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Blood Sugar Control: Berberine has been extensively studied for its ability to help manage blood sugar levels. It works by improving insulin sensitivity, reducing insulin resistance, and increasing glucose uptake in cells. Several studies have shown that berberine supplementation can be effective in lowering fasting blood sugar levels and hemoglobin A1c (HbA1c) levels in individuals with type 2 diabetes or insulin resistance.
Cholesterol Reduction: Berberine may also have a beneficial effect on lipid metabolism, leading to a reduction in total cholesterol, LDL cholesterol, and triglyceride levels. By inhibiting cholesterol synthesis in the liver and increasing LDL receptor expression, berberine helps improve lipid profiles and may reduce the risk of cardiovascular disease.
Weight Management: Some research suggests that berberine supplementation may aid in weight loss and obesity management. Berberine has been shown to increase fat metabolism, inhibit fat accumulation, and reduce appetite, resulting in potential benefits for individuals struggling with overweight or obesity.
Anti-inflammatory Properties: Berberine exhibits anti-inflammatory properties by suppressing pro-inflammatory cytokines and signaling pathways. It may help alleviate symptoms of inflammatory conditions such as arthritis, inflammatory bowel disease (IBD), and metabolic syndrome.
Antimicrobial Effects: Berberine has potent antimicrobial properties and has been traditionally used to treat various infections. It can inhibit the growth of bacteria, viruses, fungi, and parasites, making it effective against conditions such as bacterial diarrhea, fungal infections, and respiratory tract infections.
Gastrointestinal Health: Berberine has been investigated for its potential benefits in promoting gastrointestinal health. It may help alleviate symptoms of diarrhea, irritable bowel syndrome (IBS), and other gastrointestinal disorders by modulating gut microbiota, reducing inflammation, and enhancing intestinal barrier function.
Cardiovascular Health: In addition to its cholesterol-lowering effects, berberine may offer cardiovascular protection by improving endothelial function, reducing blood pressure, and preventing atherosclerosis. These properties contribute to overall heart health and may reduce the risk of cardiovascular events.
Neuroprotective Effects: Some studies suggest that berberine has neuroprotective properties and may help protect against neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Berberine exhibits antioxidant activity and can cross the blood-brain barrier, potentially exerting beneficial effects on brain function and cognitive health.
Liver Health: Berberine has been investigated for its hepatoprotective effects and may help improve liver function and reduce liver damage in conditions such as fatty liver disease, hepatitis, and liver fibrosis. It acts by reducing inflammation, oxidative stress, and lipid accumulation in the liver.
Anti-cancer Potential: Preliminary studies suggest that berberine may have anti-cancer properties and could inhibit the growth and spread of cancer cells. It may induce apoptosis (programmed cell death), inhibit angiogenesis (formation of new blood vessels), and modulate various signaling pathways involved in cancer progression.
Found in goldenseal, Chinese goldthread, barberry, tree turmeric, Oregon grape
Rank | Probiotic | Impact |
---|---|---|
genus | Bacillus | Reduces |
genus | Bifidobacterium | Increases |
genus | Pediococcus | Increases |
genus | Saccharomyces | Reduces |
no rank | unclassified Bacteria | Increases |
order | Micrococcales | Reduces |
order | Rhodospirillales | Reduces |
species | Akkermansia muciniphila | Increases |
species | Alkalihalophilus pseudofirmus | Reduces |
species | Bacillus aeolius | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
π Direct Citations | πͺπΆ Indirect Citations | Taxonomy | Rank | Effect |
---|---|---|---|---|
15 | 4 | Bacteroides | genus | Increases |
15 | 1 | Akkermansia | genus | Increases |
12 | 0 | Lactobacillus | genus | Increases |
10 | 2 | Blautia | genus | Increases |
9 | 7 | Lachnospiraceae | family | Increases |
9 | 1 | Escherichia coli | species | Decreases |
9 | 1 | Staphylococcus aureus | species | Decreases |
6 | 5 | Enterobacteriaceae | family | Decreases |
6 | 1 | Prevotella | genus | Increases |
6 | 0 | Bacillota | phylum | Decreases |
6 | 0 | Pseudomonas aeruginosa | species | Decreases |
5 | 2 | Erysipelotrichaceae | family | Increases |
5 | 0 | Bifidobacterium | genus | Increases |
4 | 12 | Bacteroidaceae | family | Increases |
4 | 11 | Lactobacillaceae | family | Increases |
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive β X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
---|---|---|---|
Abdominal Aortic Aneurysm | 0.7 | 1.1 | -0.57 |
Acne | 4.2 | 2.7 | 0.56 |
Addison's Disease (hypocortisolism) | 0.2 | 0.2 | |
ADHD | 6.5 | 5.2 | 0.25 |
Age-Related Macular Degeneration and Glaucoma | 0.7 | 0.7 | 0 |
Allergic Rhinitis (Hay Fever) | 5.4 | 7.3 | -0.35 |
Allergies | 12.6 | 12.9 | -0.02 |
Allergy to milk products | 4.4 | 6 | -0.36 |
Alopecia (Hair Loss) | 4.8 | 3.1 | 0.55 |
Alzheimer's disease | 19.2 | 16.2 | 0.19 |
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