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🍽️ trimipramine maleate salt,(prescription)

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  1. Major Depressive Disorder (MDD):

    • Trimipramine is indicated for the treatment of major depressive disorder, a mood disorder characterized by persistent feelings of sadness, hopelessness, and loss of interest or pleasure in activities.
    • It works by increasing the levels of certain neurotransmitters such as serotonin and norepinephrine in the brain, which helps to alleviate depressive symptoms.

  2. Anxiety Disorders:

    • Trimipramine may also be prescribed off-label for the treatment of anxiety disorders, including generalized anxiety disorder (GAD) and panic disorder.
    • It may help reduce anxiety symptoms such as excessive worry, nervousness, and panic attacks.

  3. Insomnia:

    • Trimipramine has sedative properties and may be prescribed to treat insomnia, especially when associated with depression.
    • It can help improve sleep continuity and quality, leading to better overall well-being.

  4. Chronic Pain Syndromes:

    • Tricyclic antidepressants like trimipramine have analgesic properties and may be used in the management of chronic pain syndromes such as neuropathic pain, fibromyalgia, and migraine headaches.
    • It may help reduce pain intensity and improve pain-related sleep disturbances.

  5. Neuropathic Pain:

    • Trimipramine may be effective in relieving neuropathic pain, which is caused by nerve damage or dysfunction.
    • It can help alleviate burning, shooting, or stabbing pain sensations often associated with conditions such as diabetic neuropathy or postherpetic neuralgia.

  6. Obsessive-Compulsive Disorder (OCD):

    • Trimipramine may be used off-label in the treatment of obsessive-compulsive disorder (OCD), a chronic condition characterized by intrusive thoughts (obsessions) and repetitive behaviors (compulsions).
    • It may help reduce the frequency and severity of obsessive-compulsive symptoms.

  7. Post-Traumatic Stress Disorder (PTSD):

    • Some studies suggest that trimipramine may be beneficial in the treatment of post-traumatic stress disorder (PTSD), particularly in individuals who experience nightmares or sleep disturbances as part of their PTSD symptoms.
    • It may help alleviate PTSD-related symptoms such as hyperarousal and re-experiencing of traumatic events.

  8. Adverse Effects:

    • Common side effects of trimipramine may include dry mouth, drowsiness, dizziness, constipation, blurred vision, weight gain, and sexual dysfunction.
    • It may also cause orthostatic hypotension (a sudden drop in blood pressure upon standing) and cardiac conduction abnormalities in some individuals.

  9. Precautions:

    • Trimipramine should be used with caution in elderly patients, as they may be more susceptible to adverse effects such as confusion, urinary retention, and falls.
    • It should not be abruptly discontinued, as withdrawal symptoms may occur. Gradual tapering of the medication is recommended under medical supervision.
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⚗️ Compensation for antibiotic usage

Data Contradictions — Limits of Certainity

Impacted of trimipramine maleate salt,(prescription) On Probiotics

Rank Probiotic Impact
species Lacticaseibacillus paracasei Reduces

Bacteria Impacted by trimipramine maleate salt,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Roseburia genus Decreases
0 1 Agathobacter genus Decreases
0 1 Bacteroides genus Decreases
0 1 Clostridioides genus Decreases
0 1 Coprococcus genus Decreases
0 1 Phocaeicola genus Decreases
0 1 Streptococcus genus Decreases
0 1 Segatella genus Decreases
0 1 Lacticaseibacillus genus Decreases
1 0 Coprococcus comes species Decreases
1 0 Segatella copri species Decreases
1 0 Agathobacter rectalis species Decreases
1 0 Bacteroides thetaiotaomicron species Decreases
1 0 Bacteroides fragilis species Decreases
1 0 Clostridioides difficile species Decreases
1 0 Phocaeicola vulgatus species Decreases
1 0 Roseburia intestinalis species Decreases
1 0 Lacticaseibacillus paracasei species Decreases
1 0 Streptococcus salivarius species Decreases
0 1 Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases
0 1 Lacticaseibacillus paracasei subsp. tolerans subspecies Decreases

Impact of trimipramine maleate salt,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.4 0.4
Acne 0.6 0.6
ADHD 1.1 0.3 2.67
Age-Related Macular Degeneration and Glaucoma 0.5 0.5
Allergic Rhinitis (Hay Fever) 0.6 0.3 1
Allergies 0.8 0.9 -0.13
Allergy to milk products 0.6 0.3 1
Alzheimer's disease 0.7 2.9 -3.14
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0.7 0.7
Ankylosing spondylitis 1.2 0.3 3
Anorexia Nervosa 0.3 1.8 -5
Antiphospholipid syndrome (APS) 1 1
Asthma 1.8 1.1 0.64
Atherosclerosis 0.7 1.1 -0.57
Atrial fibrillation 1.6 1.4 0.14
Autism 3.2 3.2 0
Autoimmune Disease 0.3 0.5 -0.67
Barrett esophagus cancer 0.3 -0.3
benign prostatic hyperplasia 0.3 -0.3
Biofilm 0.3 0.3
Bipolar Disorder 0.3 0.8 -1.67
Brain Trauma 0.3 0.8 -1.67
Breast Cancer 0.3 0.3
Cancer (General) 0.3 -0.3
Carcinoma 0.6 0.3 1
Celiac Disease 1.6 0.3 4.33
Cerebral Palsy 0.6 0.8 -0.33
Chronic Fatigue Syndrome 0.6 2.3 -2.83
Chronic Kidney Disease 0.7 1.3 -0.86
Chronic Lyme 0.4 0.8 -1
Chronic Obstructive Pulmonary Disease (COPD) 0.8 1.1 -0.38
Chronic Urticaria (Hives) 0.3 1.1 -2.67
Coagulation / Micro clot triggering bacteria 0.3 0.8 -1.67
Cognitive Function 1.1 0.8 0.38
Colorectal Cancer 2.8 1.4 1
Constipation 0.6 0.5 0.2
Coronary artery disease 0.6 2 -2.33
COVID-19 1.3 4.1 -2.15
Crohn's Disease 2.1 2 0.05
Cushing's Syndrome (hypercortisolism) 0.6 -0.6
cystic fibrosis 0.8 -0.8
deep vein thrombosis 1.3 1.1 0.18
Denture Wearers Oral Shifts 0.5 0.5
Depression 2.4 3.4 -0.42
Dermatomyositis 0.3 0.3
Eczema 0.3 0.9 -2
Endometriosis 0.9 0.8 0.13
Eosinophilic Esophagitis 0.3 -0.3
Epilepsy 1 0.3 2.33
erectile dysfunction 0.3 0.3
Fibromyalgia 0.5 1.6 -2.2
Functional constipation / chronic idiopathic constipation 1.9 2.2 -0.16
gallstone disease (gsd) 0.4 0.5 -0.25
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.7 0.3 1.33
Generalized anxiety disorder 0.9 1.4 -0.56
Glioblastoma 0.3 -0.3
Gout 0.6 0.3 1
Graves' disease 0.3 1.4 -3.67
Gulf War Syndrome 0.6 0.9 -0.5
Halitosis 0.6 0.3 1
Hashimoto's thyroiditis 1.3 0.3 3.33
Heart Failure 1.3 1 0.3
Hidradenitis Suppurativa 0.6 0.6
High Histamine/low DAO 0.5 0.5
hyperglycemia 0.2 0.3 -0.5
hypertension (High Blood Pressure 0.6 2.3 -2.83
Hypothyroidism 0.3 -0.3
Hypoxia 0.3 0.7 -1.33
IgA nephropathy (IgAN) 0.6 1.6 -1.67
Inflammatory Bowel Disease 2.4 3.5 -0.46
Insomnia 1.1 1.4 -0.27
Intelligence 0.6 0.7 -0.17
Intracranial aneurysms 0.3 0.3 0
Irritable Bowel Syndrome 2 1.7 0.18
ischemic stroke 0.6 1.1 -0.83
Liver Cirrhosis 2.3 1.4 0.64
Long COVID 2.3 1.8 0.28
Low bone mineral density 0.8 -0.8
Mast Cell Issues / mastitis 0.3 0.3 0
ME/CFS with IBS 0.3 1 -2.33
ME/CFS without IBS 0.3 0.3 0
membranous nephropathy 0.3 0.3
Menopause 0.3 0.5 -0.67
Metabolic Syndrome 1.8 2.1 -0.17
Mood Disorders 2.1 3.1 -0.48
multiple chemical sensitivity [MCS] 0.5 0.5
Multiple Sclerosis 0.8 2.9 -2.62
myasthenia gravis 0.3 0.5 -0.67
neuropathic pain 0.8 -0.8
Neuropathy (all types) 0.3 0.5 -0.67
neuropsychiatric disorders (PANDAS, PANS) 0.3 0.3
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 1.8 1.6 0.13
NonCeliac Gluten Sensitivity 0.3 0.3 0
Obesity 2.1 2.3 -0.1
obsessive-compulsive disorder 1.7 1.8 -0.06
Osteoarthritis 0.6 0.6 0
Osteoporosis 0.8 0.6 0.33
pancreatic cancer 0.3 0.3 0
Parkinson's Disease 2.4 3.5 -0.46
Polycystic ovary syndrome 2.1 1.1 0.91
Postural orthostatic tachycardia syndrome 0.3 -0.3
primary biliary cholangitis 0.3 0.3 0
Primary sclerosing cholangitis 0.6 0.3 1
Psoriasis 0.7 2.2 -2.14
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 2.1 2 0.05
Rosacea 0.5 -0.5
Schizophrenia 0.9 1.1 -0.22
scoliosis 0.3 0.3
Sjögren syndrome 0.9 0.6 0.5
Sleep Apnea 0.3 1.1 -2.67
Slow gastric motility / Gastroparesis 0.3 0.3
Small Intestinal Bacterial Overgrowth (SIBO) 0.9 0.9
Stress / posttraumatic stress disorder 0.8 1.1 -0.38
Systemic Lupus Erythematosus 1.3 0.5 1.6
Tic Disorder 0.6 0.7 -0.17
Tourette syndrome 0.3 0.3 0
Type 1 Diabetes 1.6 1.4 0.14
Type 2 Diabetes 2.7 2.6 0.04
Ulcerative colitis 1.3 3.3 -1.54
Unhealthy Ageing 2 1.3 0.54
Vitiligo 1 0.7 0.43

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