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🍽️ streptozotocin,(prescription)

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  1. Cytotoxic Effects: Streptozotocin is a cytotoxic agent that selectively destroys pancreatic beta cells, which are responsible for producing insulin. This destruction leads to the development of insulin deficiency and subsequent diabetes mellitus.

  2. Induction of Diabetes: Streptozotocin is commonly used in laboratory settings to induce experimental diabetes mellitus in animal models. By administering streptozotocin, researchers can mimic certain aspects of diabetes to study its pathophysiology, complications, and potential treatment options.

  3. Animal Research: Streptozotocin-induced diabetes is widely used in preclinical research to investigate various aspects of diabetes, including its mechanisms, progression, complications, and therapeutic interventions. Animal models of streptozotocin-induced diabetes have contributed significantly to our understanding of diabetes and the development of new treatments.

  4. Autoimmune Diabetes: Streptozotocin-induced diabetes in animal models shares similarities with type 1 diabetes in humans, which is characterized by autoimmune destruction of pancreatic beta cells. Studying streptozotocin-induced diabetes helps researchers explore the autoimmune mechanisms underlying type 1 diabetes and test potential immunomodulatory therapies.

  5. Chemical Structure: Streptozotocin is a naturally occurring compound derived from Streptomyces achromogenes bacteria. It is structurally similar to glucose and is selectively taken up by pancreatic beta cells via the glucose transporter GLUT2. Once inside the beta cells, streptozotocin induces DNA damage and cellular toxicity, leading to cell death.

  6. Administration Route: Streptozotocin is typically administered via injection, either intravenously or intraperitoneally, to induce diabetes in animal models. The dose and duration of streptozotocin treatment vary depending on the specific experimental requirements and the desired severity of diabetes induction.

  7. Clinical Use: Although streptozotocin is not commonly used in clinical practice due to its toxicity and narrow therapeutic index, it has been investigated as a chemotherapeutic agent for the treatment of certain cancers, including pancreatic islet cell tumors and metastatic insulinoma. However, its clinical utility in cancer treatment is limited by its side effects and lack of efficacy compared to other chemotherapy agents.

  8. Side Effects: In addition to its intended cytotoxic effects on pancreatic beta cells, streptozotocin may cause systemic toxicity, including gastrointestinal disturbances, hematological abnormalities, and renal toxicity. The use of streptozotocin in clinical or research settings requires careful monitoring and management of potential side effects.

  9. Limitations: While streptozotocin-induced diabetes is a valuable tool for studying certain aspects of diabetes, it does not fully recapitulate the complexity of human diabetes, particularly type 2 diabetes, which involves insulin resistance in addition to beta cell dysfunction. Researchers must consider these limitations when interpreting data from streptozotocin-induced diabetic models.

  10. Ethical Considerations: The use of streptozotocin in animal research raises ethical considerations regarding the welfare of laboratory animals. Researchers must adhere to ethical guidelines and regulations governing the use of animals in research to minimize suffering and ensure the humane treatment of experimental animals.

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Impacted of streptozotocin,(prescription) On Probiotics

Bacteria Impacted by streptozotocin,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

Impact of streptozotocin,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

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