🍽️ l(-)-vesamicol hydrochloride non-drug

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Neurotransmitter Regulation: L(-)-vesamicol hydrochloride inhibits the transport of acetylcholine into synaptic vesicles by blocking VAChT. This action reduces the release of acetylcholine, a neurotransmitter involved in various physiological processes, including muscle contraction, cognition, and memory.
Research Tool: L(-)-vesamicol hydrochloride is primarily used as a research tool in neuroscience to study the role of acetylcholine in synaptic transmission, neuronal signaling, and neurological disorders. It is commonly employed in laboratory studies to investigate the effects of altered acetylcholine levels on neuronal function and behavior.
Potential Therapeutic Applications: Although L(-)-vesamicol hydrochloride itself is not used clinically as a therapeutic agent, its mechanism of action and modulation of acetylcholine release have led to interest in its potential therapeutic applications. Researchers have explored its potential use in the treatment of conditions associated with dysregulated acetylcholine signaling, such as Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.
Toxicity and Side Effects: L(-)-vesamicol hydrochloride may exhibit toxicity and side effects, particularly at high doses or prolonged exposure. Adverse effects may include disruptions in synaptic transmission, impairment of cognitive function, and neuronal damage. Careful consideration of dosage and administration is necessary in experimental and clinical studies involving this compound.
Further Research: Despite its potential therapeutic implications, further research is needed to fully understand the safety, efficacy, and clinical relevance of L(-)-vesamicol hydrochloride in the treatment of neurological disorders. Additionally, the development of more selective and potent compounds targeting VAChT may offer new avenues for therapeutic intervention.

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Data Contradictions — Limits of Certainity

Impacted of l(-)-vesamicol hydrochloride non-drug On Probiotics

Rank	Probiotic	Impact
genus	Bifidobacterium	Reduces
species	Akkermansia muciniphila	Reduces
species	Bacteroides uniformis	Reduces
species	Bifidobacterium adolescentis	Reduces
species	Escherichia coli	Reduces

Bacteria Impacted by l(-)-vesamicol hydrochloride non-drug

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

🧙?
📓 Direct Citations	👪👶 Indirect Citations	Taxonomy	Rank	Effect
0	1	Akkermansiaceae	family	Decreases
0	1	Parabacteroides	genus	Decreases
0	1	Streptococcus	genus	Decreases
0	1	Bilophila	genus	Decreases
1	0	Akkermansia	genus	Decreases
0	1	Escherichia	genus	Decreases
0	1	Mediterraneibacter	genus	Decreases
0	1	Shigella	genus	Decreases
0	1	Fusobacterium	genus	Decreases
0	1	Thomasclavelia	genus	Decreases
0	1	Bacteroides	genus	Decreases
0	1	Clostridioides	genus	Decreases
0	1	Bifidobacterium	genus	Decreases
0	1	Dorea	genus	Decreases
0	1	Phocaeicola	genus	Decreases
0	1	Escherichia coli O1:K1:H7	no rank	Decreases
0	1	Escherichia coli O139:H1	no rank	Decreases
0	1	Escherichia coli O141:H4	no rank	Decreases
0	1	Escherichia coli O145:H34	no rank	Decreases
0	1	Escherichia coli O15:H12	no rank	Decreases
0	1	Escherichia coli O155:H21	no rank	Decreases
0	1	Escherichia coli O158:H23	no rank	Decreases
0	1	Escherichia coli O16:H48	no rank	Decreases
0	1	Escherichia coli O170:H18	no rank	Decreases
0	1	Escherichia coli O18ac:H14	no rank	Decreases
0	1	Escherichia coli O19:H7	no rank	Decreases
0	1	Escherichia coli O2:K1:H4	no rank	Decreases
0	1	Escherichia coli O2:K1:H5	no rank	Decreases
0	1	Escherichia coli O2:K1:H7	no rank	Decreases
0	1	Escherichia coli O20:H12	no rank	Decreases
0	1	Escherichia coli O25:H16	no rank	Decreases
0	1	Escherichia coli O55:H7	no rank	Decreases
0	1	Escherichia coli O68:H12	no rank	Decreases
0	1	Escherichia coli O7:H15	no rank	Decreases
0	1	Escherichia coli O78:H51	no rank	Decreases
0	1	Escherichia coli O80:H26	no rank	Decreases
0	1	Escherichia coli O84:H7	no rank	Decreases
0	1	Escherichia coli O85:H1	no rank	Decreases
0	1	environmental samples	no rank	Decreases
0	1	unclassified Akkermansia	no rank	Decreases
0	1	Escherichia coli O103	serogroup	Decreases
0	1	Escherichia coli O111	serogroup	Decreases
0	1	Escherichia coli O119	serogroup	Decreases
0	1	Escherichia coli O121	serogroup	Decreases
0	1	Escherichia coli O145	serogroup	Decreases
0	1	Escherichia coli O155	serogroup	Decreases
0	1	Escherichia coli O157	serogroup	Decreases
0	1	Escherichia coli O177	serogroup	Decreases
0	1	Escherichia coli O26	serogroup	Decreases
0	1	Escherichia coli O3	serogroup	Decreases
0	1	Escherichia coli O43	serogroup	Decreases
0	1	Escherichia coli O5	serogroup	Decreases
0	1	Escherichia coli O78	serogroup	Decreases
0	1	Escherichia coli O86	serogroup	Decreases
0	1	Escherichia coli O91	serogroup	Decreases
0	1	Escherichia coli H20	serotype	Decreases
0	1	Escherichia coli O1:H42	serotype	Decreases
0	1	Escherichia coli O1:HNT	serotype	Decreases
0	1	Escherichia coli O10:H32	serotype	Decreases
0	1	Escherichia coli O10:K5(L):H4	serotype	Decreases
0	1	Escherichia coli O100:H21	serotype	Decreases
0	1	Escherichia coli O103:H11	serotype	Decreases
0	1	Escherichia coli O103:H2	serotype	Decreases
0	1	Escherichia coli O103:H25	serotype	Decreases
0	1	Escherichia coli O104:H21	serotype	Decreases
0	1	Escherichia coli O104:H4	serotype	Decreases
0	1	Escherichia coli O111:H-	serotype	Decreases
0	1	Escherichia coli O111:H11	serotype	Decreases
0	1	Escherichia coli O111:H8	serotype	Decreases
0	1	Escherichia coli O111:NM	serotype	Decreases
0	1	Escherichia coli O112ab:H8	serotype	Decreases
0	1	Escherichia coli O112ac:H19	serotype	Decreases
0	1	Escherichia coli O113:H21	serotype	Decreases
0	1	Escherichia coli O114:H49	serotype	Decreases
0	1	Escherichia coli O118:H16	serotype	Decreases
0	1	Escherichia coli O121:H19	serotype	Decreases
0	1	Escherichia coli O121:H7	serotype	Decreases
0	1	Escherichia coli O123:H11	serotype	Decreases
0	1	Escherichia coli O125ac:K+:H10	serotype	Decreases
0	1	Escherichia coli O126:H45	serotype	Decreases
0	1	Escherichia coli O127:H27	serotype	Decreases
0	1	Escherichia coli O127:H6	serotype	Decreases
0	1	Escherichia coli O128:H2	serotype	Decreases
0	1	Escherichia coli O128ac:H12	serotype	Decreases
0	1	Escherichia coli O139:H28	serotype	Decreases
0	1	Escherichia coli O145:H25	serotype	Decreases
0	1	Escherichia coli O145:H28	serotype	Decreases
0	1	Escherichia coli O145:NM	serotype	Decreases
0	1	Escherichia coli O146:H21	serotype	Decreases
0	1	Escherichia coli O15:H18	serotype	Decreases
0	1	Escherichia coli O150:H6	serotype	Decreases
0	1	Escherichia coli O152:H23	serotype	Decreases
0	1	Escherichia coli O153:H2	serotype	Decreases
0	1	Escherichia coli O156:H25	serotype	Decreases
0	1	Escherichia coli O157:H-	serotype	Decreases
0	1	Escherichia coli O157:H43	serotype	Decreases
0	1	Escherichia coli O157:H7	serotype	Decreases
0	1	Escherichia coli O157:NM	serotype	Decreases
0	1	Escherichia coli O16:H6	serotype	Decreases
0	1	Escherichia coli O165:H25	serotype	Decreases
0	1	Escherichia coli O167:H26	serotype	Decreases
0	1	Escherichia coli O174:H2	serotype	Decreases
0	1	Escherichia coli O174:H21	serotype	Decreases
0	1	Escherichia coli O174:H8	serotype	Decreases
0	1	Escherichia coli O176:H45	serotype	Decreases
0	1	Escherichia coli O177:NM	serotype	Decreases
0	1	Escherichia coli O2:H6	serotype	Decreases
0	1	Escherichia coli O2:K2:H1	serotype	Decreases
0	1	Escherichia coli O25:H1	serotype	Decreases
0	1	Escherichia coli O25:NM	serotype	Decreases
0	1	Escherichia coli O26:H1	serotype	Decreases
0	1	Escherichia coli O26:H11	serotype	Decreases
0	1	Escherichia coli O28ac:NM	serotype	Decreases
0	1	Escherichia coli O29:H4	serotype	Decreases
0	1	Escherichia coli O32:H37	serotype	Decreases
0	1	Escherichia coli O39:NM	serotype	Decreases
0	1	Escherichia coli O44:H18	serotype	Decreases
0	1	Escherichia coli O45:H2	serotype	Decreases
0	1	Escherichia coli O6:H16	serotype	Decreases
0	1	Escherichia coli O6:H16:CFA/II	serotype	Decreases
0	1	Escherichia coli O6:K2:H1	serotype	Decreases
0	1	Escherichia coli O69:H11	serotype	Decreases
0	1	Escherichia coli O7:H4	serotype	Decreases
0	1	Escherichia coli O7:K1	serotype	Decreases
0	1	Escherichia coli O78:H12	serotype	Decreases
0	1	Escherichia coli O78:H4	serotype	Decreases
0	1	Escherichia coli O79:H7	serotype	Decreases
0	1	Escherichia coli O8:H8	serotype	Decreases
0	1	Escherichia coli O81:NM	serotype	Decreases
0	1	Escherichia coli O83:H1	serotype	Decreases
0	1	Escherichia coli O86:H34	serotype	Decreases
0	1	Escherichia coli O89m:H10	serotype	Decreases
0	1	Escherichia coli O89m:H9	serotype	Decreases
0	1	Escherichia coli O9:H10	serotype	Decreases
0	1	Escherichia coli O91:H14	serotype	Decreases
0	1	Escherichia coli O91:NM	serotype	Decreases
0	1	Escherichia coli O99:H6	serotype	Decreases
0	1	Escherichia coli ONT:H33	serotype	Decreases
1	0	Streptococcus parasanguinis	species	Decreases
1	0	Parabacteroides merdae	species	Decreases
1	0	Bilophila wadsworthia	species	Decreases
1	0	Streptococcus salivarius	species	Decreases
1	0	Akkermansia muciniphila	species	Decreases
1	0	Escherichia coli	species	Decreases
0	1	Streptococcus sp. LPB0220	species	Decreases
0	1	Streptococcus sp. HSISM1	species	Decreases
1	0	Bacteroides uniformis	species	Decreases
0	1	Streptococcus sp. FDAARGOS_192	species	Decreases
1	0	[Ruminococcus] torques	species	Decreases
1	0	Fusobacterium nucleatum	species	Decreases
1	0	Thomasclavelia ramosa	species	Decreases
0	1	Shigella dysenteriae	species	Decreases
0	1	Streptococcus lactarius	species	Decreases
0	1	Shigella flexneri	species	Decreases
0	1	Streptococcus vestibularis	species	Decreases
0	1	Escherichia albertii	species	Decreases
1	0	Bacteroides fragilis	species	Decreases
0	1	Streptococcus australis	species	Decreases
0	1	Streptococcus sp. oral taxon 061	species	Decreases
1	0	Clostridioides difficile	species	Decreases
0	1	Escherichia fergusonii	species	Decreases
0	1	Bacteroides humanifaecis	species	Decreases
0	1	Parabacteroides johnsonii	species	Decreases
0	1	Streptococcus infantis	species	Decreases
0	1	Streptococcus oralis	species	Decreases
1	0	Bifidobacterium adolescentis	species	Decreases
0	1	Shigella boydii	species	Decreases
0	1	Streptococcus gordonii	species	Decreases
1	0	Bacteroides caccae	species	Decreases
0	1	Streptococcus sp. oral taxon 431	species	Decreases
0	1	Alistipes sp. dk3624	species	Decreases
0	1	Streptococcus sp. Marseille-Q6470	species	Decreases
0	1	Bacteroides sp. CACC 737	species	Decreases
1	0	Dorea formicigenerans	species	Decreases
0	1	Streptococcus ilei	species	Decreases
0	1	Lancefieldella parvula	species	Decreases
0	1	Streptococcus koreensis	species	Decreases
0	1	Akkermansia glycaniphila	species	Decreases
0	1	Akkermansia massiliensis	species	Decreases
0	1	Candidatus Akkermansia intestinavium	species	Decreases
1	0	Phocaeicola vulgatus	species	Decreases
1	0	Bacteroides ovatus	species	Decreases
0	1	Fusobacterium nucleatum subsp. nucleatum	subspecies	Decreases

Impact of l(-)-vesamicol hydrochloride non-drug on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition	Positive Impact	Negative Impact	Benefit Ratio Impact
Abdominal Aortic Aneurysm	0.3		0.3
Acne		0.1	-0.1
ADHD	1.3		1.3
Age-Related Macular Degeneration and Glaucoma	0.1	0.4	-3
Allergic Rhinitis (Hay Fever)	1	1.6	-0.6
Allergies	1.7	0.9	0.89
Allergy to milk products	0.7	0.7	0
Alopecia (Hair Loss)	0.2		0.2
Alzheimer's disease	2.4	1.7	0.41
Amyotrophic lateral sclerosis (ALS) Motor Neuron	1	0.7	0.43
Ankylosing spondylitis	1.2	0.2	5
Anorexia Nervosa	0.7	0.5	0.4
Antiphospholipid syndrome (APS)	0.6	0.3	1
Asthma	1.5	1	0.5
Atherosclerosis	0.7	0.2	2.5
Atrial fibrillation	1	1.1	-0.1
Autism	2.4	2.7	-0.13
Autoimmune Disease	0.6	0.1	5
Barrett esophagus cancer	0.1	0.3	-2
benign prostatic hyperplasia	0.3	0.1	2
Biofilm	1.5		1.5
Bipolar Disorder	1		1
Brain Trauma	0.3	0.1	2
Breast Cancer	0.5		0.5
Cancer (General)	0.1	0.2	-1
Carcinoma	1.6	0.6	1.67
Celiac Disease	0.9	1	-0.11
Cerebral Palsy	0.6	0.1	5
Chronic Fatigue Syndrome	1.2	1.8	-0.5
Chronic Kidney Disease	1.3	0.7	0.86
Chronic Lyme	0.1	0.1	0
Chronic Obstructive Pulmonary Disease (COPD)	2	0.4	4
Chronic Urticaria (Hives)	0.8	0.5	0.6
Coagulation / Micro clot triggering bacteria	1.3	0.3	3.33
Cognitive Function	0.9	0.3	2
Colorectal Cancer	3.6	0.5	6.2
Constipation	0.4		0.4
Coronary artery disease	0.9	0.2	3.5
COVID-19	3.5	2.3	0.52
Crohn's Disease	2.9	1.4	1.07
Cushing's Syndrome (hypercortisolism)		0.1	-0.1
cystic fibrosis	0.5	0.3	0.67
d-lactic acidosis (one form of brain fog)	0.3		0.3
deep vein thrombosis	1.1	0.3	2.67
Denture Wearers Oral Shifts	0.9		0.9
Depression	3.7	2.3	0.61
Dermatomyositis	0.3	0.1	2
Eczema	0.7	1	-0.43
Endometriosis	1.5	0.3	4
Eosinophilic Esophagitis	0.1	0.3	-2
Epilepsy	1.4	1.6	-0.14
erectile dysfunction	0.5	0.1	4
Fibromyalgia	1.3	0.4	2.25
Functional constipation / chronic idiopathic constipation	1.6	1.1	0.45
gallstone disease (gsd)	1.1	0.3	2.67
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	0.5	0.3	0.67
Generalized anxiety disorder	1.2	0.6	1
Glioblastoma		0.3	-0.3
Gout	0.6	0.3	1
Graves' disease	0.5	0.5	0
Gulf War Syndrome	0.3	0.7	-1.33
Halitosis	0.7	0.3	1.33
Hashimoto's thyroiditis	0.9	0.8	0.13
Heart Failure	1.7	0.2	7.5
hemorrhagic stroke	0.6		0.6
Hidradenitis Suppurativa	0.7		0.7
High Histamine/low DAO	0.3	0.1	2
hypercholesterolemia (High Cholesterol)	0.3	0.3	0
hyperglycemia	1.2	1	0.2
Hyperlipidemia (High Blood Fats)	0.5		0.5
hypersomnia		0.3	-0.3
hypertension (High Blood Pressure	2.5	1.1	1.27
Hypothyroidism	0.2	0.1	1
Hypoxia	0.8		0.8
IgA nephropathy (IgAN)	0.9	0.4	1.25
Inflammatory Bowel Disease	3	2.2	0.36
Insomnia	0.8	0.8	0
Intelligence	0.7		0.7
Intracranial aneurysms	0.6		0.6
Irritable Bowel Syndrome	2.3	1.7	0.35
ischemic stroke	1.1	0.3	2.67
Liver Cirrhosis	2.5	1.8	0.39
Long COVID	1.6	1.3	0.23
Lung Cancer	0.7	0.4	0.75
Lymphoma	0.3		0.3
Mast Cell Issues / mastitis	0.8	0.1	7
ME/CFS with IBS	0.3	0.2	0.5
ME/CFS without IBS	0.3	0.3	0
membranous nephropathy	0.3		0.3
Menopause	0.4	0.2	1
Metabolic Syndrome	2.8	2.4	0.17
Mood Disorders	3.7	2.2	0.68
multiple chemical sensitivity [MCS]	0.9		0.9
Multiple Sclerosis	3.1	1.1	1.82
Multiple system atrophy (MSA)	1.2	0.1	11
myasthenia gravis	0.5		0.5
neuropathic pain		0.6	-0.6
Neuropathy (all types)	0.4	0.6	-0.5
neuropsychiatric disorders (PANDAS, PANS)	0.6		0.6
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	1.3	0.8	0.63
NonCeliac Gluten Sensitivity	0.5	0.1	4
Obesity	2.9	2.5	0.16
obsessive-compulsive disorder	1.9	1.1	0.73
Osteoarthritis	1	0.6	0.67
Osteoporosis	0.3	0.7	-1.33
pancreatic cancer	0.5	0.3	0.67
Parkinson's Disease	3.2	1.2	1.67
Polycystic ovary syndrome	2	0.8	1.5
Postural orthostatic tachycardia syndrome		0.1	-0.1
Premenstrual dysphoric disorder	0.1	0.4	-3
primary biliary cholangitis	0.3	0.7	-1.33
Primary sclerosing cholangitis	1.5	0.4	2.75
Psoriasis	1.1	0.8	0.38
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	1.9	0.4	3.75
Rosacea	0.3		0.3
Schizophrenia	2.1	0.7	2
scoliosis	0.3	0.3	0
Sjögren syndrome	1	1	0
Sleep Apnea	0.3	0.1	2
Slow gastric motility / Gastroparesis	0.4	0.1	3
Small Intestinal Bacterial Overgrowth (SIBO)	0.8		0.8
Stress / posttraumatic stress disorder	1.3	0.9	0.44
Systemic Lupus Erythematosus	1.5	0.1	14
Tic Disorder	0.3	0.1	2
Tourette syndrome	0.5	0.1	4
Type 1 Diabetes	1.4	0.6	1.33
Type 2 Diabetes	2.4	2.4	0
Ulcerative colitis	2.1	2	0.05
Unhealthy Ageing	1.6	0.6	1.67
Vitiligo	1	0.6	0.67

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