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🍽️ 2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate {Trimebutine}

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Data Contradictions — Limits of Certainity

Impacted of 2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate {Trimebutine} On Probiotics

Rank Probiotic Impact
genus Pediococcus Reduces
species Lactobacillus acidophilus Reduces
species Lactobacillus crispatus Reduces
species Lactobacillus gasseri Reduces
species Lactobacillus helveticus Reduces
species Lactobacillus jensenii Reduces
species Lactobacillus johnsonii Reduces
species Lactobacillus kefiranofaciens Reduces
species Lactococcus cremoris Reduces
species Lactococcus lactis Reduces
species Parabacteroides distasonis Increases
species Parabacteroides goldsteinii Increases

Bacteria Impacted by 2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate {Trimebutine}

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

🧙?

📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Bacteroidota/Chlorobiota group clade Increases
0 1 Bacteroidia class Increases
0 1 Chitinophagia class Increases
0 1 Cytophagia class Increases
0 1 Flavobacteriia class Increases
0 1 Saprospiria class Increases
0 1 Sphingobacteriia class Increases
1 0 Lachnospiraceae family Decreases
1 0 Lactobacillaceae family Decreases
1 0 Synergistaceae family Decreases
0 1 Peptostreptococcaceae family Decreases
0 1 Streptococcaceae family Decreases
0 1 Treponemataceae family Decreases
0 1 Christensenellaceae family Decreases
0 1 Acetobacteraceae family Decreases
0 1 Erysipelotrichaceae family Decreases
0 1 Eubacteriaceae family Decreases
0 1 Eubacteriales Family XIII. Incertae Sedis family Decreases
0 1 Maliibacteriaceae family Decreases
0 1 Tannerellaceae family Increases
1 0 Lactobacillus genus Decreases
1 0 Lactococcus genus Decreases
0 1 Acetatifactor genus Decreases
0 1 Acetilactobacillus genus Decreases
0 1 Acetitomaculum genus Decreases
0 1 Agathobacter genus Decreases
0 1 Agrilactobacillus genus Decreases
0 1 Aminomonas genus Decreases
0 1 Amylolactobacillus genus Decreases
0 1 Anaerobium genus Decreases
0 1 Anaerobutyricum genus Decreases
0 1 Anaerocolumna genus Decreases
0 1 Anaeromicropila genus Decreases
0 1 Anaeropeptidivorans genus Decreases
0 1 Anaerosacchariphilus genus Decreases
0 1 Anaerosporobacter genus Decreases
0 1 Anaerostipes genus Decreases
0 1 Anaerotaenia genus Decreases
0 1 Anaerotignum genus Decreases
0 1 Anthropogastromicrobium genus Decreases
0 1 Apilactobacillus genus Decreases
0 1 Bariatricus genus Decreases
0 1 Blautia genus Decreases
0 1 Bombilactobacillus genus Decreases
0 1 Brotaphodocola genus Decreases
0 1 Butyribacter genus Decreases
0 1 Butyrivibrio genus Decreases
0 1 Candidatus Epulonipiscium genus Decreases
0 1 Candidatus Tammella genus Decreases
0 1 Catenibacillus genus Decreases
0 1 Catonella genus Decreases
0 1 Chordicoccus genus Decreases
0 1 Claveliimonas genus Decreases
0 1 Cloacibacillus genus Decreases
0 1 Companilactobacillus genus Decreases
0 1 Coprococcus genus Decreases
0 1 Cuneatibacter genus Decreases
0 1 Dellaglioa genus Decreases
0 1 Diplocloster genus Decreases
0 1 Dorea genus Decreases
0 1 Eisenbergiella genus Decreases
0 1 Enterocloster genus Decreases
0 1 Extibacter genus Decreases
0 1 Faecalicatena genus Decreases
0 1 Faecalimonas genus Decreases
0 1 Frisingicoccus genus Decreases
0 1 Fructilactobacillus genus Decreases
0 1 Fructobacillus genus Decreases
0 1 Furfurilactobacillus genus Decreases
0 1 Fusicatenibacter genus Decreases
0 1 Gallintestinimicrobium genus Decreases
0 1 Gluceribacter genus Decreases
0 1 Herbinix genus Decreases
0 1 Hespellia genus Decreases
0 1 Holzapfeliella genus Decreases
0 1 Hominifimenecus genus Decreases
0 1 Hominisplanchenecus genus Decreases
0 1 Hoministercoradaptatus genus Decreases
0 1 Hominiventricola genus Decreases
0 1 Jingyaoa genus Decreases
0 1 Johnsonella genus Decreases
0 1 Jutongia genus Decreases
0 1 Kineothrix genus Decreases
0 1 Lachnoanaerobaculum genus Decreases
0 1 Lachnobacterium genus Decreases
0 1 Lachnoclostridium genus Decreases
0 1 Lachnospira genus Decreases
0 1 Lachnotalea genus Decreases
0 1 Lacrimispora genus Decreases
0 1 Lacticaseibacillus genus Decreases
0 1 Lactiplantibacillus genus Decreases
0 1 Lapidilactobacillus genus Decreases
0 1 Latilactobacillus genus Decreases
0 1 Lentilactobacillus genus Decreases
0 1 Leuconostoc genus Decreases
0 1 Levilactobacillus genus Decreases
0 1 Lientehia genus Decreases
0 1 Ligilactobacillus genus Decreases
0 1 Limosilactobacillus genus Decreases
0 1 Liquorilactobacillus genus Decreases
0 1 Loigolactobacillus genus Decreases
0 1 Luxibacter genus Decreases
0 1 Marvinbryantia genus Decreases
0 1 Mediterraneibacter genus Decreases
0 1 Merdimonas genus Decreases
0 1 Mobilitalea genus Decreases
0 1 Moryella genus Decreases
0 1 Muricomes genus Decreases
0 1 Murimonas genus Decreases
0 1 Niameybacter genus Decreases
0 1 Nicoliella genus Decreases
0 1 Novisyntrophococcus genus Decreases
0 1 Oenococcus genus Decreases
0 1 Oliverpabstia genus Decreases
0 1 Oribacterium genus Decreases
0 1 Parablautia genus Decreases
0 1 Pararoseburia genus Decreases
0 1 Parasporobacterium genus Decreases
0 1 Paucilactobacillus genus Decreases
0 1 Pediococcus genus Decreases
0 1 Periweissella genus Decreases
0 1 Porcincola genus Decreases
0 1 Pseudobutyrivibrio genus Decreases
0 1 Qiania genus Decreases
0 1 Robinsoniella genus Decreases
0 1 Roseburia genus Decreases
0 1 Sakamotonia genus Decreases
0 1 Schaedlerella genus Decreases
0 1 Schleiferilactobacillus genus Decreases
0 1 Secundilactobacillus genus Decreases
0 1 Sellimonas genus Decreases
0 1 Shuttleworthella genus Decreases
0 1 Simiaoa genus Decreases
0 1 Sporobacterium genus Decreases
0 1 Sporofaciens genus Decreases
0 1 Stomatobaculum genus Decreases
0 1 Suonthocola genus Decreases
0 1 Synergistes genus Decreases
0 1 Syntrophococcus genus Decreases
0 1 Thermanaerovibrio genus Decreases
0 1 Tyzzerella genus Decreases
0 1 Waltera genus Decreases
0 1 Wansuia genus Decreases
0 1 Weissella genus Decreases
0 1 Wujia genus Decreases
0 1 Zhenhengia genus Decreases
1 0 Parabacteroides genus Increases
0 1 environmental samples no rank Decreases
0 1 environmental samples no rank Decreases
0 1 environmental samples no rank Decreases
0 1 Lachnospiraceae incertae sedis no rank Decreases
0 1 Synergistaceae incertae sedis no rank Decreases
0 1 unclassified Lachnospiraceae no rank Decreases
0 1 unclassified Lactobacillaceae no rank Decreases
0 1 unclassified Lactobacillus no rank Decreases
0 1 unclassified Lactococcus no rank Decreases
0 1 Bacteroidetes incertae sedis no rank Increases
0 1 environmental samples no rank Increases
0 1 environmental samples no rank Increases
0 1 unclassified Bacteroidota no rank Increases
0 1 unclassified Parabacteroides no rank Increases
0 1 Eubacteriales order Decreases
0 1 Lactobacillales order Decreases
0 1 Synergistales order Decreases
0 1 unclassified Bacteroidetes Order II. order Increases
1 0 Bacteroidota phylum Increases
0 1 [Lactobacillus] rogosae species Decreases
0 1 ATCC 15434 species Decreases
0 1 Lactobacillus acetotolerans species Decreases
0 1 Lactobacillus acidophilus species Decreases
0 1 Lactobacillus alvei species Decreases
0 1 Lactobacillus amylolyticus species Decreases
0 1 Lactobacillus amylovorus species Decreases
0 1 Lactobacillus animata species Decreases
0 1 Lactobacillus apis species Decreases
0 1 Lactobacillus bombicola species Decreases
0 1 Lactobacillus brevisimilis species Decreases
0 1 Lactobacillus crispatus species Decreases
0 1 Lactobacillus delbrueckii species Decreases
0 1 Lactobacillus equicursoris species Decreases
0 1 Lactobacillus faeni species Decreases
0 1 Lactobacillus fornicalis species Decreases
0 1 Lactobacillus gallinarum species Decreases
0 1 Lactobacillus gasseri species Decreases
0 1 Lactobacillus gigeriorum species Decreases
0 1 Lactobacillus guizhouensis species Decreases
0 1 Lactobacillus hamsteri species Decreases
0 1 Lactobacillus helsingborgensis species Decreases
0 1 Lactobacillus helveticus species Decreases
0 1 Lactobacillus hominis species Decreases
0 1 Lactobacillus iners species Decreases
0 1 Lactobacillus intermedius species Decreases
0 1 Lactobacillus intestinalis species Decreases
0 1 Lactobacillus japonicus species Decreases
0 1 Lactobacillus jensenii species Decreases
0 1 Lactobacillus johnsonii species Decreases
0 1 Lactobacillus kalixensis species Decreases
0 1 Lactobacillus kefiranofaciens species Decreases
0 1 Lactobacillus kitasatonis species Decreases
0 1 Lactobacillus kullabergensis species Decreases
0 1 Lactobacillus leichmannii species Decreases
0 1 Lactobacillus letivazi species Decreases
0 1 Lactobacillus mulieris species Decreases
0 1 Lactobacillus panisapium species Decreases
0 1 Lactobacillus paragasseri species Decreases
0 1 Lactobacillus pasteurii species Decreases
0 1 Lactobacillus psittaci species Decreases
0 1 Lactobacillus rodentium species Decreases
0 1 Lactobacillus selangorensis species Decreases
0 1 Lactobacillus sp. 7_1_47FAA species Decreases
0 1 Lactobacillus sp. MYMRS/TEN2 species Decreases
0 1 Lactobacillus taiwanensis species Decreases
0 1 Lactobacillus terrae species Decreases
0 1 Lactobacillus ultunensis species Decreases
0 1 Lactococcus allomyrinae species Decreases
0 1 Lactococcus carnosus species Decreases
0 1 Lactococcus cremoris species Decreases
0 1 Lactococcus formosensis species Decreases
0 1 Lactococcus fujiensis species Decreases
0 1 Lactococcus garvieae species Decreases
0 1 Lactococcus hircilactis species Decreases
0 1 Lactococcus lactis species Decreases
0 1 Lactococcus laudensis species Decreases
0 1 Lactococcus paracarnosus species Decreases
0 1 Lactococcus petauri species Decreases
0 1 Lactococcus piscium species Decreases
0 1 Lactococcus plantarum species Decreases
0 1 Lactococcus protaetiae species Decreases
0 1 Lactococcus raffinolactis species Decreases
0 1 Lactococcus taiwanensis species Decreases
0 1 Candidatus Parabacteroides intestinavium species Increases
0 1 Candidatus Parabacteroides intestinipullorum species Increases
0 1 Parabacteroides acidifaciens species Increases
0 1 Parabacteroides chinchillae species Increases
0 1 Parabacteroides distasonis species Increases
0 1 Parabacteroides faecis species Increases
0 1 Parabacteroides goldsteinii species Increases
0 1 Parabacteroides gordonii species Increases
0 1 Parabacteroides johnsonii species Increases
0 1 Parabacteroides leei species Increases
0 1 Parabacteroides massiliensis species Increases
0 1 Parabacteroides merdae species Increases
0 1 Parabacteroides provencensis species Increases
0 1 Parabacteroides segnis species Increases
0 1 Parabacteroides timonensis species Increases
0 1 Lactobacillus casei group species group Decreases

Impact of 2-(Dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate {Trimebutine} on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Acne 0.2 1.4 -6
ADHD 1 2.1 -1.1
Age-Related Macular Degeneration and Glaucoma 0.9 0.5 0.8
Allergic Rhinitis (Hay Fever) 0.3 1.8 -5
Allergies 1.6 3.1 -0.94
Allergy to milk products 1.3 1.6 -0.23
Alopecia (Hair Loss) 1.1 0.4 1.75
Alzheimer's disease 2.3 4.9 -1.13
Amyotrophic lateral sclerosis (ALS) Motor Neuron 2.2 1.3 0.69
Ankylosing spondylitis 1.2 2.8 -1.33
Anorexia Nervosa 1.5 2.3 -0.53
Asthma 2 2 0
Atherosclerosis 1.3 0.2 5.5
Atrial fibrillation 3.3 1.6 1.06
Autism 4.5 4.4 0.02
Autoimmune Disease 0.5 0.8 -0.6
Barrett esophagus cancer 0.1 -0.1
benign prostatic hyperplasia 0.2 -0.2
Bipolar Disorder 0.5 2.4 -3.8
Brain Trauma 0.7 0.8 -0.14
Breast Cancer 0.3 0.2 0.5
Cancer (General) 0.7 -0.7
Carcinoma 1.3 1.1 0.18
Celiac Disease 2.7 2.8 -0.04
Cerebral Palsy 0.5 -0.5
Chronic Fatigue Syndrome 1.6 2.5 -0.56
Chronic Kidney Disease 0.5 3.5 -6
Chronic Lyme 0.2 -0.2
Chronic Obstructive Pulmonary Disease (COPD) 1.7 1.6 0.06
Chronic Urticaria (Hives) 1 0.2 4
Coagulation / Micro clot triggering bacteria 2.1 -2.1
Cognitive Function 2.1 2.7 -0.29
Colorectal Cancer 2.5 2.5 0
Constipation 0.7 0.5 0.4
Coronary artery disease 1.2 2.2 -0.83
COVID-19 2.7 4.1 -0.52
Crohn's Disease 3.9 4.1 -0.05
Cushing's Syndrome (hypercortisolism) 0.1 0.1
cystic fibrosis 0.3 -0.3
d-lactic acidosis (one form of brain fog) 1.5 1.5
deep vein thrombosis 0.7 1.3 -0.86
Denture Wearers Oral Shifts 0.2 0.5 -1.5
Depression 5.9 5.4 0.09
Dermatomyositis 0.3 1 -2.33
Eczema 1.3 -1.3
Endometriosis 1 2.4 -1.4
Eosinophilic Esophagitis 1 -1
Epilepsy 2.4 1.2 1
erectile dysfunction 1 0.5 1
Fibromyalgia 1.3 1.8 -0.38
Functional constipation / chronic idiopathic constipation 2.6 3.3 -0.27
gallstone disease (gsd) 1 1.3 -0.3
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 0.2 1.6 -7
Generalized anxiety disorder 0.5 0.3 0.67
Glioblastoma 0.2 0.7 -2.5
Gout 0.1 1.5 -14
Graves' disease 1.1 3.6 -2.27
Gulf War Syndrome 1.4 1.3 0.08
Halitosis 0.2 0.3 -0.5
Hashimoto's thyroiditis 1.5 1.5 0
Heart Failure 1.6 2.3 -0.44
hemorrhagic stroke 0.8 0.8 0
Hemorrhoidal disease, Hemorrhoids, Piles 0.2 0.2
Hidradenitis Suppurativa 0.2 0.3 -0.5
High Histamine/low DAO 0.7 0.2 2.5
hypercholesterolemia (High Cholesterol) 0.2 0.1 1
hyperglycemia 1.1 1 0.1
Hyperlipidemia (High Blood Fats) 0.8 1.7 -1.13
hypersomnia 1.2 -1.2
hypertension (High Blood Pressure 3.8 4.1 -0.08
Hypothyroidism 0.2 1.3 -5.5
Hypoxia 0.7 0.8 -0.14
IgA nephropathy (IgAN) 0.8 2.4 -2
Inflammatory Bowel Disease 2.5 4.2 -0.68
Insomnia 2.1 1.5 0.4
Intelligence 0.8 0.8
Intracranial aneurysms 0.3 1.3 -3.33
Irritable Bowel Syndrome 3.4 2.2 0.55
ischemic stroke 0.8 2.4 -2
Juvenile idiopathic arthritis 0.6 -0.6
Liver Cirrhosis 3.3 2.9 0.14
Long COVID 5.5 5.8 -0.05
Low bone mineral density 0.8 1 -0.25
Lung Cancer 0.2 1 -4
Lymphoma 0.1 -0.1
Mast Cell Issues / mastitis 0.8 -0.8
ME/CFS with IBS
ME/CFS without IBS 0.2 0.2 0
Menopause 0.8 -0.8
Metabolic Syndrome 4.5 3.9 0.15
Mood Disorders 6 4.9 0.22
multiple chemical sensitivity [MCS] 0.5 0.3 0.67
Multiple Sclerosis 2.8 3.1 -0.11
Multiple system atrophy (MSA) 0.5 0.2 1.5
myasthenia gravis 0.7 0.3 1.33
neuropathic pain 0.6 1 -0.67
Neuropathy (all types) 2.7 1.5 0.8
neuropsychiatric disorders (PANDAS, PANS) 1.2 -1.2
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 3.2 2.6 0.23
NonCeliac Gluten Sensitivity 1 0.5 1
Obesity 4 3.9 0.03
obsessive-compulsive disorder 0.3 2.6 -7.67
Osteoarthritis 0.7 0.7
Osteoporosis 1.5 1.9 -0.27
pancreatic cancer 0.2 1.1 -4.5
Parkinson's Disease 4.8 4.1 0.17
Peanut Allergy 0.5 -0.5
Polycystic ovary syndrome 2.5 3.6 -0.44
Postural orthostatic tachycardia syndrome 0.2 0.2 0
Premenstrual dysphoric disorder 1.7 0.2 7.5
primary biliary cholangitis 1.3 0.2 5.5
Primary sclerosing cholangitis 1.5 2.9 -0.93
Psoriasis 2.3 0.5 3.6
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 4.1 4.2 -0.02
Rosacea 1.5 -1.5
Schizophrenia 4.1 4.1 0
scoliosis 0.7 0.7
sensorineural hearing loss 0.5 -0.5
Sjögren syndrome 1.1 1.6 -0.45
Sleep Apnea 0.7 0.8 -0.14
Slow gastric motility / Gastroparesis 0.5 -0.5
Small Intestinal Bacterial Overgrowth (SIBO) 1 1
Stress / posttraumatic stress disorder 1.7 1.4 0.21
Systemic Lupus Erythematosus 2 3.3 -0.65
Tic Disorder 0.2 -0.2
Tourette syndrome 0.2 0.5 -1.5
Type 1 Diabetes 2.4 1 1.4
Type 2 Diabetes 5 3.3 0.52
Ulcerative colitis 5.6 3.3 0.7
Unhealthy Ageing 1.4 0.8 0.75
Vitiligo 1.3 0.8 0.63

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