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Bacterial Infections: Kanamycin A sulfate is primarily used to treat bacterial infections caused by susceptible organisms. It works by inhibiting bacterial protein synthesis, thereby preventing bacterial growth and replication.
Respiratory Tract Infections: Kanamycin A sulfate may be used to treat respiratory tract infections, including pneumonia, bronchitis, and bronchiectasis caused by susceptible bacteria. It is particularly effective against gram-negative bacteria.
Urinary Tract Infections: This antibiotic can be prescribed for the treatment of urinary tract infections caused by susceptible organisms, such as Escherichia coli, Proteus species, and Klebsiella pneumoniae.
Intra-abdominal Infections: Kanamycin A sulfate may be used as part of the treatment regimen for intra-abdominal infections, including peritonitis and intra-abdominal abscesses, especially in cases where other antibiotics are ineffective or contraindicated.
Skin and Soft Tissue Infections: Kanamycin A sulfate may be used to treat skin and soft tissue infections caused by susceptible bacteria, such as cellulitis, abscesses, and infected wounds.
Eye Infections: Ophthalmic preparations of kanamycin A sulfate are available for the treatment of eye infections, including bacterial conjunctivitis and keratitis caused by susceptible organisms.
Tuberculosis: Kanamycin A sulfate is sometimes used as part of combination therapy for the treatment of drug-resistant tuberculosis, particularly in cases where other first-line and second-line tuberculosis drugs are ineffective.
Cystic Fibrosis: In patients with cystic fibrosis, kanamycin A sulfate may be used to treat chronic respiratory infections caused by Pseudomonas aeruginosa and other bacteria commonly associated with the condition.
Hospital-acquired Infections: Kanamycin A sulfate may be used in hospitals to treat infections caused by multidrug-resistant bacteria, including those acquired in healthcare settings.
Adverse Effects: Common side effects associated with kanamycin A sulfate include nephrotoxicity (kidney damage), ototoxicity (hearing loss or vestibular dysfunction), and neurotoxicity (central nervous system effects). Monitoring of kidney function and hearing is necessary during treatment.
Resistance: The emergence of bacterial resistance to kanamycin A sulfate is a concern with prolonged or inappropriate use. Resistance monitoring and prudent antibiotic use are essential to mitigate the development of resistant bacterial strains.
Pregnancy and Lactation: Kanamycin A sulfate is generally considered safe for use during pregnancy and lactation when the benefits outweigh the risks. However, healthcare providers should weigh the potential risks and benefits before prescribing kanamycin A sulfate to pregnant or breastfeeding women.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
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