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Gastrointestinal Spasms: Diphemanil methylsulfate is commonly prescribed to relieve spasms and cramping in the gastrointestinal tract, including conditions such as irritable bowel syndrome (IBS), functional dyspepsia, and biliary colic. By inhibiting smooth muscle contraction in the GI tract, diphemanil methylsulfate helps alleviate symptoms such as abdominal pain, bloating, and discomfort.
Functional Disorders: Diphemanil methylsulfate may be used in the management of functional GI disorders characterized by abnormal motility or visceral hypersensitivity, such as non-ulcer dyspepsia or non-specific abdominal pain. Its antispasmodic effects can help improve symptoms and overall quality of life in individuals with these conditions.
Gallbladder Disorders: Diphemanil methylsulfate may be prescribed to relieve symptoms associated with gallbladder disorders, such as biliary colic or cholecystitis. By reducing smooth muscle spasm in the bile ducts and gallbladder, diphemanil methylsulfate can help alleviate pain and discomfort in individuals with these conditions.
Urological Disorders: In addition to its effects on the GI tract, diphemanil methylsulfate may also be used to treat certain urological disorders characterized by smooth muscle spasm, such as urinary tract spasms or bladder dysfunction. It helps relax the smooth muscles of the urinary tract, reducing urinary urgency, frequency, and incontinence.
Side Effects: Like other antimuscarinic drugs, diphemanil methylsulfate can cause side effects related to its anticholinergic activity, including dry mouth, blurred vision, constipation, urinary retention, and cognitive impairment. These side effects are typically dose-dependent and may be more pronounced in older adults or individuals with pre-existing medical conditions.
Contraindications: Diphemanil methylsulfate is contraindicated in individuals with narrow-angle glaucoma, urinary retention, severe ulcerative colitis, myasthenia gravis, or pyloric stenosis. It should be used with caution in individuals with conditions such as prostatic hypertrophy, cardiovascular disease, or gastrointestinal obstruction.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
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