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🍽️ Clomiphene citrate (Z,E)

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  1. Infertility in Women: Clomiphene citrate is a first-line treatment for anovulatory infertility, meaning infertility due to a lack of ovulation. It works by blocking estrogen receptors in the hypothalamus, leading to an increase in follicle-stimulating hormone (FSH) and luteinizing hormone (LH) secretion from the pituitary gland. This stimulates ovarian follicle development, which can result in ovulation. Clomiphene citrate may be used alone or in combination with other fertility treatments to improve the chances of conception in women with ovulatory disorders.

  2. Polycystic Ovary Syndrome (PCOS): Clomiphene citrate is often prescribed to women with PCOS who are trying to conceive. PCOS is a common endocrine disorder characterized by irregular menstrual cycles, hyperandrogenism (elevated male hormone levels), and polycystic ovaries. Clomiphene citrate can help induce ovulation and regulate menstrual cycles in women with PCOS, thereby improving fertility outcomes.

  3. Unexplained Infertility: Clomiphene citrate may be used in women with unexplained infertility, where no specific cause of infertility has been identified. By stimulating ovulation, clomiphene citrate can increase the likelihood of conception in women with unexplained infertility who have normal ovarian reserve and patent fallopian tubes.

  4. Male Factor Infertility: In some cases of male factor infertility, clomiphene citrate may be prescribed off-label to men to increase sperm production and improve sperm quality. Clomiphene citrate works by stimulating the release of gonadotropins (FSH and LH) from the pituitary gland, which in turn stimulates testosterone production and spermatogenesis (sperm production) in the testes.

  5. Luteal Phase Defect: Clomiphene citrate may be used to treat luteal phase defect, a condition where the endometrium (uterine lining) does not develop adequately to support implantation of a fertilized egg. By inducing ovulation and promoting normal ovarian function, clomiphene citrate can help improve the quality and duration of the luteal phase, which may increase the chances of successful implantation and pregnancy.

  6. Monitoring and Side Effects: During clomiphene citrate treatment, patients are typically monitored with ultrasound scans and hormonal assessments to track follicular development and ovulation. Common side effects of clomiphene citrate may include hot flashes, mood swings, breast tenderness, abdominal discomfort, headaches, and visual disturbances. Rare but serious side effects may include ovarian hyperstimulation syndrome (OHSS), multiple pregnancies (twins or higher-order multiples), and ovarian cyst formation.

  7. Contraindications and Precautions: Clomiphene citrate is contraindicated in women with liver disease, ovarian cysts, abnormal uterine bleeding, and certain hormone-sensitive cancers. It should be used with caution in women with a history of thromboembolic events, as clomiphene citrate may increase the risk of blood clots. Additionally, clomiphene citrate should only be prescribed by a qualified healthcare provider experienced in fertility treatment.

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⚗️ Compensation for antibiotic usage

Data Contradictions — Limits of Certainity

Impacted of Clomiphene citrate (Z,E) On Probiotics

Rank Probiotic Impact
genus Bacillus Reduces
genus Bifidobacterium Reduces
species Akkermansia muciniphila Reduces
species Anaerobutyricum hallii Reduces
species Bacteroides uniformis Reduces
species Bifidobacterium adolescentis Reduces
species Bifidobacterium bifidum Reduces
species Bifidobacterium breve Reduces
species Bifidobacterium catenulatum Reduces
species Bifidobacterium longum Reduces
species Blautia hansenii Reduces
species Blautia wexlerae Reduces
species Christensenella minuta Reduces
species Enterococcus faecium Reduces
species Escherichia coli Reduces
species Faecalibacterium prausnitzii Reduces
species Lacticaseibacillus paracasei Reduces
species Lactococcus cremoris Reduces
species Lactococcus lactis Reduces
species Parabacteroides distasonis Reduces
species Streptococcus thermophilus Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by Clomiphene citrate (Z,E)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Akkermansiaceae family Decreases
0 1 Roseburia genus Decreases
0 1 Lachnospira genus Decreases
0 1 Agathobacter genus Decreases
0 1 Collinsella genus Decreases
0 1 Blautia genus Decreases
0 1 Coprococcus genus Decreases
0 1 Parabacteroides genus Decreases
0 1 Lacrimispora genus Decreases
0 1 Phocaeicola genus Decreases
0 1 Clostridioides genus Decreases
0 1 Clostridium genus Decreases
0 1 Segatella genus Decreases
0 1 Lacticaseibacillus genus Decreases
0 1 Mediterraneibacter genus Decreases
0 1 Dorea genus Decreases
0 1 Streptococcus genus Decreases
0 1 Enterocloster genus Decreases
0 1 Bifidobacterium genus Decreases
0 1 Bacteroides genus Decreases
0 1 Odoribacter genus Decreases
0 1 Bilophila genus Decreases
0 1 Fusobacterium genus Decreases
0 1 Parolsenella genus Decreases
0 1 Eggerthella genus Decreases
0 1 Anaerobutyricum genus Decreases
0 1 Wansuia genus Decreases
1 0 Akkermansia genus Decreases
0 1 Butyrivibrio genus Decreases
0 1 Olsenella genus Decreases
0 1 Pseudobutyrivibrio genus Decreases
0 1 Anaerostipes genus Decreases
0 1 Flavonifractor genus Decreases
0 1 Faecalitalea genus Decreases
0 1 Komagataeibacter genus Decreases
0 1 Wujia genus Decreases
0 1 Catenibacterium genus Decreases
0 1 Ligilactobacillus genus Decreases
0 1 Massilistercora genus Decreases
0 1 Subdoligranulum genus Decreases
0 1 Qiania genus Decreases
0 1 Lachnoanaerobaculum genus Decreases
0 1 Treponema genus Decreases
0 1 Marvinbryantia genus Decreases
0 1 Novisyntrophococcus genus Decreases
0 1 Bacillus genus Decreases
0 1 Prevotella genus Decreases
0 1 Intestinibaculum genus Decreases
0 1 Eubacterium genus Decreases
0 1 Simiaoa genus Decreases
0 1 Longicatena genus Decreases
0 1 Christensenella genus Decreases
0 1 Faecalibacillus genus Decreases
0 1 Phoenicibacter genus Decreases
0 1 Allocoprobacillus genus Decreases
0 1 Thomasclavelia genus Decreases
0 1 Escherichia genus Decreases
0 1 Ruminococcus genus Decreases
0 1 Clostridium perfringens A no rank Decreases
0 1 Clostridium perfringens B no rank Decreases
0 1 Clostridium perfringens C no rank Decreases
0 1 Clostridium perfringens CPE no rank Decreases
0 1 Clostridium perfringens D no rank Decreases
0 1 Clostridium perfringens E no rank Decreases
0 1 environmental samples no rank Decreases
0 1 unclassified Akkermansia no rank Decreases
0 1 Escherichia coli O1:K1:H7 no rank Decreases
0 1 Escherichia coli O139:H1 no rank Decreases
0 1 Escherichia coli O141:H4 no rank Decreases
0 1 Escherichia coli O145:H34 no rank Decreases
0 1 Escherichia coli O15:H12 no rank Decreases
0 1 Escherichia coli O155:H21 no rank Decreases
0 1 Escherichia coli O158:H23 no rank Decreases
0 1 Escherichia coli O16:H48 no rank Decreases
0 1 Escherichia coli O170:H18 no rank Decreases
0 1 Escherichia coli O18ac:H14 no rank Decreases
0 1 Escherichia coli O19:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H4 no rank Decreases
0 1 Escherichia coli O2:K1:H5 no rank Decreases
0 1 Escherichia coli O2:K1:H7 no rank Decreases
0 1 Escherichia coli O20:H12 no rank Decreases
0 1 Escherichia coli O25:H16 no rank Decreases
0 1 Escherichia coli O55:H7 no rank Decreases
0 1 Escherichia coli O68:H12 no rank Decreases
0 1 Escherichia coli O7:H15 no rank Decreases
0 1 Escherichia coli O78:H51 no rank Decreases
0 1 Escherichia coli O80:H26 no rank Decreases
0 1 Escherichia coli O84:H7 no rank Decreases
0 1 Escherichia coli O85:H1 no rank Decreases
0 1 Escherichia coli O103 serogroup Decreases
0 1 Escherichia coli O111 serogroup Decreases
0 1 Escherichia coli O119 serogroup Decreases
0 1 Escherichia coli O121 serogroup Decreases
0 1 Escherichia coli O145 serogroup Decreases
0 1 Escherichia coli O155 serogroup Decreases
0 1 Escherichia coli O157 serogroup Decreases
0 1 Escherichia coli O177 serogroup Decreases
0 1 Escherichia coli O26 serogroup Decreases
0 1 Escherichia coli O3 serogroup Decreases
0 1 Escherichia coli O43 serogroup Decreases
0 1 Escherichia coli O5 serogroup Decreases
0 1 Escherichia coli O78 serogroup Decreases
0 1 Escherichia coli O86 serogroup Decreases
0 1 Escherichia coli O91 serogroup Decreases
0 1 Escherichia coli H20 serotype Decreases
0 1 Escherichia coli O1:H42 serotype Decreases
0 1 Escherichia coli O1:HNT serotype Decreases
0 1 Escherichia coli O10:H32 serotype Decreases
0 1 Escherichia coli O10:K5(L):H4 serotype Decreases
0 1 Escherichia coli O100:H21 serotype Decreases
0 1 Escherichia coli O103:H11 serotype Decreases
0 1 Escherichia coli O103:H2 serotype Decreases
0 1 Escherichia coli O103:H25 serotype Decreases
0 1 Escherichia coli O104:H21 serotype Decreases
0 1 Escherichia coli O104:H4 serotype Decreases
0 1 Escherichia coli O111:H- serotype Decreases
0 1 Escherichia coli O111:H11 serotype Decreases
0 1 Escherichia coli O111:H8 serotype Decreases
0 1 Escherichia coli O111:NM serotype Decreases
0 1 Escherichia coli O112ab:H8 serotype Decreases
0 1 Escherichia coli O112ac:H19 serotype Decreases
0 1 Escherichia coli O113:H21 serotype Decreases
0 1 Escherichia coli O114:H49 serotype Decreases
0 1 Escherichia coli O118:H16 serotype Decreases
0 1 Escherichia coli O121:H19 serotype Decreases
0 1 Escherichia coli O121:H7 serotype Decreases
0 1 Escherichia coli O123:H11 serotype Decreases
0 1 Escherichia coli O125ac:K+:H10 serotype Decreases
0 1 Escherichia coli O126:H45 serotype Decreases
0 1 Escherichia coli O127:H27 serotype Decreases
0 1 Escherichia coli O127:H6 serotype Decreases
0 1 Escherichia coli O128:H2 serotype Decreases
0 1 Escherichia coli O128ac:H12 serotype Decreases
0 1 Escherichia coli O139:H28 serotype Decreases
0 1 Escherichia coli O145:H25 serotype Decreases
0 1 Escherichia coli O145:H28 serotype Decreases
0 1 Escherichia coli O145:NM serotype Decreases
0 1 Escherichia coli O146:H21 serotype Decreases
0 1 Escherichia coli O15:H18 serotype Decreases
0 1 Escherichia coli O150:H6 serotype Decreases
0 1 Escherichia coli O152:H23 serotype Decreases
0 1 Escherichia coli O153:H2 serotype Decreases
0 1 Escherichia coli O156:H25 serotype Decreases
0 1 Escherichia coli O157:H- serotype Decreases
0 1 Escherichia coli O157:H43 serotype Decreases
0 1 Escherichia coli O157:H7 serotype Decreases
0 1 Escherichia coli O157:NM serotype Decreases
0 1 Escherichia coli O16:H6 serotype Decreases
0 1 Escherichia coli O165:H25 serotype Decreases
0 1 Escherichia coli O167:H26 serotype Decreases
0 1 Escherichia coli O174:H2 serotype Decreases
0 1 Escherichia coli O174:H21 serotype Decreases
0 1 Escherichia coli O174:H8 serotype Decreases
0 1 Escherichia coli O176:H45 serotype Decreases
0 1 Escherichia coli O177:NM serotype Decreases
0 1 Escherichia coli O2:H6 serotype Decreases
0 1 Escherichia coli O2:K2:H1 serotype Decreases
0 1 Escherichia coli O25:H1 serotype Decreases
0 1 Escherichia coli O25:NM serotype Decreases
0 1 Escherichia coli O26:H1 serotype Decreases
0 1 Escherichia coli O26:H11 serotype Decreases
0 1 Escherichia coli O28ac:NM serotype Decreases
0 1 Escherichia coli O29:H4 serotype Decreases
0 1 Escherichia coli O32:H37 serotype Decreases
0 1 Escherichia coli O39:NM serotype Decreases
0 1 Escherichia coli O44:H18 serotype Decreases
0 1 Escherichia coli O45:H2 serotype Decreases
0 1 Escherichia coli O6:H16 serotype Decreases
0 1 Escherichia coli O6:H16:CFA/II serotype Decreases
0 1 Escherichia coli O6:K2:H1 serotype Decreases
0 1 Escherichia coli O69:H11 serotype Decreases
0 1 Escherichia coli O7:H4 serotype Decreases
0 1 Escherichia coli O7:K1 serotype Decreases
0 1 Escherichia coli O78:H12 serotype Decreases
0 1 Escherichia coli O78:H4 serotype Decreases
0 1 Escherichia coli O79:H7 serotype Decreases
0 1 Escherichia coli O8:H8 serotype Decreases
0 1 Escherichia coli O81:NM serotype Decreases
0 1 Escherichia coli O83:H1 serotype Decreases
0 1 Escherichia coli O86:H34 serotype Decreases
0 1 Escherichia coli O89m:H10 serotype Decreases
0 1 Escherichia coli O89m:H9 serotype Decreases
0 1 Escherichia coli O9:H10 serotype Decreases
0 1 Escherichia coli O91:H14 serotype Decreases
0 1 Escherichia coli O91:NM serotype Decreases
0 1 Escherichia coli O99:H6 serotype Decreases
0 1 Escherichia coli ONT:H33 serotype Decreases
1 0 Odoribacter splanchnicus species Decreases
1 0 [Ruminococcus] torques species Decreases
1 0 Agathobacter rectalis species Decreases
1 0 Bacteroides fragilis species Decreases
1 0 Bacteroides thetaiotaomicron species Decreases
1 0 Bacteroides uniformis species Decreases
1 0 Bifidobacterium longum species Decreases
1 0 Blautia obeum species Decreases
1 0 Clostridioides difficile species Decreases
1 0 Clostridium perfringens species Decreases
1 0 Collinsella aerofaciens species Decreases
1 0 Coprococcus comes species Decreases
1 0 Dorea formicigenerans species Decreases
1 0 Enterocloster bolteae species Decreases
1 0 Lachnospira eligens species Decreases
1 0 Lacrimispora saccharolytica species Decreases
1 0 Lacticaseibacillus paracasei species Decreases
1 0 Mediterraneibacter gnavus species Decreases
1 0 Parabacteroides distasonis species Decreases
1 0 Parabacteroides merdae species Decreases
1 0 Phocaeicola vulgatus species Decreases
1 0 Roseburia hominis species Decreases
1 0 Roseburia intestinalis species Decreases
1 0 Segatella copri species Decreases
1 0 Streptococcus parasanguinis species Decreases
1 0 Streptococcus salivarius species Decreases
1 0 Bifidobacterium adolescentis species Decreases
1 0 Bilophila wadsworthia species Decreases
1 0 Fusobacterium nucleatum species Decreases
1 0 Bacteroides ovatus species Decreases
0 1 Streptococcus sp. FDAARGOS_192 species Decreases
0 1 Streptococcus sp. LPB0220 species Decreases
0 1 Streptococcus sp. HSISM1 species Decreases
1 0 Eggerthella lenta species Decreases
0 1 Bacteroides humanifaecis species Decreases
1 0 Akkermansia muciniphila species Decreases
1 0 Bacteroides caccae species Decreases
0 1 Coprococcus catus species Decreases
0 1 Segatella bryantii species Decreases
0 1 Dorea longicatena species Decreases
0 1 Bacteroides sp. CACC 737 species Decreases
0 1 Anaerobutyricum hallii species Decreases
0 1 Wansuia hejianensis species Decreases
0 1 Bifidobacterium breve species Decreases
0 1 Butyrivibrio crossotus species Decreases
0 1 Blautia sp. SC05B48 species Decreases
0 1 Ligilactobacillus ruminis species Decreases
0 1 Komagataeibacter oboediens species Decreases
0 1 Roseburia rectibacter species Decreases
0 1 Eubacterium ventriosum species Decreases
0 1 Clostridium sp. M62/1 species Decreases
0 1 Subdoligranulum variabile species Decreases
0 1 Bifidobacterium angulatum species Decreases
0 1 Clostridium sp. SY8519 species Decreases
0 1 Streptococcus vestibularis species Decreases
0 1 Eubacterium sp. MSJ-33 species Decreases
0 1 Parolsenella catena species Decreases
0 1 Pseudobutyrivibrio xylanivorans species Decreases
0 1 Blautia liquoris species Decreases
0 1 [Ruminococcus] lactaris species Decreases
0 1 Faecalibacterium duncaniae species Decreases
0 1 Coprococcus eutactus species Decreases
0 1 Faecalibacillus intestinalis species Decreases
0 1 Intestinibaculum porci species Decreases
0 1 Streptococcus lactarius species Decreases
0 1 Qiania dongpingensis species Decreases
0 1 Parolsenella massiliensis species Decreases
0 1 Wujia chipingensis species Decreases
0 1 Massilistercora timonensis species Decreases
0 1 Bacteroides sp. A1C1 species Decreases
0 1 Novisyntrophococcus fermenticellae species Decreases
0 1 Faecalitalea cylindroides species Decreases
0 1 Bacillus paralicheniformis species Decreases
0 1 Flavonifractor plautii species Decreases
0 1 Bacteroides sp. D2 species Decreases
1 0 Thomasclavelia ramosa species Decreases
0 1 Adlercreutzia equolifaciens species Decreases
0 1 Catenibacterium mitsuokai species Decreases
0 1 [Clostridium] hylemonae species Decreases
0 1 Christensenella minuta species Decreases
0 1 Collinsella stercoris species Decreases
0 1 Bacteroides luhongzhouii species Decreases
0 1 Anaerostipes hadrus species Decreases
0 1 Lachnoanaerobaculum gingivalis species Decreases
0 1 Coprococcus sp. ART55/1 species Decreases
0 1 Faecalibacterium sp. I2-3-92 species Decreases
0 1 Bacteroides sp. HF-162 species Decreases
0 1 Streptococcus gordonii species Decreases
0 1 Blautia parvula species Decreases
0 1 Leyella stercorea species Decreases
0 1 Alistipes megaguti species Decreases
0 1 Streptococcus australis species Decreases
0 1 Faecalibacterium sp. I4-1-79 species Decreases
0 1 Streptococcus sp. oral taxon 061 species Decreases
0 1 Vescimonas fastidiosa species Decreases
0 1 Faecalibacterium sp. IP-3-29 species Decreases
0 1 Longicatena caecimuris species Decreases
0 1 Simiaoa sunii species Decreases
0 1 Maliibacterium massiliense species Decreases
0 1 Marvinbryantia formatexigens species Decreases
0 1 Ruminococcus bicirculans (ex Wegman et al. 2014) species Decreases
0 1 Ruminococcus gauvreauii species Decreases
0 1 Catenibacterium sp. co_0103 species Decreases
0 1 Fannyhessea vaginae species Decreases
0 1 Actinomyces oris species Decreases
0 1 Faecalibacterium sp. HTF-F species Decreases
0 1 Bacteroides sp. M10 species Decreases
0 1 Clostridium cadaveris species Decreases
0 1 Actinomyces naeslundii species Decreases
0 1 Lachnoclostridium phocaeense species Decreases
0 1 Streptococcus suis species Decreases
0 1 Treponema peruense species Decreases
0 1 Faecalibacterium sp. I4-3-84 species Decreases
0 1 Ruminococcus champanellensis species Decreases
0 1 Faecalibacterium sp. I3-3-33 species Decreases
0 1 Faecalibacterium sp. I3-3-89 species Decreases
0 1 Faecalibacterium sp. IP-1-18 species Decreases
0 1 Parvimonas micra species Decreases
0 1 Vescimonas coprocola species Decreases
0 1 Lactococcus cremoris species Decreases
0 1 Coprobacter fastidiosus species Decreases
0 1 Mageeibacillus indolicus species Decreases
0 1 Monoglobus pectinilyticus species Decreases
0 1 Mogibacterium diversum species Decreases
0 1 Olsenella sp. oral taxon 807 species Decreases
0 1 Streptococcus infantis species Decreases
0 1 Hungatella hathewayi species Decreases
0 1 Adlercreutzia hattorii species Decreases
0 1 Streptococcus oralis species Decreases
0 1 Corynebacterium durum species Decreases
0 1 Prevotella intermedia species Decreases
0 1 Solibaculum mannosilyticum species Decreases
0 1 Eubacterium sp. c-25 species Decreases
0 1 Oscillibacter hominis species Decreases
0 1 Blautia wexlerae species Decreases
0 1 uncultured Alistipes sp. species Decreases
0 1 Bacteroides sp. DH3716P species Decreases
0 1 Blautia argi species Decreases
0 1 Coprobacter secundus species Decreases
0 1 Faecalibaculum rodentium species Decreases
0 1 Eubacterium limosum species Decreases
0 1 Treponema denticola species Decreases
0 1 Ruminococcus albus species Decreases
0 1 [Eubacterium] hominis species Decreases
0 1 Alistipes sp. dk3624 species Decreases
0 1 Streptococcus sp. oral taxon 431 species Decreases
0 1 Barnesiella viscericola species Decreases
0 1 Leyella lascolaii species Decreases
0 1 Bifidobacterium catenulatum species Decreases
0 1 Enterococcus cecorum species Decreases
0 1 Enterococcus faecium species Decreases
0 1 Butyricimonas virosa species Decreases
0 1 Flintibacter sp. KGMB00164 species Decreases
0 1 Streptococcus sp. Marseille-Q6470 species Decreases
0 1 Eubacterium callanderi species Decreases
0 1 Ruminococcus bovis species Decreases
0 1 Alistipes ihumii species Decreases
0 1 Acutalibacter muris species Decreases
0 1 Phascolarctobacterium succinatutens species Decreases
0 1 Chordicoccus furentiruminis species Decreases
0 1 Phoenicibacter congonensis species Decreases
0 1 Romboutsia ilealis species Decreases
0 1 Anaerotruncus colihominis species Decreases
0 1 Alistipes communis species Decreases
0 1 Eubacterium maltosivorans species Decreases
0 1 Alistipes senegalensis species Decreases
0 1 Phascolarctobacterium sp. Marseille-Q4147 species Decreases
0 1 Lawsonibacter asaccharolyticus species Decreases
0 1 Parafannyhessea umbonata species Decreases
0 1 Alistipes shahii species Decreases
0 1 Butyricimonas faecalis species Decreases
0 1 Streptococcus ilei species Decreases
0 1 Faecalibacterium prausnitzii species Decreases
0 1 Intestinimonas butyriciproducens species Decreases
1 0 Escherichia coli species Decreases
0 1 Bacteroides faecium species Decreases
0 1 Actinomyces sp. oral taxon 169 species Decreases
0 1 Blautia pseudococcoides species Decreases
0 1 Alistipes dispar species Decreases
0 1 Bacteroides nordii species Decreases
0 1 Eggerthella guodeyinii species Decreases
0 1 Butyricicoccus sp. GAM44 species Decreases
0 1 Ruthenibacterium lactatiformans species Decreases
0 1 Bifidobacterium bifidum species Decreases
0 1 Emergencia timonensis species Decreases
0 1 Actinomyces sp. oral taxon 171 species Decreases
0 1 [Clostridium] scindens species Decreases
0 1 Paraprevotella clara species Decreases
0 1 Amedibacterium intestinale species Decreases
0 1 Parabacteroides johnsonii species Decreases
0 1 Prevotella bivia species Decreases
0 1 Turicibacter bilis species Decreases
0 1 Pusillibacter faecalis species Decreases
0 1 Blautia hansenii species Decreases
0 1 Gordonibacter urolithinfaciens species Decreases
0 1 Streptococcus sanguinis species Decreases
0 1 Butyrivibrio fibrisolvens species Decreases
0 1 Clostridium sp. C1 species Decreases
0 1 Alistipes finegoldii species Decreases
0 1 Romboutsia sp. 13368 species Decreases
0 1 Blautia producta species Decreases
0 1 Streptococcus mutans species Decreases
0 1 Enterocloster clostridioformis species Decreases
0 1 Bacteroides xylanisolvens species Decreases
0 1 Streptococcus sp. A12 species Decreases
0 1 Enterocloster asparagiformis species Decreases
0 1 Alistipes onderdonkii species Decreases
0 1 Alistipes indistinctus species Decreases
0 1 Arabiibacter massiliensis species Decreases
0 1 Streptococcus thermophilus species Decreases
0 1 Bacteroides caecimuris species Decreases
0 1 Lactococcus lactis species Decreases
0 1 Prevotella dentalis species Decreases
0 1 Bacteroides cellulosilyticus species Decreases
1 0 Ruminococcus bromii species Decreases
0 1 Akkermansia glycaniphila species Decreases
0 1 Akkermansia massiliensis species Decreases
0 1 Candidatus Akkermansia intestinavium species Decreases
0 1 Bifidobacterium longum subsp. infantis subspecies Decreases
0 1 Bifidobacterium longum subsp. longum subspecies Decreases
0 1 Bifidobacterium longum subsp. suillum subspecies Decreases
0 1 Bifidobacterium longum subsp. suis subspecies Decreases
0 1 Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases
0 1 Lacticaseibacillus paracasei subsp. tolerans subspecies Decreases
0 1 Fusobacterium nucleatum subsp. nucleatum subspecies Decreases

Impact of Clomiphene citrate (Z,E) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 1.1 1.1
Acne 0.4 -0.4
ADHD 5.3 1.2 3.42
Age-Related Macular Degeneration and Glaucoma 1.2 0.5 1.4
Allergic Rhinitis (Hay Fever) 4.2 3.3 0.27
Allergies 7 3.4 1.06
Allergy to milk products 2.6 1.5 0.73
Alopecia (Hair Loss) 2.6 0.2 12
Alzheimer's disease 8.1 9.1 -0.12
Amyotrophic lateral sclerosis (ALS) Motor Neuron 3.7 0.6 5.17
Ankylosing spondylitis 5 2 1.5
Anorexia Nervosa 2.3 4.6 -1
Antiphospholipid syndrome (APS) 1.8 0.3 5
Asthma 6.8 3 1.27
Atherosclerosis 2.9 2.5 0.16
Atrial fibrillation 5 3 0.67
Autism 11.9 11.6 0.03
Autoimmune Disease 1 1.4 -0.4
Barrett esophagus cancer 0.3 0.5 -0.67
benign prostatic hyperplasia 0.1 0.4 -3
Biofilm 2.6 2.6
Bipolar Disorder 2.2 1.3 0.69
Brain Trauma 1.5 1.6 -0.07
Breast Cancer 0.6 0.6
Cancer (General) 0.7 3.2 -3.57
Carcinoma 5.3 3.5 0.51
Celiac Disease 3.8 4.4 -0.16
Cerebral Palsy 1.9 1.6 0.19
Chronic Fatigue Syndrome 6.6 8.7 -0.32
Chronic Kidney Disease 4.7 4.2 0.12
Chronic Lyme 0.6 0.9 -0.5
Chronic Obstructive Pulmonary Disease (COPD) 2.9 2.5 0.16
Chronic Urticaria (Hives) 1.1 1.7 -0.55
Coagulation / Micro clot triggering bacteria 1.3 2.1 -0.62
Cognitive Function 3 2.4 0.25
Colorectal Cancer 8.9 3.8 1.34
Constipation 1.5 1.1 0.36
Coronary artery disease 2.8 4.2 -0.5
COVID-19 11.9 16.2 -0.36
Crohn's Disease 10.8 8.7 0.24
Cushing's Syndrome (hypercortisolism) 1 -1
cystic fibrosis 0.2 2.3 -10.5
d-lactic acidosis (one form of brain fog) 0.2 0.2
deep vein thrombosis 2.3 2 0.15
Denture Wearers Oral Shifts 1.8 1.8
Depression 14 12.1 0.16
Dermatomyositis 0.5 0.4 0.25
Eczema 2 3.2 -0.6
Endometriosis 3.9 2 0.95
Eosinophilic Esophagitis 0.4 0.5 -0.25
Epilepsy 4.7 3 0.57
erectile dysfunction 1.1 0.4 1.75
Fibromyalgia 4.5 3.4 0.32
Functional constipation / chronic idiopathic constipation 7 6 0.17
gallstone disease (gsd) 3.6 1.4 1.57
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 2.3 2.3 0
Generalized anxiety disorder 3.4 3 0.13
giant cell arteritis 0.5 -0.5
Glioblastoma 0.1 0.7 -6
Gout 1.4 1.1 0.27
Graves' disease 1.9 3.6 -0.89
Gulf War Syndrome 1.9 2 -0.05
Halitosis 1.9 0.5 2.8
Hashimoto's thyroiditis 4.4 2.6 0.69
Heart Failure 5.5 3 0.83
hemorrhagic stroke 1.3 1.3
Hidradenitis Suppurativa 1.9 1.9
High Histamine/low DAO 1.7 0.4 3.25
hypercholesterolemia (High Cholesterol) 1 0.4 1.5
hyperglycemia 1 2.2 -1.2
Hyperlipidemia (High Blood Fats) 1.4 0.5 1.8
hypersomnia 0.2 1.3 -5.5
hypertension (High Blood Pressure 5.9 7.8 -0.32
Hypothyroidism 0.6 1.9 -2.17
Hypoxia 2.9 0.1 28
IgA nephropathy (IgAN) 2.1 5.6 -1.67
Inflammatory Bowel Disease 10 12.5 -0.25
Insomnia 3.2 3.7 -0.16
Intelligence 2.1 1.1 0.91
Intracranial aneurysms 1.8 1.2 0.5
Irritable Bowel Syndrome 7.5 7.1 0.06
ischemic stroke 3 1.6 0.88
Juvenile idiopathic arthritis 0.1 0.1 0
Liver Cirrhosis 8.4 4.8 0.75
Long COVID 9.4 10.7 -0.14
Low bone mineral density 2 -2
Lung Cancer 0.6 1.7 -1.83
Lymphoma 0.1 0.1
Mast Cell Issues / mastitis 1 1 0
ME/CFS with IBS 1.5 3.3 -1.2
ME/CFS without IBS 2.3 2.6 -0.13
membranous nephropathy 0.6 0.6
Menopause 2.4 0.8 2
Metabolic Syndrome 9.9 10.7 -0.08
Mood Disorders 13.9 10 0.39
multiple chemical sensitivity [MCS] 1.3 0.6 1.17
Multiple Sclerosis 8.6 8.6 0
Multiple system atrophy (MSA) 1.7 0.9 0.89
myasthenia gravis 0.5 1.1 -1.2
neuropathic pain 0.1 3.7 -36
Neuropathy (all types) 1.3 1.8 -0.38
neuropsychiatric disorders (PANDAS, PANS) 0.9 0.9
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 6.3 6.7 -0.06
NonCeliac Gluten Sensitivity 2.1 0.7 2
Obesity 13.4 12 0.12
obsessive-compulsive disorder 6 5.9 0.02
Osteoarthritis 3.9 1.8 1.17
Osteoporosis 1.6 2.5 -0.56
pancreatic cancer 1.3 0.5 1.6
Parkinson's Disease 10.6 9.7 0.09
Polycystic ovary syndrome 8 3.5 1.29
Postural orthostatic tachycardia syndrome 0.5 0.9 -0.8
Premenstrual dysphoric disorder 1.4 0.5 1.8
primary biliary cholangitis 1.1 2.3 -1.09
Primary sclerosing cholangitis 2.8 4.4 -0.57
Psoriasis 4 4.2 -0.05
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 9.6 5.9 0.63
Rosacea 1.2 1.1 0.09
Schizophrenia 8.7 4.2 1.07
scoliosis 0.9 1 -0.11
sensorineural hearing loss 0.4 0.4
Sjögren syndrome 2.8 4.2 -0.5
Sleep Apnea 2.2 2.1 0.05
Slow gastric motility / Gastroparesis 0.7 0.6 0.17
Small Intestinal Bacterial Overgrowth (SIBO) 2.5 0.6 3.17
Stress / posttraumatic stress disorder 3.4 3.4 0
Systemic Lupus Erythematosus 5.5 3.1 0.77
Tic Disorder 1.5 2.7 -0.8
Tourette syndrome 1.1 0.4 1.75
Type 1 Diabetes 5 5.3 -0.06
Type 2 Diabetes 11.2 9.5 0.18
Ulcerative colitis 8 9.5 -0.19
Unhealthy Ageing 6.7 3.4 0.97
Vitiligo 2.9 2.3 0.26

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