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🍽️ metyrapone,(prescription)

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  1. Suppression of Cortisol Production: Metyrapone works by inhibiting an enzyme called 11-beta-hydroxylase, which is involved in the synthesis of cortisol, a hormone produced by the adrenal glands. By blocking this enzyme, metyrapone reduces the production of cortisol.

  2. Diagnostic Testing for Adrenal Insufficiency: Metyrapone is commonly used in diagnostic testing to assess the function of the adrenal glands, particularly in cases of suspected adrenal insufficiency (also known as Addison's disease). In the metyrapone test, a single dose of metyrapone is administered to the patient, which temporarily suppresses cortisol production. Subsequent measurements of cortisol levels in the blood or urine help evaluate the integrity of the hypothalamic-pituitary-adrenal (HPA) axis, which regulates cortisol secretion.

  3. Assessment of ACTH Responsiveness: In addition to diagnosing adrenal insufficiency, the metyrapone test can also help differentiate between primary adrenal insufficiency (due to dysfunction of the adrenal glands themselves) and secondary adrenal insufficiency (due to dysfunction of the pituitary gland or hypothalamus). In cases of secondary adrenal insufficiency, administration of metyrapone may lead to decreased cortisol production but increased secretion of adrenocorticotropic hormone (ACTH), which stimulates the adrenal glands.

  4. Monitoring of Cushing's Syndrome: Metyrapone may also be used in the management of Cushing's syndrome, a condition characterized by excessive production of cortisol. By inhibiting cortisol synthesis, metyrapone can help reduce cortisol levels and alleviate symptoms associated with Cushing's syndrome, such as weight gain, hypertension, diabetes, and mood changes. However, other treatments are typically used for long-term management of Cushing's syndrome.

  5. Side Effects: Metyrapone is generally well-tolerated when used for diagnostic testing under medical supervision. Common side effects may include gastrointestinal symptoms (such as nausea, vomiting, or abdominal discomfort), dizziness, headache, and fatigue. These side effects are usually mild and transient. However, the use of metyrapone may be associated with adrenal crisis in individuals with underlying adrenal insufficiency if not managed properly.

  6. Contraindications: Metyrapone should be used with caution or avoided in individuals with liver dysfunction, as it is metabolized by the liver. It should also be used with caution in pregnant or breastfeeding women, as its safety in these populations has not been established. Additionally, metyrapone may interact with other medications, particularly those that affect liver enzyme activity or cortisol metabolism.

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⚗️ Compensation for antibiotic usage

Data Contradictions — Limits of Certainity

Impacted of metyrapone,(prescription) On Probiotics

Rank Probiotic Impact
genus Bifidobacterium Reduces
species Anaerobutyricum hallii Reduces
species Bacteroides uniformis Reduces
species Bifidobacterium adolescentis Reduces
species Bifidobacterium breve Reduces
species Bifidobacterium longum Reduces
species Christensenella minuta Reduces
species Escherichia coli Reduces
species Faecalibacterium prausnitzii Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by metyrapone,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Lachnospira genus Decreases
0 1 Clostridioides genus Decreases
0 1 Roseburia genus Decreases
0 1 Veillonella genus Decreases
0 1 Bifidobacterium genus Decreases
0 1 Eggerthella genus Decreases
0 1 Odoribacter genus Decreases
0 1 Coprococcus genus Decreases
0 1 Collinsella genus Decreases
0 1 Blautia genus Decreases
0 1 Bacteroides genus Decreases
0 1 Phocaeicola genus Decreases
0 1 Escherichia genus Decreases
0 1 Agathobacter genus Decreases
0 1 Ruminococcus genus Decreases
0 1 Segatella genus Decreases
0 1 Bilophila genus Decreases
0 1 Thomasclavelia genus Decreases
0 1 Escherichia coli O1:K1:H7 no rank Decreases
0 1 Escherichia coli O139:H1 no rank Decreases
0 1 Escherichia coli O141:H4 no rank Decreases
0 1 Escherichia coli O145:H34 no rank Decreases
0 1 Escherichia coli O15:H12 no rank Decreases
0 1 Escherichia coli O155:H21 no rank Decreases
0 1 Escherichia coli O158:H23 no rank Decreases
0 1 Escherichia coli O16:H48 no rank Decreases
0 1 Escherichia coli O170:H18 no rank Decreases
0 1 Escherichia coli O18ac:H14 no rank Decreases
0 1 Escherichia coli O19:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H4 no rank Decreases
0 1 Escherichia coli O2:K1:H5 no rank Decreases
0 1 Escherichia coli O2:K1:H7 no rank Decreases
0 1 Escherichia coli O20:H12 no rank Decreases
0 1 Escherichia coli O25:H16 no rank Decreases
0 1 Escherichia coli O55:H7 no rank Decreases
0 1 Escherichia coli O68:H12 no rank Decreases
0 1 Escherichia coli O7:H15 no rank Decreases
0 1 Escherichia coli O78:H51 no rank Decreases
0 1 Escherichia coli O80:H26 no rank Decreases
0 1 Escherichia coli O84:H7 no rank Decreases
0 1 Escherichia coli O85:H1 no rank Decreases
0 1 Escherichia coli O103 serogroup Decreases
0 1 Escherichia coli O111 serogroup Decreases
0 1 Escherichia coli O119 serogroup Decreases
0 1 Escherichia coli O121 serogroup Decreases
0 1 Escherichia coli O145 serogroup Decreases
0 1 Escherichia coli O155 serogroup Decreases
0 1 Escherichia coli O157 serogroup Decreases
0 1 Escherichia coli O177 serogroup Decreases
0 1 Escherichia coli O26 serogroup Decreases
0 1 Escherichia coli O3 serogroup Decreases
0 1 Escherichia coli O43 serogroup Decreases
0 1 Escherichia coli O5 serogroup Decreases
0 1 Escherichia coli O78 serogroup Decreases
0 1 Escherichia coli O86 serogroup Decreases
0 1 Escherichia coli O91 serogroup Decreases
0 1 Escherichia coli H20 serotype Decreases
0 1 Escherichia coli O1:H42 serotype Decreases
0 1 Escherichia coli O1:HNT serotype Decreases
0 1 Escherichia coli O10:H32 serotype Decreases
0 1 Escherichia coli O10:K5(L):H4 serotype Decreases
0 1 Escherichia coli O100:H21 serotype Decreases
0 1 Escherichia coli O103:H11 serotype Decreases
0 1 Escherichia coli O103:H2 serotype Decreases
0 1 Escherichia coli O103:H25 serotype Decreases
0 1 Escherichia coli O104:H21 serotype Decreases
0 1 Escherichia coli O104:H4 serotype Decreases
0 1 Escherichia coli O111:H- serotype Decreases
0 1 Escherichia coli O111:H11 serotype Decreases
0 1 Escherichia coli O111:H8 serotype Decreases
0 1 Escherichia coli O111:NM serotype Decreases
0 1 Escherichia coli O112ab:H8 serotype Decreases
0 1 Escherichia coli O112ac:H19 serotype Decreases
0 1 Escherichia coli O113:H21 serotype Decreases
0 1 Escherichia coli O114:H49 serotype Decreases
0 1 Escherichia coli O118:H16 serotype Decreases
0 1 Escherichia coli O121:H19 serotype Decreases
0 1 Escherichia coli O121:H7 serotype Decreases
0 1 Escherichia coli O123:H11 serotype Decreases
0 1 Escherichia coli O125ac:K+:H10 serotype Decreases
0 1 Escherichia coli O126:H45 serotype Decreases
0 1 Escherichia coli O127:H27 serotype Decreases
0 1 Escherichia coli O127:H6 serotype Decreases
0 1 Escherichia coli O128:H2 serotype Decreases
0 1 Escherichia coli O128ac:H12 serotype Decreases
0 1 Escherichia coli O139:H28 serotype Decreases
0 1 Escherichia coli O145:H25 serotype Decreases
0 1 Escherichia coli O145:H28 serotype Decreases
0 1 Escherichia coli O145:NM serotype Decreases
0 1 Escherichia coli O146:H21 serotype Decreases
0 1 Escherichia coli O15:H18 serotype Decreases
0 1 Escherichia coli O150:H6 serotype Decreases
0 1 Escherichia coli O152:H23 serotype Decreases
0 1 Escherichia coli O153:H2 serotype Decreases
0 1 Escherichia coli O156:H25 serotype Decreases
0 1 Escherichia coli O157:H- serotype Decreases
0 1 Escherichia coli O157:H43 serotype Decreases
0 1 Escherichia coli O157:H7 serotype Decreases
0 1 Escherichia coli O157:NM serotype Decreases
0 1 Escherichia coli O16:H6 serotype Decreases
0 1 Escherichia coli O165:H25 serotype Decreases
0 1 Escherichia coli O167:H26 serotype Decreases
0 1 Escherichia coli O174:H2 serotype Decreases
0 1 Escherichia coli O174:H21 serotype Decreases
0 1 Escherichia coli O174:H8 serotype Decreases
0 1 Escherichia coli O176:H45 serotype Decreases
0 1 Escherichia coli O177:NM serotype Decreases
0 1 Escherichia coli O2:H6 serotype Decreases
0 1 Escherichia coli O2:K2:H1 serotype Decreases
0 1 Escherichia coli O25:H1 serotype Decreases
0 1 Escherichia coli O25:NM serotype Decreases
0 1 Escherichia coli O26:H1 serotype Decreases
0 1 Escherichia coli O26:H11 serotype Decreases
0 1 Escherichia coli O28ac:NM serotype Decreases
0 1 Escherichia coli O29:H4 serotype Decreases
0 1 Escherichia coli O32:H37 serotype Decreases
0 1 Escherichia coli O39:NM serotype Decreases
0 1 Escherichia coli O44:H18 serotype Decreases
0 1 Escherichia coli O45:H2 serotype Decreases
0 1 Escherichia coli O6:H16 serotype Decreases
0 1 Escherichia coli O6:H16:CFA/II serotype Decreases
0 1 Escherichia coli O6:K2:H1 serotype Decreases
0 1 Escherichia coli O69:H11 serotype Decreases
0 1 Escherichia coli O7:H4 serotype Decreases
0 1 Escherichia coli O7:K1 serotype Decreases
0 1 Escherichia coli O78:H12 serotype Decreases
0 1 Escherichia coli O78:H4 serotype Decreases
0 1 Escherichia coli O79:H7 serotype Decreases
0 1 Escherichia coli O8:H8 serotype Decreases
0 1 Escherichia coli O81:NM serotype Decreases
0 1 Escherichia coli O83:H1 serotype Decreases
0 1 Escherichia coli O86:H34 serotype Decreases
0 1 Escherichia coli O89m:H10 serotype Decreases
0 1 Escherichia coli O89m:H9 serotype Decreases
0 1 Escherichia coli O9:H10 serotype Decreases
0 1 Escherichia coli O91:H14 serotype Decreases
0 1 Escherichia coli O91:NM serotype Decreases
0 1 Escherichia coli O99:H6 serotype Decreases
0 1 Escherichia coli ONT:H33 serotype Decreases
1 0 Lachnospira eligens species Decreases
1 0 Bifidobacterium longum species Decreases
1 0 Clostridioides difficile species Decreases
1 0 Roseburia hominis species Decreases
1 0 Veillonella parvula species Decreases
1 0 Eggerthella lenta species Decreases
1 0 Odoribacter splanchnicus species Decreases
1 0 Bacteroides ovatus species Decreases
1 0 Coprococcus comes species Decreases
1 0 Bacteroides thetaiotaomicron species Decreases
1 0 Bifidobacterium adolescentis species Decreases
1 0 Collinsella aerofaciens species Decreases
1 0 Blautia obeum species Decreases
1 0 Bacteroides xylanisolvens species Decreases
0 1 Bifidobacterium breve species Decreases
0 1 Veillonella rodentium species Decreases
0 1 Veillonella dispar species Decreases
0 1 Butyrivibrio crossotus species Decreases
0 1 Eggerthella guodeyinii species Decreases
0 1 Coprococcus catus species Decreases
0 1 Veillonella sp. S12025-13 species Decreases
0 1 Subdoligranulum variabile species Decreases
0 1 Wansuia hejianensis species Decreases
0 1 Veillonella nakazawae species Decreases
0 1 Ligilactobacillus ruminis species Decreases
0 1 Clostridium sp. M62/1 species Decreases
0 1 Anaerobutyricum hallii species Decreases
0 1 Dorea longicatena species Decreases
0 1 Dorea formicigenerans species Decreases
0 1 Clostridium sp. SY8519 species Decreases
0 1 Eubacterium sp. MSJ-33 species Decreases
0 1 Faecalibacterium duncaniae species Decreases
0 1 Blautia sp. SC05B48 species Decreases
1 0 Bacteroides caccae species Decreases
0 1 Roseburia rectibacter species Decreases
0 1 Lacrimispora saccharolytica species Decreases
0 1 Christensenella minuta species Decreases
0 1 Eubacterium ventriosum species Decreases
0 1 [Ruminococcus] lactaris species Decreases
0 1 Qiania dongpingensis species Decreases
0 1 Wujia chipingensis species Decreases
0 1 Veillonella rogosae species Decreases
0 1 Coprococcus eutactus species Decreases
0 1 Pseudobutyrivibrio xylanivorans species Decreases
0 1 Simiaoa sunii species Decreases
0 1 Komagataeibacter oboediens species Decreases
0 1 Maliibacterium massiliense species Decreases
0 1 Massilistercora timonensis species Decreases
0 1 Novisyntrophococcus fermenticellae species Decreases
0 1 Blautia liquoris species Decreases
0 1 Roseburia intestinalis species Decreases
0 1 [Clostridium] hylemonae species Decreases
0 1 Catenibacterium mitsuokai species Decreases
0 1 Marvinbryantia formatexigens species Decreases
0 1 Ruminococcus champanellensis species Decreases
0 1 Faecalitalea cylindroides species Decreases
0 1 Faecalibacterium prausnitzii species Decreases
0 1 Vescimonas fastidiosa species Decreases
0 1 Faecalibacterium sp. I2-3-92 species Decreases
0 1 Coprococcus sp. ART55/1 species Decreases
0 1 Faecalibacterium sp. I4-1-79 species Decreases
0 1 Intestinibaculum porci species Decreases
0 1 Faecalibacterium sp. I3-3-33 species Decreases
0 1 Lachnoclostridium phocaeense species Decreases
0 1 Bifidobacterium angulatum species Decreases
0 1 Faecalibacterium sp. IP-3-29 species Decreases
0 1 Clostridium cadaveris species Decreases
0 1 Catenibacterium sp. co_0103 species Decreases
1 0 Phocaeicola vulgatus species Decreases
0 1 Ruminococcus bicirculans (ex Wegman et al. 2014) species Decreases
0 1 Faecalibacterium sp. I3-3-89 species Decreases
1 0 Escherichia coli species Decreases
1 0 Agathobacter rectalis species Decreases
1 0 Ruminococcus bromii species Decreases
1 0 Segatella copri species Decreases
1 0 Bilophila wadsworthia species Decreases
1 0 Thomasclavelia ramosa species Decreases
1 0 Bacteroides uniformis species Decreases
0 1 Bifidobacterium longum subsp. infantis subspecies Decreases
0 1 Bifidobacterium longum subsp. longum subspecies Decreases
0 1 Bifidobacterium longum subsp. suillum subspecies Decreases
0 1 Bifidobacterium longum subsp. suis subspecies Decreases

Impact of metyrapone,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.3 0.3
Acne 0.2 -0.2
ADHD 1.8 0.6 2
Age-Related Macular Degeneration and Glaucoma 0.4 0.4
Allergic Rhinitis (Hay Fever) 0.5 1.2 -1.4
Allergies 2.6 0.8 2.25
Allergy to milk products 0.5 0.5 0
Alopecia (Hair Loss) 0.2 0.1 1
Alzheimer's disease 1.3 2.4 -0.85
Amyotrophic lateral sclerosis (ALS) Motor Neuron 1.2 0.1 11
Ankylosing spondylitis 1.2 0.4 2
Anorexia Nervosa 0.3 1.1 -2.67
Antiphospholipid syndrome (APS) 0.4 0 0
Asthma 2.4 1.1 1.18
Atherosclerosis 0.6 0.7 -0.17
Atrial fibrillation 1.2 0.5 1.4
Autism 2.6 3.4 -0.31
Autoimmune Disease 0.2 0.4 -1
Barrett esophagus cancer 0.2 0.2
benign prostatic hyperplasia 0 0.1 0
Biofilm 0.3 0.3
Bipolar Disorder 0.5 0.8 -0.6
Brain Trauma 0.3 0.7 -1.33
Breast Cancer 0.1 0.1
Cancer (General) 0.4 1.1 -1.75
Carcinoma 0.9 0.7 0.29
Celiac Disease 1.1 1.7 -0.55
Cerebral Palsy 0.5 0.5 0
Chronic Fatigue Syndrome 1.7 2.3 -0.35
Chronic Kidney Disease 1.4 1.2 0.17
Chronic Lyme 0.5 0.3 0.67
Chronic Obstructive Pulmonary Disease (COPD) 0.4 0.9 -1.25
Chronic Urticaria (Hives) 0.3 0.2 0.5
Coagulation / Micro clot triggering bacteria 0.1 0.4 -3
Cognitive Function 0.4 0.6 -0.5
Colorectal Cancer 1.1 0.9 0.22
Constipation 0.6 0.4 0.5
Coronary artery disease 0.4 1.2 -2
COVID-19 3.5 4.4 -0.26
Crohn's Disease 1.8 2.2 -0.22
Cushing's Syndrome (hypercortisolism) 0.2 -0.2
cystic fibrosis 0.1 0.9 -8
d-lactic acidosis (one form of brain fog) 0.1 0.1
deep vein thrombosis 0.3 0.4 -0.33
Denture Wearers Oral Shifts 0.4 0.4
Depression 3.3 3.7 -0.12
Dermatomyositis 0.2 -0.2
Eczema 0.3 0.4 -0.33
Endometriosis 0.8 1.2 -0.5
Eosinophilic Esophagitis 0.2 -0.2
Epilepsy 0.9 0.4 1.25
erectile dysfunction 0.1 0.2 -1
Fibromyalgia 0.8 0.7 0.14
Functional constipation / chronic idiopathic constipation 2.1 1 1.1
gallstone disease (gsd) 0.5 0.4 0.25
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.4 0.8 -1
Generalized anxiety disorder 0.7 1 -0.43
Gout 0.4 0.1 3
Graves' disease 0.6 1.1 -0.83
Gulf War Syndrome 0.2 0.4 -1
Halitosis 0.3 0.3
Hashimoto's thyroiditis 1 0.7 0.43
Heart Failure 1.5 0.9 0.67
Hidradenitis Suppurativa 0.4 0.2 1
High Histamine/low DAO 0.3 0.2 0.5
hypercholesterolemia (High Cholesterol) 0.3 0.3
hyperglycemia 0.5 0.5 0
Hyperlipidemia (High Blood Fats) 0.3 0.1 2
hypersomnia 0.2 -0.2
hypertension (High Blood Pressure 0.9 3.2 -2.56
Hypothyroidism 0.6 -0.6
Hypoxia 0.3 0.3
IgA nephropathy (IgAN) 0.3 2.3 -6.67
Inflammatory Bowel Disease 3 3.5 -0.17
Insomnia 0.7 1 -0.43
Intelligence 0.5 0.2 1.5
Intracranial aneurysms 0.2 0.2 0
Irritable Bowel Syndrome 2 1.8 0.11
ischemic stroke 1.3 0.5 1.6
Liver Cirrhosis 2.4 1 1.4
Long COVID 2.4 3.9 -0.63
Low bone mineral density 0.8 -0.8
Lung Cancer 0.2 0.4 -1
Lymphoma 0 0
Mast Cell Issues / mastitis 0 0.4 0
ME/CFS with IBS 1.4 -1.4
ME/CFS without IBS 0.7 0.6 0.17
Menopause 1.4 0.2 6
Metabolic Syndrome 1.9 3 -0.58
Mood Disorders 3.7 3 0.23
multiple chemical sensitivity [MCS] 0.2 0.2 0
Multiple Sclerosis 1.9 1.7 0.12
Multiple system atrophy (MSA) 0.5 0.3 0.67
myasthenia gravis 0 0.2 0
neuropathic pain 0.2 1.7 -7.5
Neuropathy (all types) 0.3 0.7 -1.33
neuropsychiatric disorders (PANDAS, PANS) 0.3 0.3
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 1.7 2.5 -0.47
NonCeliac Gluten Sensitivity 0.7 0.3 1.33
Obesity 3.6 2.4 0.5
obsessive-compulsive disorder 2.2 0.8 1.75
Osteoarthritis 0.4 0.5 -0.25
Osteoporosis 0.8 0.4 1
pancreatic cancer 0.2 0.2
Parkinson's Disease 2.6 2 0.3
Polycystic ovary syndrome 1.3 0.9 0.44
Postural orthostatic tachycardia syndrome 0.3 -0.3
Premenstrual dysphoric disorder 0.4 0.4
primary biliary cholangitis 0.2 0.1 1
Primary sclerosing cholangitis 0.8 0.7 0.14
Psoriasis 1 0.6 0.67
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 2.5 1.4 0.79
Rosacea 0.2 0.4 -1
Schizophrenia 2.8 1.3 1.15
scoliosis 0.3 0.6 -1
sensorineural hearing loss 0.1 0.1
Sjögren syndrome 1.1 0.8 0.38
Sleep Apnea 0.5 0.8 -0.6
Slow gastric motility / Gastroparesis 0.4 0.2 1
Small Intestinal Bacterial Overgrowth (SIBO) 0.5 0.6 -0.2
Stress / posttraumatic stress disorder 0.6 1.3 -1.17
Systemic Lupus Erythematosus 0.9 1.2 -0.33
Tic Disorder 0.3 0.6 -1
Tourette syndrome 0.1 -0.1
Type 1 Diabetes 1 2.2 -1.2
Type 2 Diabetes 2.2 2 0.1
Ulcerative colitis 1.2 2.8 -1.33
Unhealthy Ageing 1.3 0.8 0.63
Vitiligo 0.6 0.5 0.2

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