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🍽️ D-mannitol {Mannitol}

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  1. Diuretic Effect: Mannitol is commonly used as an osmotic diuretic to increase urine production and promote the excretion of excess fluids and electrolytes from the body. It is often used in the treatment of conditions such as acute kidney injury, cerebral edema, and intraocular pressure associated with conditions like glaucoma.

  2. Cerebral Edema: Mannitol is used to reduce intracranial pressure and cerebral edema following traumatic brain injury, stroke, or neurosurgery. By drawing excess fluid out of brain tissues through osmosis, mannitol can help alleviate symptoms and prevent further neurological damage.

  3. Glaucoma: Mannitol may be administered intravenously to lower intraocular pressure in acute cases of glaucoma, especially when other treatments are ineffective or contraindicated. It works by reducing fluid buildup within the eye, thereby relieving pressure on the optic nerve.

  4. Contrast-Induced Nephropathy (CIN): Mannitol is sometimes used as a prophylactic agent to prevent contrast-induced nephropathy, a form of kidney injury that can occur following certain medical imaging procedures involving contrast agents. Mannitol's diuretic properties may help flush out contrast dye and prevent its accumulation in the kidneys.

  5. Hypovolemia: Mannitol may be used as a plasma volume expander to increase blood volume and improve circulation in cases of hypovolemia (low blood volume), such as during surgery or in patients with severe dehydration or shock.

  6. Bronchial Challenge Testing: Mannitol is utilized in bronchial challenge testing to assess airway hyperresponsiveness, which is a characteristic feature of asthma. It is inhaled as a dry powder to induce bronchoconstriction, and the degree of airway narrowing is measured to diagnose and monitor asthma severity.

  7. Eye Care: Mannitol is sometimes used in ophthalmic formulations, such as eye drops or gels, to reduce corneal edema and improve corneal transparency. It may also be used to protect the cornea during certain surgical procedures or to preserve corneal tissues for transplantation.

  8. Pharmaceutical Formulations: Mannitol serves as an excipient in pharmaceutical formulations, contributing to tablet disintegration, stabilization of proteins, and maintenance of osmolarity in injectable medications.

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Data Contradictions — Limits of Certainity

Impacted of D-mannitol {Mannitol} On Probiotics

Rank Probiotic Impact
genus Bifidobacterium Increases
species Bifidobacterium adolescentis Increases
species Bifidobacterium animalis Increases
species Bifidobacterium bifidum Increases
species Bifidobacterium breve Increases
species Bifidobacterium catenulatum Increases
species Bifidobacterium longum Increases
species Bifidobacterium pseudocatenulatum Increases
species Bifidobacterium pseudolongum Increases
species Lactobacillus acidophilus Increases
species Lactobacillus crispatus Increases
species Lactobacillus gasseri Increases
species Lactobacillus helveticus Increases
species Lactobacillus jensenii Increases
species Lactobacillus johnsonii Increases
species Lactobacillus kefiranofaciens Increases
subspecies Bifidobacterium animalis subsp. lactis Increases

Bacteria Impacted by D-mannitol {Mannitol}

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Lactobacillaceae family Increases
0 1 Scardovia genus Increases
0 1 Gardnerella genus Increases
0 1 Parascardovia genus Increases
0 1 Aeriscardovia genus Increases
0 1 Alloscardovia genus Increases
0 1 Bifidobacterium genus Increases
0 1 Bombiscardovia genus Increases
0 1 Galliscardovia genus Increases
0 1 Neoscardovia genus Increases
0 1 Pseudoscardovia genus Increases
1 0 Lactobacillus genus Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 unclassified Bifidobacteriaceae (miscellaneous) no rank Increases
0 1 unclassified Bifidobacterium no rank Increases
0 1 unclassified Lactobacillus no rank Increases
0 1 Bifidobacterium saguini species Increases
0 1 Bifidobacterium pseudolongum species Increases
0 1 Lactobacillus ultunensis species Increases
0 1 Bifidobacterium asteroides species Increases
0 1 Bifidobacterium subtile species Increases
0 1 Bifidobacterium pullorum species Increases
0 1 Bifidobacterium scardovii species Increases
0 1 Bifidobacterium imperatoris species Increases
0 1 Bifidobacterium thermophilum species Increases
0 1 Bifidobacterium lemurum species Increases
0 1 Bifidobacterium eulemuris species Increases
0 1 Lactobacillus helveticus species Increases
0 1 Bifidobacterium dentium species Increases
0 1 Lactobacillus johnsonii species Increases
0 1 Lactobacillus kefiranofaciens species Increases
0 1 Lactobacillus amylolyticus species Increases
0 1 Bifidobacterium choerinum species Increases
0 1 Lactobacillus acetotolerans species Increases
0 1 Lactobacillus amylovorus species Increases
0 1 Lactobacillus iners species Increases
0 1 Bifidobacterium pseudocatenulatum species Increases
0 1 Lactobacillus taiwanensis species Increases
0 1 Lactobacillus crispatus species Increases
0 1 Lactobacillus intestinalis species Increases
0 1 Bifidobacterium angulatum species Increases
0 1 Bifidobacterium bifidum species Increases
0 1 Lactobacillus acidophilus species Increases
0 1 Lactobacillus paragasseri species Increases
0 1 Bifidobacterium adolescentis species Increases
0 1 Lactobacillus jensenii species Increases
0 1 Lactobacillus gasseri species Increases
0 1 Bifidobacterium catenulatum species Increases
0 1 [Lactobacillus] rogosae species Increases
0 1 ATCC 15434 species Increases
0 1 Bifidobacterium actinocoloniiforme species Increases
0 1 Bifidobacterium aesculapii species Increases
0 1 Bifidobacterium avesanii species Increases
0 1 Bifidobacterium biavatii species Increases
0 1 Bifidobacterium bohemicum species Increases
0 1 Bifidobacterium bombi species Increases
0 1 Bifidobacterium boum species Increases
0 1 Bifidobacterium callitrichidarum species Increases
0 1 Bifidobacterium callitrichos species Increases
0 1 Bifidobacterium commune species Increases
0 1 Bifidobacterium coryneforme species Increases
0 1 Bifidobacterium cuniculi species Increases
0 1 Bifidobacterium faecale species Increases
0 1 Bifidobacterium gallicum species Increases
0 1 Bifidobacterium indicum species Increases
0 1 Bifidobacterium magnum species Increases
0 1 Bifidobacterium merycicum species Increases
0 1 Bifidobacterium minimum species Increases
0 1 Bifidobacterium mongoliense species Increases
0 1 Bifidobacterium moukalabense species Increases
0 1 Bifidobacterium myosotis species Increases
0 1 Bifidobacterium porcinum species Increases
0 1 Bifidobacterium psychraerophilum species Increases
0 1 Bifidobacterium reuteri species Increases
0 1 Bifidobacterium ruminantium species Increases
0 1 Bifidobacterium simiae species Increases
0 1 Bifidobacterium sp. species Increases
0 1 Bifidobacterium sp. 113 species Increases
0 1 Bifidobacterium sp. 120 species Increases
0 1 Bifidobacterium sp. 138 species Increases
0 1 Bifidobacterium sp. 65947 species Increases
0 1 Bifidobacterium sp. group II-3 species Increases
0 1 Bifidobacterium sp. h12 species Increases
0 1 Bifidobacterium sp. JCM 6439 species Increases
0 1 Bifidobacterium sp. M45 species Increases
0 1 Bifidobacterium sp. MC_8 species Increases
0 1 Bifidobacterium sp. MSTE12 species Increases
0 1 Bifidobacterium sp. MSX5B species Increases
0 1 Bifidobacterium sp. N5G01 species Increases
0 1 Bifidobacterium sp. PL1 species Increases
0 1 Bifidobacterium stellenboschense species Increases
0 1 Bifidobacterium stercoris species Increases
0 1 Bifidobacterium thermacidophilum species Increases
0 1 Bifidobacterium tissieri species Increases
0 1 Bifidobacterium tsurumiense species Increases
0 1 Lactobacillus alvei species Increases
0 1 Lactobacillus animata species Increases
0 1 Lactobacillus apis species Increases
0 1 Lactobacillus bombicola species Increases
0 1 Lactobacillus brevisimilis species Increases
0 1 Lactobacillus equicursoris species Increases
0 1 Lactobacillus faeni species Increases
0 1 Lactobacillus fornicalis species Increases
0 1 Lactobacillus gallinarum species Increases
0 1 Lactobacillus gigeriorum species Increases
0 1 Lactobacillus guizhouensis species Increases
0 1 Lactobacillus hamsteri species Increases
0 1 Lactobacillus helsingborgensis species Increases
0 1 Lactobacillus hominis species Increases
0 1 Lactobacillus intermedius species Increases
0 1 Lactobacillus japonicus species Increases
0 1 Lactobacillus kalixensis species Increases
0 1 Lactobacillus kitasatonis species Increases
0 1 Lactobacillus kullabergensis species Increases
0 1 Lactobacillus leichmannii species Increases
0 1 Lactobacillus letivazi species Increases
0 1 Lactobacillus mulieris species Increases
0 1 Lactobacillus panisapium species Increases
0 1 Lactobacillus pasteurii species Increases
0 1 Lactobacillus psittaci species Increases
0 1 Lactobacillus rodentium species Increases
0 1 Lactobacillus selangorensis species Increases
0 1 Lactobacillus sp. 7_1_47FAA species Increases
0 1 Lactobacillus sp. MYMRS/TEN2 species Increases
0 1 Lactobacillus terrae species Increases
0 1 Lactobacillus delbrueckii species Increases
0 1 Bifidobacterium breve species Increases
0 1 Bifidobacterium longum species Increases
1 0 Bifidobacterium animalis species Increases
0 1 Lactobacillus casei group species group Increases
0 1 Bifidobacterium animalis subsp. animalis subspecies Increases
0 1 Bifidobacterium pullorum subsp. saeculare subspecies Increases
0 1 Bifidobacterium animalis subsp. lactis subspecies Increases
0 1 Bifidobacterium pullorum subsp. gallinarum subspecies Increases

Impact of D-mannitol {Mannitol} on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Acne 1 1
ADHD 0.9 1 -0.11
Allergic Rhinitis (Hay Fever) 2 0.3 5.67
Allergies 1.3 2.1 -0.62
Allergy to milk products 0.3 0.3
Alzheimer's disease 0.5 1.2 -1.4
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0.9 -0.9
Ankylosing spondylitis 0.8 0.3 1.67
Anorexia Nervosa 0.3 -0.3
Asthma 1.3 1.3 0
Atherosclerosis 0.9 -0.9
Atrial fibrillation 0.3 0.9 -2
Autism 1.6 1.3 0.23
Autoimmune Disease 0.9 0.3 2
Biofilm 0.2 -0.2
Brain Trauma 0.9 0.3 2
Breast Cancer 0.3 -0.3
Cancer (General) 1.7 1.7
Carcinoma 0.3 0.3 0
Celiac Disease 2.1 1.4 0.5
Cerebral Palsy 0.3 -0.3
Chronic Fatigue Syndrome 0.9 0.3 2
Chronic Kidney Disease 0.8 0 0
Chronic Obstructive Pulmonary Disease (COPD) 0.6 -0.6
Cognitive Function 1 0.4 1.5
Colorectal Cancer 0.9 1.1 -0.22
Coronary artery disease 0.6 0.6
COVID-19 1.5 1.6 -0.07
Crohn's Disease 0.9 0.9 0
cystic fibrosis 0.5 0.5
d-lactic acidosis (one form of brain fog) 1 -1
Denture Wearers Oral Shifts 0.6 0 0
Depression 1.9 2.3 -0.21
Dermatomyositis 0.3 0.3
Eczema 0.7 0.1 6
Endometriosis 0.9 0.9 0
Epilepsy 0.9 0.3 2
erectile dysfunction 0.3 0.3
Fibromyalgia 0.9 0.9 0
Functional constipation / chronic idiopathic constipation 0.9 0.7 0.29
gallstone disease (gsd) 0.9 0.2 3.5
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.2 0.2
Generalized anxiety disorder 0.7 0.7
Graves' disease 0.9 0.9 0
Gulf War Syndrome 0.3 0.3
Hashimoto's thyroiditis 1 0.3 2.33
Heart Failure 0.9 0.6 0.5
High Histamine/low DAO 0.3 0.6 -1
hyperglycemia 0.9 0.9
Hyperlipidemia (High Blood Fats) 0.8 0.3 1.67
hypertension (High Blood Pressure 2.1 0.9 1.33
Hypothyroidism 0.3 0.3
Hypoxia 0.9 0.9 0
IgA nephropathy (IgAN) 0.9 0.9
Inflammatory Bowel Disease 1.7 0.9 0.89
Insomnia 0.2 0.7 -2.5
Intracranial aneurysms 0.9 0.9
Irritable Bowel Syndrome 0.9 0.9 0
ischemic stroke 1.3 -1.3
Liver Cirrhosis 1 0.9 0.11
Long COVID 1.7 1.1 0.55
Mast Cell Issues / mastitis 0.3 0.3
ME/CFS with IBS 0.3 0.3
ME/CFS without IBS 0.3 0.3
Menopause 1.3 0.7 0.86
Metabolic Syndrome 2.7 1.3 1.08
Mood Disorders 1.9 2.5 -0.32
multiple chemical sensitivity [MCS] 0.6 -0.6
Multiple Sclerosis 1.3 1.3 0
Multiple system atrophy (MSA) 0.4 0.6 -0.5
Neuropathy (all types) 0.6 -0.6
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 1.8 0.8 1.25
NonCeliac Gluten Sensitivity 0.9 0.3 2
Obesity 2.5 1.2 1.08
obsessive-compulsive disorder 1.5 1.5
Osteoarthritis 0.4 0.4
Osteoporosis 0.9 1.2 -0.33
Parkinson's Disease 1.3 1.3 0
Polycystic ovary syndrome 0.9 0.9 0
Postural orthostatic tachycardia syndrome 0.3 0.3
Premenstrual dysphoric disorder 0.3 -0.3
primary biliary cholangitis 0.6 -0.6
Primary sclerosing cholangitis 0.6 -0.6
Psoriasis 0.9 -0.9
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 1 1.5 -0.5
Rosacea 0.9 0.3 2
Schizophrenia 1 2 -1
Sjögren syndrome 0.5 0.5 0
Sleep Apnea 0.6 -0.6
Slow gastric motility / Gastroparesis 0.9 0.9
Small Intestinal Bacterial Overgrowth (SIBO) 0.5 0.6 -0.2
Stress / posttraumatic stress disorder 0.3 0.9 -2
Systemic Lupus Erythematosus 1.1 0.6 0.83
Tic Disorder 0.3 0.3
Tourette syndrome 0.6 0.6
Type 1 Diabetes 1.7 0.6 1.83
Type 2 Diabetes 1.7 1.3 0.31
Ulcerative colitis 1.9 1.1 0.73
Unhealthy Ageing 1.4 0.6 1.33
Vitiligo 0.3 0.3 0

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