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🍽️ lithocholic acid non-drug

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  1. Cholestatic Liver Injury: Lithocholic acid has been implicated in the pathogenesis of cholestatic liver diseases, where bile flow is impaired. In conditions such as primary biliary cholangitis (PBC) or intrahepatic cholestasis of pregnancy (ICP), lithocholic acid levels may increase due to impaired bile acid transport and metabolism, leading to liver injury and inflammation.

  2. Gallstone Formation: High lithocholic acid levels in bile have been associated with an increased risk of gallstone formation. Lithocholic acid is more hydrophobic than other bile acids, and its precipitation in bile can contribute to the formation of cholesterol gallstones.

  3. Colon Cancer Risk: Prolonged exposure to elevated levels of lithocholic acid in the colon has been linked to an increased risk of colorectal cancer. Lithocholic acid has been shown to induce DNA damage, promote inflammation, and alter cell proliferation and apoptosis in the colonic epithelium, potentially contributing to carcinogenesis.

  4. Inflammatory Bowel Disease (IBD): Lithocholic acid has been implicated in the pathogenesis of inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. Elevated levels of lithocholic acid in the gut lumen may disrupt intestinal barrier function, trigger inflammation, and exacerbate disease activity in susceptible individuals.

  5. Metabolic Syndrome and Cardiovascular Disease: Some studies suggest that lithocholic acid may contribute to metabolic syndrome and cardiovascular disease by promoting insulin resistance, dyslipidemia, and vascular inflammation. Elevated lithocholic acid levels have been observed in individuals with obesity, type 2 diabetes, and atherosclerosis.

  6. Neurological Disorders: Emerging evidence suggests a potential role of lithocholic acid in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Lithocholic acid has been shown to induce neurotoxicity, mitochondrial dysfunction, and oxidative stress in neuronal cells, although further research is needed to elucidate its exact mechanisms.

  7. Gut Microbiota Dysbiosis: Changes in the composition and metabolism of the gut microbiota can influence lithocholic acid levels and vice versa. Dysbiosis of the gut microbiota, characterized by alterations in microbial diversity and function, may lead to abnormal bile acid metabolism and contribute to various gastrointestinal and metabolic disorders.

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Impacted of lithocholic acid non-drug On Probiotics

Bacteria Impacted by lithocholic acid non-drug

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

Impact of lithocholic acid non-drug on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

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