🍽️ Metaproterenol sulfate, orciprenaline sulfate

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Bronchodilation: Metaproterenol sulfate works by stimulating beta-2 adrenergic receptors in the smooth muscle of the airways. Activation of these receptors leads to relaxation of the bronchial smooth muscle, resulting in bronchodilation. This effect helps to alleviate bronchospasm, improve airflow, and relieve symptoms such as wheezing, shortness of breath, and chest tightness in conditions like asthma and COPD.
Acute Asthma Attacks: Metaproterenol sulfate is often used as a rescue medication to quickly relieve symptoms during acute asthma attacks. Its fast-acting bronchodilator effects help to rapidly open up narrowed airways, allowing for easier breathing and improved oxygenation.
Maintenance Therapy: In addition to its use as a rescue medication, metaproterenol sulfate may also be prescribed as a maintenance therapy for individuals with persistent asthma or COPD. Regular use of the medication helps to prevent or minimize bronchospasm and maintain stable lung function over time.
Exercise-Induced Bronchospasm: Metaproterenol sulfate may be used prophylactically before exercise or physical activity to prevent exercise-induced bronchospasm in individuals with asthma or exercise-induced asthma. By opening up the airways, it can help improve exercise tolerance and reduce the risk of asthma symptoms during physical exertion.
Side Effects: Common side effects associated with metaproterenol sulfate may include palpitations, tremor, nervousness, headache, dizziness, nausea, and throat irritation. These side effects are usually mild and transient. Rare but potentially serious side effects may include cardiac arrhythmias (irregular heart rhythms), hypertension (high blood pressure), hypokalemia (low potassium levels), and paradoxical bronchospasm (worsening of breathing difficulty).
Tolerance and Loss of Effectiveness: Prolonged use of metaproterenol sulfate may lead to tolerance, where the medication becomes less effective over time. This phenomenon may necessitate dose adjustments or the addition of other medications to maintain optimal asthma control.
Contraindications: Metaproterenol sulfate is contraindicated in patients with a known hypersensitivity to the medication or its components. It should be used with caution in patients with certain cardiovascular conditions such as severe hypertension, tachyarrhythmias (rapid heart rhythms), and ischemic heart disease.
Drug Interactions: Metaproterenol sulfate may interact with other medications that affect heart rate or blood pressure, such as beta-blockers, calcium channel blockers, and monoamine oxidase inhibitors (MAOIs). Concurrent use of these medications may potentiate or attenuate the effects of metaproterenol sulfate, necessitating careful monitoring and dose adjustments.
Administration: Metaproterenol sulfate is typically administered via inhalation using a metered-dose inhaler (MDI) or a nebulizer device. Proper inhalation technique is important to ensure optimal drug delivery to the lungs and maximize therapeutic efficacy.

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Data Contradictions — Limits of Certainity

Impacted of Metaproterenol sulfate, orciprenaline sulfate On Probiotics

Rank	Probiotic	Impact
genus	Bifidobacterium	Reduces
species	Bifidobacterium adolescentis	Reduces
species	Bifidobacterium breve	Reduces
species	Bifidobacterium longum	Reduces
species	Escherichia coli	Reduces
species	Veillonella atypica	Reduces
subspecies	Bifidobacterium longum subsp. infantis	Reduces
subspecies	Bifidobacterium longum subsp. longum	Reduces

Bacteria Impacted by Metaproterenol sulfate, orciprenaline sulfate

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

🧙?
📓 Direct Citations	👪👶 Indirect Citations	Taxonomy	Rank	Effect
0	1	Collinsella	genus	Decreases
0	1	Ruminococcus	genus	Decreases
0	1	Roseburia	genus	Decreases
0	1	Veillonella	genus	Decreases
0	1	Bacteroides	genus	Decreases
0	1	Odoribacter	genus	Decreases
0	1	Bifidobacterium	genus	Decreases
0	1	Lachnospira	genus	Decreases
0	1	Parolsenella	genus	Decreases
0	1	Blautia	genus	Decreases
0	1	Agathobacter	genus	Decreases
0	1	Eggerthella	genus	Decreases
0	1	Clostridioides	genus	Decreases
0	1	Enterocloster	genus	Decreases
0	1	Mediterraneibacter	genus	Decreases
0	1	Coprococcus	genus	Decreases
0	1	Dorea	genus	Decreases
0	1	Escherichia	genus	Decreases
0	1	Escherichia coli O1:K1:H7	no rank	Decreases
0	1	Escherichia coli O139:H1	no rank	Decreases
0	1	Escherichia coli O141:H4	no rank	Decreases
0	1	Escherichia coli O145:H34	no rank	Decreases
0	1	Escherichia coli O15:H12	no rank	Decreases
0	1	Escherichia coli O155:H21	no rank	Decreases
0	1	Escherichia coli O158:H23	no rank	Decreases
0	1	Escherichia coli O16:H48	no rank	Decreases
0	1	Escherichia coli O170:H18	no rank	Decreases
0	1	Escherichia coli O18ac:H14	no rank	Decreases
0	1	Escherichia coli O19:H7	no rank	Decreases
0	1	Escherichia coli O2:K1:H4	no rank	Decreases
0	1	Escherichia coli O2:K1:H5	no rank	Decreases
0	1	Escherichia coli O2:K1:H7	no rank	Decreases
0	1	Escherichia coli O20:H12	no rank	Decreases
0	1	Escherichia coli O25:H16	no rank	Decreases
0	1	Escherichia coli O55:H7	no rank	Decreases
0	1	Escherichia coli O68:H12	no rank	Decreases
0	1	Escherichia coli O7:H15	no rank	Decreases
0	1	Escherichia coli O78:H51	no rank	Decreases
0	1	Escherichia coli O80:H26	no rank	Decreases
0	1	Escherichia coli O84:H7	no rank	Decreases
0	1	Escherichia coli O85:H1	no rank	Decreases
0	1	Escherichia coli O103	serogroup	Decreases
0	1	Escherichia coli O111	serogroup	Decreases
0	1	Escherichia coli O119	serogroup	Decreases
0	1	Escherichia coli O121	serogroup	Decreases
0	1	Escherichia coli O145	serogroup	Decreases
0	1	Escherichia coli O155	serogroup	Decreases
0	1	Escherichia coli O157	serogroup	Decreases
0	1	Escherichia coli O177	serogroup	Decreases
0	1	Escherichia coli O26	serogroup	Decreases
0	1	Escherichia coli O3	serogroup	Decreases
0	1	Escherichia coli O43	serogroup	Decreases
0	1	Escherichia coli O5	serogroup	Decreases
0	1	Escherichia coli O78	serogroup	Decreases
0	1	Escherichia coli O86	serogroup	Decreases
0	1	Escherichia coli O91	serogroup	Decreases
0	1	Escherichia coli H20	serotype	Decreases
0	1	Escherichia coli O1:H42	serotype	Decreases
0	1	Escherichia coli O1:HNT	serotype	Decreases
0	1	Escherichia coli O10:H32	serotype	Decreases
0	1	Escherichia coli O10:K5(L):H4	serotype	Decreases
0	1	Escherichia coli O100:H21	serotype	Decreases
0	1	Escherichia coli O103:H11	serotype	Decreases
0	1	Escherichia coli O103:H2	serotype	Decreases
0	1	Escherichia coli O103:H25	serotype	Decreases
0	1	Escherichia coli O104:H21	serotype	Decreases
0	1	Escherichia coli O104:H4	serotype	Decreases
0	1	Escherichia coli O111:H-	serotype	Decreases
0	1	Escherichia coli O111:H11	serotype	Decreases
0	1	Escherichia coli O111:H8	serotype	Decreases
0	1	Escherichia coli O111:NM	serotype	Decreases
0	1	Escherichia coli O112ab:H8	serotype	Decreases
0	1	Escherichia coli O112ac:H19	serotype	Decreases
0	1	Escherichia coli O113:H21	serotype	Decreases
0	1	Escherichia coli O114:H49	serotype	Decreases
0	1	Escherichia coli O118:H16	serotype	Decreases
0	1	Escherichia coli O121:H19	serotype	Decreases
0	1	Escherichia coli O121:H7	serotype	Decreases
0	1	Escherichia coli O123:H11	serotype	Decreases
0	1	Escherichia coli O125ac:K+:H10	serotype	Decreases
0	1	Escherichia coli O126:H45	serotype	Decreases
0	1	Escherichia coli O127:H27	serotype	Decreases
0	1	Escherichia coli O127:H6	serotype	Decreases
0	1	Escherichia coli O128:H2	serotype	Decreases
0	1	Escherichia coli O128ac:H12	serotype	Decreases
0	1	Escherichia coli O139:H28	serotype	Decreases
0	1	Escherichia coli O145:H25	serotype	Decreases
0	1	Escherichia coli O145:H28	serotype	Decreases
0	1	Escherichia coli O145:NM	serotype	Decreases
0	1	Escherichia coli O146:H21	serotype	Decreases
0	1	Escherichia coli O15:H18	serotype	Decreases
0	1	Escherichia coli O150:H6	serotype	Decreases
0	1	Escherichia coli O152:H23	serotype	Decreases
0	1	Escherichia coli O153:H2	serotype	Decreases
0	1	Escherichia coli O156:H25	serotype	Decreases
0	1	Escherichia coli O157:H-	serotype	Decreases
0	1	Escherichia coli O157:H43	serotype	Decreases
0	1	Escherichia coli O157:H7	serotype	Decreases
0	1	Escherichia coli O157:NM	serotype	Decreases
0	1	Escherichia coli O16:H6	serotype	Decreases
0	1	Escherichia coli O165:H25	serotype	Decreases
0	1	Escherichia coli O167:H26	serotype	Decreases
0	1	Escherichia coli O174:H2	serotype	Decreases
0	1	Escherichia coli O174:H21	serotype	Decreases
0	1	Escherichia coli O174:H8	serotype	Decreases
0	1	Escherichia coli O176:H45	serotype	Decreases
0	1	Escherichia coli O177:NM	serotype	Decreases
0	1	Escherichia coli O2:H6	serotype	Decreases
0	1	Escherichia coli O2:K2:H1	serotype	Decreases
0	1	Escherichia coli O25:H1	serotype	Decreases
0	1	Escherichia coli O25:NM	serotype	Decreases
0	1	Escherichia coli O26:H1	serotype	Decreases
0	1	Escherichia coli O26:H11	serotype	Decreases
0	1	Escherichia coli O28ac:NM	serotype	Decreases
0	1	Escherichia coli O29:H4	serotype	Decreases
0	1	Escherichia coli O32:H37	serotype	Decreases
0	1	Escherichia coli O39:NM	serotype	Decreases
0	1	Escherichia coli O44:H18	serotype	Decreases
0	1	Escherichia coli O45:H2	serotype	Decreases
0	1	Escherichia coli O6:H16	serotype	Decreases
0	1	Escherichia coli O6:H16:CFA/II	serotype	Decreases
0	1	Escherichia coli O6:K2:H1	serotype	Decreases
0	1	Escherichia coli O69:H11	serotype	Decreases
0	1	Escherichia coli O7:H4	serotype	Decreases
0	1	Escherichia coli O7:K1	serotype	Decreases
0	1	Escherichia coli O78:H12	serotype	Decreases
0	1	Escherichia coli O78:H4	serotype	Decreases
0	1	Escherichia coli O79:H7	serotype	Decreases
0	1	Escherichia coli O8:H8	serotype	Decreases
0	1	Escherichia coli O81:NM	serotype	Decreases
0	1	Escherichia coli O83:H1	serotype	Decreases
0	1	Escherichia coli O86:H34	serotype	Decreases
0	1	Escherichia coli O89m:H10	serotype	Decreases
0	1	Escherichia coli O89m:H9	serotype	Decreases
0	1	Escherichia coli O9:H10	serotype	Decreases
0	1	Escherichia coli O91:H14	serotype	Decreases
0	1	Escherichia coli O91:NM	serotype	Decreases
0	1	Escherichia coli O99:H6	serotype	Decreases
0	1	Escherichia coli ONT:H33	serotype	Decreases
1	0	Bacteroides ovatus	species	Decreases
1	0	Ruminococcus bromii	species	Decreases
1	0	Roseburia hominis	species	Decreases
1	0	Collinsella aerofaciens	species	Decreases
1	0	Bifidobacterium longum	species	Decreases
1	0	Veillonella parvula	species	Decreases
1	0	Bacteroides caccae	species	Decreases
1	0	Odoribacter splanchnicus	species	Decreases
1	0	Bacteroides xylanisolvens	species	Decreases
1	0	Lachnospira eligens	species	Decreases
0	1	Bacteroides luhongzhouii	species	Decreases
0	1	Veillonella rodentium	species	Decreases
0	1	Bacteroides sp. D2	species	Decreases
0	1	Bacteroides sp. M10	species	Decreases
0	1	Bifidobacterium breve	species	Decreases
0	1	Veillonella dispar	species	Decreases
0	1	Bacteroides sp. DH3716P	species	Decreases
0	1	Veillonella sp. S12025-13	species	Decreases
0	1	Veillonella nakazawae	species	Decreases
0	1	Parolsenella massiliensis	species	Decreases
1	0	Bifidobacterium adolescentis	species	Decreases
1	0	Blautia obeum	species	Decreases
0	1	Collinsella stercoris	species	Decreases
0	1	Bacteroides faecium	species	Decreases
1	0	Agathobacter rectalis	species	Decreases
0	1	Veillonella rogosae	species	Decreases
0	1	Parolsenella catena	species	Decreases
0	1	Bacteroides caecimuris	species	Decreases
0	1	Veillonella atypica	species	Decreases
0	1	Parafannyhessea umbonata	species	Decreases
0	1	Butyricimonas virosa	species	Decreases
1	0	Eggerthella lenta	species	Decreases
0	1	Coprobacter secundus	species	Decreases
0	1	Butyricimonas faecalis	species	Decreases
0	1	Barnesiella viscericola	species	Decreases
0	1	Alistipes sp. dk3624	species	Decreases
0	1	Alistipes megaguti	species	Decreases
1	0	Clostridioides difficile	species	Decreases
1	0	Enterocloster bolteae	species	Decreases
1	0	[Ruminococcus] torques	species	Decreases
1	0	Coprococcus comes	species	Decreases
1	0	Dorea formicigenerans	species	Decreases
1	0	Escherichia coli	species	Decreases
0	1	Bifidobacterium longum subsp. infantis	subspecies	Decreases
0	1	Bifidobacterium longum subsp. longum	subspecies	Decreases
0	1	Bifidobacterium longum subsp. suillum	subspecies	Decreases
0	1	Bifidobacterium longum subsp. suis	subspecies	Decreases

Impact of Metaproterenol sulfate, orciprenaline sulfate on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition	Positive Impact	Negative Impact	Benefit Ratio Impact
Acne		0.2	-0.2
ADHD	2.5	0.1	24
Age-Related Macular Degeneration and Glaucoma	0.3		0.3
Allergic Rhinitis (Hay Fever)	0.6	1	-0.67
Allergies	2.4	1.5	0.6
Allergy to milk products	1	0.5	1
Alopecia (Hair Loss)	0.5		0.5
Alzheimer's disease	2.1	3.3	-0.57
Amyotrophic lateral sclerosis (ALS) Motor Neuron	0.8	0.3	1.67
Ankylosing spondylitis	1.4	0.7	1
Anorexia Nervosa	0.6	1.4	-1.33
Antiphospholipid syndrome (APS)	0		0
Asthma	2.2	1.2	0.83
Atherosclerosis	1.2	0.7	0.71
Atrial fibrillation	1.4	0.6	1.33
Autism	2.6	3.1	-0.19
Autoimmune Disease	0.2	0.5	-1.5
Barrett esophagus cancer	0.3		0.3
benign prostatic hyperplasia	0	0.3	0
Biofilm	0.3		0.3
Bipolar Disorder	0.6	1	-0.67
Brain Trauma	0.6	1.1	-0.83
Breast Cancer	0		0
Cancer (General)	0.5	1.5	-2
Carcinoma	1.6	1.5	0.07
Celiac Disease	1	2.1	-1.1
Cerebral Palsy	0.7	0.9	-0.29
Chronic Fatigue Syndrome	2.6	2	0.3
Chronic Kidney Disease	1.7	1.2	0.42
Chronic Lyme	0.1	0.6	-5
Chronic Obstructive Pulmonary Disease (COPD)	0.3	0.8	-1.67
Chronic Urticaria (Hives)	0.3		0.3
Coagulation / Micro clot triggering bacteria	0	0.7	0
Cognitive Function	1.2	0.7	0.71
Colorectal Cancer	1.4	1.3	0.08
Constipation	0.7	0.4	0.75
Coronary artery disease	0.8	1.3	-0.63
COVID-19	3.7	5	-0.35
Crohn's Disease	2.2	2.5	-0.14
Cushing's Syndrome (hypercortisolism)		0.3	-0.3
cystic fibrosis	0	1	0
d-lactic acidosis (one form of brain fog)	0		0
deep vein thrombosis	0.1	0.9	-8
Denture Wearers Oral Shifts	0.5		0.5
Depression	3.6	4.5	-0.25
Dermatomyositis		0.2	-0.2
Eczema	0.3	0.4	-0.33
Endometriosis	0.6	1.3	-1.17
Eosinophilic Esophagitis		0.3	-0.3
Epilepsy	1	0.5	1
erectile dysfunction	0.3	0.2	0.5
Fibromyalgia	0.7	0.5	0.4
Functional constipation / chronic idiopathic constipation	2.4	1.8	0.33
gallstone disease (gsd)	0.7	0.5	0.4
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	0.3	0.5	-0.67
Generalized anxiety disorder	0.5	1.1	-1.2
Gout	1.5	0	0
Graves' disease	1.4	1.9	-0.36
Gulf War Syndrome	0.1	0.2	-1
Halitosis	0.5		0.5
Hashimoto's thyroiditis	1.5	0.7	1.14
Heart Failure	1	1	0
hemorrhagic stroke	0		0
Hidradenitis Suppurativa	0.4	0.3	0.33
High Histamine/low DAO	0.3	0.5	-0.67
hypercholesterolemia (High Cholesterol)	0.2		0.2
hyperglycemia	0.5	0.5	0
Hyperlipidemia (High Blood Fats)	0.6	0.4	0.5
hypersomnia		0.5	-0.5
hypertension (High Blood Pressure	1.5	3.1	-1.07
Hypothyroidism		0.4	-0.4
Hypoxia	0.5		0.5
IgA nephropathy (IgAN)	0.6	2.4	-3
Inflammatory Bowel Disease	3	4.2	-0.4
Insomnia	0.7	1.6	-1.29
Intelligence	0.5		0.5
Intracranial aneurysms	0.6	0.5	0.2
Irritable Bowel Syndrome	3.1	2.6	0.19
ischemic stroke	1.7	0.6	1.83
Liver Cirrhosis	3	1.4	1.14
Long COVID	2.4	4.6	-0.92
Low bone mineral density		0.5	-0.5
Lung Cancer	0.5	0.4	0.25
Lymphoma	0		0
Mast Cell Issues / mastitis	0	0.5	0
ME/CFS with IBS	0.1	0.7	-6
ME/CFS without IBS	0.2	0.5	-1.5
Menopause	1.6	0.3	4.33
Metabolic Syndrome	3	3.3	-0.1
Mood Disorders	4.1	3.8	0.08
multiple chemical sensitivity [MCS]	0.3	0.1	2
Multiple Sclerosis	2	1.8	0.11
Multiple system atrophy (MSA)	0.6	0.6	0
myasthenia gravis	0	0.3	0
neuropathic pain	0.1	2	-19
Neuropathy (all types)	0.1	0.7	-6
neuropsychiatric disorders (PANDAS, PANS)	0.2		0.2
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	2.4	2.6	-0.08
NonCeliac Gluten Sensitivity	1	0.4	1.5
Obesity	4.9	2.4	1.04
obsessive-compulsive disorder	2.2	1	1.2
Osteoarthritis	0.3	0.8	-1.67
Osteoporosis	1.2	0.6	1
pancreatic cancer	0.2		0.2
Parkinson's Disease	3.1	1.9	0.63
Polycystic ovary syndrome	2	2	0
Postural orthostatic tachycardia syndrome		0.2	-0.2
Premenstrual dysphoric disorder	0.7		0.7
primary biliary cholangitis	0.3	0.4	-0.33
Primary sclerosing cholangitis	1.2	0.6	1
Psoriasis	1.5	0.8	0.88
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	3.7	2	0.85
Rosacea	0.6	0.3	1
Schizophrenia	3.3	1.6	1.06
scoliosis	0.1	0.6	-5
Sjögren syndrome	1.2	0.8	0.5
Sleep Apnea	0.6	0.7	-0.17
Slow gastric motility / Gastroparesis	0.8	0.2	3
Small Intestinal Bacterial Overgrowth (SIBO)	0.6	0.6	0
Stress / posttraumatic stress disorder	0.8	1.3	-0.63
Systemic Lupus Erythematosus	0.9	1.3	-0.44
Tic Disorder	0.5	0.6	-0.2
Tourette syndrome	0	0.3	0
Type 1 Diabetes	1.6	2.2	-0.38
Type 2 Diabetes	3.2	1.8	0.78
Ulcerative colitis	1	2.6	-1.6
Unhealthy Ageing	0.9	0.9	0
Vitiligo	0.9	0.4	1.25

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