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Urinary Tract Infections (UTIs): Ofloxacin is commonly prescribed to treat UTIs, including cystitis (bladder infection) and pyelonephritis (kidney infection), caused by susceptible bacteria.
Prostatitis: It may also be used to treat acute and chronic bacterial prostatitis, an inflammation of the prostate gland typically caused by bacterial infection.
Gastrointestinal Infections: Ofloxacin can be effective in treating bacterial gastroenteritis caused by enteric pathogens such as Escherichia coli, Salmonella, Shigella, and Campylobacter.
Respiratory Tract Infections: Ofloxacin may be used to treat respiratory tract infections, including bacterial pneumonia, bronchitis, and exacerbations of chronic obstructive pulmonary disease (COPD).
Skin and Soft Tissue Infections: Ofloxacin may be effective against certain bacterial skin infections, such as cellulitis and abscesses, when caused by susceptible organisms.
Eye Infections: Ofloxacin ophthalmic solution is used to treat bacterial eye infections such as conjunctivitis and corneal ulcers.
Sexually Transmitted Infections (STIs): Ofloxacin has been used in the past to treat certain sexually transmitted infections, such as gonorrhea, although its use for this purpose is now limited due to increasing resistance.
Ear Infections: Ofloxacin may be prescribed for the treatment of bacterial otitis externa (swimmer's ear) and acute otitis media (middle ear infection) in certain cases.
Mechanism of Action: Ofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV enzymes, essential for bacterial DNA replication, transcription, repair, and recombination. This leads to bactericidal activity against susceptible bacteria.
Dosage and Administration: Ofloxacin is available in various formulations, including tablets, oral suspension, ophthalmic solution, and otic solution. The dosage and duration of treatment depend on the type and severity of the infection, as well as the patient's age, renal function, and medical history.
Adverse Effects: Common side effects of ofloxacin may include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and abdominal discomfort. Other potential side effects include headache, dizziness, insomnia, and skin rash. Rare but serious adverse effects may include tendon rupture, peripheral neuropathy, and allergic reactions.
Precautions: Ofloxacin should be used with caution in patients with a history of tendon disorders, peripheral neuropathy, or myasthenia gravis. It should be avoided in pregnant women, breastfeeding mothers, and children, as it may cause adverse effects on fetal development and cartilage growth.
Drug Interactions: Ofloxacin may interact with certain medications, including antacids containing aluminum or magnesium, iron supplements, and certain anticoagulants. It is important to consult a healthcare professional before taking ofloxacin concurrently with other medications.
Resistance: The widespread use of fluoroquinolone antibiotics has led to the emergence of bacterial resistance, limiting the effectiveness of ofloxacin and other drugs in its class. Therefore, it should be used judiciously and only when necessary to minimize the risk of resistance.
(a-vid, adios, aflox, akilen, albact, alcin, aloflox, an fu le, anex-of, anli, ao di fu kang, ao wei te, aofuxing, apo oflox, apo-ofloxacin, armbid, armbid-nt, avicin, bact-o, bacteflox, bacter-nz, bactivid, bactorax, bacus, bei li de, bestoflox, betaflox, bioquil, castrov-o, ceemi-o, cefcoff, cefolac-o, cefoped-ab, ceftilox-o, celixim-o, celsus ofloxacin, cewap-o, chekmet, cifgen-o, civet-of, clancef-o, crinux-o, danoflox, dexaflox, di ke luo, dizoflox, doloket-o, dong kang ming, dostrip-o, drovid, earflo otic, easyflox, ecuflox, edilox-s, emtax-of, epicoflocin, epixime-of, ermofan, esfix-o, ethiflox, eukinoft, exocin, exocine 0.3%, exopred, extacef plus, fei ning da, ficsi-of, fixi-ab, fixica-o, fixicom-o, fixifine-o, flagynor, flocet, floksan, flotavid, flovid, floxa west, floxagen, floxal, floxal ud, floxar-oz, floxavid, floxedol, floxika, floximox, floxoday, floxstat, floxur, floxzen, fugacin, gamoflo, geiluoxian#144;, grafloxin, gramfix-of, grenis-oflo, hao te, harpoon, healthibact, heng run, hifen plus, ibacnol, inflobact, inflobact-d, inflobid, inflobid-d, inflobid-nxt, inoflex, inoflox, jedcoflacin, jiefu, kafra, kinflocin, kiroll, klonalflox, konovid, litcef-of, loxinter, macpod-o, mahacef plus, maloflox, marromel 0.3%, masterflox, medofloxine, mefoxa, menazin, menefloks, mergexin, microbac, mifloxin, milixim-o, mofcare, monoflocet, monofloxofta, monoox, newflox oftalmico, nida, nilavid, nizanof, nomxime-o, nostil, nufafloqo, nuo qing, o-cebran, o-tab, obact, obactin, obenasin, obid-nt, occidal, occufloxine 0.3%, ocin, octacin, octavic, octin, ocuflox, ocuflox 0.3%, ofax, ofbeat, ofcin, offal, office, ofkozin, ofla, oflacin, oflage, oflaprime, oflex, oflicin, oflicin 0.3%, oflict, oflin, oflo, oflo tad, oflocee, oflocet, oflocheck, oflocin, oflocol, oflocom, oflodal, oflodex, oflodinex, oflodis, oflogen, ofloguide, oflohexal, ofloject, oflomac, oflomac-dx, oflomed, oflomil, oflosol, oflostar, oflosyn, oflotas, oflotas-aversi, oflovid, oflovir, oflox, oflox 0.3%, oflox-ct, ofloxa-vision, ofloxacin - 1 a pharma, ofloxacin - ark, ofloxacin - southwest synthetic, ofloxacin - sunve pharm, ofloxacin - team pharm, ofloxacin - xinhua pharm, ofloxacin 0.3% chos, ofloxacin 0.3% sigmatec, ofloxacin 0.3% tanabe, ofloxacin 0.3% teva, ofloxacin 0.3% wakamoto, ofloxacin abz, ofloxacin al, ofloxacin borisovskiy, ofloxacin daewon, ofloxacin dr. reddy's, ofloxacin indo farma, ofloxacin ogb dexa, ofloxacin pacific, ofloxacin ratiopharm, ofloxacin sandoz, ofloxacin sawai, ofloxacin sedico, ofloxacin stada, ofloxacin stada uro, ofloxacin stulln, ofloxacin tanabe, ofloxacin teva, ofloxacin ultra, ofloxacin unimed, ofloxacin-darnitsa, ofloxacin-pos, ofloxacin-ratiopharm, ofloxacina, ofloxacina bactoflox, ofloxacina laropharm, ofloxacina loficer, ofloxacina mylan, ofloxacina poen, ofloxacina ratiopharm, ofloxacine arrow, ofloxacine biogaran, ofloxacine cf, ofloxacine cristers, ofloxacine eberth, ofloxacine eg, ofloxacine evolugen, ofloxacine macopharma, ofloxacine mylan, ofloxacine mylan pharma, ofloxacine pch, ofloxacine ranbaxy, ofloxacine regiomedica, ofloxacine sandoz, ofloxacine stulln, ofloxacine teva, ofloxacine winthrop, ofloxacine zentiva, ofloxacine-pos, ofloxacino, ofloxacino combix, ofloxacino g.e.s., ofloxacino ges, ofloxacino ranbaxy, ofloxacino teva, ofloxamed, ofloxat 0.3%, ofloxin, ofloxin 0.3%, oflux-e, ofras, oftector 0.3%, ofus, ofzac, oharaxin, oharaxin 0.3%, olcavit 0.3%, olcefone-ab, olfi, olpit, olpit-nz, operan, opool 0.3%, optiflox, optiflox 0.3%, orecil nf, orfix-o, oriwel-cf, orixa, orocin, osani-ds, osani-nt, ostrid, otoflox, otoxin, otoxin 0.3%, ottoflox, oxacid, oxacin, oxal, oxalic, oxit, oxitil-of, pharex ofloxacin, pharflox, pharxacin 0.3%, podobid-o, polypod-o, poncoquin, ponebac, pranoflox, proxcef-of, qinolon, quiflural, quinofree, quinovid, quotavil, ricime-of, rilox, rofloxan, rui da, rutix, sandoz ofloxacin, sanicif-ox, satrogyl-o, seffix plus, sensoflox, sifizaim plus, sinflo, starfix-of, sufix-ox, surnox, tabrin, tafloc, tai fu kang, talocin-c, tariflox, tariflox 0.3%, tarifron, tarifron 0.3%, tarivan, tarivid, tarivid 0.3%, tarivid ophtalmic, tarivid otic, tarivid otic solution, tarivid richter, tarixacin 0.3%, tarizart, tarizart 0.3%, taroflox, tatsumixin, taxpik-of, telbit, terioxan, thamic, tisol, tocodox-of, trafloxal, tricef-o, tructum, typhicure, uflox, uniflox 0.3%, uro-tarivid, urostat, vaxim-of, vioson, viotisone, visiren, vista, wokocef-o, x-life of, xaflo, xatron 0.3%, xibit-of, ximep-o, xin long ofloxacin, xinlituo, xiomix-o, yan hua xing, yang da ning, yelcef-o, zanocin, zelavel, zenflox, zenflox forte, zenflox-d, zenflox-nt, zenof, zeph-of, zevid, zifi-o, zipod-o, zo, zo-d, zofex, zoxakind-o, zyflox)
Rank | Probiotic | Impact |
---|---|---|
species | Acinetobacter calcoaceticus | Reduces |
species | Bacteroides uniformis | Reduces |
species | Escherichia coli | Reduces |
species | Phocaeicola coprocola | Reduces |
species | Pseudomonas sp. cn4902 | Reduces |
species group | Pseudomonas putida group | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
π Direct Citations | πͺπΆ Indirect Citations | Taxonomy | Rank | Effect |
---|---|---|---|---|
6 | 0 | Escherichia coli | species | Decreases |
4 | 2 | Escherichia | genus | Decreases |
4 | 0 | Kluyvera | genus | Decreases |
4 | 0 | Pseudomonas aeruginosa | species | Decreases |
3 | 1 | Staphylococcus aureus | species | Decreases |
3 | 1 | Pseudomonas aeruginosa group | species group | Decreases |
3 | 0 | Citrobacter | genus | Decreases |
3 | 0 | Enterobacter | genus | Decreases |
3 | 0 | Klebsiella | genus | Decreases |
3 | 0 | Morganella | genus | Decreases |
3 | 0 | Pseudomonas | genus | Decreases |
3 | 0 | Salmonella | genus | Decreases |
3 | 0 | Bacteroides fragilis | species | Decreases |
3 | 0 | Morganella morganii | species | Decreases |
2 | 2 | Staphylococcus | genus | Decreases |
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive β X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
---|---|---|---|
Abdominal Aortic Aneurysm | 1 | 1 | |
Acne | 1.9 | 1.9 | |
Addison's Disease (hypocortisolism) | 0.5 | 0.5 | |
ADHD | 2.4 | 1 | 1.4 |
Age-Related Macular Degeneration and Glaucoma | 1 | 1 | |
Allergic Rhinitis (Hay Fever) | 3.8 | 1.3 | 1.92 |
Allergies | 4.7 | 2.4 | 0.96 |
Allergy to milk products | 2.7 | 1 | 1.7 |
Alopecia (Hair Loss) | 0.7 | 0.7 | |
Alzheimer's disease | 4.7 | 4.5 | 0.04 |
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