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🍽️ 3-Methylbutanoic acid {isovaleric acid}

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  1. Isovaleric Acidemia (IVA): Isovaleric acidemia is a rare genetic metabolic disorder characterized by a deficiency of the enzyme isovaleryl-CoA dehydrogenase, which is involved in the metabolism of leucine. As a result, individuals with isovaleric acidemia are unable to properly break down leucine, leading to the accumulation of isovaleric acid and its derivatives in the body. High levels of isovaleric acid can be toxic and cause a range of symptoms, including metabolic acidosis, vomiting, poor feeding, lethargy, developmental delays, seizures, and a distinctive odor resembling sweaty feet or cheese. Without prompt treatment, isovaleric acidemia can lead to life-threatening complications such as metabolic crises and neurological damage.

  2. Ketoacidosis: In individuals with isovaleric acidemia or other metabolic disorders associated with impaired leucine metabolism, the accumulation of isovaleric acid and its metabolites can disrupt normal metabolic processes and lead to ketoacidosis. Ketoacidosis is a serious condition characterized by elevated levels of ketones and acidic pH in the blood, which can cause symptoms such as rapid breathing, fruity-scented breath, confusion, and coma if left untreated. Ketoacidosis requires immediate medical intervention to correct metabolic imbalances and prevent complications.

  3. Odor Disorders: The distinctive odor associated with isovaleric acidemia, often described as "sweaty feet" or "cheesy," is caused by the accumulation of isovaleric acid and its derivatives in the body. This odor may be present in the sweat, urine, breath, and body secretions of affected individuals and can be a characteristic feature used for diagnostic purposes. However, it is important to note that not all individuals with isovaleric acidemia may exhibit this odor, and other factors may contribute to body odor in different individuals.

  4. Treatment: Management of isovaleric acidemia typically involves dietary restrictions to limit the intake of leucine and other branched-chain amino acids, as well as supplementation with special medical formulas designed to provide essential nutrients while minimizing the accumulation of toxic metabolites. In some cases, medications such as carnitine or antibiotics may be used to help manage symptoms and prevent metabolic crises. Regular monitoring of metabolic parameters, nutritional status, and growth is essential to optimize outcomes and prevent long-term complications in individuals with isovaleric acidemia.

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Data Contradictions — Limits of Certainity

Impacted of 3-Methylbutanoic acid {isovaleric acid} On Probiotics

Rank Probiotic Impact

Bacteria Impacted by 3-Methylbutanoic acid {isovaleric acid}

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
1 0 Betaproteobacteria class Increases
0 1 Fusobacteriia class Increases
0 1 Muribaculaceae family Increases
0 1 Balneicellaceae family Increases
0 1 Paludibacteraceae family Increases
0 1 Salinivirgaceae family Increases
0 1 Tenuifilaceae family Increases
1 0 Bacteroidaceae family Increases
1 0 Barnesiellaceae family Increases
1 0 Dysgonomonadaceae family Increases
1 0 Marinifilaceae family Increases
1 0 Marinilabiliaceae family Increases
1 0 Odoribacteraceae family Increases
1 0 Porphyromonadaceae family Increases
1 0 Prevotellaceae family Increases
1 0 Prolixibacteraceae family Increases
1 0 Rikenellaceae family Increases
1 0 Tannerellaceae family Increases
0 1 Anaerorhabdus genus Decreases
0 1 Campylobacter genus Decreases
0 1 Tannerella genus Increases
0 1 Microbacter genus Increases
0 1 Dysgonomonas genus Increases
0 1 Pseudoprevotella genus Increases
0 1 Hoylesella genus Increases
0 1 Proteiniphilum genus Increases
0 1 Acetobacteroides genus Increases
0 1 Alkalitalea genus Increases
0 1 Anaerocella genus Increases
0 1 Anaerophaga genus Increases
0 1 Aquipluma genus Increases
0 1 Breznakibacter genus Increases
0 1 Candidatus Azobacteroides genus Increases
0 1 Candidatus Cryptobacteroides genus Increases
0 1 Candidatus Egerieousia genus Increases
0 1 Candidatus Limisoma genus Increases
0 1 Candidatus Onthomorpha genus Increases
0 1 Candidatus Vestibaculum genus Increases
0 1 Carboxylicivirga genus Increases
0 1 Culturomica genus Increases
0 1 Draconibacterium genus Increases
0 1 Falsiporphyromonas genus Increases
0 1 Fermentimonas genus Increases
0 1 Gabonia genus Increases
0 1 Gabonibacter genus Increases
0 1 Gallalistipes genus Increases
0 1 Geofilum genus Increases
0 1 Hallella genus Increases
0 1 Labilibacter genus Increases
0 1 Labilibaculum genus Increases
0 1 Lascolabacillus genus Increases
0 1 Macellibacteroides genus Increases
0 1 Mangroviflexus genus Increases
0 1 Maribellus genus Increases
0 1 Marinifilum genus Increases
0 1 Marinilabilia genus Increases
0 1 Mariniphaga genus Increases
0 1 Marseilla genus Increases
0 1 Massiliprevotella genus Increases
0 1 Mediterranea genus Increases
0 1 Meniscus genus Increases
0 1 Metaprevotella genus Increases
0 1 Millionella genus Increases
0 1 Mucinivorans genus Increases
0 1 Prevotellamassilia genus Increases
0 1 Prolixibacter genus Increases
0 1 Rikenella genus Increases
0 1 Roseimarinus genus Increases
0 1 Ruminofilibacter genus Increases
0 1 Saccharicrinis genus Increases
0 1 Sanguibacteroides genus Increases
0 1 Sunxiuqinia genus Increases
0 1 Tangfeifania genus Increases
0 1 Thermophagus genus Increases
0 1 Tidjanibacter genus Increases
0 1 Phocaeicola genus Increases
0 1 Segatella genus Increases
0 1 Leyella genus Increases
0 1 Odoribacter genus Increases
0 1 Petrimonas genus Increases
0 1 Alkaliflexus genus Increases
0 1 Bacteroidaceae incertae sedis no rank Increases
0 1 Betaproteobacteria incertae sedis no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 Rikenellaceae incertae sedis no rank Increases
0 1 unclassified Bacteroidaceae no rank Increases
0 1 unclassified Barnesiellaceae no rank Increases
0 1 unclassified Betaproteobacteria no rank Increases
0 1 unclassified Fusobacteriota no rank Increases
0 1 unclassified Marinifilaceae no rank Increases
0 1 unclassified Odoribacteraceae no rank Increases
0 1 unclassified Porphyromonadaceae no rank Increases
0 1 unclassified Prevotellaceae no rank Increases
0 1 unclassified Rikenellaceae no rank Increases
0 1 unclassified Tannerellaceae no rank Increases
1 0 Bacteroidales incertae sedis no rank Increases
0 1 Neisseriales order Increases
0 1 Nitrosomonadales order Increases
0 1 Rhodocyclales order Increases
0 1 Ferrovales order Increases
0 1 Marinilabiliales order Increases
0 1 Burkholderiales order Increases
1 0 Bacteroidales order Increases
0 1 Pseudomonadota phylum Increases
1 0 Fusobacteriota phylum Increases
1 0 Campylobacter jejuni species Decreases
0 1 Campylobacter jejuni 10186 strain Decreases
0 1 Campylobacter jejuni 10227 strain Decreases
0 1 Campylobacter jejuni 20176 strain Decreases
0 1 Campylobacter jejuni 255 strain Decreases
0 1 Campylobacter jejuni 30286 strain Decreases
0 1 Campylobacter jejuni 30318 strain Decreases
0 1 Campylobacter jejuni 32488 strain Decreases
0 1 Campylobacter jejuni 4031 strain Decreases
0 1 Campylobacter jejuni BJ-CJD101 strain Decreases
0 1 Campylobacter jejuni BJ-CJGB95377 strain Decreases
0 1 Campylobacter jejuni BJ-CJGB96114 strain Decreases
0 1 Campylobacter jejuni BJ-CJGB96299 strain Decreases
0 1 Campylobacter jejuni BJ-CJGB96G25 strain Decreases
0 1 Campylobacter jejuni Cj1 strain Decreases
0 1 Campylobacter jejuni Cj2 strain Decreases
0 1 Campylobacter jejuni Cj3 strain Decreases
0 1 Campylobacter jejuni Cj5 strain Decreases
0 1 Campylobacter jejuni CVM 41900 strain Decreases
0 1 Campylobacter jejuni CVM 41902 strain Decreases
0 1 Campylobacter jejuni CVM 41905 strain Decreases
0 1 Campylobacter jejuni CVM 41908 strain Decreases
0 1 Campylobacter jejuni CVM 41910 strain Decreases
0 1 Campylobacter jejuni CVM 41912 strain Decreases
0 1 Campylobacter jejuni CVM 41914 strain Decreases
0 1 Campylobacter jejuni CVM 41918 strain Decreases
0 1 Campylobacter jejuni CVM 41921 strain Decreases
0 1 Campylobacter jejuni CVM 41922 strain Decreases
0 1 Campylobacter jejuni CVM 41923 strain Decreases
0 1 Campylobacter jejuni CVM 41927 strain Decreases
0 1 Campylobacter jejuni CVM 41933 strain Decreases
0 1 Campylobacter jejuni CVM 41934 strain Decreases
0 1 Campylobacter jejuni CVM 41936 strain Decreases
0 1 Campylobacter jejuni CVM 41943 strain Decreases
0 1 Campylobacter jejuni CVM 41946 strain Decreases
0 1 Campylobacter jejuni CVM 41964 strain Decreases
0 1 Campylobacter jejuni CVM 41973 strain Decreases
0 1 Campylobacter jejuni CVM 41974 strain Decreases
0 1 Campylobacter jejuni CVM 41975 strain Decreases
0 1 Campylobacter jejuni CVM 41985 strain Decreases
0 1 Campylobacter jejuni g113 strain Decreases
0 1 Campylobacter jejuni HB-CJGB-LC strain Decreases
0 1 Campylobacter jejuni HB-CJGB-LL strain Decreases
0 1 Campylobacter jejuni HB-CJGB-LXC strain Decreases
0 1 Campylobacter jejuni HB-CJGB-QYT strain Decreases
0 1 Campylobacter jejuni HB-CJGB-XWM strain Decreases
0 1 Campylobacter jejuni HB-CJGB-ZB strain Decreases
0 1 Campylobacter jejuni HB-CJGB-ZHX strain Decreases
0 1 Campylobacter jejuni HB-CJGB-ZX strain Decreases
0 1 Campylobacter jejuni K1 strain Decreases
0 1 Campylobacter jejuni RM1221 strain Decreases
0 1 Campylobacter jejuni str. NCCP No. 15742 strain Decreases
0 1 Campylobacter jejuni X strain Decreases
0 1 Campylobacter jejuni subsp. doylei subspecies Decreases
0 1 Campylobacter jejuni subsp. jejuni subspecies Decreases

Impact of 3-Methylbutanoic acid {isovaleric acid} on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Acne 0.6 -0.6
ADHD 0.6 1.8 -2
Allergic Rhinitis (Hay Fever) 0.6 0.6 0
Allergies 2.4 1.2 1
Allergy to milk products 0.6 0.6
Alopecia (Hair Loss) 0 0
Alzheimer's disease 1.1 0.6 0.83
Amyotrophic lateral sclerosis (ALS) Motor Neuron 1.7 -1.7
Ankylosing spondylitis 1.2 1.8 -0.5
Anorexia Nervosa 0.5 0.6 -0.2
Asthma 0.3 1.8 -5
Atherosclerosis 0.3 0.3
Atrial fibrillation 0.9 0.6 0.5
Autism 3.6 3.5 0.03
Barrett esophagus cancer 0.3 -0.3
Bipolar Disorder 0.3 1.2 -3
Brain Trauma 1.2 1.2
Cancer (General) 0.6 -0.6
Carcinoma 0.8 0.5 0.6
Celiac Disease 1.7 0.6 1.83
Chronic Fatigue Syndrome 1.1 2.4 -1.18
Chronic Kidney Disease 0.6 0.6 0
Chronic Obstructive Pulmonary Disease (COPD) 0.3 0 0
Chronic Urticaria (Hives) 0 0
Cognitive Function 1.7 2.4 -0.41
Colorectal Cancer 2.3 3.3 -0.43
Constipation 0.6 1.2 -1
Coronary artery disease 0.5 0.5
COVID-19 2.7 3 -0.11
Crohn's Disease 0.8 2.1 -1.63
Denture Wearers Oral Shifts 0.3 0.3
Depression 4.4 5.6 -0.27
Dermatomyositis 0 0
Eczema 1.2 -1.2
Endometriosis 1.4 0.6 1.33
Eosinophilic Esophagitis 0 0
Epilepsy 1.4 1.8 -0.29
Functional constipation / chronic idiopathic constipation 0.6 2.9 -3.83
gallstone disease (gsd) 0 0
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.9 1.2 -0.33
Generalized anxiety disorder 1.2 0 0
giant cell arteritis 0.6 -0.6
Gout 0.6 2.4 -3
Graves' disease 1.2 1.8 -0.5
Gulf War Syndrome 0.6 -0.6
Halitosis 0.3 0 0
Heart Failure 0 0.3 0
hemorrhagic stroke 0.6 0.6 0
Hemorrhoidal disease, Hemorrhoids, Piles 0.6 -0.6
Hidradenitis Suppurativa 0.6 0.6
High Histamine/low DAO 0.6 0.6
hypercholesterolemia (High Cholesterol) 0.5 -0.5
hyperglycemia 0.6 -0.6
Hyperlipidemia (High Blood Fats) 1.2 0 0
hypersomnia 0.6 0.6 0
hypertension (High Blood Pressure 1.2 1.5 -0.25
Inflammatory Bowel Disease 1.4 2.4 -0.71
Insomnia 0.6 1.2 -1
Intelligence 1.2 1.2
Intracranial aneurysms 1.2 0.6 1
Irritable Bowel Syndrome 0.3 1.8 -5
ischemic stroke 0.6 0.6 0
Juvenile idiopathic arthritis 1.2 -1.2
Liver Cirrhosis 0.3 2.1 -6
Long COVID 5 3 0.67
Lung Cancer 1.2 1.2
Mast Cell Issues / mastitis 1.2 0 0
Metabolic Syndrome 1.4 2.1 -0.5
Mood Disorders 4 5.3 -0.32
Multiple Sclerosis 0.6 0 0
Neuropathy (all types) 0 0
neuropsychiatric disorders (PANDAS, PANS) 1.7 -1.7
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 1.8 1.8 0
NonCeliac Gluten Sensitivity 0.6 0 0
Obesity 3.8 2.9 0.31
obsessive-compulsive disorder 0.6 0 0
Osteoporosis 1.2 1.2 0
pancreatic cancer 0.5 -0.5
Parkinson's Disease 0.6 3.3 -4.5
Peanut Allergy 0.6 0 0
Polycystic ovary syndrome 3 1.2 1.5
primary biliary cholangitis 0.3 0 0
Primary sclerosing cholangitis 1.2 -1.2
Psoriasis 0.6 -0.6
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 1.8 1.3 0.38
Rosacea 0.6 0.6
Schizophrenia 0.8 2.4 -2
sensorineural hearing loss 0.6 -0.6
Sjögren syndrome 0 0.5 0
Sleep Apnea 0.6 0.6
Systemic Lupus Erythematosus 2.7 2.4 0.13
Tic Disorder 0.6 0.5 0.2
Type 1 Diabetes 0 0.6 0
Type 2 Diabetes 0.9 2.1 -1.33
Ulcerative colitis 2.3 0.7 2.29
Unhealthy Ageing 0.8 0.8
Vitiligo 0.6 0.6 0

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