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🍽️ humic substances {Humic,Fulvic acids}

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  1. Antioxidant Properties: Humic substances contain antioxidant compounds that may help neutralize harmful free radicals in the body, reducing oxidative stress and inflammation. By scavenging free radicals, humic substances may offer protective effects against various chronic diseases associated with oxidative damage, such as cardiovascular disease, neurodegenerative disorders, and certain types of cancer.

  2. Immune Modulation: Some studies suggest that humic substances may possess immunomodulatory properties, meaning they can modulate the activity of the immune system. By regulating immune responses, humic substances may help support immune function and enhance the body's ability to defend against infections, allergies, and autoimmune disorders. However, further research is needed to fully understand the mechanisms underlying these effects and their clinical significance.

  3. Gastrointestinal Health: Humic substances have been investigated for their potential benefits in promoting gastrointestinal health. It is proposed that humic substances may support digestive function, enhance nutrient absorption, and maintain gut microbiota balance. Additionally, some studies suggest that humic substances may have prebiotic properties, stimulating the growth of beneficial bacteria in the gut and contributing to overall gut health.

  4. Detoxification: Humic substances have been proposed to have detoxifying properties, assisting the body in removing toxins, heavy metals, and other harmful substances. By binding to toxins and facilitating their excretion, humic substances may help protect against toxic overload and reduce the risk of toxin-related health conditions. However, more research is needed to evaluate the efficacy of humic substances as detoxifying agents and their potential clinical applications.

  5. Skin Health: Topical applications of humic substances have been explored for their potential benefits in promoting skin health and wound healing. Humic substances may exhibit anti-inflammatory, antimicrobial, and antioxidant properties that could help alleviate skin conditions such as eczema, acne, and dermatitis. Additionally, humic substances may support tissue repair and regeneration, speeding up the healing process of wounds and ulcers.

  6. Anti-inflammatory Effects: Humic substances may exert anti-inflammatory effects by modulating inflammatory pathways and cytokine production. As inflammation plays a role in the pathogenesis of various chronic diseases, including arthritis, asthma, and inflammatory bowel disease, the anti-inflammatory properties of humic substances may have therapeutic potential in managing these conditions. However, more research is needed to elucidate the mechanisms of action and assess their clinical efficacy.

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Data Contradictions — Limits of Certainity

Impacted of humic substances {Humic,Fulvic acids} On Probiotics

Rank Probiotic Impact
species Bacteroides uniformis Reduces

Bacteria Impacted by humic substances {Humic,Fulvic acids}

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

🧙?

📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Terrabacteria group clade Decreases
0 1 Bacilli class Decreases
0 1 Clostridia class Decreases
0 1 Desulfuribacillia class Decreases
0 1 Dethiobacteria class Decreases
0 1 Erysipelotrichia class Decreases
0 1 Limnochordia class Decreases
0 1 Negativicutes class Decreases
0 1 Thermolithobacteria class Decreases
0 1 Tissierellia class Decreases
0 1 Bacteroidaceae family Decreases
0 1 Oscillospiraceae family Decreases
0 1 Selenomonadaceae family Decreases
0 1 Comamonadaceae family Increases
0 1 Prevotellaceae family Increases
1 0 Anaerovibrio genus Decreases
1 0 Bacteroides genus Decreases
1 0 Oscillospira genus Decreases
1 0 Ruminococcus genus Decreases
0 1 Subdoligranulum genus Decreases
0 1 Vescimonas genus Decreases
0 1 Coprococcus genus Decreases
0 1 Wansuia genus Decreases
0 1 Christensenella genus Decreases
0 1 Komagataeibacter genus Decreases
0 1 Maliibacterium genus Decreases
0 1 Butyrivibrio genus Decreases
0 1 Mageeibacillus genus Decreases
0 1 Oscillibacter genus Decreases
0 1 Wujia genus Decreases
0 1 Intestinimonas genus Decreases
0 1 Eubacterium genus Decreases
0 1 Simiaoa genus Decreases
0 1 Catenibacterium genus Decreases
0 1 Dorea genus Decreases
0 1 Monoglobus genus Decreases
0 1 Ligilactobacillus genus Decreases
0 1 Massilistercora genus Decreases
0 1 Treponema genus Decreases
0 1 Pusillibacter genus Decreases
0 1 Lawsonibacter genus Decreases
0 1 Novisyntrophococcus genus Decreases
0 1 Anaerobutyricum genus Decreases
0 1 Intestinibaculum genus Decreases
0 1 Flintibacter genus Decreases
0 1 Lachnospira genus Decreases
0 1 Lacrimispora genus Decreases
0 1 Acutalibacter genus Decreases
0 1 Roseburia genus Decreases
0 1 Qiania genus Decreases
0 1 Chordicoccus genus Decreases
0 1 Pseudobutyrivibrio genus Decreases
0 1 Faecalibacillus genus Decreases
0 1 Solibaculum genus Decreases
0 1 Anaerotruncus genus Decreases
0 1 Faecalitalea genus Decreases
0 1 Faecalibacterium genus Decreases
0 1 Longicatena genus Decreases
0 1 Ruthenibacterium genus Decreases
0 1 Marvinbryantia genus Decreases
0 1 Adlercreutzia genus Decreases
0 1 Leyella genus Increases
0 1 Hoylesella genus Increases
0 1 Segatella genus Increases
1 0 Curvibacter genus Increases
1 0 Prevotella genus Increases
0 1 Bacillota incertae sedis no rank Decreases
0 1 Bacillota sensu stricto incertae sedis no rank Decreases
0 1 environmental samples no rank Decreases
0 1 environmental samples no rank Decreases
0 1 environmental samples no rank Decreases
0 1 environmental samples no rank Decreases
0 1 environmental samples no rank Decreases
0 1 unclassified Anaerovibrio no rank Decreases
0 1 unclassified Bacillota no rank Decreases
0 1 unclassified Bacteroides no rank Decreases
0 1 unclassified Oscillospira no rank Decreases
0 1 unclassified Ruminococcus no rank Decreases
0 1 environmental samples no rank Increases
0 1 unclassified Curvibacter no rank Increases
0 1 unclassified Prevotella no rank Increases
1 0 Bacillota phylum Decreases
0 1 Spirochaetota phylum Decreases
0 1 Bacteroides bouchesdurhonensis QSV445 Decreases
0 1 Anaerovibrio lipolyticus species Decreases
0 1 Anaerovibrio slackiae species Decreases
0 1 Bacteroides acidifaciens species Decreases
0 1 Bacteroides caccae species Decreases
0 1 Bacteroides caecigallinarum species Decreases
0 1 Bacteroides caecimuri species Decreases
0 1 Bacteroides caecimuris species Decreases
0 1 Bacteroides cellulosilyticus species Decreases
0 1 Bacteroides chinchillae species Decreases
0 1 Bacteroides clarus species Decreases
0 1 Bacteroides congonensis species Decreases
0 1 Bacteroides coprosuis species Decreases
0 1 Bacteroides cutis species Decreases
0 1 Bacteroides denticanum species Decreases
0 1 Bacteroides difficilis species Decreases
0 1 Bacteroides eggerthii species Decreases
0 1 Bacteroides faecalis species Decreases
0 1 Bacteroides faecichinchillae species Decreases
0 1 Bacteroides faecis species Decreases
0 1 Bacteroides faecium species Decreases
0 1 Bacteroides finegoldii species Decreases
0 1 Bacteroides fluxus species Decreases
0 1 Bacteroides fragilis species Decreases
0 1 Bacteroides galacturonicus species Decreases
0 1 Bacteroides gallinaceum species Decreases
0 1 Bacteroides gallinarum species Decreases
0 1 Bacteroides graminisolvens species Decreases
0 1 Bacteroides helcogenes species Decreases
0 1 Bacteroides heparinolyticus species Decreases
0 1 Bacteroides humanifaecis species Decreases
0 1 Bacteroides ihuae species Decreases
0 1 Bacteroides ilei species Decreases
0 1 Bacteroides intestinalis species Decreases
0 1 Bacteroides koreensis species Decreases
0 1 Bacteroides kribbi species Decreases
0 1 Bacteroides luhongzhouii species Decreases
0 1 Bacteroides luti species Decreases
0 1 Bacteroides mediterraneensis species Decreases
0 1 Bacteroides muris (ex Fokt et al. 2023) species Decreases
0 1 Bacteroides ndongoniae species Decreases
0 1 Bacteroides nordii species Decreases
0 1 Bacteroides oleiciplenus species Decreases
0 1 Bacteroides ovatus species Decreases
0 1 Bacteroides parvus species Decreases
0 1 Bacteroides propionicifaciens species Decreases
0 1 Bacteroides propionicigenes species Decreases
0 1 Bacteroides pyogenes species Decreases
0 1 Bacteroides reticulotermitis species Decreases
0 1 Bacteroides rhinocerotis species Decreases
0 1 Bacteroides rodentium species Decreases
0 1 Bacteroides salyersiae species Decreases
0 1 Bacteroides sp species Decreases
0 1 Bacteroides sp. C13EG172 species Decreases
0 1 Bacteroides stercorirosoris species Decreases
0 1 Bacteroides stercoris species Decreases
0 1 Bacteroides thetaiotaomicron species Decreases
0 1 Bacteroides timonensis species Decreases
0 1 Bacteroides uniformis species Decreases
0 1 Bacteroides xylanisolvens species Decreases
0 1 Bacteroides zhangwenhongii species Decreases
0 1 Bacteroides zoogleoformans species Decreases
0 1 Candidatus Bacteroides intestinigallinarum species Decreases
0 1 Oscillospira guilliermondii species Decreases
0 1 Ruminococcus albus species Decreases
0 1 Ruminococcus bicirculans (ex Wegman et al. 2014) species Decreases
0 1 Ruminococcus bovis species Decreases
0 1 Ruminococcus bromii species Decreases
0 1 Ruminococcus callidus species Decreases
0 1 Ruminococcus champanellensis species Decreases
0 1 Ruminococcus difficilis species Decreases
0 1 Ruminococcus flavefaciens species Decreases
0 1 Ruminococcus gauvreauii species Decreases
0 1 Ruminococcus hominis species Decreases
0 1 Ruminococcus intestinalis species Decreases
0 1 Ruminococcus turbiniformis species Decreases
0 1 Candidatus Prevotella avicola species Increases
0 1 Candidatus Prevotella stercoripullorum species Increases
0 1 Curvibacter gracilis species Increases
0 1 Curvibacter lanceolatus species Increases
0 1 Curvibacter putative symbiont of Hydra magnipapillata species Increases
0 1 Prevotella amnii species Increases
0 1 Prevotella aurantiaca species Increases
0 1 Prevotella bivia species Increases
0 1 Prevotella brunnea species Increases
0 1 Prevotella communis species Increases
0 1 Prevotella conceptionensis species Increases
0 1 Prevotella corporis species Increases
0 1 Prevotella dentalis species Increases
0 1 Prevotella dentasini species Increases
0 1 Prevotella denticola species Increases
0 1 Prevotella disiens species Increases
0 1 Prevotella falsenii species Increases
0 1 Prevotella fusca species Increases
0 1 Prevotella herbatica species Increases
0 1 Prevotella histicola species Increases
0 1 Prevotella intermedia species Increases
0 1 Prevotella jejuni species Increases
0 1 Prevotella marseillensis species Increases
0 1 Prevotella melaninogenica species Increases
0 1 Prevotella merdae species Increases
0 1 Prevotella micans species Increases
0 1 Prevotella multiformis species Increases
0 1 Prevotella nigrescens species Increases
0 1 Prevotella pallens species Increases
0 1 Prevotella pectinovora species Increases
0 1 Prevotella phocaeensis species Increases
0 1 Prevotella scopos species Increases
0 1 Prevotella sp. P5-119 species Increases
0 1 Prevotella veroralis species Increases
0 1 Xylanibacter brevis species Increases
0 1 Xylanibacter oryzae species Increases
0 1 Xylanibacter rarus species Increases
0 1 Xylanibacter ruminicola species Increases

Impact of humic substances {Humic,Fulvic acids} on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.3 0.7 -1.33
Acne 0.5 0.7 -0.4
ADHD 1.7 1.8 -0.06
Age-Related Macular Degeneration and Glaucoma 0.3 0.3 0
Allergic Rhinitis (Hay Fever) 0.6 0.7 -0.17
Allergies 2.4 3.2 -0.33
Allergy to milk products 2.2 1.1 1
Alopecia (Hair Loss) 1 0.2 4
Alzheimer's disease 4.2 4.4 -0.05
Amyotrophic lateral sclerosis (ALS) Motor Neuron 1.1 1.5 -0.36
Ankylosing spondylitis 2.7 2.6 0.04
Anorexia Nervosa 0.7 1.9 -1.71
Antiphospholipid syndrome (APS) 0.2 0.2
Asthma 2.1 2.7 -0.29
Atherosclerosis 1.3 1.2 0.08
Atrial fibrillation 2.2 1.5 0.47
Autism 4.6 3.7 0.24
Autoimmune Disease 0.8 -0.8
benign prostatic hyperplasia 0.9 -0.9
Biofilm 0.2 -0.2
Bipolar Disorder 2.4 2.5 -0.04
Brain Trauma 1.2 1.4 -0.17
Cancer (General) 0.5 0.8 -0.6
Carcinoma 2.1 2.7 -0.29
Celiac Disease 1.6 2.8 -0.75
Cerebral Palsy 1.3 1.8 -0.38
Chronic Fatigue Syndrome 2.8 2.5 0.12
Chronic Kidney Disease 1.6 1.9 -0.19
Chronic Lyme 0.6 -0.6
Chronic Obstructive Pulmonary Disease (COPD) 1.4 1.5 -0.07
Chronic Urticaria (Hives) 0.6 0.3 1
Coagulation / Micro clot triggering bacteria 0.3 1.3 -3.33
Cognitive Function 2.4 1.1 1.18
Colorectal Cancer 4 2 1
Constipation 2.7 0.5 4.4
Coronary artery disease 1.4 2.4 -0.71
COVID-19 3.9 6.4 -0.64
Crohn's Disease 3.9 5.3 -0.36
Cushing's Syndrome (hypercortisolism) 0.5 -0.5
cystic fibrosis 1.2 -1.2
deep vein thrombosis 0.5 1.8 -2.6
Depression 5.3 4.8 0.1
Dermatomyositis 0.6 -0.6
Eczema 0.4 0.3 0.33
Endometriosis 2.5 1.7 0.47
Eosinophilic Esophagitis 1.3 -1.3
Epilepsy 2.1 1.9 0.11
erectile dysfunction 0.7 0.3 1.33
Fibromyalgia 0.3 0.9 -2
Functional constipation / chronic idiopathic constipation 4.8 3.5 0.37
gallstone disease (gsd) 1.5 0.4 2.75
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 1.6 0.9 0.78
Generalized anxiety disorder 0.9 1.5 -0.67
Glioblastoma 0.8 0.4 1
Gout 2.2 1.1 1
Graves' disease 1.3 3.3 -1.54
Gulf War Syndrome 0.9 0.3 2
Halitosis 0.8 1 -0.25
Hashimoto's thyroiditis 2.6 1.5 0.73
Heart Failure 3 2.4 0.25
hemorrhagic stroke 0.3 0.2 0.5
Hemorrhoidal disease, Hemorrhoids, Piles 0.5 0.5
Hidradenitis Suppurativa 0.6 1.1 -0.83
High Histamine/low DAO 0.4 0.6 -0.5
hypercholesterolemia (High Cholesterol) 0.5 0.7 -0.4
hyperglycemia 0.1 0.7 -6
Hyperlipidemia (High Blood Fats) 0.3 0.3 0
hypersomnia 0.6 -0.6
hypertension (High Blood Pressure 2.7 3.3 -0.22
Hypothyroidism 0.6 1.9 -2.17
Hypoxia 1.6 1.6
IgA nephropathy (IgAN) 2.3 2 0.15
Inflammatory Bowel Disease 3.1 4.1 -0.32
Insomnia 1.9 3.7 -0.95
Intelligence 2.7 0.5 4.4
Intracranial aneurysms 1.5 0.8 0.88
Irritable Bowel Syndrome 3.9 3.8 0.03
ischemic stroke 1.6 1.5 0.07
Juvenile idiopathic arthritis 0.6 -0.6
Liver Cirrhosis 3.1 3.4 -0.1
Long COVID 3.3 4.8 -0.45
Low bone mineral density 1.1 -1.1
Lung Cancer 0.3 1.1 -2.67
Mast Cell Issues / mastitis 1.4 0.7 1
ME/CFS with IBS 0.6 -0.6
ME/CFS without IBS 0.6 -0.6
membranous nephropathy 0.6 -0.6
Menopause 0.2 1 -4
Metabolic Syndrome 5.4 5.5 -0.02
Mood Disorders 5.2 5 0.04
Multiple Sclerosis 1.8 3 -0.67
Multiple system atrophy (MSA) 0.5 -0.5
myasthenia gravis 0.1 0.4 -3
neuropathic pain 0.8 -0.8
Neuropathy (all types) 0.7 0.1 6
neuropsychiatric disorders (PANDAS, PANS) 0.3 0.6 -1
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 2.8 3.7 -0.32
NonCeliac Gluten Sensitivity 1.3 1.1 0.18
Obesity 5.4 5.8 -0.07
obsessive-compulsive disorder 2.5 1.6 0.56
Osteoarthritis 0.8 2.4 -2
Osteoporosis 1.2 1.8 -0.5
pancreatic cancer 0.3 0.2 0.5
Parkinson's Disease 4.2 4.6 -0.1
Polycystic ovary syndrome 2.7 3.6 -0.33
Postural orthostatic tachycardia syndrome 0.2 -0.2
primary biliary cholangitis 0.3 1.4 -3.67
Primary sclerosing cholangitis 0.5 1.3 -1.6
Psoriasis 2.2 1.7 0.29
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 4.4 3.2 0.38
Rosacea 0.5 0.6 -0.2
Schizophrenia 2.8 3.3 -0.18
scoliosis 1.2 0.5 1.4
sensorineural hearing loss 0.2 -0.2
Sjögren syndrome 1.3 1.9 -0.46
Sleep Apnea 2 1.1 0.82
Slow gastric motility / Gastroparesis 1.8 0.6 2
Small Intestinal Bacterial Overgrowth (SIBO) 1.1 1.1 0
Stress / posttraumatic stress disorder 0.9 2.2 -1.44
Systemic Lupus Erythematosus 2.3 2.6 -0.13
Tic Disorder 1.8 0.9 1
Tourette syndrome 0.1 0.8 -7
Type 1 Diabetes 3.2 2.6 0.23
Type 2 Diabetes 5.2 5.3 -0.02
Ulcerative colitis 3.6 4.7 -0.31
Unhealthy Ageing 1.6 1.3 0.23
Vitiligo 1.5 0.3 4

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