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🍽️ mafenide hydrochloride (antibiotic)

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  1. Burn Wounds: Mafenide hydrochloride is used to prevent and treat infections in burn wounds. Burn injuries create an open wound that is vulnerable to bacterial colonization and infection. Mafenide hydrochloride works by penetrating the burned tissue and inhibiting the growth of a wide range of bacteria, including gram-positive and gram-negative organisms.

  2. Antibacterial Action: Mafenide hydrochloride exerts its antibacterial action by interfering with the synthesis of folic acid within bacterial cells, which is essential for bacterial growth and replication. By inhibiting folic acid synthesis, mafenide hydrochloride effectively kills bacteria and prevents their proliferation within the burn wound.

  3. Broad Spectrum: Mafenide hydrochloride has a broad spectrum of activity against many types of bacteria commonly found in burn wounds, including Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter species, Staphylococcus aureus, and Streptococcus pyogenes.

  4. Penetrating Action: Mafenide hydrochloride has the ability to penetrate eschar, the dead tissue that forms over the burn wound, allowing it to reach the underlying viable tissue where bacteria may proliferate. This penetration enhances its effectiveness in preventing and treating infections.

  5. Reduction of Sepsis Risk: By preventing and treating infections in burn wounds, mafenide hydrochloride helps reduce the risk of systemic infection (sepsis) and other complications associated with severe burns. Prompt and effective treatment with mafenide hydrochloride is essential for optimizing wound healing and preventing further tissue damage.

  6. Pain Management: Mafenide hydrochloride may cause a stinging or burning sensation upon application, which can be managed with appropriate wound care and pain management techniques. Despite this discomfort, the benefits of preventing and treating infections outweigh the temporary discomfort associated with its use.

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βš—οΈ Compensation for antibiotic usage

Data Contradictions β€” Limits of Certainity

Impacted of mafenide hydrochloride (antibiotic) On Probiotics

Bacteria Impacted by mafenide hydrochloride (antibiotic)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

Impact of mafenide hydrochloride (antibiotic) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

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