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Anticancer Effects: Methotrexate is primarily used as a chemotherapy agent to treat various types of cancer, including leukemia, lymphoma, breast cancer, lung cancer, and head and neck cancers. It works by inhibiting the growth of cancer cells and preventing their reproduction.
Immunosuppressive Effects: Methotrexate is also used as an immunosuppressive agent to treat autoimmune diseases such as rheumatoid arthritis, psoriasis, psoriatic arthritis, systemic lupus erythematosus (SLE), and inflammatory bowel disease (Crohn's disease and ulcerative colitis). It helps control inflammation and suppresses the immune system's abnormal response.
Ectopic Pregnancy: Methotrexate is used to treat ectopic pregnancies, a condition where a fertilized egg implants outside the uterus, usually in the fallopian tube. Methotrexate stops the growth of the embryo, allowing the body to reabsorb it.
Folate Antagonist: Methotrexate works by inhibiting the enzyme dihydrofolate reductase, which is involved in the synthesis of DNA, RNA, and proteins. By blocking folate metabolism, methotrexate interferes with the proliferation of rapidly dividing cells, including cancer cells and activated immune cells.
Side Effects: Methotrexate can cause a range of side effects, including nausea, vomiting, diarrhea, mouth sores, hair loss, fatigue, headache, dizziness, and skin rashes. These side effects can vary in severity and may require dose adjustments or additional medications to manage.
Bone Marrow Suppression: Methotrexate can suppress bone marrow function, leading to a decrease in the production of blood cells (red blood cells, white blood cells, and platelets). This can result in anemia, leukopenia (low white blood cell count), and thrombocytopenia (low platelet count), increasing the risk of infections and bleeding.
Hepatotoxicity: Methotrexate can cause liver toxicity, characterized by elevated liver enzymes (transaminases) and, in rare cases, liver damage or failure. Regular monitoring of liver function tests is necessary during methotrexate therapy.
Pulmonary Toxicity: In some cases, methotrexate can cause lung problems such as pneumonitis or interstitial lung disease, leading to symptoms like cough, shortness of breath, and chest pain.
Renal Toxicity: Methotrexate can affect kidney function, particularly at high doses or in patients with preexisting kidney disease. Renal toxicity may manifest as elevated serum creatinine levels, decreased urine output, or kidney damage.
Teratogenicity: Methotrexate is contraindicated during pregnancy due to its teratogenic effects, which can cause birth defects or fetal death. Women of childbearing age should use effective contraception during methotrexate treatment and for a period afterward.
Potential for Drug Interactions: Methotrexate can interact with other medications, supplements, or herbal products, potentially affecting its efficacy or increasing the risk of side effects. It's essential for healthcare providers to review a patient's medication regimen carefully before initiating methotrexate therapy.
| Rank | Probiotic | Impact |
|---|---|---|
| genus | Bacillus | Reduces |
| genus | Bifidobacterium | Reduces |
| species | Akkermansia muciniphila | Reduces |
| species | Anaerobutyricum hallii | Reduces |
| species | Bacteroides uniformis | Reduces |
| species | Bifidobacterium adolescentis | Reduces |
| species | Bifidobacterium breve | Reduces |
| species | Bifidobacterium catenulatum | Reduces |
| species | Bifidobacterium longum | Reduces |
| species | Blautia hansenii | Reduces |
| species | Blautia wexlerae | Reduces |
| species | Christensenella minuta | Reduces |
| species | Enterococcus faecium | Reduces |
| species | Escherichia coli | Reduces |
| species | Lacticaseibacillus paracasei | Reduces |
| species | Lactococcus cremoris | Reduces |
| species | Lactococcus lactis | Reduces |
| species | Parabacteroides distasonis | Reduces |
| species | Streptococcus thermophilus | Reduces |
| species | Veillonella atypica | Reduces |
| subspecies | Bifidobacterium longum subsp. infantis | Reduces |
| subspecies | Bifidobacterium longum subsp. longum | Reduces |
We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.
| 📓 Direct Citations | 👪👶 Indirect Citations | Taxonomy | Rank | Effect |
|---|---|---|---|---|
| 0 | 1 | Akkermansiaceae | family | Decreases |
| 0 | 1 | Streptococcus | genus | Decreases |
| 0 | 1 | Lacticaseibacillus | genus | Decreases |
| 0 | 1 | Veillonella | genus | Decreases |
| 0 | 1 | Thomasclavelia | genus | Decreases |
| 0 | 1 | Phocaeicola | genus | Decreases |
| 0 | 1 | Enterocloster | genus | Decreases |
| 0 | 1 | Clostridium | genus | Decreases |
| 0 | 1 | Agathobacter | genus | Decreases |
| 0 | 1 | Dorea | genus | Decreases |
| 0 | 1 | Mediterraneibacter | genus | Decreases |
| 0 | 1 | Roseburia | genus | Decreases |
| 0 | 1 | Odoribacter | genus | Decreases |
| 1 | 0 | Akkermansia | genus | Decreases |
| 0 | 1 | Blautia | genus | Decreases |
| 0 | 1 | Clostridioides | genus | Decreases |
| 0 | 1 | Bifidobacterium | genus | Decreases |
| 0 | 1 | Bacteroides | genus | Decreases |
| 0 | 1 | Lacrimispora | genus | Decreases |
| 0 | 1 | Eggerthella | genus | Decreases |
| 0 | 1 | Flavonifractor | genus | Decreases |
| 0 | 1 | Olsenella | genus | Decreases |
| 0 | 1 | Fannyhessea | genus | Decreases |
| 0 | 1 | Faecalibaculum | genus | Decreases |
| 0 | 1 | Phoenicibacter | genus | Decreases |
| 0 | 1 | Anaerobutyricum | genus | Decreases |
| 0 | 1 | Gemella | genus | Decreases |
| 0 | 1 | Butyricicoccus | genus | Decreases |
| 0 | 1 | Bacillus | genus | Decreases |
| 0 | 1 | Pseudobutyrivibrio | genus | Decreases |
| 0 | 1 | Lachnospira | genus | Decreases |
| 0 | 1 | Escherichia | genus | Decreases |
| 0 | 1 | Parabacteroides | genus | Decreases |
| 0 | 1 | Collinsella | genus | Decreases |
| 0 | 1 | Clostridium perfringens A | no rank | Decreases |
| 0 | 1 | Clostridium perfringens B | no rank | Decreases |
| 0 | 1 | Clostridium perfringens C | no rank | Decreases |
| 0 | 1 | Clostridium perfringens CPE | no rank | Decreases |
| 0 | 1 | Clostridium perfringens D | no rank | Decreases |
| 0 | 1 | Clostridium perfringens E | no rank | Decreases |
| 0 | 1 | environmental samples | no rank | Decreases |
| 0 | 1 | unclassified Akkermansia | no rank | Decreases |
| 0 | 1 | Escherichia coli O1:K1:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O139:H1 | no rank | Decreases |
| 0 | 1 | Escherichia coli O141:H4 | no rank | Decreases |
| 0 | 1 | Escherichia coli O145:H34 | no rank | Decreases |
| 0 | 1 | Escherichia coli O15:H12 | no rank | Decreases |
| 0 | 1 | Escherichia coli O155:H21 | no rank | Decreases |
| 0 | 1 | Escherichia coli O158:H23 | no rank | Decreases |
| 0 | 1 | Escherichia coli O16:H48 | no rank | Decreases |
| 0 | 1 | Escherichia coli O170:H18 | no rank | Decreases |
| 0 | 1 | Escherichia coli O18ac:H14 | no rank | Decreases |
| 0 | 1 | Escherichia coli O19:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O2:K1:H4 | no rank | Decreases |
| 0 | 1 | Escherichia coli O2:K1:H5 | no rank | Decreases |
| 0 | 1 | Escherichia coli O2:K1:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O20:H12 | no rank | Decreases |
| 0 | 1 | Escherichia coli O25:H16 | no rank | Decreases |
| 0 | 1 | Escherichia coli O55:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O68:H12 | no rank | Decreases |
| 0 | 1 | Escherichia coli O7:H15 | no rank | Decreases |
| 0 | 1 | Escherichia coli O78:H51 | no rank | Decreases |
| 0 | 1 | Escherichia coli O80:H26 | no rank | Decreases |
| 0 | 1 | Escherichia coli O84:H7 | no rank | Decreases |
| 0 | 1 | Escherichia coli O85:H1 | no rank | Decreases |
| 0 | 1 | Escherichia coli O103 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O111 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O119 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O121 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O145 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O155 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O157 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O177 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O26 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O3 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O43 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O5 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O78 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O86 | serogroup | Decreases |
| 0 | 1 | Escherichia coli O91 | serogroup | Decreases |
| 0 | 1 | Escherichia coli H20 | serotype | Decreases |
| 0 | 1 | Escherichia coli O1:H42 | serotype | Decreases |
| 0 | 1 | Escherichia coli O1:HNT | serotype | Decreases |
| 0 | 1 | Escherichia coli O10:H32 | serotype | Decreases |
| 0 | 1 | Escherichia coli O10:K5(L):H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O100:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli O103:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O103:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O103:H25 | serotype | Decreases |
| 0 | 1 | Escherichia coli O104:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli O104:H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O111:H- | serotype | Decreases |
| 0 | 1 | Escherichia coli O111:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O111:H8 | serotype | Decreases |
| 0 | 1 | Escherichia coli O111:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O112ab:H8 | serotype | Decreases |
| 0 | 1 | Escherichia coli O112ac:H19 | serotype | Decreases |
| 0 | 1 | Escherichia coli O113:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli O114:H49 | serotype | Decreases |
| 0 | 1 | Escherichia coli O118:H16 | serotype | Decreases |
| 0 | 1 | Escherichia coli O121:H19 | serotype | Decreases |
| 0 | 1 | Escherichia coli O121:H7 | serotype | Decreases |
| 0 | 1 | Escherichia coli O123:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O125ac:K+:H10 | serotype | Decreases |
| 0 | 1 | Escherichia coli O126:H45 | serotype | Decreases |
| 0 | 1 | Escherichia coli O127:H27 | serotype | Decreases |
| 0 | 1 | Escherichia coli O127:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O128:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O128ac:H12 | serotype | Decreases |
| 0 | 1 | Escherichia coli O139:H28 | serotype | Decreases |
| 0 | 1 | Escherichia coli O145:H25 | serotype | Decreases |
| 0 | 1 | Escherichia coli O145:H28 | serotype | Decreases |
| 0 | 1 | Escherichia coli O145:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O146:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli O15:H18 | serotype | Decreases |
| 0 | 1 | Escherichia coli O150:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O152:H23 | serotype | Decreases |
| 0 | 1 | Escherichia coli O153:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O156:H25 | serotype | Decreases |
| 0 | 1 | Escherichia coli O157:H- | serotype | Decreases |
| 0 | 1 | Escherichia coli O157:H43 | serotype | Decreases |
| 0 | 1 | Escherichia coli O157:H7 | serotype | Decreases |
| 0 | 1 | Escherichia coli O157:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O16:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O165:H25 | serotype | Decreases |
| 0 | 1 | Escherichia coli O167:H26 | serotype | Decreases |
| 0 | 1 | Escherichia coli O174:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O174:H21 | serotype | Decreases |
| 0 | 1 | Escherichia coli O174:H8 | serotype | Decreases |
| 0 | 1 | Escherichia coli O176:H45 | serotype | Decreases |
| 0 | 1 | Escherichia coli O177:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O2:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli O2:K2:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O25:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O25:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O26:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O26:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O28ac:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O29:H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O32:H37 | serotype | Decreases |
| 0 | 1 | Escherichia coli O39:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O44:H18 | serotype | Decreases |
| 0 | 1 | Escherichia coli O45:H2 | serotype | Decreases |
| 0 | 1 | Escherichia coli O6:H16 | serotype | Decreases |
| 0 | 1 | Escherichia coli O6:H16:CFA/II | serotype | Decreases |
| 0 | 1 | Escherichia coli O6:K2:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O69:H11 | serotype | Decreases |
| 0 | 1 | Escherichia coli O7:H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O7:K1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O78:H12 | serotype | Decreases |
| 0 | 1 | Escherichia coli O78:H4 | serotype | Decreases |
| 0 | 1 | Escherichia coli O79:H7 | serotype | Decreases |
| 0 | 1 | Escherichia coli O8:H8 | serotype | Decreases |
| 0 | 1 | Escherichia coli O81:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O83:H1 | serotype | Decreases |
| 0 | 1 | Escherichia coli O86:H34 | serotype | Decreases |
| 0 | 1 | Escherichia coli O89m:H10 | serotype | Decreases |
| 0 | 1 | Escherichia coli O89m:H9 | serotype | Decreases |
| 0 | 1 | Escherichia coli O9:H10 | serotype | Decreases |
| 0 | 1 | Escherichia coli O91:H14 | serotype | Decreases |
| 0 | 1 | Escherichia coli O91:NM | serotype | Decreases |
| 0 | 1 | Escherichia coli O99:H6 | serotype | Decreases |
| 0 | 1 | Escherichia coli ONT:H33 | serotype | Decreases |
| 1 | 0 | Bifidobacterium adolescentis | species | Decreases |
| 1 | 0 | Odoribacter splanchnicus | species | Decreases |
| 1 | 0 | Agathobacter rectalis | species | Decreases |
| 1 | 0 | Bacteroides uniformis | species | Decreases |
| 1 | 0 | Clostridium perfringens | species | Decreases |
| 1 | 0 | Dorea formicigenerans | species | Decreases |
| 1 | 0 | Enterocloster bolteae | species | Decreases |
| 1 | 0 | Lacticaseibacillus paracasei | species | Decreases |
| 1 | 0 | Mediterraneibacter gnavus | species | Decreases |
| 1 | 0 | Phocaeicola vulgatus | species | Decreases |
| 1 | 0 | Roseburia hominis | species | Decreases |
| 1 | 0 | Streptococcus parasanguinis | species | Decreases |
| 1 | 0 | Streptococcus salivarius | species | Decreases |
| 1 | 0 | Thomasclavelia ramosa | species | Decreases |
| 1 | 0 | Veillonella parvula | species | Decreases |
| 1 | 0 | Akkermansia muciniphila | species | Decreases |
| 1 | 0 | Blautia obeum | species | Decreases |
| 1 | 0 | Bacteroides fragilis | species | Decreases |
| 1 | 0 | Clostridioides difficile | species | Decreases |
| 1 | 0 | Bacteroides xylanisolvens | species | Decreases |
| 1 | 0 | Bacteroides ovatus | species | Decreases |
| 1 | 0 | [Ruminococcus] torques | species | Decreases |
| 1 | 0 | Lacrimispora saccharolytica | species | Decreases |
| 1 | 0 | Roseburia intestinalis | species | Decreases |
| 0 | 1 | Streptococcus sp. FDAARGOS_192 | species | Decreases |
| 1 | 0 | Eggerthella lenta | species | Decreases |
| 0 | 1 | Streptococcus sp. LPB0220 | species | Decreases |
| 0 | 1 | Streptococcus sp. HSISM1 | species | Decreases |
| 0 | 1 | Veillonella rodentium | species | Decreases |
| 1 | 0 | Bifidobacterium longum | species | Decreases |
| 0 | 1 | Veillonella dispar | species | Decreases |
| 0 | 1 | Bacteroides sp. CACC 737 | species | Decreases |
| 0 | 1 | Veillonella sp. S12025-13 | species | Decreases |
| 0 | 1 | Bifidobacterium angulatum | species | Decreases |
| 0 | 1 | Veillonella nakazawae | species | Decreases |
| 1 | 0 | Bacteroides thetaiotaomicron | species | Decreases |
| 0 | 1 | Streptococcus vestibularis | species | Decreases |
| 0 | 1 | Coprococcus catus | species | Decreases |
| 0 | 1 | Veillonella rogosae | species | Decreases |
| 0 | 1 | Anaerobutyricum hallii | species | Decreases |
| 0 | 1 | Streptococcus lactarius | species | Decreases |
| 0 | 1 | Dorea longicatena | species | Decreases |
| 0 | 1 | Bacteroides humanifaecis | species | Decreases |
| 0 | 1 | Bacteroides sp. A1C1 | species | Decreases |
| 0 | 1 | Blautia sp. SC05B48 | species | Decreases |
| 0 | 1 | Flavonifractor plautii | species | Decreases |
| 0 | 1 | Wansuia hejianensis | species | Decreases |
| 0 | 1 | Bacteroides luhongzhouii | species | Decreases |
| 0 | 1 | Komagataeibacter oboediens | species | Decreases |
| 0 | 1 | Actinomyces naeslundii | species | Decreases |
| 0 | 1 | Coprococcus comes | species | Decreases |
| 0 | 1 | Bacteroides sp. HF-162 | species | Decreases |
| 0 | 1 | Alistipes megaguti | species | Decreases |
| 0 | 1 | Streptococcus gordonii | species | Decreases |
| 0 | 1 | Blautia parvula | species | Decreases |
| 0 | 1 | Ligilactobacillus ruminis | species | Decreases |
| 0 | 1 | Streptococcus australis | species | Decreases |
| 0 | 1 | Butyrivibrio crossotus | species | Decreases |
| 0 | 1 | Streptococcus sp. oral taxon 061 | species | Decreases |
| 0 | 1 | uncultured Alistipes sp. | species | Decreases |
| 0 | 1 | Eubacterium ventriosum | species | Decreases |
| 0 | 1 | Subdoligranulum variabile | species | Decreases |
| 1 | 0 | Lachnospira eligens | species | Decreases |
| 0 | 1 | Blautia argi | species | Decreases |
| 0 | 1 | Roseburia rectibacter | species | Decreases |
| 0 | 1 | Olsenella sp. oral taxon 807 | species | Decreases |
| 0 | 1 | Veillonella atypica | species | Decreases |
| 0 | 1 | Adlercreutzia equolifaciens | species | Decreases |
| 0 | 1 | Bacillus paralicheniformis | species | Decreases |
| 0 | 1 | Coprobacter fastidiosus | species | Decreases |
| 0 | 1 | Clostridium sp. M62/1 | species | Decreases |
| 0 | 1 | Fannyhessea vaginae | species | Decreases |
| 0 | 1 | Blautia liquoris | species | Decreases |
| 0 | 1 | Clostridium sp. SY8519 | species | Decreases |
| 0 | 1 | Eubacterium sp. MSJ-33 | species | Decreases |
| 0 | 1 | Qiania dongpingensis | species | Decreases |
| 0 | 1 | Streptococcus infantis | species | Decreases |
| 0 | 1 | Streptococcus oralis | species | Decreases |
| 0 | 1 | Actinomyces oris | species | Decreases |
| 0 | 1 | Eggerthella guodeyinii | species | Decreases |
| 0 | 1 | Faecalibacillus intestinalis | species | Decreases |
| 0 | 1 | Novisyntrophococcus fermenticellae | species | Decreases |
| 0 | 1 | Intestinibaculum porci | species | Decreases |
| 0 | 1 | Alistipes sp. dk3624 | species | Decreases |
| 0 | 1 | Christensenella minuta | species | Decreases |
| 0 | 1 | Faecalitalea cylindroides | species | Decreases |
| 0 | 1 | Pseudobutyrivibrio xylanivorans | species | Decreases |
| 0 | 1 | Faecalibacterium duncaniae | species | Decreases |
| 0 | 1 | Bacteroides sp. DH3716P | species | Decreases |
| 0 | 1 | Bacteroides sp. D2 | species | Decreases |
| 0 | 1 | Coprococcus eutactus | species | Decreases |
| 0 | 1 | Massilistercora timonensis | species | Decreases |
| 0 | 1 | Wujia chipingensis | species | Decreases |
| 0 | 1 | Alistipes onderdonkii | species | Decreases |
| 0 | 1 | Vescimonas fastidiosa | species | Decreases |
| 0 | 1 | Anaerostipes hadrus | species | Decreases |
| 0 | 1 | Alistipes ihumii | species | Decreases |
| 0 | 1 | Hungatella hathewayi | species | Decreases |
| 0 | 1 | [Ruminococcus] lactaris | species | Decreases |
| 0 | 1 | Alistipes finegoldii | species | Decreases |
| 0 | 1 | Maliibacterium massiliense | species | Decreases |
| 0 | 1 | Ruminococcus gauvreauii | species | Decreases |
| 0 | 1 | Alistipes dispar | species | Decreases |
| 0 | 1 | Barnesiella viscericola | species | Decreases |
| 0 | 1 | Ruminococcus albus | species | Decreases |
| 0 | 1 | Streptococcus sp. oral taxon 431 | species | Decreases |
| 0 | 1 | Corynebacterium durum | species | Decreases |
| 0 | 1 | Mogibacterium diversum | species | Decreases |
| 0 | 1 | Phoenicibacter congonensis | species | Decreases |
| 0 | 1 | Streptococcus sp. Marseille-Q6470 | species | Decreases |
| 0 | 1 | Parvimonas micra | species | Decreases |
| 0 | 1 | Longicatena caecimuris | species | Decreases |
| 1 | 0 | Bacteroides caccae | species | Decreases |
| 0 | 1 | [Clostridium] hylemonae | species | Decreases |
| 0 | 1 | Marvinbryantia formatexigens | species | Decreases |
| 0 | 1 | Catenibacterium mitsuokai | species | Decreases |
| 0 | 1 | Streptococcus suis | species | Decreases |
| 0 | 1 | Lachnoanaerobaculum gingivalis | species | Decreases |
| 0 | 1 | Eubacterium limosum | species | Decreases |
| 0 | 1 | Lachnoclostridium phocaeense | species | Decreases |
| 0 | 1 | Actinomyces sp. oral taxon 171 | species | Decreases |
| 0 | 1 | Ruminococcus champanellensis | species | Decreases |
| 0 | 1 | Enterocloster clostridioformis | species | Decreases |
| 0 | 1 | Coprococcus sp. ART55/1 | species | Decreases |
| 0 | 1 | Bacteroides sp. M10 | species | Decreases |
| 0 | 1 | Bifidobacterium catenulatum | species | Decreases |
| 0 | 1 | Ruthenibacterium lactatiformans | species | Decreases |
| 0 | 1 | Clostridium cadaveris | species | Decreases |
| 0 | 1 | Streptococcus ilei | species | Decreases |
| 0 | 1 | Eubacterium sp. c-25 | species | Decreases |
| 0 | 1 | Vescimonas coprocola | species | Decreases |
| 0 | 1 | Ruminococcus bicirculans (ex Wegman et al. 2014) | species | Decreases |
| 0 | 1 | Simiaoa sunii | species | Decreases |
| 0 | 1 | Faecalibacterium sp. I2-3-92 | species | Decreases |
| 0 | 1 | Eubacterium callanderi | species | Decreases |
| 0 | 1 | Bacteroides nordii | species | Decreases |
| 0 | 1 | Faecalibacterium sp. I4-1-79 | species | Decreases |
| 0 | 1 | [Eubacterium] hominis | species | Decreases |
| 0 | 1 | Lactococcus cremoris | species | Decreases |
| 0 | 1 | Mageeibacillus indolicus | species | Decreases |
| 0 | 1 | Leyella stercorea | species | Decreases |
| 0 | 1 | Treponema denticola | species | Decreases |
| 0 | 1 | Bacteroides faecium | species | Decreases |
| 0 | 1 | Faecalibacterium sp. IP-3-29 | species | Decreases |
| 0 | 1 | Eubacterium maltosivorans | species | Decreases |
| 0 | 1 | Monoglobus pectinilyticus | species | Decreases |
| 0 | 1 | Anaerostipes caccae | species | Decreases |
| 0 | 1 | Faecalibaculum rodentium | species | Decreases |
| 0 | 1 | Adlercreutzia hattorii | species | Decreases |
| 0 | 1 | Phascolarctobacterium succinatutens | species | Decreases |
| 0 | 1 | Faecalibacterium sp. HTF-F | species | Decreases |
| 0 | 1 | Acutalibacter muris | species | Decreases |
| 0 | 1 | Faecalibacterium sp. I4-3-84 | species | Decreases |
| 0 | 1 | Actinomyces sp. oral taxon 169 | species | Decreases |
| 0 | 1 | Clostridium sp. C1 | species | Decreases |
| 0 | 1 | Solibaculum mannosilyticum | species | Decreases |
| 0 | 1 | Faecalibacterium sp. IP-1-18 | species | Decreases |
| 0 | 1 | Blautia wexlerae | species | Decreases |
| 0 | 1 | Catenibacterium sp. co_0103 | species | Decreases |
| 0 | 1 | Faecalibacterium sp. I3-3-33 | species | Decreases |
| 0 | 1 | Butyricimonas virosa | species | Decreases |
| 0 | 1 | Treponema peruense | species | Decreases |
| 0 | 1 | Oscillibacter hominis | species | Decreases |
| 0 | 1 | [Clostridium] scindens | species | Decreases |
| 0 | 1 | Faecalibacterium sp. I3-3-89 | species | Decreases |
| 0 | 1 | Enterococcus faecium | species | Decreases |
| 0 | 1 | Lactococcus lactis | species | Decreases |
| 0 | 1 | Alistipes indistinctus | species | Decreases |
| 0 | 1 | Streptococcus sanguinis | species | Decreases |
| 0 | 1 | Anaerotruncus colihominis | species | Decreases |
| 0 | 1 | Blautia hansenii | species | Decreases |
| 0 | 1 | Flintibacter sp. KGMB00164 | species | Decreases |
| 0 | 1 | Streptococcus sp. A12 | species | Decreases |
| 0 | 1 | Butyricicoccus sp. GAM44 | species | Decreases |
| 0 | 1 | Bifidobacterium breve | species | Decreases |
| 0 | 1 | Romboutsia ilealis | species | Decreases |
| 0 | 1 | Enterococcus cecorum | species | Decreases |
| 0 | 1 | Intestinimonas butyriciproducens | species | Decreases |
| 0 | 1 | Gordonibacter urolithinfaciens | species | Decreases |
| 0 | 1 | Streptococcus mutans | species | Decreases |
| 0 | 1 | Enterocloster asparagiformis | species | Decreases |
| 0 | 1 | Ruminococcus bovis | species | Decreases |
| 0 | 1 | Streptococcus thermophilus | species | Decreases |
| 0 | 1 | Bacteroides cellulosilyticus | species | Decreases |
| 0 | 1 | Campylobacter coli | species | Decreases |
| 0 | 1 | Dysosmobacter welbionis | species | Decreases |
| 1 | 0 | Parabacteroides merdae | species | Decreases |
| 0 | 1 | Akkermansia glycaniphila | species | Decreases |
| 0 | 1 | Akkermansia massiliensis | species | Decreases |
| 0 | 1 | Candidatus Akkermansia intestinavium | species | Decreases |
| 1 | 0 | Escherichia coli | species | Decreases |
| 1 | 0 | Collinsella aerofaciens | species | Decreases |
| 1 | 0 | Parabacteroides distasonis | species | Decreases |
| 0 | 1 | Lacticaseibacillus paracasei subsp. paracasei | subspecies | Decreases |
| 0 | 1 | Lacticaseibacillus paracasei subsp. tolerans | subspecies | Decreases |
| 0 | 1 | Bifidobacterium longum subsp. infantis | subspecies | Decreases |
| 0 | 1 | Bifidobacterium longum subsp. longum | subspecies | Decreases |
| 0 | 1 | Bifidobacterium longum subsp. suillum | subspecies | Decreases |
| 0 | 1 | Bifidobacterium longum subsp. suis | subspecies | Decreases |
A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.
We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.
Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.
| Condition | Positive Impact | Negative Impact | Benefit Ratio Impact |
|---|---|---|---|
| Abdominal Aortic Aneurysm | 0.2 | 0.2 | |
| Acne | 0.3 | -0.3 | |
| ADHD | 4 | 0.5 | 7 |
| Age-Related Macular Degeneration and Glaucoma | 0.9 | 0 | 0 |
| Allergic Rhinitis (Hay Fever) | 3.1 | 3.1 | 0 |
| Allergies | 5.1 | 2.5 | 1.04 |
| Allergy to milk products | 1.4 | 0.7 | 1 |
| Alopecia (Hair Loss) | 1 | 0.1 | 9 |
| Alzheimer's disease | 5.4 | 6.7 | -0.24 |
| Amyotrophic lateral sclerosis (ALS) Motor Neuron | 2.7 | 0.7 | 2.86 |
| Ankylosing spondylitis | 3.1 | 0.9 | 2.44 |
| Anorexia Nervosa | 1.6 | 3.3 | -1.06 |
| Antiphospholipid syndrome (APS) | 1.2 | 1.2 | |
| Asthma | 5.5 | 3.5 | 0.57 |
| Atherosclerosis | 1.4 | 2.2 | -0.57 |
| Atrial fibrillation | 3.4 | 1.3 | 1.62 |
| Autism | 9.5 | 7.9 | 0.2 |
| Autoimmune Disease | 0.8 | 1.1 | -0.38 |
| Barrett esophagus cancer | 0.5 | 0.5 | 0 |
| benign prostatic hyperplasia | 0 | 0.2 | 0 |
| Biofilm | 2.5 | 2.5 | |
| Bipolar Disorder | 1.3 | 1 | 0.3 |
| Brain Trauma | 0.9 | 0.8 | 0.13 |
| Breast Cancer | 0.1 | 0.1 | |
| Cancer (General) | 0.8 | 2.7 | -2.38 |
| Carcinoma | 2.3 | 1.6 | 0.44 |
| Celiac Disease | 3.5 | 2.8 | 0.25 |
| Cerebral Palsy | 2.3 | 0.9 | 1.56 |
| Chronic Fatigue Syndrome | 6.4 | 5.8 | 0.1 |
| Chronic Kidney Disease | 3.4 | 2.1 | 0.62 |
| Chronic Lyme | 0.5 | 0.6 | -0.2 |
| Chronic Obstructive Pulmonary Disease (COPD) | 2.7 | 1.4 | 0.93 |
| Chronic Urticaria (Hives) | 1.6 | 1.1 | 0.45 |
| Coagulation / Micro clot triggering bacteria | 0.8 | 1.2 | -0.5 |
| Cognitive Function | 1.7 | 2 | -0.18 |
| Colorectal Cancer | 6.6 | 2.7 | 1.44 |
| Constipation | 1 | 0.6 | 0.67 |
| Coronary artery disease | 1.9 | 3.1 | -0.63 |
| COVID-19 | 10.1 | 12.9 | -0.28 |
| Crohn's Disease | 6.8 | 4.8 | 0.42 |
| Cushing's Syndrome (hypercortisolism) | 0.8 | -0.8 | |
| cystic fibrosis | 0.1 | 1.8 | -17 |
| d-lactic acidosis (one form of brain fog) | 0.2 | 0.2 | |
| deep vein thrombosis | 1.1 | 1.3 | -0.18 |
| Denture Wearers Oral Shifts | 1.9 | 1.9 | |
| Depression | 10.2 | 8.2 | 0.24 |
| Dermatomyositis | 0.5 | 0.2 | 1.5 |
| Eczema | 2.1 | 3.1 | -0.48 |
| Endometriosis | 2 | 1.4 | 0.43 |
| Eosinophilic Esophagitis | 1 | -1 | |
| Epilepsy | 3 | 1.8 | 0.67 |
| erectile dysfunction | 0.8 | 0.2 | 3 |
| Fibromyalgia | 3.5 | 1.9 | 0.84 |
| Functional constipation / chronic idiopathic constipation | 4.4 | 3 | 0.47 |
| gallstone disease (gsd) | 3.2 | 0.9 | 2.56 |
| Gastroesophageal reflux disease (Gerd) including Barrett's esophagus | 1.7 | 1.8 | -0.06 |
| Generalized anxiety disorder | 2.2 | 2.1 | 0.05 |
| giant cell arteritis | 0.5 | -0.5 | |
| Glioblastoma | 0.5 | -0.5 | |
| Gout | 1.6 | 0.9 | 0.78 |
| Graves' disease | 1 | 2.7 | -1.7 |
| Gulf War Syndrome | 1.3 | 1.9 | -0.46 |
| Halitosis | 1.2 | 0.6 | 1 |
| Hashimoto's thyroiditis | 3.6 | 1.2 | 2 |
| Heart Failure | 2.9 | 2 | 0.45 |
| hemorrhagic stroke | 0.5 | 0.5 | |
| Hidradenitis Suppurativa | 0.8 | 0.5 | 0.6 |
| High Histamine/low DAO | 1.5 | 0.2 | 6.5 |
| hypercholesterolemia (High Cholesterol) | 0.9 | 0.7 | 0.29 |
| hyperglycemia | 1.6 | 1.7 | -0.06 |
| Hyperlipidemia (High Blood Fats) | 0.7 | 0.1 | 6 |
| hypersomnia | 0.2 | 0.3 | -0.5 |
| hypertension (High Blood Pressure | 3.4 | 4.9 | -0.44 |
| Hypothyroidism | 0.4 | 0.8 | -1 |
| Hypoxia | 2.5 | 2.5 | |
| IgA nephropathy (IgAN) | 1 | 4.7 | -3.7 |
| Inflammatory Bowel Disease | 9 | 8.3 | 0.08 |
| Insomnia | 2.7 | 3.6 | -0.33 |
| Intelligence | 1.8 | 1.8 | |
| Intracranial aneurysms | 0.5 | 0.2 | 1.5 |
| Irritable Bowel Syndrome | 6.1 | 5.2 | 0.17 |
| ischemic stroke | 2.2 | 1.1 | 1 |
| Juvenile idiopathic arthritis | 0.1 | 0.1 | |
| Liver Cirrhosis | 7 | 4.1 | 0.71 |
| Long COVID | 7.2 | 5.3 | 0.36 |
| Low bone mineral density | 0.7 | -0.7 | |
| Lung Cancer | 0.2 | 1.6 | -7 |
| Lymphoma | 0 | 0 | |
| Mast Cell Issues / mastitis | 0.5 | 0.2 | 1.5 |
| ME/CFS with IBS | 1.7 | 2.3 | -0.35 |
| ME/CFS without IBS | 2.4 | 1.8 | 0.33 |
| membranous nephropathy | 0.5 | 0.5 | |
| Menopause | 2.3 | 0.8 | 1.87 |
| Metabolic Syndrome | 5.5 | 8.4 | -0.53 |
| Mood Disorders | 10.7 | 6.3 | 0.7 |
| multiple chemical sensitivity [MCS] | 2 | 0.3 | 5.67 |
| Multiple Sclerosis | 6.9 | 5.1 | 0.35 |
| Multiple system atrophy (MSA) | 2.2 | 0.5 | 3.4 |
| myasthenia gravis | 0.5 | 0.8 | -0.6 |
| neuropathic pain | 0.2 | 2.3 | -10.5 |
| Neuropathy (all types) | 1.2 | 1.1 | 0.09 |
| neuropsychiatric disorders (PANDAS, PANS) | 0.9 | 0.1 | 8 |
| Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic | 4.3 | 4.8 | -0.12 |
| NonCeliac Gluten Sensitivity | 1.6 | 0.5 | 2.2 |
| Obesity | 8.5 | 8.2 | 0.04 |
| obsessive-compulsive disorder | 5.1 | 4.1 | 0.24 |
| Osteoarthritis | 3.8 | 1.4 | 1.71 |
| Osteoporosis | 1.8 | 2.4 | -0.33 |
| pancreatic cancer | 0.8 | 0.5 | 0.6 |
| Parkinson's Disease | 7.3 | 7 | 0.04 |
| Polycystic ovary syndrome | 4.6 | 2.7 | 0.7 |
| Postural orthostatic tachycardia syndrome | 0.5 | 0.2 | 1.5 |
| Premenstrual dysphoric disorder | 0.6 | 0.1 | 5 |
| primary biliary cholangitis | 1.5 | 1.6 | -0.07 |
| Primary sclerosing cholangitis | 3.3 | 2.3 | 0.43 |
| Psoriasis | 3.6 | 1.9 | 0.89 |
| rheumatoid arthritis (RA),Spondyloarthritis (SpA) | 4.6 | 4.3 | 0.07 |
| Rosacea | 0.8 | 0.8 | 0 |
| Schizophrenia | 6.9 | 2.6 | 1.65 |
| scoliosis | 0.2 | 0.1 | 1 |
| sensorineural hearing loss | 0.3 | 0.3 | |
| Sjögren syndrome | 2.5 | 3 | -0.2 |
| Sleep Apnea | 1.1 | 1 | 0.1 |
| Slow gastric motility / Gastroparesis | 0.8 | 0.3 | 1.67 |
| Small Intestinal Bacterial Overgrowth (SIBO) | 1.9 | 0.3 | 5.33 |
| Stress / posttraumatic stress disorder | 2.2 | 1.8 | 0.22 |
| Systemic Lupus Erythematosus | 4 | 1.8 | 1.22 |
| Tic Disorder | 1.4 | 1.1 | 0.27 |
| Tourette syndrome | 1.2 | 0.2 | 5 |
| Type 1 Diabetes | 4.4 | 3.7 | 0.19 |
| Type 2 Diabetes | 7.3 | 7.5 | -0.03 |
| Ulcerative colitis | 6.5 | 6.5 | 0 |
| Unhealthy Ageing | 5.2 | 1.8 | 1.89 |
| Vitiligo | 1.6 | 1.2 | 0.33 |
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