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🍽️ clofazimine (antibiotic)

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  1. Leprosy (Hansen's Disease): Clofazimine is one of the key medications used in the multidrug therapy (MDT) regimen for treating leprosy. It is particularly effective against the leprosy bacillus (Mycobacterium leprae) and is used to kill the bacteria and control the symptoms of the disease.

  2. Mycobacterial Infections: Clofazimine has also been used off-label to treat other mycobacterial infections, such as Mycobacterium avium complex (MAC) infections in patients with HIV/AIDS.

  3. Antimicrobial Activity: Clofazimine exhibits a broad spectrum of antimicrobial activity against various bacteria, including Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium kansasii, and others.

  4. Anti-inflammatory Effects: Clofazimine has been reported to possess anti-inflammatory properties, which may contribute to its therapeutic effects in conditions like leprosy, where inflammation plays a significant role in tissue damage and nerve injury.

  5. Immune Modulation: There is some evidence to suggest that clofazimine may modulate the immune response, potentially enhancing the body's ability to fight off infections.

  6. Skin Discoloration: One notable side effect of clofazimine is skin discoloration. It can cause reddish-brown or blackish discoloration of the skin, especially in areas exposed to sunlight. This side effect is usually reversible upon discontinuation of the medication but may persist for some time.

  7. Gastrointestinal Effects: Clofazimine can cause gastrointestinal side effects such as nausea, vomiting, and abdominal pain. These side effects are usually mild and transient but may require discontinuation of the medication in some cases.

  8. Ocular Effects: Prolonged use of clofazimine may lead to ocular side effects, including dryness, itching, and pigmentation of the conjunctiva and cornea. Regular ophthalmologic monitoring is recommended for patients on long-term clofazimine therapy.

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⚗️ Compensation for antibiotic usage

Data Contradictions — Limits of Certainity

Impacted of clofazimine (antibiotic) On Probiotics

Rank Probiotic Impact
genus Bifidobacterium Reduces
species Bacteroides uniformis Reduces
species Bifidobacterium adolescentis Reduces
species Bifidobacterium longum Reduces
species Escherichia coli Reduces
species Lacticaseibacillus paracasei Reduces
species Parabacteroides distasonis Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by clofazimine (antibiotic)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 2 Mycobacteriaceae family Decreases
1 1 Mycobacterium genus Decreases
0 1 Escherichia genus Decreases
0 1 Dorea genus Decreases
0 1 Roseburia genus Decreases
1 0 Mycobacteroides genus Decreases
0 1 Parabacteroides genus Decreases
0 1 Ruminococcus genus Decreases
0 1 Agathobacter genus Decreases
0 1 Bacteroides genus Decreases
0 1 Bifidobacterium genus Decreases
0 1 Clostridioides genus Decreases
0 1 Collinsella genus Decreases
0 1 Coprococcus genus Decreases
0 1 Eggerthella genus Decreases
0 1 Fusobacterium genus Decreases
0 1 Lachnospira genus Decreases
0 1 Lacrimispora genus Decreases
0 1 Mediterraneibacter genus Decreases
0 1 Odoribacter genus Decreases
0 1 Phocaeicola genus Decreases
0 1 Streptococcus genus Decreases
0 1 Veillonella genus Decreases
0 1 Clostridium genus Decreases
0 1 Segatella genus Decreases
0 1 Blautia genus Decreases
0 1 Thomasclavelia genus Decreases
0 1 Lacticaseibacillus genus Decreases
0 1 Escherichia coli O25:H16 no rank Decreases
0 1 Clostridium perfringens A no rank Decreases
0 1 Clostridium perfringens C no rank Decreases
0 1 Clostridium perfringens CPE no rank Decreases
0 1 environmental samples no rank Decreases
0 1 Escherichia coli O145:H34 no rank Decreases
0 1 Escherichia coli O16:H48 no rank Decreases
0 1 unclassified Mycobacterium no rank Decreases
0 1 Clostridium perfringens D no rank Decreases
0 1 Escherichia coli O141:H4 no rank Decreases
0 1 Clostridium perfringens B no rank Decreases
0 1 Escherichia coli O139:H1 no rank Decreases
0 1 Clostridium perfringens E no rank Decreases
0 1 Escherichia coli O80:H26 no rank Decreases
0 1 Escherichia coli O158:H23 no rank Decreases
0 1 Escherichia coli O84:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H4 no rank Decreases
0 1 Escherichia coli O2:K1:H7 no rank Decreases
0 1 Escherichia coli O78:H51 no rank Decreases
0 1 Escherichia coli O18ac:H14 no rank Decreases
0 1 Escherichia coli O85:H1 no rank Decreases
0 1 Escherichia coli O7:H15 no rank Decreases
0 1 Escherichia coli O68:H12 no rank Decreases
0 1 Escherichia coli O55:H7 no rank Decreases
0 1 Escherichia coli O1:K1:H7 no rank Decreases
0 1 Escherichia coli O15:H12 no rank Decreases
0 1 Escherichia coli O170:H18 no rank Decreases
0 1 Escherichia coli O155:H21 no rank Decreases
0 1 Escherichia coli O19:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H5 no rank Decreases
0 1 Escherichia coli O20:H12 no rank Decreases
0 1 Escherichia coli O111 serogroup Decreases
0 1 Escherichia coli O121 serogroup Decreases
0 1 Escherichia coli O155 serogroup Decreases
0 1 Escherichia coli O177 serogroup Decreases
0 1 Escherichia coli O26 serogroup Decreases
0 1 Escherichia coli O3 serogroup Decreases
0 1 Escherichia coli O5 serogroup Decreases
0 1 Escherichia coli O86 serogroup Decreases
0 1 Escherichia coli O91 serogroup Decreases
0 1 Escherichia coli O103 serogroup Decreases
0 1 Escherichia coli O78 serogroup Decreases
0 1 Escherichia coli O43 serogroup Decreases
0 1 Escherichia coli O119 serogroup Decreases
0 1 Escherichia coli O157 serogroup Decreases
0 1 Escherichia coli O145 serogroup Decreases
0 1 Escherichia coli O1:HNT serotype Decreases
0 1 Escherichia coli O10:K5(L):H4 serotype Decreases
0 1 Escherichia coli O103:H11 serotype Decreases
0 1 Escherichia coli O103:H25 serotype Decreases
0 1 Escherichia coli O104:H21 serotype Decreases
0 1 Escherichia coli O111:H11 serotype Decreases
0 1 Escherichia coli O111:H8 serotype Decreases
0 1 Escherichia coli O112ac:H19 serotype Decreases
0 1 Escherichia coli O114:H49 serotype Decreases
0 1 Escherichia coli O118:H16 serotype Decreases
0 1 Escherichia coli O121:H7 serotype Decreases
0 1 Escherichia coli O123:H11 serotype Decreases
0 1 Escherichia coli O127:H27 serotype Decreases
0 1 Escherichia coli O127:H6 serotype Decreases
0 1 Escherichia coli O128:H2 serotype Decreases
0 1 Escherichia coli O128ac:H12 serotype Decreases
0 1 Escherichia coli O145:H25 serotype Decreases
0 1 Escherichia coli O145:NM serotype Decreases
0 1 Escherichia coli O146:H21 serotype Decreases
0 1 Escherichia coli O153:H2 serotype Decreases
0 1 Escherichia coli O156:H25 serotype Decreases
0 1 Escherichia coli O157:H43 serotype Decreases
0 1 Escherichia coli O157:NM serotype Decreases
0 1 Escherichia coli O165:H25 serotype Decreases
0 1 Escherichia coli O174:H2 serotype Decreases
0 1 Escherichia coli O174:H21 serotype Decreases
0 1 Escherichia coli O174:H8 serotype Decreases
0 1 Escherichia coli O176:H45 serotype Decreases
0 1 Escherichia coli O177:NM serotype Decreases
0 1 Escherichia coli O26:H1 serotype Decreases
0 1 Escherichia coli O28ac:NM serotype Decreases
0 1 Escherichia coli O29:H4 serotype Decreases
0 1 Escherichia coli O32:H37 serotype Decreases
0 1 Escherichia coli O6:H16:CFA/II serotype Decreases
0 1 Escherichia coli O69:H11 serotype Decreases
0 1 Escherichia coli O78:H12 serotype Decreases
0 1 Escherichia coli O79:H7 serotype Decreases
0 1 Escherichia coli O81:NM serotype Decreases
0 1 Escherichia coli O86:H34 serotype Decreases
0 1 Escherichia coli O91:H14 serotype Decreases
0 1 Escherichia coli O91:NM serotype Decreases
0 1 Escherichia coli ONT:H33 serotype Decreases
0 1 Escherichia coli O100:H21 serotype Decreases
0 1 Escherichia coli O121:H19 serotype Decreases
0 1 Escherichia coli O157:H7 serotype Decreases
0 1 Escherichia coli O16:H6 serotype Decreases
0 1 Escherichia coli O89m:H9 serotype Decreases
0 1 Escherichia coli O111:H- serotype Decreases
0 1 Escherichia coli O113:H21 serotype Decreases
0 1 Escherichia coli H20 serotype Decreases
0 1 Escherichia coli O150:H6 serotype Decreases
0 1 Escherichia coli O111:NM serotype Decreases
0 1 Escherichia coli O112ab:H8 serotype Decreases
0 1 Escherichia coli O99:H6 serotype Decreases
0 1 Escherichia coli O26:H11 serotype Decreases
0 1 Escherichia coli O145:H28 serotype Decreases
0 1 Escherichia coli O126:H45 serotype Decreases
0 1 Escherichia coli O2:H6 serotype Decreases
0 1 Escherichia coli O7:H4 serotype Decreases
0 1 Escherichia coli O1:H42 serotype Decreases
0 1 Escherichia coli O25:NM serotype Decreases
0 1 Escherichia coli O25:H1 serotype Decreases
0 1 Escherichia coli O7:K1 serotype Decreases
0 1 Escherichia coli O125ac:K+:H10 serotype Decreases
0 1 Escherichia coli O6:K2:H1 serotype Decreases
0 1 Escherichia coli O152:H23 serotype Decreases
0 1 Escherichia coli O15:H18 serotype Decreases
0 1 Escherichia coli O39:NM serotype Decreases
0 1 Escherichia coli O44:H18 serotype Decreases
0 1 Escherichia coli O2:K2:H1 serotype Decreases
0 1 Escherichia coli O8:H8 serotype Decreases
0 1 Escherichia coli O89m:H10 serotype Decreases
0 1 Escherichia coli O10:H32 serotype Decreases
0 1 Escherichia coli O6:H16 serotype Decreases
0 1 Escherichia coli O157:H- serotype Decreases
0 1 Escherichia coli O45:H2 serotype Decreases
0 1 Escherichia coli O103:H2 serotype Decreases
0 1 Escherichia coli O167:H26 serotype Decreases
0 1 Escherichia coli O104:H4 serotype Decreases
0 1 Escherichia coli O83:H1 serotype Decreases
0 1 Escherichia coli O9:H10 serotype Decreases
0 1 Escherichia coli O78:H4 serotype Decreases
0 1 Escherichia coli O139:H28 serotype Decreases
2 0 Mycobacterium avium species Decreases
1 0 [Ruminococcus] torques species Decreases
1 0 Agathobacter rectalis species Decreases
1 0 Bacteroides caccae species Decreases
1 0 Bacteroides fragilis species Decreases
1 0 Bacteroides ovatus species Decreases
1 0 Bacteroides thetaiotaomicron species Decreases
1 0 Bacteroides uniformis species Decreases
1 0 Bacteroides xylanisolvens species Decreases
1 0 Bifidobacterium longum species Decreases
1 0 Blautia obeum species Decreases
1 0 Clostridioides difficile species Decreases
1 0 Clostridium perfringens species Decreases
1 0 Collinsella aerofaciens species Decreases
1 0 Coprococcus comes species Decreases
1 0 Dorea formicigenerans species Decreases
1 0 Eggerthella lenta species Decreases
1 0 Lachnospira eligens species Decreases
1 0 Lacrimispora saccharolytica species Decreases
1 0 Lacticaseibacillus paracasei species Decreases
1 0 Mediterraneibacter gnavus species Decreases
1 0 Odoribacter splanchnicus species Decreases
1 0 Parabacteroides distasonis species Decreases
1 0 Parabacteroides merdae species Decreases
1 0 Phocaeicola vulgatus species Decreases
1 0 Roseburia hominis species Decreases
1 0 Roseburia intestinalis species Decreases
1 0 Ruminococcus bromii species Decreases
1 0 Segatella copri species Decreases
1 0 Streptococcus parasanguinis species Decreases
1 0 Streptococcus salivarius species Decreases
1 0 Thomasclavelia ramosa species Decreases
1 0 Veillonella parvula species Decreases
0 1 Mycobacteroides abscessus species Decreases
1 0 Bifidobacterium adolescentis species Decreases
0 1 Mycobacteroides chelonae species Decreases
0 1 [Mycobacterium] stephanolepidis species Decreases
0 1 Candidatus Mycobacterium methanotrophicum species Decreases
0 1 Mycobacterium adipatum species Decreases
0 1 Mycobacterium aquaticum species Decreases
0 1 Mycobacterium basiliense species Decreases
0 1 Mycobacterium botniense species Decreases
0 1 Mycobacterium branderi species Decreases
0 1 Mycobacterium buckleii species Decreases
0 1 Mycobacterium colombiense species Decreases
0 1 Mycobacterium conspicuum species Decreases
0 1 Mycobacterium cookii species Decreases
0 1 Mycobacterium dioxanotrophicus species Decreases
0 1 Mycobacterium gallinarum species Decreases
0 1 Mycobacterium gastri species Decreases
0 1 Mycobacterium gordonae species Decreases
0 1 Mycobacterium haemophilum species Decreases
0 1 Mycobacterium heckeshornense species Decreases
0 1 Mycobacterium hyorhinis species Decreases
0 1 Mycobacterium intracellulare species Decreases
0 1 Mycobacterium kansasii species Decreases
0 1 Mycobacterium lacticola species Decreases
0 1 Mycobacterium lacus species Decreases
0 1 Mycobacterium lehmannii species Decreases
0 1 Mycobacterium leprae species Decreases
0 1 Mycobacterium lepraemurium species Decreases
0 1 Mycobacterium lepromatosis species Decreases
0 1 Mycobacterium malmoense species Decreases
0 1 Mycobacterium mantenii species Decreases
0 1 Mycobacterium marseillense species Decreases
0 1 Mycobacterium neglectum species Decreases
0 1 Mycobacterium noviomagense species Decreases
0 1 Mycobacterium novum species Decreases
0 1 Mycobacterium ostraviense species Decreases
0 1 Mycobacterium paraintracellulare species Decreases
0 1 Mycobacterium paraseoulense species Decreases
0 1 Mycobacterium paraterrae species Decreases
0 1 Mycobacterium riyadhense species Decreases
0 1 Mycobacterium seoulense species Decreases
0 1 Mycobacterium shinjukuense species Decreases
0 1 Mycobacterium simulans species Decreases
0 1 Mycobacterium spongiae species Decreases
0 1 Mycobacterium sydneyiensis species Decreases
0 1 Mycobacterium szulgai species Decreases
0 1 Mycobacterium talmoniae species Decreases
0 1 Mycobacterium vicinigordonae species Decreases
0 1 Mycobacterium xenopi species Decreases
0 1 Mycobacteroides immunogenum species Decreases
0 1 Mycobacteroides salmoniphilum species Decreases
0 1 Mycobacteroides saopaulense species Decreases
0 1 Mycolicibacterium grossiae species Decreases
1 0 Fusobacterium nucleatum species Decreases
1 0 Escherichia coli species Decreases
0 1 Mycobacterium paragordonae species Decreases
1 2 Mycobacterium avium complex (MAC) species group Decreases
0 1 Mycobacterium simiae complex species group Decreases
0 1 Mycobacterium tuberculosis complex species group Decreases
0 1 Mycobacterium ulcerans group species group Decreases
0 2 Mycobacterium avium subsp. hominissuis subspecies Decreases
0 2 Mycobacterium avium subsp. paratuberculosis subspecies Decreases
0 1 Bifidobacterium longum subsp. longum subspecies Decreases
0 1 Bifidobacterium longum subsp. infantis subspecies Decreases
0 1 Bifidobacterium longum subsp. suis subspecies Decreases
0 1 Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases
0 1 Fusobacterium nucleatum subsp. nucleatum subspecies Decreases
0 1 Lacticaseibacillus paracasei subsp. tolerans subspecies Decreases
0 1 Bifidobacterium longum subsp. suillum subspecies Decreases

Impact of clofazimine (antibiotic) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.6 0.6
Acne 0.6 0.9 -0.5
ADHD 5.4 0.9 5
Age-Related Macular Degeneration and Glaucoma 1.1 0.4 1.75
Allergic Rhinitis (Hay Fever) 3.4 2.4 0.42
Allergies 7.1 3.4 1.09
Allergy to milk products 1.5 1.6 -0.07
Alopecia (Hair Loss) 1.6 1.6
Alzheimer's disease 5.6 7.7 -0.38
Amyotrophic lateral sclerosis (ALS) Motor Neuron 3.2 0.4 7
Ankylosing spondylitis 4.3 1.8 1.39
Anorexia Nervosa 1.6 3.2 -1
Antiphospholipid syndrome (APS) 2.3 2.3
Asthma 6 2.3 1.61
Atherosclerosis 2.1 2.5 -0.19
Atrial fibrillation 4.1 2.8 0.46
Autism 10.2 10 0.02
Autoimmune Disease 1.2 1 0.2
Barrett esophagus cancer 0.6 0.3 1
benign prostatic hyperplasia 0.6 0.3 1
Biofilm 2 2
Bipolar Disorder 2.1 1.7 0.24
Brain Trauma 0.9 1.4 -0.56
Breast Cancer 0.2 0.2
Cancer (General) 0.9 3.3 -2.67
Carcinoma 4.2 2.6 0.62
Celiac Disease 3 3.5 -0.17
Cerebral Palsy 1.4 1.3 0.08
Chronic Fatigue Syndrome 5.5 7.1 -0.29
Chronic Kidney Disease 5.2 2.6 1
Chronic Lyme 0.6 0.8 -0.33
Chronic Obstructive Pulmonary Disease (COPD) 2.4 2 0.2
Chronic Urticaria (Hives) 1.5 1.2 0.25
Coagulation / Micro clot triggering bacteria 1.4 1.3 0.08
Cognitive Function 3.6 1.6 1.25
Colorectal Cancer 7.4 2.3 2.22
Constipation 2.1 0.7 2
Coronary artery disease 2.5 3 -0.2
COVID-19 11 13.8 -0.25
Crohn's Disease 9 5.8 0.55
Cushing's Syndrome (hypercortisolism) 0.9 -0.9
cystic fibrosis 1.7 1.8 -0.06
d-lactic acidosis (one form of brain fog) 0.1 0.1
deep vein thrombosis 2.7 1.4 0.93
Denture Wearers Oral Shifts 1.6 1.6
Depression 11.5 9.9 0.16
Dermatomyositis 0.3 0.3 0
Eczema 2.7 2.6 0.04
Endometriosis 3 2.1 0.43
Eosinophilic Esophagitis 0.3 0.6 -1
Epilepsy 3.5 1.7 1.06
erectile dysfunction 2.6 0.3 7.67
Fibromyalgia 3.7 2.6 0.42
Functional constipation / chronic idiopathic constipation 6.3 4.9 0.29
gallstone disease (gsd) 3.8 1.1 2.45
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 1.9 1.2 0.58
Generalized anxiety disorder 2.9 2.5 0.16
giant cell arteritis 0.2 -0.2
Glioblastoma 0.3 -0.3
Gout 2.4 0.8 2
Graves' disease 2.3 3.3 -0.43
Gulf War Syndrome 0.9 1.5 -0.67
Halitosis 1.3 0.3 3.33
Hashimoto's thyroiditis 4.8 1.5 2.2
Heart Failure 4.7 1.9 1.47
hemorrhagic stroke 1.3 1.3
Hidradenitis Suppurativa 1.5 0.3 4
High Histamine/low DAO 1.4 0.6 1.33
hypercholesterolemia (High Cholesterol) 0.6 0.6
hyperglycemia 1.9 1.1 0.73
Hyperlipidemia (High Blood Fats) 0.6 0.3 1
hypersomnia 0.4 -0.4
hypertension (High Blood Pressure 4.7 6 -0.28
Hypothyroidism 1 -1
Hypoxia 3.1 0.9 2.44
IgA nephropathy (IgAN) 1.9 5.5 -1.89
Inflammatory Bowel Disease 9.5 9.8 -0.03
Insomnia 2.5 2.4 0.04
Intelligence 1.5 0.6 1.5
Intracranial aneurysms 1.4 0.6 1.33
Irritable Bowel Syndrome 7.9 5.6 0.41
ischemic stroke 2.7 1.7 0.59
Liver Cirrhosis 7.9 3.4 1.32
Long COVID 7.6 8.5 -0.12
Low bone mineral density 1.1 -1.1
Lung Cancer 1.2 1 0.2
Lymphoma 0.6 0.6
Mast Cell Issues / mastitis 1 0.9 0.11
ME/CFS with IBS 0.5 2.4 -3.8
ME/CFS without IBS 2 2.4 -0.2
membranous nephropathy 0.3 0.3
Menopause 2.1 0.5 3.2
Metabolic Syndrome 7.6 8.2 -0.08
Mood Disorders 11.4 8.4 0.36
multiple chemical sensitivity [MCS] 1.2 0.1 11
Multiple Sclerosis 8.1 7 0.16
Multiple system atrophy (MSA) 1.2 0.7 0.71
myasthenia gravis 1.2 0.7 0.71
neuropathic pain 0.3 3.1 -9.33
Neuropathy (all types) 0.7 2.2 -2.14
neuropsychiatric disorders (PANDAS, PANS) 0.7 0.7
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 6 4.8 0.25
NonCeliac Gluten Sensitivity 1.3 0.6 1.17
Obesity 10.3 8.4 0.23
obsessive-compulsive disorder 6.5 4.2 0.55
Osteoarthritis 3.3 1.2 1.75
Osteoporosis 2.5 1.3 0.92
pancreatic cancer 0.7 0.3 1.33
Parkinson's Disease 8.1 8.3 -0.02
Polycystic ovary syndrome 7.9 2.9 1.72
Postural orthostatic tachycardia syndrome 0.2 0.6 -2
Premenstrual dysphoric disorder 0.7 0.4 0.75
primary biliary cholangitis 1.2 1.7 -0.42
Primary sclerosing cholangitis 3 3.2 -0.07
Psoriasis 3.4 3.4 0
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 9.2 4.7 0.96
Rosacea 1.2 0.7 0.71
Schizophrenia 6.9 3.1 1.23
scoliosis 0.4 0.9 -1.25
Sjögren syndrome 3.2 3.2 0
Sleep Apnea 2.2 1.8 0.22
Slow gastric motility / Gastroparesis 1 0.3 2.33
Small Intestinal Bacterial Overgrowth (SIBO) 1.7 0.6 1.83
Stress / posttraumatic stress disorder 2.7 2.7 0
Systemic Lupus Erythematosus 5 2.4 1.08
Tic Disorder 1.5 1.8 -0.2
Tourette syndrome 0.9 0.3 2
Type 1 Diabetes 4.7 4.3 0.09
Type 2 Diabetes 8.6 7.4 0.16
Ulcerative colitis 6 7.4 -0.23
Unhealthy Ageing 5.4 2.4 1.25
Vitiligo 3 1.5 1

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