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🍽️ etoposide,(prescription)

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  1. Antineoplastic Activity: Etoposide is a cytotoxic agent that interferes with the replication and transcription of DNA in rapidly dividing cells, including cancer cells. It is effective against a wide range of cancers, including small cell lung cancer, testicular cancer, lymphomas, leukemias, and certain types of solid tumors.

  2. Treatment of Small Cell Lung Cancer: Etoposide is commonly used in combination with other chemotherapy agents for the treatment of small cell lung cancer (SCLC). It is often administered in combination with cisplatin or carboplatin as part of first-line chemotherapy regimens for SCLC.

  3. Treatment of Testicular Cancer: Etoposide is an essential component of chemotherapy regimens used for the treatment of testicular cancer, including both seminoma and non-seminoma types. It may be used in combination with other chemotherapy drugs such as cisplatin and bleomycin.

  4. Treatment of Lymphomas and Leukemias: Etoposide is used in the treatment of various types of lymphomas and leukemias, including Hodgkin's lymphoma, non-Hodgkin's lymphoma, acute lymphoblastic leukemia (ALL), and acute myeloid leukemia (AML). It may be administered as part of combination chemotherapy regimens.

  5. Mechanism of Action: Etoposide exerts its anticancer effects by inhibiting the enzyme topoisomerase II, which plays a crucial role in DNA replication and repair. By inhibiting topoisomerase II, etoposide induces DNA strand breaks and prevents DNA from being resealed, ultimately leading to cell death.

  6. Administration: Etoposide is typically administered intravenously in a hospital or clinical setting. It may also be given orally in certain cases. The dosage and schedule of etoposide administration depend on various factors, including the type and stage of cancer being treated, the patient's overall health, and the presence of other medical conditions.

  7. Side Effects: Common side effects associated with etoposide treatment include nausea, vomiting, diarrhea, mucositis (inflammation of the mucous membranes), myelosuppression (decreased production of blood cells), hair loss (alopecia), and fatigue. These side effects are usually temporary and reversible after treatment discontinuation.

  8. Bone Marrow Suppression: Etoposide can cause bone marrow suppression, resulting in a decrease in the production of white blood cells, red blood cells, and platelets. This may increase the risk of infections, anemia, and bleeding. Regular monitoring of blood cell counts is essential during etoposide treatment.

  9. Infusion Reactions: Infusion reactions, including hypersensitivity reactions and anaphylaxis, may occur during or shortly after etoposide administration. Patients should be closely monitored for signs of infusion reactions, and appropriate supportive care should be provided as needed.

  10. Other Adverse Effects: Rare but serious adverse effects of etoposide include secondary malignancies, allergic reactions, liver toxicity, kidney toxicity, and neurotoxicity. Patients should be monitored closely for these potential complications during etoposide therapy.

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Data Contradictions — Limits of Certainity

Impacted of etoposide,(prescription) On Probiotics

Rank Probiotic Impact
genus Bifidobacterium Reduces
species Akkermansia muciniphila Reduces
species Bacteroides uniformis Reduces
species Bifidobacterium adolescentis Reduces
species Bifidobacterium longum Reduces
species Escherichia coli Reduces
species Lacticaseibacillus paracasei Reduces
species Parabacteroides distasonis Reduces
subspecies Bifidobacterium longum subsp. infantis Reduces
subspecies Bifidobacterium longum subsp. longum Reduces

Bacteria Impacted by etoposide,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations 👪👶 Indirect Citations Taxonomy Rank Effect
0 1 Akkermansiaceae family Decreases
0 1 Escherichia genus Decreases
0 1 Dorea genus Decreases
0 1 Roseburia genus Decreases
0 1 Parabacteroides genus Decreases
0 1 Ruminococcus genus Decreases
0 1 Agathobacter genus Decreases
0 1 Bacteroides genus Decreases
0 1 Bifidobacterium genus Decreases
0 1 Bilophila genus Decreases
0 1 Clostridioides genus Decreases
0 1 Collinsella genus Decreases
0 1 Coprococcus genus Decreases
0 1 Eggerthella genus Decreases
0 1 Fusobacterium genus Decreases
0 1 Lachnospira genus Decreases
0 1 Lacrimispora genus Decreases
0 1 Mediterraneibacter genus Decreases
0 1 Phocaeicola genus Decreases
0 1 Streptococcus genus Decreases
0 1 Clostridium genus Decreases
0 1 Enterocloster genus Decreases
0 1 Blautia genus Decreases
1 0 Akkermansia genus Decreases
0 1 Thomasclavelia genus Decreases
0 1 Lacticaseibacillus genus Decreases
0 1 Escherichia coli O25:H16 no rank Decreases
0 1 Clostridium perfringens A no rank Decreases
0 1 Clostridium perfringens C no rank Decreases
0 1 Clostridium perfringens CPE no rank Decreases
0 1 environmental samples no rank Decreases
0 1 Escherichia coli O145:H34 no rank Decreases
0 1 Escherichia coli O16:H48 no rank Decreases
0 1 unclassified Akkermansia no rank Decreases
0 1 Clostridium perfringens D no rank Decreases
0 1 Escherichia coli O141:H4 no rank Decreases
0 1 Clostridium perfringens B no rank Decreases
0 1 Escherichia coli O139:H1 no rank Decreases
0 1 Clostridium perfringens E no rank Decreases
0 1 Escherichia coli O80:H26 no rank Decreases
0 1 Escherichia coli O158:H23 no rank Decreases
0 1 Escherichia coli O84:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H4 no rank Decreases
0 1 Escherichia coli O2:K1:H7 no rank Decreases
0 1 Escherichia coli O78:H51 no rank Decreases
0 1 Escherichia coli O18ac:H14 no rank Decreases
0 1 Escherichia coli O85:H1 no rank Decreases
0 1 Escherichia coli O7:H15 no rank Decreases
0 1 Escherichia coli O68:H12 no rank Decreases
0 1 Escherichia coli O55:H7 no rank Decreases
0 1 Escherichia coli O1:K1:H7 no rank Decreases
0 1 Escherichia coli O15:H12 no rank Decreases
0 1 Escherichia coli O170:H18 no rank Decreases
0 1 Escherichia coli O155:H21 no rank Decreases
0 1 Escherichia coli O19:H7 no rank Decreases
0 1 Escherichia coli O2:K1:H5 no rank Decreases
0 1 Escherichia coli O20:H12 no rank Decreases
0 1 Escherichia coli O111 serogroup Decreases
0 1 Escherichia coli O121 serogroup Decreases
0 1 Escherichia coli O155 serogroup Decreases
0 1 Escherichia coli O177 serogroup Decreases
0 1 Escherichia coli O26 serogroup Decreases
0 1 Escherichia coli O3 serogroup Decreases
0 1 Escherichia coli O5 serogroup Decreases
0 1 Escherichia coli O86 serogroup Decreases
0 1 Escherichia coli O91 serogroup Decreases
0 1 Escherichia coli O103 serogroup Decreases
0 1 Escherichia coli O78 serogroup Decreases
0 1 Escherichia coli O43 serogroup Decreases
0 1 Escherichia coli O119 serogroup Decreases
0 1 Escherichia coli O157 serogroup Decreases
0 1 Escherichia coli O145 serogroup Decreases
0 1 Escherichia coli O1:HNT serotype Decreases
0 1 Escherichia coli O10:K5(L):H4 serotype Decreases
0 1 Escherichia coli O103:H11 serotype Decreases
0 1 Escherichia coli O103:H25 serotype Decreases
0 1 Escherichia coli O104:H21 serotype Decreases
0 1 Escherichia coli O111:H11 serotype Decreases
0 1 Escherichia coli O111:H8 serotype Decreases
0 1 Escherichia coli O112ac:H19 serotype Decreases
0 1 Escherichia coli O114:H49 serotype Decreases
0 1 Escherichia coli O118:H16 serotype Decreases
0 1 Escherichia coli O121:H7 serotype Decreases
0 1 Escherichia coli O123:H11 serotype Decreases
0 1 Escherichia coli O127:H27 serotype Decreases
0 1 Escherichia coli O127:H6 serotype Decreases
0 1 Escherichia coli O128:H2 serotype Decreases
0 1 Escherichia coli O128ac:H12 serotype Decreases
0 1 Escherichia coli O145:H25 serotype Decreases
0 1 Escherichia coli O145:NM serotype Decreases
0 1 Escherichia coli O146:H21 serotype Decreases
0 1 Escherichia coli O153:H2 serotype Decreases
0 1 Escherichia coli O156:H25 serotype Decreases
0 1 Escherichia coli O157:H43 serotype Decreases
0 1 Escherichia coli O157:NM serotype Decreases
0 1 Escherichia coli O165:H25 serotype Decreases
0 1 Escherichia coli O174:H2 serotype Decreases
0 1 Escherichia coli O174:H21 serotype Decreases
0 1 Escherichia coli O174:H8 serotype Decreases
0 1 Escherichia coli O176:H45 serotype Decreases
0 1 Escherichia coli O177:NM serotype Decreases
0 1 Escherichia coli O26:H1 serotype Decreases
0 1 Escherichia coli O28ac:NM serotype Decreases
0 1 Escherichia coli O29:H4 serotype Decreases
0 1 Escherichia coli O32:H37 serotype Decreases
0 1 Escherichia coli O6:H16:CFA/II serotype Decreases
0 1 Escherichia coli O69:H11 serotype Decreases
0 1 Escherichia coli O78:H12 serotype Decreases
0 1 Escherichia coli O79:H7 serotype Decreases
0 1 Escherichia coli O81:NM serotype Decreases
0 1 Escherichia coli O86:H34 serotype Decreases
0 1 Escherichia coli O91:H14 serotype Decreases
0 1 Escherichia coli O91:NM serotype Decreases
0 1 Escherichia coli ONT:H33 serotype Decreases
0 1 Escherichia coli O100:H21 serotype Decreases
0 1 Escherichia coli O121:H19 serotype Decreases
0 1 Escherichia coli O157:H7 serotype Decreases
0 1 Escherichia coli O16:H6 serotype Decreases
0 1 Escherichia coli O89m:H9 serotype Decreases
0 1 Escherichia coli O111:H- serotype Decreases
0 1 Escherichia coli O113:H21 serotype Decreases
0 1 Escherichia coli H20 serotype Decreases
0 1 Escherichia coli O150:H6 serotype Decreases
0 1 Escherichia coli O111:NM serotype Decreases
0 1 Escherichia coli O112ab:H8 serotype Decreases
0 1 Escherichia coli O99:H6 serotype Decreases
0 1 Escherichia coli O26:H11 serotype Decreases
0 1 Escherichia coli O145:H28 serotype Decreases
0 1 Escherichia coli O126:H45 serotype Decreases
0 1 Escherichia coli O2:H6 serotype Decreases
0 1 Escherichia coli O7:H4 serotype Decreases
0 1 Escherichia coli O1:H42 serotype Decreases
0 1 Escherichia coli O25:NM serotype Decreases
0 1 Escherichia coli O25:H1 serotype Decreases
0 1 Escherichia coli O7:K1 serotype Decreases
0 1 Escherichia coli O125ac:K+:H10 serotype Decreases
0 1 Escherichia coli O6:K2:H1 serotype Decreases
0 1 Escherichia coli O152:H23 serotype Decreases
0 1 Escherichia coli O15:H18 serotype Decreases
0 1 Escherichia coli O39:NM serotype Decreases
0 1 Escherichia coli O44:H18 serotype Decreases
0 1 Escherichia coli O2:K2:H1 serotype Decreases
0 1 Escherichia coli O8:H8 serotype Decreases
0 1 Escherichia coli O89m:H10 serotype Decreases
0 1 Escherichia coli O10:H32 serotype Decreases
0 1 Escherichia coli O6:H16 serotype Decreases
0 1 Escherichia coli O157:H- serotype Decreases
0 1 Escherichia coli O45:H2 serotype Decreases
0 1 Escherichia coli O103:H2 serotype Decreases
0 1 Escherichia coli O167:H26 serotype Decreases
0 1 Escherichia coli O104:H4 serotype Decreases
0 1 Escherichia coli O83:H1 serotype Decreases
0 1 Escherichia coli O9:H10 serotype Decreases
0 1 Escherichia coli O78:H4 serotype Decreases
0 1 Escherichia coli O139:H28 serotype Decreases
1 0 Eggerthella lenta species Decreases
1 0 [Ruminococcus] torques species Decreases
1 0 Agathobacter rectalis species Decreases
1 0 Bifidobacterium adolescentis species Decreases
1 0 Blautia obeum species Decreases
1 0 Clostridioides difficile species Decreases
1 0 Clostridium perfringens species Decreases
1 0 Collinsella aerofaciens species Decreases
1 0 Coprococcus comes species Decreases
1 0 Dorea formicigenerans species Decreases
1 0 Enterocloster bolteae species Decreases
1 0 Lacrimispora saccharolytica species Decreases
1 0 Lacticaseibacillus paracasei species Decreases
1 0 Mediterraneibacter gnavus species Decreases
1 0 Parabacteroides distasonis species Decreases
1 0 Phocaeicola vulgatus species Decreases
1 0 Roseburia hominis species Decreases
1 0 Roseburia intestinalis species Decreases
1 0 Ruminococcus bromii species Decreases
1 0 Streptococcus parasanguinis species Decreases
1 0 Streptococcus salivarius species Decreases
1 0 Thomasclavelia ramosa species Decreases
1 0 Bacteroides fragilis species Decreases
1 0 Fusobacterium nucleatum species Decreases
1 0 Escherichia coli species Decreases
1 0 Parabacteroides merdae species Decreases
0 1 Akkermansia massiliensis species Decreases
0 1 Candidatus Akkermansia intestinavium species Decreases
1 0 Bifidobacterium longum species Decreases
1 0 Bacteroides uniformis species Decreases
1 0 Lachnospira eligens species Decreases
1 0 Akkermansia muciniphila species Decreases
1 0 Bacteroides thetaiotaomicron species Decreases
1 0 Bilophila wadsworthia species Decreases
0 1 Akkermansia glycaniphila species Decreases
0 1 Bifidobacterium longum subsp. longum subspecies Decreases
0 1 Bifidobacterium longum subsp. infantis subspecies Decreases
0 1 Bifidobacterium longum subsp. suis subspecies Decreases
0 1 Lacticaseibacillus paracasei subsp. paracasei subspecies Decreases
0 1 Fusobacterium nucleatum subsp. nucleatum subspecies Decreases
0 1 Lacticaseibacillus paracasei subsp. tolerans subspecies Decreases
0 1 Bifidobacterium longum subsp. suillum subspecies Decreases

Impact of etoposide,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive   X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition Positive Impact Negative Impact Benefit Ratio Impact
Abdominal Aortic Aneurysm 0.4 0.4
Acne 0.6 0.9 -0.5
ADHD 3.5 0.9 2.89
Age-Related Macular Degeneration and Glaucoma 1.1 0.4 1.75
Allergic Rhinitis (Hay Fever) 3.4 2.5 0.36
Allergies 6.7 3.1 1.16
Allergy to milk products 1.9 1.6 0.19
Alopecia (Hair Loss) 1.6 1.6
Alzheimer's disease 5.1 6.5 -0.27
Amyotrophic lateral sclerosis (ALS) Motor Neuron 2.6 0.8 2.25
Ankylosing spondylitis 3.8 1.8 1.11
Anorexia Nervosa 1.6 2.8 -0.75
Antiphospholipid syndrome (APS) 1.4 0.3 3.67
Asthma 5.3 2.2 1.41
Atherosclerosis 2.3 2 0.15
Atrial fibrillation 3.7 2.5 0.48
Autism 9.8 8.7 0.13
Autoimmune Disease 1.2 1 0.2
Barrett esophagus cancer 0.3 0.3 0
benign prostatic hyperplasia 0.6 0.3 1
Biofilm 2.4 2.4
Bipolar Disorder 2.4 1.4 0.71
Brain Trauma 0.9 1.4 -0.56
Breast Cancer 0.9 0.9
Cancer (General) 0.3 2.4 -7
Carcinoma 4.5 2.3 0.96
Celiac Disease 2.7 2.9 -0.07
Cerebral Palsy 1.1 1.3 -0.18
Chronic Fatigue Syndrome 5.2 6 -0.15
Chronic Kidney Disease 4.3 3 0.43
Chronic Lyme 0.6 0.8 -0.33
Chronic Obstructive Pulmonary Disease (COPD) 2.5 1.7 0.47
Chronic Urticaria (Hives) 1.5 0.6 1.5
Coagulation / Micro clot triggering bacteria 1.7 1.3 0.31
Cognitive Function 3.6 1.3 1.77
Colorectal Cancer 8.4 2.6 2.23
Constipation 2.1 0.7 2
Coronary artery disease 2.8 2.3 0.22
COVID-19 8.8 10.3 -0.17
Crohn's Disease 8.5 5.2 0.63
Cushing's Syndrome (hypercortisolism) 0.9 -0.9
cystic fibrosis 1 1.9 -0.9
d-lactic acidosis (one form of brain fog) 0.4 0.4
deep vein thrombosis 3.3 1.4 1.36
Denture Wearers Oral Shifts 1.4 1.4
Depression 11.7 9.8 0.19
Dermatomyositis 0.3 0.3 0
Eczema 2 2.5 -0.25
Endometriosis 3.3 1.8 0.83
Eosinophilic Esophagitis 0.3 0.3 0
Epilepsy 3.7 1.7 1.18
erectile dysfunction 2.6 0.3 7.67
Fibromyalgia 3.4 1.6 1.13
Functional constipation / chronic idiopathic constipation 5.3 3.6 0.47
gallstone disease (gsd) 3.7 1.2 2.08
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus 1.9 1.2 0.58
Generalized anxiety disorder 3.2 2.2 0.45
giant cell arteritis 0.2 -0.2
Glioblastoma 0.3 -0.3
Gout 0.9 0.9 0
Graves' disease 1.6 3 -0.88
Gulf War Syndrome 0.9 1.1 -0.22
Halitosis 1.4 0.3 3.67
Hashimoto's thyroiditis 3.6 1.8 1
Heart Failure 4.6 1.9 1.42
hemorrhagic stroke 1.3 1.3
Hidradenitis Suppurativa 1.4 1.4
High Histamine/low DAO 1.7 0.6 1.83
hypercholesterolemia (High Cholesterol) 0.6 0.1 5
hyperglycemia 2.2 1.3 0.69
Hyperlipidemia (High Blood Fats) 0.9 0.3 2
hypersomnia 0.7 -0.7
hypertension (High Blood Pressure 4.6 4.7 -0.02
Hypothyroidism 0.1 1 -9
Hypoxia 3.4 0.3 10.33
IgA nephropathy (IgAN) 1.9 2.1 -0.11
Inflammatory Bowel Disease 9.3 8.8 0.06
Insomnia 2.2 2.3 -0.05
Intelligence 1.4 1.4
Intracranial aneurysms 1.4 0.6 1.33
Irritable Bowel Syndrome 6.7 4.2 0.6
ischemic stroke 2.4 1.7 0.41
Liver Cirrhosis 7.2 4.6 0.57
Long COVID 6.7 7.3 -0.09
Low bone mineral density 1.1 -1.1
Lung Cancer 0.9 1.2 -0.33
Lymphoma 0.6 0.6
Mast Cell Issues / mastitis 1.4 0.9 0.56
ME/CFS with IBS 1.1 2.4 -1.18
ME/CFS without IBS 2.1 2.4 -0.14
membranous nephropathy 0.3 0.3
Menopause 1.1 0.6 0.83
Metabolic Syndrome 7.3 7.2 0.01
Mood Disorders 10.8 7.7 0.4
multiple chemical sensitivity [MCS] 1 0.1 9
Multiple Sclerosis 7.8 5.8 0.34
Multiple system atrophy (MSA) 1.4 0.7 1
myasthenia gravis 0.9 0.7 0.29
neuropathic pain 0.3 2.6 -7.67
Neuropathy (all types) 0.8 1.6 -1
neuropsychiatric disorders (PANDAS, PANS) 0.7 0.7
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic 4.8 4.4 0.09
NonCeliac Gluten Sensitivity 1.4 0.6 1.33
Obesity 9.7 9.2 0.05
obsessive-compulsive disorder 5.4 3.5 0.54
Osteoarthritis 2.9 1.2 1.42
Osteoporosis 2.2 1.4 0.57
pancreatic cancer 0.8 0.3 1.67
Parkinson's Disease 9.1 7.3 0.25
Polycystic ovary syndrome 7.5 3 1.5
Postural orthostatic tachycardia syndrome 0.2 0.6 -2
Premenstrual dysphoric disorder 0.7 0.4 0.75
primary biliary cholangitis 0.9 1.3 -0.44
Primary sclerosing cholangitis 2.1 3.2 -0.52
Psoriasis 3.4 2.9 0.17
rheumatoid arthritis (RA),Spondyloarthritis (SpA) 8.1 4 1.02
Rosacea 1.2 0.7 0.71
Schizophrenia 5.4 2.8 0.93
scoliosis 0.7 0.7 0
Sjögren syndrome 1.4 2.8 -1
Sleep Apnea 2.2 1.8 0.22
Slow gastric motility / Gastroparesis 1 0.3 2.33
Small Intestinal Bacterial Overgrowth (SIBO) 1.8 0.2 8
Stress / posttraumatic stress disorder 3.1 2.9 0.07
Systemic Lupus Erythematosus 4.2 2.2 0.91
Tic Disorder 1.2 1.2 0
Tourette syndrome 0.9 0.3 2
Type 1 Diabetes 3.6 4 -0.11
Type 2 Diabetes 8.8 6.6 0.33
Ulcerative colitis 6.3 5.5 0.15
Unhealthy Ageing 6.3 2.2 1.86
Vitiligo 2.4 1.6 0.5

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