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Tendon Rupture: Like other fluoroquinolone antibiotics, clinafloxacin has been associated with an increased risk of tendon ruptures, particularly in the Achilles tendon. This risk may be higher in older adults, those taking corticosteroids, and individuals with a history of tendon disorders.
Peripheral Neuropathy: Clinafloxacin, along with other fluoroquinolones, has been linked to peripheral neuropathy, which involves damage to the nerves outside of the brain and spinal cord. Symptoms may include pain, tingling, numbness, or weakness in the extremities.
Central Nervous System Effects: Some individuals taking clinafloxacin may experience central nervous system side effects such as dizziness, headache, confusion, or hallucinations. These effects are usually reversible but can be concerning, especially in vulnerable populations.
Cardiovascular Effects: There have been reports of cardiovascular adverse effects associated with clinafloxacin, including QT interval prolongation, which can lead to a potentially life-threatening arrhythmia known as torsades de pointes.
Hepatotoxicity: Clinafloxacin can cause liver toxicity, leading to elevated liver enzymes, hepatitis, or liver failure in rare cases. Symptoms may include jaundice (yellowing of the skin or eyes), abdominal pain, or dark urine.
Photosensitivity: Like other fluoroquinolones, clinafloxacin may increase the skin's sensitivity to sunlight, leading to sunburn or skin rash with sun exposure.
Gastrointestinal Effects: Common gastrointestinal side effects of clinafloxacin may include nausea, vomiting, diarrhea, or abdominal discomfort.
Allergic Reactions: Some individuals may experience allergic reactions to clinafloxacin, which can manifest as rash, itching, swelling, or difficulty breathing. Severe allergic reactions like anaphylaxis are rare but can occur.
Musculoskeletal Effects: In addition to tendon ruptures, clinafloxacin may rarely cause muscle weakness or muscle pain, particularly in individuals with underlying muscle disorders.
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
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