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Antioxidant Properties: Grape seed extract is known for its potent antioxidant effects, which help neutralize free radicals and reduce oxidative stress in the body. Antioxidants play a crucial role in protecting cells from damage caused by reactive oxygen species (ROS) and may help prevent chronic diseases such as cardiovascular disease, cancer, and neurodegenerative disorders.
Cardiovascular Health: Grape seed extract has been studied for its potential benefits in supporting cardiovascular health. It may help improve blood circulation, reduce blood pressure, and lower cholesterol levels. Grape seed extract contains flavonoids and OPCs that promote vasodilation (widening of blood vessels), inhibit platelet aggregation (clumping), and reduce inflammation in the blood vessels, thereby reducing the risk of heart disease and stroke.
Anti-inflammatory Effects: Grape seed extract exhibits anti-inflammatory properties, which may help reduce inflammation in various tissues and organs. It can inhibit the production of pro-inflammatory cytokines and enzymes, thereby alleviating symptoms of inflammatory conditions such as arthritis, asthma, and inflammatory bowel disease (IBD).
Skin Health: Grape seed extract is often used in skincare products for its potential benefits in promoting skin health. It contains antioxidants that help protect the skin from oxidative damage caused by UV radiation, pollution, and other environmental stressors. Grape seed extract may help improve skin elasticity, reduce the appearance of wrinkles and fine lines, and promote wound healing.
Eye Health: Grape seed extract has been studied for its potential benefits in supporting eye health. It contains antioxidants that help protect the retina and lens from oxidative damage, reducing the risk of age-related macular degeneration (AMD), cataracts, and other eye disorders. Grape seed extract may also improve blood flow to the eyes and reduce inflammation in the eye tissues.
Cancer Prevention: Some research suggests that grape seed extract may have potential anticancer effects, inhibiting the growth and spread of cancer cells. It contains bioactive compounds that may induce apoptosis (programmed cell death) in cancer cells, inhibit tumor angiogenesis (the formation of new blood vessels that feed tumors), and prevent metastasis (the spread of cancer to other parts of the body). However, more studies are needed to fully understand its effects on cancer prevention and treatment.
Diabetes Management: Grape seed extract has been investigated for its potential role in managing diabetes and improving blood sugar control. It may help increase insulin sensitivity, reduce oxidative stress, and improve endothelial function, thereby contributing to better glycemic control in individuals with diabetes or prediabetes.
Cognitive Function: Some studies suggest that grape seed extract may have cognitive-enhancing effects. It contains antioxidants that help protect neurons from oxidative damage and improve cerebral blood flow, which may support cognitive function and reduce the risk of age-related cognitive decline, Alzheimer's disease, and other neurodegenerative disorders.
| Rank | Probiotic | Impact |
|---|---|---|
| genus | Bifidobacterium | Increases |
| species | Akkermansia muciniphila | Increases |
| species | Bacteroides uniformis | Increases |
| species | Bifidobacterium adolescentis | Increases |
| species | Bifidobacterium animalis | Increases |
| species | Bifidobacterium bifidum | Increases |
| species | Bifidobacterium breve | Increases |
| species | Bifidobacterium catenulatum | Increases |
| species | Bifidobacterium longum | Increases |
| species | Bifidobacterium pseudocatenulatum | Increases |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
| 📓 Direct Citations | 👪👶 Indirect Citations | Taxonomy | Rank | Effect |
|---|---|---|---|---|
| 3 | 2 | Akkermansia | genus | Increases |
| 3 | 2 | Akkermansia muciniphila | species | Increases |
| 3 | 0 | Escherichia coli | species | Decreases |
| 2 | 1 | Escherichia coli O157:H7 | serotype | Decreases |
| 2 | 0 | Bacteroides | genus | Increases |
| 2 | 0 | Lactobacillus | genus | Increases |
| 2 | 0 | Bifidobacterium | genus | Increases |
| 2 | 0 | Listeria monocytogenes | species | Decreases |
| 1 | 1 | Salmonella | genus | Decreases |
| 1 | 1 | Klebsiella | genus | Decreases |
| 1 | 1 | Salmonella enterica | species | Decreases |
| 1 | 1 | Klebsiella pneumoniae | species | Decreases |
| 1 | 1 | Bacteroides ovatus | species | Decreases |
| 1 | 1 | Bacteroides acidifaciens | species | Increases |
| 1 | 0 | Clostridia | class | Increases |
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Abdominal Aortic Aneurysm | 0.5 | 0.5 | |
| Acne | 3.7 | 1.1 | 2.36 |
| Addison's Disease (hypocortisolism) | 0.5 | 0.5 | |
| ADHD | 3.8 | 2.8 | 0.36 |
| Age-Related Macular Degeneration and Glaucoma | 0.3 | 0.3 | |
| Allergic Rhinitis (Hay Fever) | 4.6 | 2.6 | 0.77 |
| Allergies | 6.9 | 5.7 | 0.21 |
| Allergy to milk products | 1.8 | 1.8 | 0 |
| Alopecia (Hair Loss) | 1.1 | 1.5 | -0.36 |
| Alzheimer's disease | 4.8 | 5.3 | -0.1 |
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