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🍽️ mianserine hydrochloride,(prescription)

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  1. Antidepressant Effects: Mianserin is classified as a tetracyclic antidepressant (TeCA) and works by increasing the levels of serotonin and noradrenaline in the brain. These neurotransmitters are involved in regulating mood, emotions, and feelings of well-being. By enhancing their activity, mianserin helps alleviate symptoms of depression.

  2. Treatment of Depression: Mianserin is indicated for the treatment of major depressive disorder (MDD). It may be prescribed for individuals experiencing persistent feelings of sadness, hopelessness, loss of interest or pleasure in activities, changes in appetite or weight, sleep disturbances, fatigue, feelings of worthlessness or guilt, difficulty concentrating, or suicidal thoughts.

  3. Symptom Improvement: Mianserin helps improve depressive symptoms, including mood disturbances, anxiety, agitation, sleep disturbances, and physical symptoms such as changes in appetite or energy levels.

  4. Onset of Action: Like other antidepressants, mianserin may take several weeks to exert its full therapeutic effects. Patients are advised to continue taking the medication as prescribed even if they do not notice immediate improvement in their symptoms.

  5. Dosage Adjustment: The dosage of mianserin is individualized based on the patient's response to treatment and tolerability. Healthcare providers may start with a low dose and gradually increase it to achieve optimal therapeutic effects while minimizing side effects.

  6. Side Effects: Common side effects of mianserin may include drowsiness, dizziness, dry mouth, blurred vision, constipation, increased appetite, weight gain, and sexual dysfunction. These side effects are usually mild and transient, but if they persist or worsen, patients should consult their healthcare provider.

  7. Serotonin Syndrome: Mianserin, like other antidepressants, may rarely cause serotonin syndrome when taken in combination with other medications that increase serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), or monoamine oxidase inhibitors (MAOIs). Symptoms of serotonin syndrome include agitation, hallucinations, rapid heartbeat, high blood pressure, fever, excessive sweating, tremors, muscle rigidity, and seizures. Immediate medical attention is required if these symptoms occur.

  8. Withdrawal Symptoms: Abrupt discontinuation of mianserin may lead to withdrawal symptoms, including dizziness, nausea, headache, irritability, insomnia, and flu-like symptoms. To minimize the risk of withdrawal reactions, the dosage of mianserin should be gradually tapered under the supervision of a healthcare provider when discontinuing treatment.

  9. Monitoring: Patients taking mianserin should be closely monitored for changes in mood, behavior, or suicidal ideation, especially when starting or adjusting the dosage of the medication. Healthcare providers may conduct regular follow-up appointments to assess treatment response and monitor for adverse effects.

  10. Contraindications: Mianserin is contraindicated in individuals with a known hypersensitivity to the drug, as well as in patients with acute intoxication with alcohol, barbiturates, or other central nervous system depressants. Additionally, mianserin should not be used concomitantly with MAOIs or within two weeks of discontinuing MAOI therapy due to the risk of serotonin syndrome.

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⚗️ Compensation for antibiotic usage

Data Contradictions — Limits of Certainity

Impacted of mianserine hydrochloride,(prescription) On Probiotics

Rank Probiotic Impact
genus Bifidobacterium Reduces
species Akkermansia muciniphila Reduces
species Anaerobutyricum hallii Reduces
species Bacteroides uniformis Reduces
species Bifidobacterium longum Reduces
species Christensenella minuta Reduces
species Escherichia coli Reduces
species Faecalibacterium prausnitzii Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by mianserine hydrochloride,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Akkermansiaceae family Decreases
0 1 Agathobacter genus Decreases
0 1 Coprococcus genus Decreases
0 1 Lachnospira genus Decreases
0 1 Eggerthella genus Decreases
1 0 Akkermansia genus Decreases
0 1 Clostridioides genus Decreases
0 1 Ruminococcus genus Decreases
0 1 Wujia genus Decreases
0 1 Bilophila genus Decreases
0 1 Phocaeicola genus Decreases
0 1 Segatella genus Decreases
0 1 Bacteroides genus Decreases
0 1 Bifidobacterium genus Decreases
0 1 Escherichia genus Decreases
0 1 Veillonella genus Decreases
0 1 Blautia genus Decreases
0 1 Streptococcus genus Decreases
0 1 environmental samples no rank Decreases
0 1 unclassified Akkermansia no rank Decreases
0 1 Escherichia coli O1:K1:H7 no rank Decreases
0 1 Escherichia coli O139:H1 no rank Decreases
0 1 Escherichia coli O141:H4 no rank Decreases
0 1 Escherichia coli O145:H34 no rank Decreases
0 1 Escherichia coli O15:H12 no rank Decreases
0 1 Escherichia coli O155:H21 no rank Decreases
0 1 Escherichia coli O158:H23 no rank Decreases
0 1 Escherichia coli O16:H48 no rank Decreases
0 1 Escherichia coli O170:H18 no rank Decreases
0 1 Escherichia coli O18ac:H14 no rank Decreases
0 1 Escherichia coli O19:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H4 no rank Decreases
0 1 Escherichia coli O2:K1:H5 no rank Decreases
0 1 Escherichia coli O2:K1:H7 no rank Decreases
0 1 Escherichia coli O20:H12 no rank Decreases
0 1 Escherichia coli O25:H16 no rank Decreases
0 1 Escherichia coli O55:H7 no rank Decreases
0 1 Escherichia coli O68:H12 no rank Decreases
0 1 Escherichia coli O7:H15 no rank Decreases
0 1 Escherichia coli O78:H51 no rank Decreases
0 1 Escherichia coli O80:H26 no rank Decreases
0 1 Escherichia coli O84:H7 no rank Decreases
0 1 Escherichia coli O85:H1 no rank Decreases
0 1 Escherichia coli O103 serogroup Decreases
0 1 Escherichia coli O111 serogroup Decreases
0 1 Escherichia coli O119 serogroup Decreases
0 1 Escherichia coli O121 serogroup Decreases
0 1 Escherichia coli O145 serogroup Decreases
0 1 Escherichia coli O155 serogroup Decreases
0 1 Escherichia coli O157 serogroup Decreases
0 1 Escherichia coli O177 serogroup Decreases
0 1 Escherichia coli O26 serogroup Decreases
0 1 Escherichia coli O3 serogroup Decreases
0 1 Escherichia coli O43 serogroup Decreases
0 1 Escherichia coli O5 serogroup Decreases
0 1 Escherichia coli O78 serogroup Decreases
0 1 Escherichia coli O86 serogroup Decreases
0 1 Escherichia coli O91 serogroup Decreases
0 1 Escherichia coli H20 serotype Decreases
0 1 Escherichia coli O1:H42 serotype Decreases
0 1 Escherichia coli O1:HNT serotype Decreases
0 1 Escherichia coli O10:H32 serotype Decreases
0 1 Escherichia coli O10:K5(L):H4 serotype Decreases
0 1 Escherichia coli O100:H21 serotype Decreases
0 1 Escherichia coli O103:H11 serotype Decreases
0 1 Escherichia coli O103:H2 serotype Decreases
0 1 Escherichia coli O103:H25 serotype Decreases
0 1 Escherichia coli O104:H21 serotype Decreases
0 1 Escherichia coli O104:H4 serotype Decreases
0 1 Escherichia coli O111:H- serotype Decreases
0 1 Escherichia coli O111:H11 serotype Decreases
0 1 Escherichia coli O111:H8 serotype Decreases
0 1 Escherichia coli O111:NM serotype Decreases
0 1 Escherichia coli O112ab:H8 serotype Decreases
0 1 Escherichia coli O112ac:H19 serotype Decreases
0 1 Escherichia coli O113:H21 serotype Decreases
0 1 Escherichia coli O114:H49 serotype Decreases
0 1 Escherichia coli O118:H16 serotype Decreases
0 1 Escherichia coli O121:H19 serotype Decreases
0 1 Escherichia coli O121:H7 serotype Decreases
0 1 Escherichia coli O123:H11 serotype Decreases
0 1 Escherichia coli O125ac:K+:H10 serotype Decreases
0 1 Escherichia coli O126:H45 serotype Decreases
0 1 Escherichia coli O127:H27 serotype Decreases
0 1 Escherichia coli O127:H6 serotype Decreases
0 1 Escherichia coli O128:H2 serotype Decreases
0 1 Escherichia coli O128ac:H12 serotype Decreases
0 1 Escherichia coli O139:H28 serotype Decreases
0 1 Escherichia coli O145:H25 serotype Decreases
0 1 Escherichia coli O145:H28 serotype Decreases
0 1 Escherichia coli O145:NM serotype Decreases
0 1 Escherichia coli O146:H21 serotype Decreases
0 1 Escherichia coli O15:H18 serotype Decreases
0 1 Escherichia coli O150:H6 serotype Decreases
0 1 Escherichia coli O152:H23 serotype Decreases
0 1 Escherichia coli O153:H2 serotype Decreases
0 1 Escherichia coli O156:H25 serotype Decreases
0 1 Escherichia coli O157:H- serotype Decreases
0 1 Escherichia coli O157:H43 serotype Decreases
0 1 Escherichia coli O157:H7 serotype Decreases
0 1 Escherichia coli O157:NM serotype Decreases
0 1 Escherichia coli O16:H6 serotype Decreases
0 1 Escherichia coli O165:H25 serotype Decreases
0 1 Escherichia coli O167:H26 serotype Decreases
0 1 Escherichia coli O174:H2 serotype Decreases
0 1 Escherichia coli O174:H21 serotype Decreases
0 1 Escherichia coli O174:H8 serotype Decreases
0 1 Escherichia coli O176:H45 serotype Decreases
0 1 Escherichia coli O177:NM serotype Decreases
0 1 Escherichia coli O2:H6 serotype Decreases
0 1 Escherichia coli O2:K2:H1 serotype Decreases
0 1 Escherichia coli O25:H1 serotype Decreases
0 1 Escherichia coli O25:NM serotype Decreases
0 1 Escherichia coli O26:H1 serotype Decreases
0 1 Escherichia coli O26:H11 serotype Decreases
0 1 Escherichia coli O28ac:NM serotype Decreases
0 1 Escherichia coli O29:H4 serotype Decreases
0 1 Escherichia coli O32:H37 serotype Decreases
0 1 Escherichia coli O39:NM serotype Decreases
0 1 Escherichia coli O44:H18 serotype Decreases
0 1 Escherichia coli O45:H2 serotype Decreases
0 1 Escherichia coli O6:H16 serotype Decreases
0 1 Escherichia coli O6:H16:CFA/II serotype Decreases
0 1 Escherichia coli O6:K2:H1 serotype Decreases
0 1 Escherichia coli O69:H11 serotype Decreases
0 1 Escherichia coli O7:H4 serotype Decreases
0 1 Escherichia coli O7:K1 serotype Decreases
0 1 Escherichia coli O78:H12 serotype Decreases
0 1 Escherichia coli O78:H4 serotype Decreases
0 1 Escherichia coli O79:H7 serotype Decreases
0 1 Escherichia coli O8:H8 serotype Decreases
0 1 Escherichia coli O81:NM serotype Decreases
0 1 Escherichia coli O83:H1 serotype Decreases
0 1 Escherichia coli O86:H34 serotype Decreases
0 1 Escherichia coli O89m:H10 serotype Decreases
0 1 Escherichia coli O89m:H9 serotype Decreases
0 1 Escherichia coli O9:H10 serotype Decreases
0 1 Escherichia coli O91:H14 serotype Decreases
0 1 Escherichia coli O91:NM serotype Decreases
0 1 Escherichia coli O99:H6 serotype Decreases
0 1 Escherichia coli ONT:H33 serotype Decreases
1 0 Eggerthella lenta species Decreases
1 0 Akkermansia muciniphila species Decreases
1 0 Agathobacter rectalis species Decreases
1 0 Coprococcus comes species Decreases
1 0 Lachnospira eligens species Decreases
1 0 Clostridioides difficile species Decreases
1 0 Ruminococcus bromii species Decreases
0 1 Eggerthella guodeyinii species Decreases
1 0 Bacteroides uniformis species Decreases
1 0 Bilophila wadsworthia species Decreases
1 0 Bacteroides fragilis species Decreases
1 0 Phocaeicola vulgatus species Decreases
1 0 Segatella copri species Decreases
0 1 Coprococcus catus species Decreases
0 1 Dorea longicatena species Decreases
0 1 Butyrivibrio crossotus species Decreases
0 1 Wansuia hejianensis species Decreases
0 1 Anaerobutyricum hallii species Decreases
0 1 Blautia sp. SC05B48 species Decreases
0 1 Dorea formicigenerans species Decreases
0 1 Ligilactobacillus ruminis species Decreases
0 1 Wujia chipingensis species Decreases
0 1 Coprococcus eutactus species Decreases
0 1 Eubacterium sp. MSJ-33 species Decreases
0 1 Clostridium sp. M62/1 species Decreases
0 1 [Ruminococcus] lactaris species Decreases
0 1 Roseburia hominis species Decreases
0 1 Roseburia rectibacter species Decreases
0 1 Pseudobutyrivibrio xylanivorans species Decreases
0 1 Lacrimispora saccharolytica species Decreases
0 1 Blautia liquoris species Decreases
0 1 Subdoligranulum variabile species Decreases
1 0 Bacteroides ovatus species Decreases
0 1 Komagataeibacter oboediens species Decreases
0 1 Eubacterium ventriosum species Decreases
0 1 Novisyntrophococcus fermenticellae species Decreases
0 1 Christensenella minuta species Decreases
0 1 Clostridium sp. SY8519 species Decreases
0 1 Faecalibacterium duncaniae species Decreases
0 1 Simiaoa sunii species Decreases
0 1 Faecalitalea cylindroides species Decreases
0 1 Coprococcus sp. ART55/1 species Decreases
0 1 Qiania dongpingensis species Decreases
0 1 Lachnoanaerobaculum gingivalis species Decreases
0 1 Maliibacterium massiliense species Decreases
0 1 Faecalibacterium prausnitzii species Decreases
0 1 Ruminococcus bicirculans (ex Wegman et al. 2014) species Decreases
0 1 Roseburia intestinalis species Decreases
0 1 Catenibacterium mitsuokai species Decreases
0 1 Faecalibacterium sp. I4-1-79 species Decreases
0 1 Massilistercora timonensis species Decreases
0 1 Marvinbryantia formatexigens species Decreases
0 1 Ruminococcus champanellensis species Decreases
1 0 Bifidobacterium longum species Decreases
0 1 Akkermansia glycaniphila species Decreases
0 1 Akkermansia massiliensis species Decreases
0 1 Candidatus Akkermansia intestinavium species Decreases
0 1 Faecalibacillus intestinalis species Decreases
0 1 [Ruminococcus] torques species Decreases
0 1 Catenibacterium sp. co_0103 species Decreases
0 1 [Clostridium] hylemonae species Decreases
0 1 Vescimonas fastidiosa species Decreases
0 1 Faecalibacterium sp. HTF-F species Decreases
0 1 Intestinibaculum porci species Decreases
0 1 Lachnoclostridium phocaeense species Decreases
0 1 Faecalibacterium sp. I2-3-92 species Decreases
0 1 Clostridium cadaveris species Decreases
1 0 Escherichia coli species Decreases
1 0 Veillonella parvula species Decreases
1 0 Bacteroides thetaiotaomicron species Decreases
1 0 Blautia obeum species Decreases
1 0 Streptococcus parasanguinis species Decreases
0 1 Bifidobacterium longum subsp. infantis subspecies Decreases
0 1 Bifidobacterium longum subsp. longum subspecies Decreases
0 1 Bifidobacterium longum subsp. suillum subspecies Decreases
0 1 Bifidobacterium longum subsp. suis subspecies Decreases

Impact of mianserine hydrochloride,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.1 0.1
Acne 0.1 -0.1
ADHD 1.1 1 0.1
Age-Related Macular Degeneration and Glaucoma 0.1 0.1
Allergic Rhinitis (Hay Fever) 0.3 0.7 -1.33
Allergies 2.1 1.8 0.17
Allergy to milk products 1.4 0.3 3.67
Alopecia (Hair Loss) 0 0.1 0
Alzheimer's disease 2.1 2.9 -0.38
Amyotrophic lateral sclerosis (ALS) Motor Neuron 2.4 0.9 1.67
Ankylosing spondylitis 1.2 0.6 1
Anorexia Nervosa 0.2 1.4 -6
Antiphospholipid syndrome (APS) 0.3 0.1 2
Asthma 1.7 1.3 0.31
Atherosclerosis 0.7 0.4 0.75
Atrial fibrillation 1.9 1 0.9
Autism 3.8 4.4 -0.16
Autoimmune Disease 0.1 0.1 0
Barrett esophagus cancer 0 0 0
benign prostatic hyperplasia 0.1 0.1 0
Biofilm 0.2 0.2
Bipolar Disorder 0.8 0.9 -0.13
Brain Trauma 0.1 0.4 -3
Breast Cancer 0.1 0.1
Cancer (General) 0 0.1 0
Carcinoma 0.8 0.3 1.67
Celiac Disease 0.7 1.2 -0.71
Cerebral Palsy 0.5 0.2 1.5
Chronic Fatigue Syndrome 2.1 3 -0.43
Chronic Kidney Disease 1.2 2.3 -0.92
Chronic Lyme 0.4 0.1 3
Chronic Obstructive Pulmonary Disease (COPD) 0.6 0.8 -0.33
Chronic Urticaria (Hives) 0.2 1.1 -4.5
Coagulation / Micro clot triggering bacteria 0.2 0.2 0
Cognitive Function 0.3 0.1 2
Colorectal Cancer 1.4 0.9 0.56
Constipation 0.8 0 0
Coronary artery disease 0.9 1.5 -0.67
COVID-19 2.9 5.6 -0.93
Crohn's Disease 2.3 3.7 -0.61
Cushing's Syndrome (hypercortisolism) 0.2 -0.2
cystic fibrosis 0.2 0.1 1
d-lactic acidosis (one form of brain fog) 0.1 0.1
deep vein thrombosis 1 0.2 4
Denture Wearers Oral Shifts 0.1 0.1
Depression 3.6 4.6 -0.28
Dermatomyositis 0 0.1 0
Eczema 0.2 0.2 0
Endometriosis 0.8 1.1 -0.38
Eosinophilic Esophagitis 0.1 -0.1
Epilepsy 1 1.1 -0.1
erectile dysfunction 0.1 0.1 0
Fibromyalgia 0.4 1.2 -2
Functional constipation / chronic idiopathic constipation 1.9 1.1 0.73
gallstone disease (gsd) 0.5 0.4 0.25
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.5 0.6 -0.2
Generalized anxiety disorder 1.3 1 0.3
Glioblastoma 0 0
Gout 0.6 0.7 -0.17
Graves' disease 0.3 0.5 -0.67
Gulf War Syndrome 0.4 1.2 -2
Halitosis 0.1 0 0
Hashimoto's thyroiditis 1.1 1.1 0
Heart Failure 1.8 1.4 0.29
Hidradenitis Suppurativa 0.5 0 0
High Histamine/low DAO 0.1 0.2 -1
hypercholesterolemia (High Cholesterol) 0.1 0.6 -5
hyperglycemia 0.4 1.2 -2
Hyperlipidemia (High Blood Fats) 0.5 0.5
hypersomnia 0.1 -0.1
hypertension (High Blood Pressure 1.8 2.3 -0.28
Hypothyroidism 0.3 0.8 -1.67
Hypoxia 0.4 0.4
IgA nephropathy (IgAN) 0.6 1.4 -1.33
Inflammatory Bowel Disease 2.7 4.7 -0.74
Insomnia 0.7 2.1 -2
Intelligence 0.8 0.3 1.67
Intracranial aneurysms 0.2 0.4 -1
Irritable Bowel Syndrome 1.9 2.7 -0.42
ischemic stroke 0.6 0.7 -0.17
Liver Cirrhosis 2.5 2.1 0.19
Long COVID 2.8 3.4 -0.21
Low bone mineral density 0.9 -0.9
Lung Cancer 0.1 1.1 -10
Lymphoma 0.1 0.1
Mast Cell Issues / mastitis 0.1 0.6 -5
ME/CFS with IBS 0 1.4 0
ME/CFS without IBS 1.1 0.4 1.75
membranous nephropathy 0 0
Menopause 0.4 0.3 0.33
Metabolic Syndrome 2.1 2.8 -0.33
Mood Disorders 4.3 4.3 0
multiple chemical sensitivity [MCS] 0.4 0.1 3
Multiple Sclerosis 2.6 2.5 0.04
Multiple system atrophy (MSA) 1.1 0.2 4.5
myasthenia gravis 0.1 0.1
neuropathic pain 0.3 1 -2.33
Neuropathy (all types) 0.7 0.2 2.5
neuropsychiatric disorders (PANDAS, PANS) 0.1 0.1
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 1.2 3 -1.5
NonCeliac Gluten Sensitivity 1.1 0.1 10
Obesity 3.2 3.2 0
obsessive-compulsive disorder 2.3 1.9 0.21
Osteoarthritis 0.5 0.8 -0.6
Osteoporosis 0.6 0.7 -0.17
pancreatic cancer 0 0 0
Parkinson's Disease 3.7 3 0.23
Polycystic ovary syndrome 1.6 1 0.6
Postural orthostatic tachycardia syndrome 0.5 -0.5
Premenstrual dysphoric disorder 0.1 0.1
primary biliary cholangitis 0.1 0.2 -1
Primary sclerosing cholangitis 0.2 0.9 -3.5
Psoriasis 1 1.9 -0.9
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 2.6 1.5 0.73
Rosacea 0.3 0.1 2
Schizophrenia 2.7 1.4 0.93
scoliosis 0.6 0.9 -0.5
sensorineural hearing loss 0.1 0.1
Sjögren syndrome 0.5 0.9 -0.8
Sleep Apnea 0.6 0.8 -0.33
Slow gastric motility / Gastroparesis 0.4 0.1 3
Small Intestinal Bacterial Overgrowth (SIBO) 0.6 0.1 5
Stress / posttraumatic stress disorder 0.5 1.9 -2.8
Systemic Lupus Erythematosus 1.2 0.7 0.71
Tic Disorder 0.3 0.4 -0.33
Tourette syndrome 0.3 0.1 2
Type 1 Diabetes 1.9 1.2 0.58
Type 2 Diabetes 2.8 2.5 0.12
Ulcerative colitis 1.2 3.4 -1.83
Unhealthy Ageing 1.8 1.4 0.29
Vitiligo 0.8 1 -0.25

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