🍽️ clofibric acid non-drug

Hypolipidemic Effects: Clofibric acid belongs to a class of drugs known as fibric acid derivatives, which are primarily used to lower lipid levels in the blood. These drugs work by activating peroxisome proliferator-activated receptor alpha (PPAR-α), leading to increased lipolysis and decreased synthesis of triglycerides. However, clofibric acid itself is not widely used for this purpose due to its relatively weak lipid-lowering effects compared to other fibric acid derivatives like gemfibrozil and fenofibrate.

Anti-inflammatory Properties: Clofibric acid has been shown to exhibit anti-inflammatory effects, possibly through its modulation of PPAR-α activity. Some studies suggest that it may have potential therapeutic applications in inflammatory conditions, although further research is needed to elucidate its mechanisms of action and efficacy.

Metabolism and Excretion: Clofibric acid is primarily metabolized in the liver and excreted in the urine. It undergoes conjugation with glycine to form clofibryl glycine, which is then excreted. The pharmacokinetics of clofibric acid have been studied in relation to its lipid-lowering effects and potential adverse effects.

Adverse Effects: While clofibric acid has been associated with beneficial effects on lipid metabolism and inflammation in some studies, it may also be associated with certain adverse effects. These may include gastrointestinal disturbances, liver toxicity, and muscle-related adverse effects such as myopathy or rhabdomyolysis. However, because clofibric acid is not commonly used clinically, the prevalence and severity of adverse effects associated with its use are not well-characterized.

Drug Interactions: Clofibric acid may interact with other medications, particularly those metabolized by the cytochrome P450 system or those that affect lipid metabolism. Healthcare providers should be aware of potential drug interactions when prescribing or considering the use of clofibric acid.