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Gram-Negative Infections: Aztreonam is primarily effective against gram-negative bacteria, including:
Respiratory Tract Infections: Aztreonam may be used to treat respiratory tract infections, including pneumonia and bronchitis, caused by susceptible gram-negative bacteria.
Urinary Tract Infections (UTIs): Aztreonam may be prescribed for the treatment of UTIs caused by susceptible gram-negative bacteria, including Escherichia coli and Klebsiella species.
Intra-Abdominal Infections: Aztreonam may be used as part of the treatment regimen for intra-abdominal infections, including peritonitis and infections of the biliary tract, caused by susceptible gram-negative bacteria.
Skin and Soft Tissue Infections: Aztreonam may be effective in the treatment of skin and soft tissue infections caused by susceptible gram-negative bacteria, including cellulitis and wound infections.
Gynecological Infections: Aztreonam may be used to treat gynecological infections caused by susceptible gram-negative bacteria, such as pelvic inflammatory disease (PID).
Septicemia: Aztreonam may be used in the treatment of septicemia (bloodstream infection) caused by susceptible gram-negative bacteria.
Safety Considerations: Aztreonam is generally well-tolerated, with common side effects including nausea, vomiting, diarrhea, and injection site reactions. Serious adverse effects such as allergic reactions and superinfections may occur but are rare.
Cross-Reactivity: Aztreonam is structurally different from penicillins and cephalosporins and may be used in patients with allergies to these antibiotics. However, caution should be exercised, and patients should be monitored for potential allergic reactions.
Limited Spectrum: Aztreonam has a limited spectrum of activity compared to other antibiotics and is primarily effective against gram-negative bacteria. It is not effective against gram-positive bacteria or anaerobic organisms.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive β X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
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