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Anticonvulsant Properties: Dimethadione works by suppressing abnormal electrical activity in the brain, making it effective in preventing seizures. It is thought to exert its anticonvulsant effects by blocking voltage-gated sodium channels and inhibiting the spread of epileptic discharges.
Epilepsy Treatment: Dimethadione was primarily used in the treatment of epilepsy, including generalized tonic-clonic seizures, partial seizures, and absence seizures (petit mal seizures). It was often prescribed when other anticonvulsant medications were ineffective or poorly tolerated.
Discontinuation: Dimethadione has largely been discontinued due to concerns about its safety and tolerability compared to newer anticonvulsant medications. It is no longer recommended as a first-line treatment for epilepsy, and alternative medications with better safety profiles are preferred.
Side Effects: Dimethadione is associated with a range of side effects, including dizziness, drowsiness, fatigue, nausea, vomiting, and gastrointestinal disturbances. It can also cause more serious adverse effects such as liver toxicity, hematologic abnormalities (including aplastic anemia and leukopenia), and skin reactions (such as Stevens-Johnson syndrome).
Hepatotoxicity: One of the most significant concerns associated with dimethadione use is hepatotoxicity, or liver damage. Cases of severe hepatotoxicity, including liver failure and death, have been reported with the use of dimethadione, particularly in children. As a result, regular liver function tests were required during treatment with dimethadione to monitor for signs of liver damage.
Drug Interactions: Dimethadione may interact with other medications, including other anticonvulsants and drugs metabolized by the liver. Careful monitoring and adjustment of dosage may be necessary when dimethadione is used in combination with other medications to minimize the risk of adverse effects and drug interactions.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive β X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
Explanations /Info /Descriptions are influenced by Large Language Models and may not be accurate and include some hallucinations.Please report any to us for correction.
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