🍽️ cefdinir (antibiotic)

Bacterial Infections: Cefdinir is effective against a wide range of bacterial infections, including those of the respiratory tract (e.g., pneumonia, bronchitis, sinusitis), skin and soft tissues, urinary tract (e.g., cystitis), and middle ear infections (otitis media).

Mechanism of Action: Cefdinir works by inhibiting bacterial cell wall synthesis, leading to cell wall disruption and bacterial cell death. It achieves this by binding to penicillin-binding proteins (PBPs), similar to other beta-lactam antibiotics.

Spectrum of Activity: Cefdinir has a broad spectrum of activity against Gram-positive bacteria, including Streptococcus pneumoniae and Streptococcus pyogenes, as well as some Gram-negative bacteria like Haemophilus influenzae and Moraxella catarrhalis.

Oral Administration: Cefdinir is typically administered orally, either as capsules or as a suspension. This makes it convenient for outpatient treatment of infections, especially in children who may have difficulty swallowing pills.

Dosage and Duration: The dosage and duration of cefdinir treatment depend on the type and severity of the infection, as well as the patient's age, weight, and renal function. It is important to complete the full course of treatment as prescribed by the healthcare provider to ensure eradication of the infection.

Adverse Effects: Common adverse effects of cefdinir include gastrointestinal symptoms such as diarrhea, nausea, vomiting, and abdominal pain. Skin rash, itching, and allergic reactions may occur, particularly in individuals with a history of penicillin allergy. Anaphylactic reactions are rare but can be severe.

Superinfections: Prolonged or repeated use of cefdinir can lead to the development of superinfections caused by resistant organisms or fungi. Careful monitoring for the emergence of secondary infections is important during treatment.

Drug Interactions: Cefdinir may interact with other medications, including antacids containing aluminum or magnesium, which can reduce its absorption. It is recommended to space the administration of cefdinir and antacids by at least 2 hours.

Renal Impairment: Dosage adjustment may be necessary in patients with renal impairment, as cefdinir is primarily excreted by the kidneys. Accumulation of the drug can occur in patients with impaired renal function, leading to potential toxicity.

Pediatric Use: Cefdinir is commonly used in pediatric patients for the treatment of various bacterial infections. The dosing regimen may need adjustment based on the child's age and weight.