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Heart Failure: Digoxin can help improve symptoms of heart failure by increasing the force of contraction of the heart muscle, thereby improving the heart's ability to pump blood.
Atrial Fibrillation: Digoxin can help control the heart rate in people with atrial fibrillation, a condition characterized by irregular and often rapid heart rate.
Atrial Flutter: Similar to atrial fibrillation, digoxin can help control heart rate in people with atrial flutter, another type of irregular heart rhythm.
Supraventricular Tachycardia: Digoxin can also be used to control heart rate in certain types of supraventricular tachycardia, a rapid heart rhythm originating above the ventricles.
Toxicity: However, digoxin can also be toxic at high doses, leading to symptoms such as nausea, vomiting, confusion, and visual disturbances. Therefore, it is essential to monitor blood levels of digoxin carefully when administering it therapeutically.
| Rank | Probiotic | Impact |
|---|---|---|
| species | Anaerobutyricum hallii | Reduces |
| species | Blautia wexlerae | Reduces |
| species | Christensenella minuta | Reduces |
| species | Enterococcus faecium | Reduces |
| species | Lacticaseibacillus paracasei | Reduces |
| species | Lactococcus cremoris | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
| 📓 Direct Citations | 👪👶 Indirect Citations | Taxonomy | Rank | Effect |
|---|---|---|---|---|
| 0 | 1 | Coprococcus | genus | Decreases |
| 0 | 1 | Blautia | genus | Decreases |
| 0 | 1 | Dorea | genus | Decreases |
| 0 | 1 | Anaerobutyricum | genus | Decreases |
| 0 | 1 | Wansuia | genus | Decreases |
| 0 | 1 | Roseburia | genus | Decreases |
| 0 | 1 | Lacticaseibacillus | genus | Decreases |
| 1 | 0 | Coprococcus comes | species | Decreases |
| 1 | 0 | Blautia obeum | species | Decreases |
| 0 | 1 | Dorea longicatena | species | Decreases |
| 0 | 1 | Coprococcus catus | species | Decreases |
| 0 | 1 | Dorea formicigenerans | species | Decreases |
| 0 | 1 | Anaerobutyricum hallii | species | Decreases |
| 0 | 1 | Wansuia hejianensis | species | Decreases |
| 0 | 1 | Blautia sp. SC05B48 | species | Decreases |
| 0 | 1 | Komagataeibacter oboediens | species | Decreases |
| 0 | 1 | Ligilactobacillus ruminis | species | Decreases |
| 0 | 1 | Subdoligranulum variabile | species | Decreases |
| 0 | 1 | Lactococcus cremoris | species | Decreases |
| 0 | 1 | Lacrimispora saccharolytica | species | Decreases |
| 0 | 1 | Adlercreutzia equolifaciens | species | Decreases |
| 0 | 1 | Streptococcus suis | species | Decreases |
| 1 | 0 | Roseburia intestinalis | species | Decreases |
| 0 | 1 | Eubacterium ventriosum | species | Decreases |
| 0 | 1 | Clostridium sp. M62/1 | species | Decreases |
| 0 | 1 | [Ruminococcus] torques | species | Decreases |
| 0 | 1 | Clostridium sp. SY8519 | species | Decreases |
| 0 | 1 | Butyrivibrio crossotus | species | Decreases |
| 0 | 1 | Christensenella minuta | species | Decreases |
| 0 | 1 | [Ruminococcus] lactaris | species | Decreases |
| 0 | 1 | Coprococcus eutactus | species | Decreases |
| 0 | 1 | Blautia liquoris | species | Decreases |
| 0 | 1 | Adlercreutzia hattorii | species | Decreases |
| 0 | 1 | Massilistercora timonensis | species | Decreases |
| 0 | 1 | Faecalitalea cylindroides | species | Decreases |
| 0 | 1 | Faecalibacterium duncaniae | species | Decreases |
| 0 | 1 | Lachnoanaerobaculum gingivalis | species | Decreases |
| 0 | 1 | Catenibacterium mitsuokai | species | Decreases |
| 0 | 1 | Maliibacterium massiliense | species | Decreases |
| 0 | 1 | Coprococcus sp. ART55/1 | species | Decreases |
| 0 | 1 | Eubacterium sp. c-25 | species | Decreases |
| 0 | 1 | Mageeibacillus indolicus | species | Decreases |
| 0 | 1 | Parvimonas micra | species | Decreases |
| 0 | 1 | Eubacterium sp. MSJ-33 | species | Decreases |
| 0 | 1 | [Clostridium] hylemonae | species | Decreases |
| 0 | 1 | Qiania dongpingensis | species | Decreases |
| 0 | 1 | Vescimonas fastidiosa | species | Decreases |
| 0 | 1 | Novisyntrophococcus fermenticellae | species | Decreases |
| 0 | 1 | Faecalibacillus intestinalis | species | Decreases |
| 0 | 1 | Fannyhessea vaginae | species | Decreases |
| 0 | 1 | Acutalibacter muris | species | Decreases |
| 0 | 1 | Mogibacterium diversum | species | Decreases |
| 0 | 1 | Roseburia hominis | species | Decreases |
| 0 | 1 | Actinomyces oris | species | Decreases |
| 0 | 1 | Anaerostipes hadrus | species | Decreases |
| 0 | 1 | Treponema peruense | species | Decreases |
| 0 | 1 | Enterococcus faecium | species | Decreases |
| 0 | 1 | Bacillus paralicheniformis | species | Decreases |
| 0 | 1 | Intestinibaculum porci | species | Decreases |
| 0 | 1 | Chordicoccus furentiruminis | species | Decreases |
| 0 | 1 | Catenibacterium sp. co_0103 | species | Decreases |
| 0 | 1 | Faecalibacterium sp. I2-3-92 | species | Decreases |
| 0 | 1 | Ruminococcus champanellensis | species | Decreases |
| 0 | 1 | Lachnoclostridium phocaeense | species | Decreases |
| 0 | 1 | Longicatena caecimuris | species | Decreases |
| 0 | 1 | Clostridium cadaveris | species | Decreases |
| 0 | 1 | Roseburia rectibacter | species | Decreases |
| 0 | 1 | Faecalibacterium sp. IP-3-29 | species | Decreases |
| 0 | 1 | Faecalibacterium sp. I4-1-79 | species | Decreases |
| 0 | 1 | Eubacterium limosum | species | Decreases |
| 0 | 1 | Faecalibacterium sp. HTF-F | species | Decreases |
| 0 | 1 | Faecalibaculum rodentium | species | Decreases |
| 0 | 1 | Marvinbryantia formatexigens | species | Decreases |
| 0 | 1 | Pseudobutyrivibrio xylanivorans | species | Decreases |
| 0 | 1 | Corynebacterium durum | species | Decreases |
| 0 | 1 | Treponema denticola | species | Decreases |
| 0 | 1 | Actinomyces naeslundii | species | Decreases |
| 0 | 1 | Vescimonas coprocola | species | Decreases |
| 0 | 1 | Emergencia timonensis | species | Decreases |
| 0 | 1 | Blautia wexlerae | species | Decreases |
| 0 | 1 | Ruminococcus gauvreauii | species | Decreases |
| 0 | 1 | Solibaculum mannosilyticum | species | Decreases |
| 0 | 1 | Ruminococcus bicirculans (ex Wegman et al. 2014) | species | Decreases |
| 0 | 1 | Wujia chipingensis | species | Decreases |
| 0 | 1 | Monoglobus pectinilyticus | species | Decreases |
| 0 | 1 | [Eubacterium] hominis | species | Decreases |
| 0 | 1 | Faecalibacterium sp. I3-3-89 | species | Decreases |
| 0 | 1 | Eubacterium callanderi | species | Decreases |
| 0 | 1 | Olsenella sp. oral taxon 807 | species | Decreases |
| 0 | 1 | Lawsonibacter asaccharolyticus | species | Decreases |
| 0 | 1 | Ruthenibacterium lactatiformans | species | Decreases |
| 0 | 1 | Phascolarctobacterium succinatutens | species | Decreases |
| 0 | 1 | Faecalibacterium sp. I4-3-84 | species | Decreases |
| 0 | 1 | Eubacterium maltosivorans | species | Decreases |
| 0 | 1 | [Clostridium] scindens | species | Decreases |
| 0 | 1 | Butyricicoccus sp. GAM44 | species | Decreases |
| 0 | 1 | Faecalibacterium sp. IP-1-18 | species | Decreases |
| 0 | 1 | Phoenicibacter congonensis | species | Decreases |
| 0 | 1 | Actinomyces sp. oral taxon 169 | species | Decreases |
| 0 | 1 | Ruminococcus albus | species | Decreases |
| 0 | 1 | Clostridium sp. C1 | species | Decreases |
| 0 | 1 | Phascolarctobacterium sp. Marseille-Q4147 | species | Decreases |
| 0 | 1 | Butyrivibrio fibrisolvens | species | Decreases |
| 0 | 1 | Flintibacter sp. KGMB00164 | species | Decreases |
| 0 | 1 | Oscillibacter hominis | species | Decreases |
| 0 | 1 | Enterococcus cecorum | species | Decreases |
| 0 | 1 | Actinomyces sp. oral taxon 171 | species | Decreases |
| 0 | 1 | Streptococcus sanguinis | species | Decreases |
| 0 | 1 | Pusillibacter faecalis | species | Decreases |
| 0 | 1 | Faecalibacterium sp. I3-3-33 | species | Decreases |
| 0 | 1 | Intestinimonas butyriciproducens | species | Decreases |
| 0 | 1 | Ruminococcus bovis | species | Decreases |
| 1 | 0 | Lacticaseibacillus paracasei | species | Decreases |
| 0 | 1 | Lacticaseibacillus paracasei subsp. paracasei | subspecies | Decreases |
| 0 | 1 | Lacticaseibacillus paracasei subsp. tolerans | subspecies | Decreases |
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| ADHD | 0.1 | 0.8 | -7 |
| Age-Related Macular Degeneration and Glaucoma | 0.4 | 0.4 | |
| Allergic Rhinitis (Hay Fever) | 0.5 | 0.3 | 0.67 |
| Allergies | 1.3 | 1.3 | |
| Allergy to milk products | 0.4 | 0.3 | 0.33 |
| Alopecia (Hair Loss) | 0.4 | 0.1 | 3 |
| Alzheimer's disease | 0.8 | 1.5 | -0.88 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 0.5 | 0.1 | 4 |
| Ankylosing spondylitis | 0.4 | 0.4 | |
| Anorexia Nervosa | 0.3 | 0.4 | -0.33 |
| Antiphospholipid syndrome (APS) | 0.2 | 0.2 | |
| Asthma | 0.5 | 0.1 | 4 |
| Atherosclerosis | 0.3 | 0.3 | 0 |
| Atrial fibrillation | 0.7 | 0.7 | |
| Autism | 1.2 | 1 | 0.2 |
| Autoimmune Disease | 0.1 | -0.1 | |
| Biofilm | 0.1 | 0.1 | |
| Bipolar Disorder | 0.5 | -0.5 | |
| Brain Trauma | 0.1 | 0.1 | 0 |
| Cancer (General) | 0.2 | -0.2 | |
| Carcinoma | 0.4 | 0.4 | 0 |
| Celiac Disease | 0.2 | 0.4 | -1 |
| Cerebral Palsy | 0.4 | -0.4 | |
| Chronic Fatigue Syndrome | 0.5 | 2.6 | -4.2 |
| Chronic Kidney Disease | 0.6 | 1 | -0.67 |
| Chronic Lyme | 0.1 | -0.1 | |
| Chronic Obstructive Pulmonary Disease (COPD) | 0.4 | 0.5 | -0.25 |
| Coagulation / Micro clot triggering bacteria | 0.4 | -0.4 | |
| Cognitive Function | 0.1 | 0.1 | 0 |
| Colorectal Cancer | 0.5 | 0.3 | 0.67 |
| Constipation | 0.4 | -0.4 | |
| Coronary artery disease | 0.2 | 1.1 | -4.5 |
| COVID-19 | 1.5 | 3.3 | -1.2 |
| Crohn's Disease | 1 | 1.1 | -0.1 |
| cystic fibrosis | 0.4 | -0.4 | |
| deep vein thrombosis | 0.4 | 0.1 | 3 |
| Denture Wearers Oral Shifts | 0.1 | 0.1 | |
| Depression | 1.3 | 2.1 | -0.62 |
| Endometriosis | 0.7 | 0.5 | 0.4 |
| Epilepsy | 0.4 | 0.3 | 0.33 |
| Fibromyalgia | 0.8 | 0.6 | 0.33 |
| Functional constipation / chronic idiopathic constipation | 0.5 | 0.9 | -0.8 |
| gallstone disease (gsd) | 0.5 | 0.1 | 4 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 1.1 | -1.1 | |
| Generalized anxiety disorder | 0.6 | 0.4 | 0.5 |
| Gout | 0.4 | -0.4 | |
| Graves' disease | 0.6 | -0.6 | |
| Gulf War Syndrome | 0.6 | 0.6 | |
| Hashimoto's thyroiditis | 0.9 | 0.2 | 3.5 |
| Heart Failure | 0.5 | 0.6 | -0.2 |
| hemorrhagic stroke | 0.1 | 0.1 | |
| High Histamine/low DAO | 0.1 | 0.1 | |
| hypercholesterolemia (High Cholesterol) | 0.1 | -0.1 | |
| hyperglycemia | 0.3 | -0.3 | |
| hypersomnia | 0.3 | -0.3 | |
| hypertension (High Blood Pressure | 0.6 | 0.9 | -0.5 |
| Hypothyroidism | 0.6 | -0.6 | |
| Hypoxia | 0.1 | 0.1 | |
| IgA nephropathy (IgAN) | 0.3 | -0.3 | |
| Inflammatory Bowel Disease | 0.4 | 2.2 | -4.5 |
| Insomnia | 1 | 0.4 | 1.5 |
| Intelligence | 0.4 | 0.4 | |
| Intracranial aneurysms | 0.3 | 0.4 | -0.33 |
| Irritable Bowel Syndrome | 0.7 | 0.5 | 0.4 |
| ischemic stroke | 0.3 | 0.1 | 2 |
| Liver Cirrhosis | 1 | 0.6 | 0.67 |
| Long COVID | 1.4 | 1.8 | -0.29 |
| Low bone mineral density | 0.8 | -0.8 | |
| Lung Cancer | 0.6 | -0.6 | |
| Mast Cell Issues / mastitis | 0.4 | -0.4 | |
| ME/CFS with IBS | 2.1 | -2.1 | |
| ME/CFS without IBS | 0.4 | 0.6 | -0.5 |
| Menopause | 0.2 | 0.2 | 0 |
| Metabolic Syndrome | 1 | 1.4 | -0.4 |
| Mood Disorders | 1.3 | 1.4 | -0.08 |
| multiple chemical sensitivity [MCS] | 0.3 | -0.3 | |
| Multiple Sclerosis | 0.6 | 1.2 | -1 |
| Multiple system atrophy (MSA) | 0.1 | 0.3 | -2 |
| myasthenia gravis | 0.1 | -0.1 | |
| neuropathic pain | 0.2 | -0.2 | |
| Neuropathy (all types) | 0.3 | 0.1 | 2 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 0.8 | 1.4 | -0.75 |
| NonCeliac Gluten Sensitivity | 0.3 | 0.3 | |
| Obesity | 2 | 1.4 | 0.43 |
| obsessive-compulsive disorder | 1 | 0.9 | 0.11 |
| Osteoarthritis | 0.7 | 0.2 | 2.5 |
| Osteoporosis | 0.1 | 0.4 | -3 |
| Parkinson's Disease | 1.8 | 1.8 | 0 |
| Polycystic ovary syndrome | 1.3 | 0.4 | 2.25 |
| Postural orthostatic tachycardia syndrome | 0.4 | -0.4 | |
| Premenstrual dysphoric disorder | 0.3 | 0.3 | |
| primary biliary cholangitis | 0.1 | 0.1 | |
| Primary sclerosing cholangitis | 0.1 | 1.6 | -15 |
| Psoriasis | 0.5 | 0.5 | 0 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 1.3 | 0.8 | 0.63 |
| Rosacea | 0.2 | 0.1 | 1 |
| Schizophrenia | 1 | 0.7 | 0.43 |
| scoliosis | 0.5 | 0.5 | |
| sensorineural hearing loss | 0.4 | 0.4 | |
| Sjögren syndrome | 0.3 | 0.4 | -0.33 |
| Sleep Apnea | 0.7 | 0.7 | 0 |
| Small Intestinal Bacterial Overgrowth (SIBO) | 0.5 | 0.5 | |
| Stress / posttraumatic stress disorder | 0.2 | 0.5 | -1.5 |
| Systemic Lupus Erythematosus | 0.7 | 0.6 | 0.17 |
| Tic Disorder | 0.5 | -0.5 | |
| Tourette syndrome | 0.1 | 0.1 | |
| Type 1 Diabetes | 0.8 | 0.3 | 1.67 |
| Type 2 Diabetes | 1.2 | 0.9 | 0.33 |
| Ulcerative colitis | 0.7 | 1 | -0.43 |
| Unhealthy Ageing | 0.7 | 0.5 | 0.4 |
| Vitiligo | 0.6 | -0.6 |
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