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🍽️ xamoterol hemifumarate,(prescription)

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  1. Cardiac Effects: Xamoterol acts as a selective beta-1 adrenergic receptor agonist, meaning it primarily affects the beta-1 receptors in the heart. By stimulating these receptors, xamoterol increases the strength and efficiency of heart muscle contractions, leading to improved cardiac output and blood flow.

  2. Treatment of Heart Failure: Xamoterol is indicated for the management of chronic heart failure, a condition characterized by the heart's inability to pump blood effectively. By enhancing cardiac contractility, xamoterol helps alleviate symptoms such as shortness of breath, fatigue, and fluid retention associated with heart failure.

  3. Beta-Blocking Activity: Despite its beta-adrenergic agonist activity, xamoterol also exhibits some degree of beta-blocking (antagonistic) effects, particularly at higher doses. This dual mechanism of action helps to improve heart function while minimizing the risk of excessive sympathetic stimulation, which can exacerbate heart failure.

  4. Reduction of Heart Rate: Xamoterol may decrease heart rate by inhibiting the effects of sympathetic nervous system activity on the heart. This effect can be beneficial in certain patients with heart failure who have elevated resting heart rates.

  5. Vasodilation: Xamoterol has vasodilatory properties, meaning it relaxes and widens blood vessels. This vasodilation reduces peripheral resistance to blood flow, easing the workload on the heart and improving overall cardiovascular function.

  6. Adverse Effects: Like all medications, xamoterol can cause side effects. Common side effects may include dizziness, headache, fatigue, nausea, and gastrointestinal disturbances. Some patients may experience bradycardia (slow heart rate) or hypotension (low blood pressure) as a result of xamoterol therapy.

  7. Contraindications: Xamoterol is contraindicated in patients with certain cardiac conditions, including severe bradycardia, heart block, cardiogenic shock, and decompensated heart failure requiring intravenous inotropic therapy. It should not be used in patients with a history of bronchospasm or asthma due to its beta-adrenergic effects.

  8. Monitoring: Patients receiving xamoterol therapy should be closely monitored for signs of worsening heart failure, electrolyte imbalances, and adverse drug reactions. Dosage adjustments may be necessary based on individual patient response and tolerance.

  9. Interactions: Xamoterol may interact with other medications, particularly other cardiovascular drugs such as beta-blockers, calcium channel blockers, and antiarrhythmics. Combining xamoterol with these medications can potentiate or attenuate their effects, so careful monitoring is essential.

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⚗️ Compensation for antibiotic usage

Data Contradictions — Limits of Certainity

Impacted of xamoterol hemifumarate,(prescription) On Probiotics

Rank Probiotic Impact
genus Bifidobacterium Reduces
species Akkermansia muciniphila Reduces
species Anaerobutyricum hallii Reduces
species Bifidobacterium adolescentis Reduces
species Bifidobacterium breve Reduces
species Bifidobacterium longum Reduces
species Escherichia coli Reduces
species Lacticaseibacillus paracasei Reduces
species Veillonella atypica Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by xamoterol hemifumarate,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Akkermansiaceae family Decreases
0 1 Ruminococcus genus Decreases
0 1 Odoribacter genus Decreases
0 1 Blautia genus Decreases
0 1 Dorea genus Decreases
0 1 Veillonella genus Decreases
0 1 Bifidobacterium genus Decreases
0 1 Roseburia genus Decreases
0 1 Collinsella genus Decreases
0 1 Agathobacter genus Decreases
0 1 Eggerthella genus Decreases
0 1 Thomasclavelia genus Decreases
0 1 Bacteroides genus Decreases
1 0 Akkermansia genus Decreases
0 1 Lachnospira genus Decreases
0 1 Clostridioides genus Decreases
0 1 Mediterraneibacter genus Decreases
0 1 Escherichia genus Decreases
0 1 Lacrimispora genus Decreases
0 1 Clostridium genus Decreases
0 1 Fusobacterium genus Decreases
0 1 Segatella genus Decreases
0 1 Lacticaseibacillus genus Decreases
0 1 Escherichia coli O1:K1:H7 no rank Decreases
0 1 Escherichia coli O139:H1 no rank Decreases
0 1 Escherichia coli O141:H4 no rank Decreases
0 1 Escherichia coli O145:H34 no rank Decreases
0 1 Escherichia coli O15:H12 no rank Decreases
0 1 Escherichia coli O155:H21 no rank Decreases
0 1 Escherichia coli O158:H23 no rank Decreases
0 1 Escherichia coli O16:H48 no rank Decreases
0 1 Escherichia coli O170:H18 no rank Decreases
0 1 Escherichia coli O18ac:H14 no rank Decreases
0 1 Escherichia coli O19:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H4 no rank Decreases
0 1 Escherichia coli O2:K1:H5 no rank Decreases
0 1 Escherichia coli O2:K1:H7 no rank Decreases
0 1 Escherichia coli O20:H12 no rank Decreases
0 1 Escherichia coli O25:H16 no rank Decreases
0 1 Escherichia coli O55:H7 no rank Decreases
0 1 Escherichia coli O68:H12 no rank Decreases
0 1 Escherichia coli O7:H15 no rank Decreases
0 1 Escherichia coli O78:H51 no rank Decreases
0 1 Escherichia coli O80:H26 no rank Decreases
0 1 Escherichia coli O84:H7 no rank Decreases
0 1 Escherichia coli O85:H1 no rank Decreases
0 1 environmental samples no rank Decreases
0 1 unclassified Akkermansia no rank Decreases
0 1 Clostridium perfringens A no rank Decreases
0 1 Clostridium perfringens B no rank Decreases
0 1 Clostridium perfringens C no rank Decreases
0 1 Clostridium perfringens CPE no rank Decreases
0 1 Clostridium perfringens D no rank Decreases
0 1 Clostridium perfringens E no rank Decreases
0 1 Escherichia coli O103 serogroup Decreases
0 1 Escherichia coli O111 serogroup Decreases
0 1 Escherichia coli O119 serogroup Decreases
0 1 Escherichia coli O121 serogroup Decreases
0 1 Escherichia coli O145 serogroup Decreases
0 1 Escherichia coli O155 serogroup Decreases
0 1 Escherichia coli O157 serogroup Decreases
0 1 Escherichia coli O177 serogroup Decreases
0 1 Escherichia coli O26 serogroup Decreases
0 1 Escherichia coli O3 serogroup Decreases
0 1 Escherichia coli O43 serogroup Decreases
0 1 Escherichia coli O5 serogroup Decreases
0 1 Escherichia coli O78 serogroup Decreases
0 1 Escherichia coli O86 serogroup Decreases
0 1 Escherichia coli O91 serogroup Decreases
0 1 Escherichia coli H20 serotype Decreases
0 1 Escherichia coli O1:H42 serotype Decreases
0 1 Escherichia coli O1:HNT serotype Decreases
0 1 Escherichia coli O10:H32 serotype Decreases
0 1 Escherichia coli O10:K5(L):H4 serotype Decreases
0 1 Escherichia coli O100:H21 serotype Decreases
0 1 Escherichia coli O103:H11 serotype Decreases
0 1 Escherichia coli O103:H2 serotype Decreases
0 1 Escherichia coli O103:H25 serotype Decreases
0 1 Escherichia coli O104:H21 serotype Decreases
0 1 Escherichia coli O104:H4 serotype Decreases
0 1 Escherichia coli O111:H- serotype Decreases
0 1 Escherichia coli O111:H11 serotype Decreases
0 1 Escherichia coli O111:H8 serotype Decreases
0 1 Escherichia coli O111:NM serotype Decreases
0 1 Escherichia coli O112ab:H8 serotype Decreases
0 1 Escherichia coli O112ac:H19 serotype Decreases
0 1 Escherichia coli O113:H21 serotype Decreases
0 1 Escherichia coli O114:H49 serotype Decreases
0 1 Escherichia coli O118:H16 serotype Decreases
0 1 Escherichia coli O121:H19 serotype Decreases
0 1 Escherichia coli O121:H7 serotype Decreases
0 1 Escherichia coli O123:H11 serotype Decreases
0 1 Escherichia coli O125ac:K+:H10 serotype Decreases
0 1 Escherichia coli O126:H45 serotype Decreases
0 1 Escherichia coli O127:H27 serotype Decreases
0 1 Escherichia coli O127:H6 serotype Decreases
0 1 Escherichia coli O128:H2 serotype Decreases
0 1 Escherichia coli O128ac:H12 serotype Decreases
0 1 Escherichia coli O139:H28 serotype Decreases
0 1 Escherichia coli O145:H25 serotype Decreases
0 1 Escherichia coli O145:H28 serotype Decreases
0 1 Escherichia coli O145:NM serotype Decreases
0 1 Escherichia coli O146:H21 serotype Decreases
0 1 Escherichia coli O15:H18 serotype Decreases
0 1 Escherichia coli O150:H6 serotype Decreases
0 1 Escherichia coli O152:H23 serotype Decreases
0 1 Escherichia coli O153:H2 serotype Decreases
0 1 Escherichia coli O156:H25 serotype Decreases
0 1 Escherichia coli O157:H- serotype Decreases
0 1 Escherichia coli O157:H43 serotype Decreases
0 1 Escherichia coli O157:H7 serotype Decreases
0 1 Escherichia coli O157:NM serotype Decreases
0 1 Escherichia coli O16:H6 serotype Decreases
0 1 Escherichia coli O165:H25 serotype Decreases
0 1 Escherichia coli O167:H26 serotype Decreases
0 1 Escherichia coli O174:H2 serotype Decreases
0 1 Escherichia coli O174:H21 serotype Decreases
0 1 Escherichia coli O174:H8 serotype Decreases
0 1 Escherichia coli O176:H45 serotype Decreases
0 1 Escherichia coli O177:NM serotype Decreases
0 1 Escherichia coli O2:H6 serotype Decreases
0 1 Escherichia coli O2:K2:H1 serotype Decreases
0 1 Escherichia coli O25:H1 serotype Decreases
0 1 Escherichia coli O25:NM serotype Decreases
0 1 Escherichia coli O26:H1 serotype Decreases
0 1 Escherichia coli O26:H11 serotype Decreases
0 1 Escherichia coli O28ac:NM serotype Decreases
0 1 Escherichia coli O29:H4 serotype Decreases
0 1 Escherichia coli O32:H37 serotype Decreases
0 1 Escherichia coli O39:NM serotype Decreases
0 1 Escherichia coli O44:H18 serotype Decreases
0 1 Escherichia coli O45:H2 serotype Decreases
0 1 Escherichia coli O6:H16 serotype Decreases
0 1 Escherichia coli O6:H16:CFA/II serotype Decreases
0 1 Escherichia coli O6:K2:H1 serotype Decreases
0 1 Escherichia coli O69:H11 serotype Decreases
0 1 Escherichia coli O7:H4 serotype Decreases
0 1 Escherichia coli O7:K1 serotype Decreases
0 1 Escherichia coli O78:H12 serotype Decreases
0 1 Escherichia coli O78:H4 serotype Decreases
0 1 Escherichia coli O79:H7 serotype Decreases
0 1 Escherichia coli O8:H8 serotype Decreases
0 1 Escherichia coli O81:NM serotype Decreases
0 1 Escherichia coli O83:H1 serotype Decreases
0 1 Escherichia coli O86:H34 serotype Decreases
0 1 Escherichia coli O89m:H10 serotype Decreases
0 1 Escherichia coli O89m:H9 serotype Decreases
0 1 Escherichia coli O9:H10 serotype Decreases
0 1 Escherichia coli O91:H14 serotype Decreases
0 1 Escherichia coli O91:NM serotype Decreases
0 1 Escherichia coli O99:H6 serotype Decreases
0 1 Escherichia coli ONT:H33 serotype Decreases
1 0 Ruminococcus bromii species Decreases
1 0 Bacteroides xylanisolvens species Decreases
1 0 Roseburia hominis species Decreases
1 0 Odoribacter splanchnicus species Decreases
1 0 Blautia obeum species Decreases
1 0 Bifidobacterium adolescentis species Decreases
1 0 Dorea formicigenerans species Decreases
1 0 Veillonella parvula species Decreases
1 0 Bifidobacterium longum species Decreases
1 0 Collinsella aerofaciens species Decreases
1 0 Bacteroides caccae species Decreases
1 0 Agathobacter rectalis species Decreases
1 0 Eggerthella lenta species Decreases
1 0 Thomasclavelia ramosa species Decreases
1 0 Akkermansia muciniphila species Decreases
1 0 Lachnospira eligens species Decreases
1 0 Roseburia intestinalis species Decreases
0 1 Veillonella rodentium species Decreases
1 0 Bacteroides thetaiotaomicron species Decreases
1 0 Bacteroides ovatus species Decreases
0 1 Veillonella dispar species Decreases
0 1 Bacteroides luhongzhouii species Decreases
0 1 Bifidobacterium angulatum species Decreases
1 0 Clostridioides difficile species Decreases
0 1 Veillonella sp. S12025-13 species Decreases
0 1 Veillonella nakazawae species Decreases
1 0 [Ruminococcus] torques species Decreases
1 0 Escherichia coli species Decreases
0 1 Coprobacter secundus species Decreases
0 1 Actinomyces naeslundii species Decreases
0 1 uncultured Alistipes sp. species Decreases
0 1 Barnesiella viscericola species Decreases
0 1 Butyricimonas virosa species Decreases
0 1 Coprococcus catus species Decreases
0 1 Alistipes megaguti species Decreases
0 1 Anaerobutyricum hallii species Decreases
0 1 Veillonella rogosae species Decreases
0 1 Bifidobacterium breve species Decreases
0 1 Fannyhessea vaginae species Decreases
0 1 Dorea longicatena species Decreases
0 1 Olsenella sp. oral taxon 807 species Decreases
0 1 Blautia sp. SC05B48 species Decreases
0 1 Wansuia hejianensis species Decreases
0 1 Ruminococcus albus species Decreases
0 1 Coprobacter fastidiosus species Decreases
0 1 Adlercreutzia equolifaciens species Decreases
0 1 Eubacterium ventriosum species Decreases
0 1 Alistipes sp. dk3624 species Decreases
0 1 Butyrivibrio crossotus species Decreases
0 1 Eggerthella guodeyinii species Decreases
0 1 Roseburia rectibacter species Decreases
0 1 Bacteroides sp. DH3716P species Decreases
0 1 Parolsenella catena species Decreases
0 1 Coprococcus comes species Decreases
0 1 Komagataeibacter oboediens species Decreases
0 1 Alistipes senegalensis species Decreases
0 1 Alistipes ihumii species Decreases
0 1 Ligilactobacillus ruminis species Decreases
0 1 Eubacterium sp. MSJ-33 species Decreases
0 1 Alistipes finegoldii species Decreases
1 0 Lacrimispora saccharolytica species Decreases
0 1 Alistipes dispar species Decreases
0 1 Wujia chipingensis species Decreases
0 1 Alistipes shahii species Decreases
0 1 Alistipes communis species Decreases
0 1 Faecalibacillus intestinalis species Decreases
0 1 Alistipes onderdonkii species Decreases
0 1 Intestinibaculum porci species Decreases
0 1 Pseudobutyrivibrio xylanivorans species Decreases
0 1 Subdoligranulum variabile species Decreases
0 1 Bacteroides faecium species Decreases
0 1 Actinomyces oris species Decreases
0 1 Phoenicibacter congonensis species Decreases
0 1 Clostridium sp. SY8519 species Decreases
0 1 Veillonella atypica species Decreases
0 1 Clostridium sp. M62/1 species Decreases
0 1 Actinomyces sp. oral taxon 171 species Decreases
0 1 Bacillus paralicheniformis species Decreases
0 1 Simiaoa sunii species Decreases
0 1 Coprococcus eutactus species Decreases
0 1 Parolsenella massiliensis species Decreases
1 0 Bacteroides fragilis species Decreases
1 0 Clostridium perfringens species Decreases
1 0 Fusobacterium nucleatum species Decreases
0 1 Akkermansia glycaniphila species Decreases
0 1 Akkermansia massiliensis species Decreases
0 1 Candidatus Akkermansia intestinavium species Decreases
1 0 Segatella copri species Decreases
1 0 Lacticaseibacillus paracasei species Decreases
0 1 Bifidobacterium longum subsp. infantis subspecies Decreases
0 1 Bifidobacterium longum subsp. longum subspecies Decreases
0 1 Bifidobacterium longum subsp. suillum subspecies Decreases
0 1 Bifidobacterium longum subsp. suis subspecies Decreases
0 1 Fusobacterium nucleatum subsp. nucleatum subspecies Decreases
0 1 Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases
0 1 Lacticaseibacillus paracasei subsp. tolerans subspecies Decreases

Impact of xamoterol hemifumarate,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.2 0.2
Acne 0.2 -0.2
ADHD 2.2 0.4 4.5
Age-Related Macular Degeneration and Glaucoma 0.6 0.6
Allergic Rhinitis (Hay Fever) 1 1.4 -0.4
Allergies 3.7 2.3 0.61
Allergy to milk products 1.1 0.6 0.83
Alopecia (Hair Loss) 0.7 0.7
Alzheimer's disease 2.8 3.8 -0.36
Amyotrophic lateral sclerosis (ALS) Motor Neuron 1.6 0.8 1
Ankylosing spondylitis 1.8 0.6 2
Anorexia Nervosa 0.8 1.6 -1
Antiphospholipid syndrome (APS) 0.6 0.6
Asthma 2.6 1.7 0.53
Atherosclerosis 1.2 1.2 0
Atrial fibrillation 1.8 0.8 1.25
Autism 3.7 4.2 -0.14
Autoimmune Disease 0.3 0.4 -0.33
Barrett esophagus cancer 0.2 0.2
benign prostatic hyperplasia 0.1 0.1 0
Biofilm 0.4 0.4
Bipolar Disorder 0.7 0.9 -0.29
Brain Trauma 0.4 0.9 -1.25
Breast Cancer 0.2 0.2
Cancer (General) 0.5 1.4 -1.8
Carcinoma 1.9 1.6 0.19
Celiac Disease 1.4 2.3 -0.64
Cerebral Palsy 0.7 0.9 -0.29
Chronic Fatigue Syndrome 2.7 3.7 -0.37
Chronic Kidney Disease 1.8 1.2 0.5
Chronic Lyme 0.2 0.3 -0.5
Chronic Obstructive Pulmonary Disease (COPD) 0.4 0.6 -0.5
Chronic Urticaria (Hives) 0.5 0.4 0.25
Coagulation / Micro clot triggering bacteria 0.2 0.8 -3
Cognitive Function 1.1 0.7 0.57
Colorectal Cancer 2.1 1.2 0.75
Constipation 0.7 0.5 0.4
Coronary artery disease 1 1.6 -0.6
COVID-19 5.7 7.9 -0.39
Crohn's Disease 2.8 3.3 -0.18
Cushing's Syndrome (hypercortisolism) 0.1 -0.1
cystic fibrosis 0.2 1.3 -5.5
d-lactic acidosis (one form of brain fog) 0.1 0.1
deep vein thrombosis 0.5 0.7 -0.4
Denture Wearers Oral Shifts 0.5 0.5
Depression 4.5 5 -0.11
Dermatomyositis 0.2 -0.2
Eczema 0.3 0.8 -1.67
Endometriosis 1.1 1.3 -0.18
Eosinophilic Esophagitis 0 0.2 0
Epilepsy 1.4 1 0.4
erectile dysfunction 0.3 0.2 0.5
Fibromyalgia 1.5 0.5 2
Functional constipation / chronic idiopathic constipation 2.2 1.9 0.16
gallstone disease (gsd) 1.4 0.6 1.33
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.4 1 -1.5
Generalized anxiety disorder 0.9 0.9 0
giant cell arteritis 0 0
Gout 1.6 0.2 7
Graves' disease 1.1 1.8 -0.64
Gulf War Syndrome 0.3 0.9 -2
Halitosis 0.4 0.4
Hashimoto's thyroiditis 2.1 0.8 1.63
Heart Failure 1.2 1.6 -0.33
hemorrhagic stroke 0.3 0.3
Hidradenitis Suppurativa 0.3 0.2 0.5
High Histamine/low DAO 0.4 0.5 -0.25
hypercholesterolemia (High Cholesterol) 0.5 0.3 0.67
hyperglycemia 0.7 1 -0.43
Hyperlipidemia (High Blood Fats) 0.5 0.2 1.5
hypersomnia 0.4 -0.4
hypertension (High Blood Pressure 2.1 3.6 -0.71
Hypothyroidism 0.1 0.6 -5
Hypoxia 0.8 0.8
IgA nephropathy (IgAN) 0.6 2 -2.33
Inflammatory Bowel Disease 3.3 5.9 -0.79
Insomnia 1 1.9 -0.9
Intelligence 0.5 0 0
Intracranial aneurysms 0.8 0.2 3
Irritable Bowel Syndrome 3.9 2.1 0.86
ischemic stroke 1.7 0.6 1.83
Liver Cirrhosis 3.7 2 0.85
Long COVID 3.3 5.4 -0.64
Low bone mineral density 0.5 -0.5
Lung Cancer 0.4 1.4 -2.5
Lymphoma 0.1 0.1
Mast Cell Issues / mastitis 0.1 0.5 -4
ME/CFS with IBS 0 1.9 0
ME/CFS without IBS 0.6 1.2 -1
Menopause 1.3 0.5 1.6
Metabolic Syndrome 3.3 4.1 -0.24
Mood Disorders 4.8 3.8 0.26
multiple chemical sensitivity [MCS] 0.4 0.3 0.33
Multiple Sclerosis 2.9 2.5 0.16
Multiple system atrophy (MSA) 1.1 0.8 0.38
myasthenia gravis 0.1 0.2 -1
neuropathic pain 0.2 1.9 -8.5
Neuropathy (all types) 0.6 0.8 -0.33
neuropsychiatric disorders (PANDAS, PANS) 0.4 0.4
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 2.7 3.7 -0.37
NonCeliac Gluten Sensitivity 1.2 0.4 2
Obesity 5.7 3.7 0.54
obsessive-compulsive disorder 2.6 1.7 0.53
Osteoarthritis 1.1 0.8 0.38
Osteoporosis 1.1 1.1 0
pancreatic cancer 0.3 0.3
Parkinson's Disease 4.4 3.2 0.38
Polycystic ovary syndrome 2.5 2.2 0.14
Postural orthostatic tachycardia syndrome 0 0.2 0
Premenstrual dysphoric disorder 0.6 0.6
primary biliary cholangitis 0.5 0.2 1.5
Primary sclerosing cholangitis 1 1.3 -0.3
Psoriasis 2.2 1 1.2
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 4.1 2.2 0.86
Rosacea 0.7 0.2 2.5
Schizophrenia 3.7 1.7 1.18
scoliosis 0.3 0.6 -1
sensorineural hearing loss 0.1 0.1
Sjögren syndrome 1.4 1.5 -0.07
Sleep Apnea 1.1 0.8 0.38
Slow gastric motility / Gastroparesis 0.8 0.2 3
Small Intestinal Bacterial Overgrowth (SIBO) 0.6 0.4 0.5
Stress / posttraumatic stress disorder 1.1 1.3 -0.18
Systemic Lupus Erythematosus 1.3 1.5 -0.15
Tic Disorder 0.6 0.8 -0.33
Tourette syndrome 0.4 0.1 3
Type 1 Diabetes 1.6 2.1 -0.31
Type 2 Diabetes 3.5 3.1 0.13
Ulcerative colitis 2 3.1 -0.55
Unhealthy Ageing 1.2 1.3 -0.08
Vitiligo 0.9 0.6 0.5

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