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🍽️ SAM-e

AI Engines For more Details: Perplexity  Kagi Labs  You 

  1. Depression: SAM-e has been investigated as a potential treatment for depression. Studies suggest that SAM-e may help alleviate symptoms of depression by increasing levels of neurotransmitters such as serotonin, dopamine, and norepinephrine in the brain. Some research indicates that SAM-e may be as effective as conventional antidepressants in improving mood.

  2. Osteoarthritis: SAM-e has shown promise in the treatment of osteoarthritis, a degenerative joint disease characterized by cartilage breakdown and inflammation. SAM-e may help reduce pain, stiffness, and inflammation in individuals with osteoarthritis. It is believed to work by supporting cartilage repair and reducing the production of inflammatory molecules in the joints.

  3. Liver Health: SAM-e plays a crucial role in liver function and may help protect against liver damage caused by various factors, including alcohol consumption, medication use, and liver disease. SAM-e has been studied for its potential hepatoprotective effects and its ability to support liver detoxification pathways.

  4. Fibromyalgia: Some studies suggest that SAM-e supplementation may help improve symptoms of fibromyalgia, a chronic pain condition characterized by widespread musculoskeletal pain, fatigue, and mood disturbances. SAM-e may help reduce pain and fatigue in individuals with fibromyalgia and improve overall well-being.

  5. Cognitive Function: SAM-e may have neuroprotective properties and may help support cognitive function and mental clarity. Some research indicates that SAM-e supplementation may benefit individuals with cognitive impairment or age-related cognitive decline. It may also help improve mood and cognitive symptoms in conditions such as Alzheimer's disease and dementia.

  6. Mood Disorders: In addition to depression, SAM-e has been studied for its potential therapeutic effects on other mood disorders, including anxiety and bipolar disorder. SAM-e may help stabilize mood and reduce symptoms of anxiety and mania in individuals with bipolar disorder. However, more research is needed to fully understand its effects on mood disorders.

  7. Fatty Liver Disease: SAM-e may be beneficial in the management of non-alcoholic fatty liver disease (NAFLD), a condition characterized by the accumulation of fat in the liver. SAM-e may help improve liver function, reduce liver inflammation, and prevent the progression of NAFLD to more severe liver conditions such as non-alcoholic steatohepatitis (NASH) and cirrhosis.

  8. Cardiovascular Health: Some studies suggest that SAM-e may have cardioprotective effects and may help reduce the risk of cardiovascular diseases such as heart disease and stroke. SAM-e may help lower levels of homocysteine, an amino acid associated with an increased risk of cardiovascular events when elevated.

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⚗️ Compensation for antibiotic usage

Data Contradictions — Limits of Certainity

Impacted of SAM-e On Probiotics

Rank Probiotic Impact
species Bacillus aeolius Increases
species Bacillus horti Increases
species Bacillus infernus Increases
species Bacillus pumilus Increases
species Bacillus thermotolerans Increases
species Escherichia coli Increases
species group Bacillus cereus group Increases

Bacteria Impacted by SAM-e

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Lysinibacillus genus Increases
0 1 Escherichia genus Increases
0 1 Escherichia coli O20:H12 no rank Increases
0 1 Escherichia coli O2:K1:H5 no rank Increases
0 1 Escherichia coli O19:H7 no rank Increases
0 1 Escherichia coli O155:H21 no rank Increases
0 1 Escherichia coli O170:H18 no rank Increases
0 1 Escherichia coli O15:H12 no rank Increases
0 1 Escherichia coli O1:K1:H7 no rank Increases
0 1 Escherichia coli O55:H7 no rank Increases
0 1 Escherichia coli O68:H12 no rank Increases
0 1 Escherichia coli O7:H15 no rank Increases
0 1 Escherichia coli O85:H1 no rank Increases
0 1 Escherichia coli O18ac:H14 no rank Increases
0 1 Escherichia coli O78:H51 no rank Increases
0 1 Escherichia coli O2:K1:H7 no rank Increases
0 1 Escherichia coli O2:K1:H4 no rank Increases
0 1 Escherichia coli O84:H7 no rank Increases
0 1 Escherichia coli O158:H23 no rank Increases
0 1 Escherichia coli O80:H26 no rank Increases
0 1 Escherichia coli O139:H1 no rank Increases
0 1 Escherichia coli O141:H4 no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 Escherichia coli O145:H34 no rank Increases
0 1 Escherichia coli O16:H48 no rank Increases
0 1 unclassified Bacillus (in: firmicutes) no rank Increases
0 1 unclassified Escherichia no rank Increases
0 1 unclassified Kluyvera no rank Increases
0 1 Escherichia coli O25:H16 no rank Increases
0 1 Escherichia coli O145 serogroup Increases
0 1 Escherichia coli O157 serogroup Increases
0 1 Escherichia coli O119 serogroup Increases
0 1 Escherichia coli O43 serogroup Increases
0 1 Escherichia coli O78 serogroup Increases
0 1 Escherichia coli O103 serogroup Increases
0 1 Escherichia coli O91 serogroup Increases
0 1 Escherichia coli O111 serogroup Increases
0 1 Escherichia coli O121 serogroup Increases
0 1 Escherichia coli O155 serogroup Increases
0 1 Escherichia coli O177 serogroup Increases
0 1 Escherichia coli O26 serogroup Increases
0 1 Escherichia coli O3 serogroup Increases
0 1 Escherichia coli O5 serogroup Increases
0 1 Escherichia coli O86 serogroup Increases
0 1 Escherichia coli O139:H28 serotype Increases
0 1 Escherichia coli O78:H4 serotype Increases
0 1 Escherichia coli O9:H10 serotype Increases
0 1 Escherichia coli O83:H1 serotype Increases
0 1 Escherichia coli O104:H4 serotype Increases
0 1 Escherichia coli O167:H26 serotype Increases
0 1 Escherichia coli O103:H2 serotype Increases
0 1 Escherichia coli O45:H2 serotype Increases
0 1 Escherichia coli O157:H- serotype Increases
0 1 Escherichia coli O6:H16 serotype Increases
0 1 Escherichia coli O10:H32 serotype Increases
0 1 Escherichia coli O89m:H10 serotype Increases
0 1 Escherichia coli O8:H8 serotype Increases
0 1 Escherichia coli O2:K2:H1 serotype Increases
0 1 Escherichia coli O44:H18 serotype Increases
0 1 Escherichia coli O39:NM serotype Increases
0 1 Escherichia coli O15:H18 serotype Increases
0 1 Escherichia coli O152:H23 serotype Increases
0 1 Escherichia coli O6:K2:H1 serotype Increases
0 1 Escherichia coli O125ac:K+:H10 serotype Increases
0 1 Escherichia coli O7:K1 serotype Increases
0 1 Escherichia coli O25:H1 serotype Increases
0 1 Escherichia coli O25:NM serotype Increases
0 1 Escherichia coli O1:H42 serotype Increases
0 1 Escherichia coli O7:H4 serotype Increases
0 1 Escherichia coli O2:H6 serotype Increases
0 1 Escherichia coli O126:H45 serotype Increases
0 1 Escherichia coli O145:H28 serotype Increases
0 1 Escherichia coli O26:H11 serotype Increases
0 1 Escherichia coli O99:H6 serotype Increases
0 1 Escherichia coli O112ab:H8 serotype Increases
0 1 Escherichia coli O111:NM serotype Increases
0 1 Escherichia coli O150:H6 serotype Increases
0 1 Escherichia coli H20 serotype Increases
0 1 Escherichia coli O113:H21 serotype Increases
0 1 Escherichia coli O111:H- serotype Increases
0 1 Escherichia coli O89m:H9 serotype Increases
0 1 Escherichia coli O16:H6 serotype Increases
0 1 Escherichia coli O157:H7 serotype Increases
0 1 Escherichia coli O121:H19 serotype Increases
0 1 Escherichia coli O100:H21 serotype Increases
0 1 Escherichia coli O10:K5(L):H4 serotype Increases
0 1 Escherichia coli O103:H11 serotype Increases
0 1 Escherichia coli O103:H25 serotype Increases
0 1 Escherichia coli O104:H21 serotype Increases
0 1 Escherichia coli O111:H11 serotype Increases
0 1 Escherichia coli O111:H8 serotype Increases
0 1 Escherichia coli O112ac:H19 serotype Increases
0 1 Escherichia coli O114:H49 serotype Increases
0 1 Escherichia coli O118:H16 serotype Increases
0 1 Escherichia coli O121:H7 serotype Increases
0 1 Escherichia coli O123:H11 serotype Increases
0 1 Escherichia coli O127:H27 serotype Increases
0 1 Escherichia coli O127:H6 serotype Increases
0 1 Escherichia coli O128:H2 serotype Increases
0 1 Escherichia coli O128ac:H12 serotype Increases
0 1 Escherichia coli O145:H25 serotype Increases
0 1 Escherichia coli O145:NM serotype Increases
0 1 Escherichia coli O146:H21 serotype Increases
0 1 Escherichia coli O153:H2 serotype Increases
0 1 Escherichia coli O156:H25 serotype Increases
0 1 Escherichia coli O157:H43 serotype Increases
0 1 Escherichia coli O157:NM serotype Increases
0 1 Escherichia coli O165:H25 serotype Increases
0 1 Escherichia coli O174:H2 serotype Increases
0 1 Escherichia coli O174:H21 serotype Increases
0 1 Escherichia coli O174:H8 serotype Increases
0 1 Escherichia coli O176:H45 serotype Increases
0 1 Escherichia coli O177:NM serotype Increases
0 1 Escherichia coli O26:H1 serotype Increases
0 1 Escherichia coli O28ac:NM serotype Increases
0 1 Escherichia coli O29:H4 serotype Increases
0 1 Escherichia coli O32:H37 serotype Increases
0 1 Escherichia coli O6:H16:CFA/II serotype Increases
0 1 Escherichia coli O69:H11 serotype Increases
0 1 Escherichia coli O78:H12 serotype Increases
0 1 Escherichia coli O79:H7 serotype Increases
0 1 Escherichia coli O81:NM serotype Increases
0 1 Escherichia coli O86:H34 serotype Increases
0 1 Escherichia coli O91:H14 serotype Increases
0 1 Escherichia coli O91:NM serotype Increases
0 1 Escherichia coli ONT:H33 serotype Increases
0 1 Escherichia coli O1:HNT serotype Increases
0 1 Escherichia ruysiae species Increases
0 1 Kluyvera genomosp. 3 species Increases
0 1 Escherichia marmotae species Increases
0 1 Kluyvera intermedia species Increases
0 1 Escherichia fergusonii species Increases
0 1 Bacillus glycinifermentans species Increases
0 1 Bacillus aeolius species Increases
0 1 Bacillus aerius species Increases
0 1 Bacillus alcaliinulinus species Increases
0 1 Bacillus alkalicellulosilyticus species Increases
0 1 Bacillus alveayuensis species Increases
0 1 Bacillus aquiflavi species Increases
0 1 Bacillus arachidis species Increases
0 1 Bacillus arbutinivorans species Increases
0 1 Bacillus badius species Increases
0 1 Bacillus benzoevorans species Increases
0 1 Bacillus cabrialesii species Increases
0 1 Bacillus canaveralius species Increases
0 1 Bacillus carboniphilus species Increases
0 1 Bacillus coahuilensis species Increases
0 1 Bacillus djibelorensis species Increases
0 1 Bacillus ferrariarum species Increases
0 1 Bacillus fonticola species Increases
0 1 Bacillus freudenreichii species Increases
0 1 Bacillus gobiensis species Increases
0 1 Bacillus hackensackii species Increases
0 1 Bacillus haynesii species Increases
0 1 Bacillus horti species Increases
0 1 Bacillus infantis species Increases
0 1 Bacillus infernus species Increases
0 1 Bacillus intestinalis Tetz and Tetz 2017 species Increases
0 1 Bacillus isabeliae species Increases
0 1 Bacillus mediterraneensis species Increases
0 1 Bacillus methanolicus species Increases
0 1 Bacillus nematocida species Increases
0 1 Bacillus olivae species Increases
0 1 Bacillus pakistanensis species Increases
0 1 Bacillus pseudomegaterium species Increases
0 1 Bacillus rugosus species Increases
0 1 Bacillus shandongensis species Increases
0 1 Bacillus shivajii species Increases
0 1 Bacillus smithii species Increases
0 1 Bacillus solimangrovi species Increases
0 1 Bacillus thermoamyloliquefaciens species Increases
0 1 Bacillus thermoproteolyticus species Increases
0 1 Bacillus thermotolerans species Increases
0 1 Bacillus tianmuensis species Increases
0 1 Bacillus weihaiensis species Increases
0 1 Bacillus xiamenensis species Increases
0 1 Cytobacillus dafuensis species Increases
0 1 Kluyvera cryocrescens species Increases
0 1 Kluyvera georgiana species Increases
0 1 Bacillus safensis species Increases
0 1 Escherichia albertii species Increases
0 1 Bacillus pumilus species Increases
0 1 Kluyvera ascorbata species Increases
1 0 Escherichia coli species Increases
1 0 Lysinibacillus sphaericus species Increases
0 1 Bacillus altitudinis complex species group Increases
0 1 Bacillus cereus group species group Increases
0 1 Bacillus subtilis group species group Increases
0 1 Escherichia coli APEC O1 strain Increases
0 1 Escherichia coli IAI39 strain Increases
0 1 Escherichia coli ED1a strain Increases
0 1 Escherichia coli K-12 strain Increases
0 1 Escherichia coli UMNF18 strain Increases
0 1 Escherichia coli FAP1 strain Increases
0 1 Escherichia coli SE11 strain Increases
0 1 Escherichia coli O15:H11 strain Increases
0 1 Escherichia coli O178:H19 strain Increases
0 1 Escherichia coli O157:H16 strain Increases
0 1 Escherichia coli ATCC 8739 strain Increases
0 1 Escherichia coli O22:H8 strain Increases
0 1 Escherichia coli O169:H41 strain Increases
0 1 Escherichia coli VR50 strain Increases
0 1 Escherichia coli UM146 strain Increases
0 1 Escherichia coli E110019 strain Increases
0 1 Escherichia coli IHE3034 strain Increases
0 1 Escherichia coli CFT073 strain Increases
0 1 Escherichia coli SE15 strain Increases
0 1 Escherichia coli LF82 strain Increases
0 1 Escherichia coli PMV-1 strain Increases
0 1 Escherichia coli APEC O2-211 strain Increases
0 1 Escherichia coli APEC IMT5155 strain Increases
0 1 Escherichia coli B str. REL606 strain Increases
0 1 Escherichia coli 'BL21-Gold(DE3)pLysS AG' strain Increases
0 1 Escherichia coli D9 strain Increases
0 1 Escherichia coli DORA_A_5_14_21 strain Increases
0 1 Escherichia coli G3/10 strain Increases
0 1 Escherichia coli HS strain Increases
0 1 Escherichia coli HVH 154 (4-5636698) strain Increases
0 1 Escherichia coli HVH 175 (4-3405184) strain Increases
0 1 Escherichia coli KO11FL strain Increases
0 1 Escherichia coli M12 strain Increases
0 1 Escherichia coli M17 strain Increases
0 1 Escherichia coli M8 strain Increases
0 1 Escherichia coli MS 107-1 strain Increases
0 1 Escherichia coli MS 115-1 strain Increases
0 1 Escherichia coli Nissle 1917 strain Increases
0 1 Escherichia coli P12b strain Increases
0 1 Escherichia coli PCN033 strain Increases
0 1 Escherichia coli STEC_DG131-3 strain Increases
0 1 Escherichia coli TW11917 strain Increases
0 1 Escherichia coli UMEA 3271-1 strain Increases
0 1 Escherichia coli UMN026 strain Increases
0 1 Escherichia coli UTI89 strain Increases
0 1 Escherichia coli ECC-1470 strain Increases

Impact of SAM-e on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Allergic Rhinitis (Hay Fever) 0.6 0.6 0
Allergies 1.2 -1.2
Allergy to milk products 0.6 0.6 0
Alzheimer's disease 0.6 0.6 0
Amyotrophic lateral sclerosis (ALS) Motor Neuron 0.6 1.2 -1
Ankylosing spondylitis 1.2 -1.2
Antiphospholipid syndrome (APS) 0.6 -0.6
Asthma 0.6 -0.6
Atherosclerosis 0.6 -0.6
Atrial fibrillation 0.6 0.6
Autism 1.2 0.6 1
Autoimmune Disease 0.6 -0.6
benign prostatic hyperplasia 0.6 -0.6
Biofilm 0.6 -0.6
Bipolar Disorder 0.6 -0.6
Breast Cancer 0.6 -0.6
Carcinoma 0.6 -0.6
Celiac Disease 0.6 -0.6
Chronic Fatigue Syndrome 0.6 -0.6
Chronic Kidney Disease 0.6 -0.6
Chronic Obstructive Pulmonary Disease (COPD) 0.6 -0.6
Chronic Urticaria (Hives) 1.2 -1.2
Coagulation / Micro clot triggering bacteria 1.2 -1.2
Colorectal Cancer 0.6 1.5 -1.5
Constipation 1.2 -1.2
Coronary artery disease 1.2 -1.2
COVID-19 1.2 -1.2
Crohn's Disease 1.2 -1.2
cystic fibrosis 1.2 -1.2
d-lactic acidosis (one form of brain fog) 0.6 -0.6
deep vein thrombosis 1.2 -1.2
Depression 0.6 1.2 -1
Eczema 0.6 -0.6
Endometriosis 0.6 1.2 -1
Epilepsy 1.2 -1.2
erectile dysfunction 0.6 -0.6
Functional constipation / chronic idiopathic constipation 1.2 -1.2
gallstone disease (gsd) 1.2 -1.2
Generalized anxiety disorder 1.2 -1.2
Heart Failure 1.2 -1.2
High Histamine/low DAO 0.8 -0.8
hypercholesterolemia (High Cholesterol) 0.6 -0.6
hyperglycemia 1.2 -1.2
hypertension (High Blood Pressure 0.6 -0.6
Hypothyroidism 0.6 -0.6
Hypoxia 1.2 -1.2
Inflammatory Bowel Disease 0.6 1.2 -1
Intelligence 0.6 -0.6
Irritable Bowel Syndrome 1.2 -1.2
ischemic stroke 0.6 0.6 0
Liver Cirrhosis 0.6 1.2 -1
Long COVID 0.6 -0.6
Lung Cancer 0.6 -0.6
Lymphoma 0.6 -0.6
Mast Cell Issues / mastitis 0.6 -0.6
Metabolic Syndrome 1.2 -1.2
Mood Disorders 0.6 0.6 0
Multiple Sclerosis 0.6 -0.6
myasthenia gravis 0.6 -0.6
Neuropathy (all types) 0.6 0.6
neuropsychiatric disorders (PANDAS, PANS) 0.6 -0.6
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 1.2 -1.2
Obesity 1.2 -1.2
obsessive-compulsive disorder 1.2 -1.2
Osteoarthritis 0.6 -0.6
Osteoporosis 0.6 -0.6
pancreatic cancer 0.6 -0.6
Parkinson's Disease 0.6 1.2 -1
Polycystic ovary syndrome 0.6 -0.6
Psoriasis 0.6 -0.6
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 0.6 -0.6
Rosacea 0.3 -0.3
Schizophrenia 0.6 -0.6
scoliosis 0.6 -0.6
Sjögren syndrome 0.6 -0.6
Slow gastric motility / Gastroparesis 0.6 -0.6
Small Intestinal Bacterial Overgrowth (SIBO) 0.6 -0.6
Stress / posttraumatic stress disorder 0.6 -0.6
Systemic Lupus Erythematosus 0.6 -0.6
Type 1 Diabetes 0.6 -0.6
Type 2 Diabetes 0.6 1.2 -1
Ulcerative colitis 1.2 -1.2

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