases
0 1 Bifidobacterium genus Decreases
0 1 Bilophila genus Decreases
0 1 Clostridioides genus Decreases
0 1 Collinsella genus Decreases
0 1 Eggerthella genus Decreases
0 1 Fusobacterium genus Decreases
0 1 Lachnospira genus Decreases
0 1 Lacrimispora genus Decreases
0 1 Mediterraneibacter genus Decreases
0 1 Odoribacter genus Decreases
0 1 Veillonella genus Decreases
0 1 Segatella genus Decreases
0 1 Enterocloster genus Decreases
0 1 Blautia genus Decreases
0 1 Thomasclavelia genus Decreases
0 1 Lacticaseibacillus genus Decreases
0 1 Escherichia coli O25:H16 no rank Decreases
0 1 environmental samples no rank Decreases
0 1 Escherichia coli O145:H34 no rank Decreases
0 1 Escherichia coli O16:H48 no rank Decreases
0 1 unclassified Akkermansia no rank Decreases
0 1 Escherichia coli O141:H4 no rank Decreases
0 1 Escherichia coli O139:H1 no rank Decreases
0 1 Escherichia coli O80:H26 no rank Decreases
0 1 Escherichia coli O158:H23 no rank Decreases
0 1 Escherichia coli O84:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H4 no rank Decreases
0 1 Escherichia coli O2:K1:H7 no rank Decreases
0 1 Escherichia coli O78:H51 no rank Decreases
0 1 Escherichia coli O18ac:H14 no rank Decreases
0 1 Escherichia coli O85:H1 no rank Decreases
0 1 Escherichia coli O7:H15 no rank Decreases
0 1 Escherichia coli O68:H12 no rank Decreases
0 1 Escherichia coli O55:H7 no rank Decreases
0 1 Escherichia coli O1:K1:H7 no rank Decreases
0 1 Escherichia coli O15:H12 no rank Decreases
0 1 Escherichia coli O170:H18 no rank Decreases
0 1 Escherichia coli O155:H21 no rank Decreases
0 1 Escherichia coli O19:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H5 no rank Decreases
0 1 Escherichia coli O20:H12 no rank Decreases
0 1 Escherichia coli O111 serogroup Decreases
0 1 Escherichia coli O121 serogroup Decreases
0 1 Escherichia coli O155 serogroup Decreases
0 1 Escherichia coli O177 serogroup Decreases
0 1 Escherichia coli O26 serogroup Decreases
0 1 Escherichia coli O3 serogroup Decreases
0 1 Escherichia coli O5 serogroup Decreases
0 1 Escherichia coli O86 serogroup Decreases
0 1 Escherichia coli O91 serogroup Decreases
0 1 Escherichia coli O103 serogroup Decreases
0 1 Escherichia coli O78 serogroup Decreases
0 1 Escherichia coli O43 serogroup Decreases
0 1 Escherichia coli O119 serogroup Decreases
0 1 Escherichia coli O157 serogroup Decreases
0 1 Escherichia coli O145 serogroup Decreases
0 1 Escherichia coli O1:HNT serotype Decreases
0 1 Escherichia coli O10:K5(L):H4 serotype Decreases
0 1 Escherichia coli O103:H11 serotype Decreases
0 1 Escherichia coli O103:H25 serotype Decreases
0 1 Escherichia coli O104:H21 serotype Decreases
0 1 Escherichia coli O111:H11 serotype Decreases
0 1 Escherichia coli O111:H8 serotype Decreases
0 1 Escherichia coli O112ac:H19 serotype Decreases
0 1 Escherichia coli O114:H49 serotype Decreases
0 1 Escherichia coli O118:H16 serotype Decreases
0 1 Escherichia coli O121:H7 serotype Decreases
0 1 Escherichia coli O123:H11 serotype Decreases
0 1 Escherichia coli O127:H27 serotype Decreases
0 1 Escherichia coli O127:H6 serotype Decreases
0 1 Escherichia coli O128:H2 serotype Decreases
0 1 Escherichia coli O128ac:H12 serotype Decreases
0 1 Escherichia coli O145:H25 serotype Decreases
0 1 Escherichia coli O145:NM serotype Decreases
0 1 Escherichia coli O146:H21 serotype Decreases
0 1 Escherichia coli O153:H2 serotype Decreases
0 1 Escherichia coli O156:H25 serotype Decreases
0 1 Escherichia coli O157:H43 serotype Decreases
0 1 Escherichia coli O157:NM serotype Decreases
0 1 Escherichia coli O165:H25 serotype Decreases
0 1 Escherichia coli O174:H2 serotype Decreases
0 1 Escherichia coli O174:H21 serotype Decreases
0 1 Escherichia coli O174:H8 serotype Decreases
0 1 Escherichia coli O176:H45 serotype Decreases
0 1 Escherichia coli O177:NM serotype Decreases
0 1 Escherichia coli O26:H1 serotype Decreases
0 1 Escherichia coli O28ac:NM serotype Decreases
0 1 Escherichia coli O29:H4 serotype Decreases
0 1 Escherichia coli O32:H37 serotype Decreases
0 1 Escherichia coli O6:H16:CFA/II serotype Decreases
0 1 Escherichia coli O69:H11 serotype Decreases
0 1 Escherichia coli O78:H12 serotype Decreases
0 1 Escherichia coli O79:H7 serotype Decreases
0 1 Escherichia coli O81:NM serotype Decreases
0 1 Escherichia coli O86:H34 serotype Decreases
0 1 Escherichia coli O91:H14 serotype Decreases
0 1 Escherichia coli O91:NM serotype Decreases
0 1 Escherichia coli ONT:H33 serotype Decreases
0 1 Escherichia coli O100:H21 serotype Decreases
0 1 Escherichia coli O121:H19 serotype Decreases
0 1 Escherichia coli O157:H7 serotype Decreases
0 1 Escherichia coli O16:H6 serotype Decreases
0 1 Escherichia coli O89m:H9 serotype Decreases
0 1 Escherichia coli O111:H- serotype Decreases
0 1 Escherichia coli O113:H21 serotype Decreases
0 1 Escherichia coli H20 serotype Decreases
0 1 Escherichia coli O150:H6 serotype Decreases
0 1 Escherichia coli O111:NM serotype Decreases
0 1 Escherichia coli O112ab:H8 serotype Decreases
0 1 Escherichia coli O99:H6 serotype Decreases
0 1 Escherichia coli O26:H11 serotype Decreases
0 1 Escherichia coli O145:H28 serotype Decreases
0 1 Escherichia coli O126:H45 serotype Decreases
0 1 Escherichia coli O2:H6 serotype Decreases
0 1 Escherichia coli O7:H4 serotype Decreases
0 1 Escherichia coli O1:H42 serotype Decreases
0 1 Escherichia coli O25:NM serotype Decreases
0 1 Escherichia coli O25:H1 serotype Decreases
0 1 Escherichia coli O7:K1 serotype Decreases
0 1 Escherichia coli O125ac:K+:H10 serotype Decreases
0 1 Escherichia coli O6:K2:H1 serotype Decreases
0 1 Escherichia coli O152:H23 serotype Decreases
0 1 Escherichia coli O15:H18 serotype Decreases
0 1 Escherichia coli O39:NM serotype Decreases
0 1 Escherichia coli O44:H18 serotype Decreases
0 1 Escherichia coli O2:K2:H1 serotype Decreases
0 1 Escherichia coli O8:H8 serotype Decreases
0 1 Escherichia coli O89m:H10 serotype Decreases
0 1 Escherichia coli O10:H32 serotype Decreases
0 1 Escherichia coli O6:H16 serotype Decreases
0 1 Escherichia coli O157:H- serotype Decreases
0 1 Escherichia coli O45:H2 serotype Decreases
0 1 Escherichia coli O103:H2 serotype Decreases
0 1 Escherichia coli O167:H26 serotype Decreases
0 1 Escherichia coli O104:H4 serotype Decreases
0 1 Escherichia coli O83:H1 serotype Decreases
0 1 Escherichia coli O9:H10 serotype Decreases
0 1 Escherichia coli O78:H4 serotype Decreases
0 1 Escherichia coli O139:H28 serotype Decreases
1 0 Bacteroides ovatus species Decreases
1 0 Lachnospira eligens species Decreases
1 0 Akkermansia muciniphila species Decreases
1 0 Bacteroides xylanisolvens species Decreases
1 0 Odoribacter splanchnicus species Decreases
1 0 Veillonella parvula species Decreases
1 0 Bifidobacterium adolescentis species Decreases
1 0 Bilophila wadsworthia species Decreases
1 0 Roseburia intestinalis species Decreases
1 0 Bacteroides thetaiotaomicron species Decreases
1 0 Lacrimispora saccharolytica species Decreases
1 0 Fusobacterium nucleatum species Decreases
1 0 Roseburia hominis species Decreases
1 0 Clostridioides difficile species Decreases
1 0 Bifidobacterium longum species Decreases
1 0 Dorea formicigenerans species Decreases
1 0 Enterocloster bolteae species Decreases
1 0 Bacteroides caccae species Decreases
1 0 Escherichia coli species Decreases
0 1 Akkermansia massiliensis species Decreases
0 1 Candidatus Akkermansia intestinavium species Decreases
1 0 Eggerthella lenta species Decreases
1 0 Ruminococcus bromii species Decreases
1 0 Collinsella aerofaciens species Decreases
1 0 Bacteroides fragilis species Decreases
1 0 Thomasclavelia ramosa species Decreases
1 0 Blautia obeum species Decreases
1 0 Bacteroides uniformis species Decreases
1 0 [Ruminococcus] torques species Decreases
1 0 Segatella copri species Decreases
1 0 Lacticaseibacillus paracasei species Decreases
1 0 Parabacteroides merdae species Decreases
0 1 Akkermansia glycaniphila species Decreases
0 1 Bifidobacterium longum subsp. longum subspecies Decreases
0 1 Bifidobacterium longum subsp. infantis subspecies Decreases
0 1 Bifidobacterium longum subsp. suis subspecies Decreases
0 1 Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases
0 1 Fusobacterium nucleatum subsp. nucleatum subspecies Decreases
0 1 Lacticaseibacillus paracasei subsp. tolerans subspecies Decreases
0 1 Bifidobacterium longum subsp. suillum subspecies Decreases

Impact of norgestrel-(-)-d,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.8 0.8
Acne 0.3 0.4 -0.33
ADHD 4.2 0.6 6
Age-Related Macular Degeneration and Glaucoma 1.1 0.4 1.75
Allergic Rhinitis (Hay Fever) 2.3 1.9 0.21
Allergies 5.9 4.4 0.34
Allergy to milk products 1.8 1.6 0.13
Alopecia (Hair Loss) 1 1
Alzheimer's disease 7 5.1 0.37
Amyotrophic lateral sclerosis (ALS) Motor Neuron 3.5 1.2 1.92
Ankylosing spondylitis 3.5 1.2 1.92
Anorexia Nervosa 1.2 2 -0.67
Antiphospholipid syndrome (APS) 1.3 0.3 3.33
Asthma 4.1 2.9 0.41
Atherosclerosis 1.9 2.3 -0.21
Atrial fibrillation 2.8 2 0.4
Autism 7.2 7.7 -0.07
Autoimmune Disease 0.9 0.8 0.13
Barrett esophagus cancer 0.6 0.6
benign prostatic hyperplasia 0.6 0.3 1
Biofilm 1 1
Bipolar Disorder 2.2 1.4 0.57
Brain Trauma 0.6 1.4 -1.33
Breast Cancer 1 0.3 2.33
Cancer (General) 0.9 1.7 -0.89
Carcinoma 4.8 2.6 0.85
Celiac Disease 1.9 3.9 -1.05
Cerebral Palsy 1.2 1.3 -0.08
Chronic Fatigue Syndrome 3.9 3.5 0.11
Chronic Kidney Disease 3.6 1.9 0.89
Chronic Lyme 0.4 0.8 -1
Chronic Obstructive Pulmonary Disease (COPD) 0.9 1.4 -0.56
Chronic Urticaria (Hives) 1.2 0.9 0.33
Coagulation / Micro clot triggering bacteria 1.3 1 0.3
Cognitive Function 2.9 1.1 1.64
Colorectal Cancer 7 2.4 1.92
Constipation 1.5 0.9 0.67
Coronary artery disease 1.5 1.7 -0.13
COVID-19 7.6 8.7 -0.14
Crohn's Disease 6.3 5.5 0.15
Cushing's Syndrome (hypercortisolism) 0.3 -0.3
cystic fibrosis 0.9 1.8 -1
d-lactic acidosis (one form of brain fog) 0.3 0.3
deep vein thrombosis 2.9 1.1 1.64
Denture Wearers Oral Shifts 1 1
Depression 8.4 7.2 0.17
Dermatomyositis 0.3 -0.3
Eczema 1.2 1.6 -0.33
Endometriosis 2.6 2 0.3
Eosinophilic Esophagitis 0.3 0.3 0
Epilepsy 2.7 2.2 0.23
erectile dysfunction 1.4 0.3 3.67
Fibromyalgia 2.5 1.4 0.79
Functional constipation / chronic idiopathic constipation 4.5 2.8 0.61
gallstone disease (gsd) 2.8 1.5 0.87
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 1.2 0.5 1.4
Generalized anxiety disorder 2.3 1.9 0.21
Gout 2.5 1 1.5
Graves' disease 1.9 2.7 -0.42
Gulf War Syndrome 0.1 1.9 -18
Halitosis 1.3 1.3
Hashimoto's thyroiditis 3.4 1.7 1
Heart Failure 3.4 1.6 1.13
hemorrhagic stroke 1.3 1.3
Hidradenitis Suppurativa 1.2 0.3 3
High Histamine/low DAO 0.8 0.6 0.33
hypercholesterolemia (High Cholesterol) 0.6 0.6 0
hyperglycemia 2.1 2.1 0
Hyperlipidemia (High Blood Fats) 1.2 0.3 3
hypersomnia 0.7 -0.7
hypertension (High Blood Pressure 4.3 5.2 -0.21
Hypothyroidism 0.4 0.7 -0.75
Hypoxia 2.8 0.4 6
IgA nephropathy (IgAN) 1.6 3.8 -1.37
Inflammatory Bowel Disease 6.5 6.9 -0.06
Insomnia 1.6 2.8 -0.75
Intelligence 0.7 0.1 6
Intracranial aneurysms 1.4 0.6 1.33
Irritable Bowel Syndrome 6.7 4.5 0.49
ischemic stroke 2.8 1.4 1
Liver Cirrhosis 6.5 4.7 0.38
Long COVID 5.2 7.1 -0.37
Low bone mineral density 0.8 -0.8
Lung Cancer 1.2 1.6 -0.33
Lymphoma 0.6 0.6
Mast Cell Issues / mastitis 1 0.6 0.67
ME/CFS with IBS 0.3 1.1 -2.67
ME/CFS without IBS 0.6 1.5 -1.5
Menopause 1.6 0.9 0.78
Metabolic Syndrome 6.5 6.7 -0.03
Mood Disorders 8.7 5.4 0.61
multiple chemical sensitivity [MCS] 0.7 0.1 6
Multiple Sclerosis 5 3.3 0.52
Multiple system atrophy (MSA) 1.4 0.7 1
myasthenia gravis 0.6 0.5 0.2
neuropathic pain 0.3 3.3 -10
Neuropathy (all types) 0.8 2.4 -2
neuropsychiatric disorders (PANDAS, PANS) 0.6 0.6
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 4.9 4.2 0.17
NonCeliac Gluten Sensitivity 1.9 0.6 2.17
Obesity 9 7.3 0.23
obsessive-compulsive disorder 4 2.4 0.67
Osteoarthritis 1.3 1.3 0
Osteoporosis 2.9 1.9 0.53
pancreatic cancer 1.9 0.3 5.33
Parkinson's Disease 6.5 5.1 0.27
Polycystic ovary syndrome 3.6 2.8 0.29
Postural orthostatic tachycardia syndrome 0.3 -0.3
Premenstrual dysphoric disorder 0.7 0.4 0.75
primary biliary cholangitis 0.9 0.7 0.29
Primary sclerosing cholangitis 1.9 1 0.9
Psoriasis 2.4 2 0.2
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 6.4 3.2 1
Rosacea 0.7 0.8 -0.14
Schizophrenia 6.3 2.9 1.17
scoliosis 0.3 1.2 -3
Sjögren syndrome 2.5 2.4 0.04
Sleep Apnea 1.9 1.6 0.19
Slow gastric motility / Gastroparesis 1.2 0.3 3
Small Intestinal Bacterial Overgrowth (SIBO) 1.2 0.4 2
Stress / posttraumatic stress disorder 3.1 2.7 0.15
Systemic Lupus Erythematosus 3.1 2.3 0.35
Tic Disorder 0.6 1.3 -1.17
Tourette syndrome 0.9 0.3 2
Type 1 Diabetes 3.9 3 0.3
Type 2 Diabetes 6.3 6.4 -0.02
Ulcerative colitis 4.6 5.8 -0.26
Unhealthy Ageing 3.5 1.9 0.84
Vitiligo 1.8 1.1 0.64

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