🍽️ estradiol valerate,(prescription)

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Menopausal Symptom Relief: Estradiol valerate is commonly prescribed to alleviate symptoms associated with menopause, such as hot flashes, night sweats, vaginal dryness, mood swings, and sleep disturbances. By replenishing estrogen levels in the body, estradiol valerate can help reduce the severity and frequency of these symptoms, improving overall quality of life for menopausal women.
Prevention of Osteoporosis: Estrogen, including estradiol valerate, plays a crucial role in maintaining bone density and strength. Hormone replacement therapy with estradiol valerate may help prevent or slow down the progression of osteoporosis, a condition characterized by weakened and brittle bones that are more prone to fractures. It is especially beneficial for postmenopausal women who are at an increased risk of developing osteoporosis due to estrogen deficiency.
Vaginal Atrophy and Dryness: Estradiol valerate therapy, particularly in vaginal formulations such as creams, tablets, or rings, is used to treat vaginal atrophy and dryness in menopausal women. By replenishing estrogen levels in the vaginal tissues, estradiol valerate can restore moisture, elasticity, and thickness to the vaginal lining, reducing symptoms such as itching, burning, and discomfort during intercourse.
Hypoestrogenism: Estradiol valerate may be prescribed to individuals with conditions characterized by low estrogen levels, such as primary ovarian insufficiency (premature ovarian failure), hypogonadism, or certain surgical menopause situations (e.g., oophorectomy). Supplemental estradiol valerate helps maintain estrogen levels within the normal physiological range, supporting overall health and well-being.
Gender-Affirming Hormone Therapy: In transgender women (individuals assigned male at birth but who identify and live as female), estradiol valerate is used as part of gender-affirming hormone therapy to induce feminization of secondary sexual characteristics, such as breast development, redistribution of body fat, and reduction of facial/body hair growth. It is often administered in combination with anti-androgens to suppress testosterone levels.
Endometrial Cancer Risk: Unopposed estrogen therapy, meaning estrogen without a progestin component, can increase the risk of endometrial hyperplasia (overgrowth of the uterine lining) and endometrial cancer in women who have not undergone a hysterectomy. Therefore, estrogen therapy is often combined with a progestin in women with an intact uterus to prevent endometrial hyperplasia and reduce the risk of endometrial cancer.
Breast Cancer Risk: The use of estrogen therapy, including estradiol valerate-containing formulations, has been associated with an increased risk of breast cancer, particularly with long-term use and in women with certain risk factors. The decision to initiate estrogen therapy should be individualized based on a thorough assessment of each patient's medical history, risk factors, and treatment goals, weighing the potential benefits against the risks.

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Data Contradictions — Limits of Certainity

Impacted of estradiol valerate,(prescription) On Probiotics

Rank	Probiotic	Impact
genus	Bifidobacterium	Reduces
species	Akkermansia muciniphila	Increases
species	Bacteroides uniformis	Reduces
species	Bifidobacterium adolescentis	Reduces
species	Bifidobacterium longum	Reduces
species	Escherichia coli	Reduces
species	Lacticaseibacillus paracasei	Reduces
species	Parabacteroides distasonis	Reduces
subspecies	Bifidobacterium longum subsp. infantis	Reduces
subspecies	Bifidobacterium longum subsp. longum	Reduces

Bacteria Impacted by estradiol valerate,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

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📓 Direct Citations	👪👶 Indirect Citations	Taxonomy	Rank	Effect
1	0	Streptococcaceae	family	Decreases
0	1	Akkermansiaceae	family	Increases
0	2	Streptococcus	genus	Decreases
0	1	Escherichia	genus	Decreases
0	1	Dorea	genus	Decreases
0	1	Roseburia	genus	Decreases
0	1	Parabacteroides	genus	Decreases
0	1	Ruminococcus	genus	Decreases
0	1	Agathobacter	genus	Decreases
0	1	Bacteroides	genus	Decreases
0	1	Bifidobacterium	genus	Decreases
0	1	Bilophila	genus	Decreases
0	1	Clostridioides	genus	Decreases
0	1	Collinsella	genus	Decreases
0	1	Coprococcus	genus	Decreases
0	1	Floricoccus	genus	Decreases
0	1	Fusobacterium	genus	Decreases
0	1	Lactovum	genus	Decreases
0	1	Mediterraneibacter	genus	Decreases
0	1	Odoribacter	genus	Decreases
0	1	Phocaeicola	genus	Decreases
0	1	Porphyromonas	genus	Decreases
0	1	Clostridium	genus	Decreases
0	1	Segatella	genus	Decreases
0	1	Enterocloster	genus	Decreases
0	1	Blautia	genus	Decreases
0	1	Lactococcus	genus	Decreases
0	1	Lacticaseibacillus	genus	Decreases
1	0	Akkermansia	genus	Increases
0	1	Escherichia coli O25:H16	no rank	Decreases
0	1	Clostridium perfringens A	no rank	Decreases
0	1	Clostridium perfringens C	no rank	Decreases
0	1	Clostridium perfringens CPE	no rank	Decreases
0	1	Escherichia coli O145:H34	no rank	Decreases
0	1	Escherichia coli O16:H48	no rank	Decreases
0	1	unclassified Streptococcaceae	no rank	Decreases
0	1	Clostridium perfringens D	no rank	Decreases
0	1	Escherichia coli O141:H4	no rank	Decreases
0	1	Clostridium perfringens B	no rank	Decreases
0	1	Escherichia coli O139:H1	no rank	Decreases
0	1	Clostridium perfringens E	no rank	Decreases
0	1	Escherichia coli O80:H26	no rank	Decreases
0	1	Escherichia coli O158:H23	no rank	Decreases
0	1	Escherichia coli O84:H7	no rank	Decreases
0	1	Escherichia coli O2:K1:H4	no rank	Decreases
0	1	Escherichia coli O2:K1:H7	no rank	Decreases
0	1	Escherichia coli O78:H51	no rank	Decreases
0	1	Escherichia coli O18ac:H14	no rank	Decreases
0	1	Escherichia coli O85:H1	no rank	Decreases
0	1	Escherichia coli O7:H15	no rank	Decreases
0	1	Escherichia coli O68:H12	no rank	Decreases
0	1	Escherichia coli O55:H7	no rank	Decreases
0	1	Escherichia coli O1:K1:H7	no rank	Decreases
0	1	Escherichia coli O15:H12	no rank	Decreases
0	1	Escherichia coli O170:H18	no rank	Decreases
0	1	Escherichia coli O155:H21	no rank	Decreases
0	1	Escherichia coli O19:H7	no rank	Decreases
0	1	Escherichia coli O2:K1:H5	no rank	Decreases
0	1	Escherichia coli O20:H12	no rank	Decreases
0	1	environmental samples	no rank	Increases
0	1	unclassified Akkermansia	no rank	Increases
0	1	Lactobacillales	order	Decreases
0	1	Escherichia coli O111	serogroup	Decreases
0	1	Escherichia coli O121	serogroup	Decreases
0	1	Escherichia coli O155	serogroup	Decreases
0	1	Escherichia coli O177	serogroup	Decreases
0	1	Escherichia coli O26	serogroup	Decreases
0	1	Escherichia coli O3	serogroup	Decreases
0	1	Escherichia coli O5	serogroup	Decreases
0	1	Escherichia coli O86	serogroup	Decreases
0	1	Escherichia coli O91	serogroup	Decreases
0	1	Escherichia coli O103	serogroup	Decreases
0	1	Escherichia coli O78	serogroup	Decreases
0	1	Escherichia coli O43	serogroup	Decreases
0	1	Escherichia coli O119	serogroup	Decreases
0	1	Escherichia coli O157	serogroup	Decreases
0	1	Escherichia coli O145	serogroup	Decreases
0	1	Escherichia coli O1:HNT	serotype	Decreases
0	1	Escherichia coli O10:K5(L):H4	serotype	Decreases
0	1	Escherichia coli O103:H11	serotype	Decreases
0	1	Escherichia coli O103:H25	serotype	Decreases
0	1	Escherichia coli O104:H21	serotype	Decreases
0	1	Escherichia coli O111:H11	serotype	Decreases
0	1	Escherichia coli O111:H8	serotype	Decreases
0	1	Escherichia coli O112ac:H19	serotype	Decreases
0	1	Escherichia coli O114:H49	serotype	Decreases
0	1	Escherichia coli O118:H16	serotype	Decreases
0	1	Escherichia coli O121:H7	serotype	Decreases
0	1	Escherichia coli O123:H11	serotype	Decreases
0	1	Escherichia coli O127:H27	serotype	Decreases
0	1	Escherichia coli O127:H6	serotype	Decreases
0	1	Escherichia coli O128:H2	serotype	Decreases
0	1	Escherichia coli O128ac:H12	serotype	Decreases
0	1	Escherichia coli O145:H25	serotype	Decreases
0	1	Escherichia coli O145:NM	serotype	Decreases
0	1	Escherichia coli O146:H21	serotype	Decreases
0	1	Escherichia coli O153:H2	serotype	Decreases
0	1	Escherichia coli O156:H25	serotype	Decreases
0	1	Escherichia coli O157:H43	serotype	Decreases
0	1	Escherichia coli O157:NM	serotype	Decreases
0	1	Escherichia coli O165:H25	serotype	Decreases
0	1	Escherichia coli O174:H2	serotype	Decreases
0	1	Escherichia coli O174:H21	serotype	Decreases
0	1	Escherichia coli O174:H8	serotype	Decreases
0	1	Escherichia coli O176:H45	serotype	Decreases
0	1	Escherichia coli O177:NM	serotype	Decreases
0	1	Escherichia coli O26:H1	serotype	Decreases
0	1	Escherichia coli O28ac:NM	serotype	Decreases
0	1	Escherichia coli O29:H4	serotype	Decreases
0	1	Escherichia coli O32:H37	serotype	Decreases
0	1	Escherichia coli O6:H16:CFA/II	serotype	Decreases
0	1	Escherichia coli O69:H11	serotype	Decreases
0	1	Escherichia coli O78:H12	serotype	Decreases
0	1	Escherichia coli O79:H7	serotype	Decreases
0	1	Escherichia coli O81:NM	serotype	Decreases
0	1	Escherichia coli O86:H34	serotype	Decreases
0	1	Escherichia coli O91:H14	serotype	Decreases
0	1	Escherichia coli O91:NM	serotype	Decreases
0	1	Escherichia coli ONT:H33	serotype	Decreases
0	1	Escherichia coli O100:H21	serotype	Decreases
0	1	Escherichia coli O121:H19	serotype	Decreases
0	1	Escherichia coli O157:H7	serotype	Decreases
0	1	Escherichia coli O16:H6	serotype	Decreases
0	1	Escherichia coli O89m:H9	serotype	Decreases
0	1	Escherichia coli O111:H-	serotype	Decreases
0	1	Escherichia coli O113:H21	serotype	Decreases
0	1	Escherichia coli H20	serotype	Decreases
0	1	Escherichia coli O150:H6	serotype	Decreases
0	1	Escherichia coli O111:NM	serotype	Decreases
0	1	Escherichia coli O112ab:H8	serotype	Decreases
0	1	Escherichia coli O99:H6	serotype	Decreases
0	1	Escherichia coli O26:H11	serotype	Decreases
0	1	Escherichia coli O145:H28	serotype	Decreases
0	1	Escherichia coli O126:H45	serotype	Decreases
0	1	Escherichia coli O2:H6	serotype	Decreases
0	1	Escherichia coli O7:H4	serotype	Decreases
0	1	Escherichia coli O1:H42	serotype	Decreases
0	1	Escherichia coli O25:NM	serotype	Decreases
0	1	Escherichia coli O25:H1	serotype	Decreases
0	1	Escherichia coli O7:K1	serotype	Decreases
0	1	Escherichia coli O125ac:K+:H10	serotype	Decreases
0	1	Escherichia coli O6:K2:H1	serotype	Decreases
0	1	Escherichia coli O152:H23	serotype	Decreases
0	1	Escherichia coli O15:H18	serotype	Decreases
0	1	Escherichia coli O39:NM	serotype	Decreases
0	1	Escherichia coli O44:H18	serotype	Decreases
0	1	Escherichia coli O2:K2:H1	serotype	Decreases
0	1	Escherichia coli O8:H8	serotype	Decreases
0	1	Escherichia coli O89m:H10	serotype	Decreases
0	1	Escherichia coli O10:H32	serotype	Decreases
0	1	Escherichia coli O6:H16	serotype	Decreases
0	1	Escherichia coli O157:H-	serotype	Decreases
0	1	Escherichia coli O45:H2	serotype	Decreases
0	1	Escherichia coli O103:H2	serotype	Decreases
0	1	Escherichia coli O167:H26	serotype	Decreases
0	1	Escherichia coli O104:H4	serotype	Decreases
0	1	Escherichia coli O83:H1	serotype	Decreases
0	1	Escherichia coli O9:H10	serotype	Decreases
0	1	Escherichia coli O78:H4	serotype	Decreases
0	1	Escherichia coli O139:H28	serotype	Decreases
1	0	Bifidobacterium adolescentis	species	Decreases
1	0	Bilophila wadsworthia	species	Decreases
1	0	[Ruminococcus] torques	species	Decreases
1	0	Agathobacter rectalis	species	Decreases
1	0	Bacteroides caccae	species	Decreases
1	0	Bacteroides fragilis	species	Decreases
1	0	Bacteroides uniformis	species	Decreases
1	0	Bacteroides xylanisolvens	species	Decreases
1	0	Bifidobacterium longum	species	Decreases
1	0	Clostridioides difficile	species	Decreases
1	0	Clostridium perfringens	species	Decreases
1	0	Coprococcus comes	species	Decreases
1	0	Lacticaseibacillus paracasei	species	Decreases
1	0	Mediterraneibacter gnavus	species	Decreases
1	0	Parabacteroides distasonis	species	Decreases
1	0	Parabacteroides merdae	species	Decreases
1	0	Phocaeicola vulgatus	species	Decreases
1	0	Roseburia intestinalis	species	Decreases
1	0	Ruminococcus bromii	species	Decreases
1	0	Segatella copri	species	Decreases
1	0	Streptococcus salivarius	species	Decreases
1	0	Dorea formicigenerans	species	Decreases
1	0	Bacteroides thetaiotaomicron	species	Decreases
1	0	Porphyromonas gingivalis	species	Decreases
1	0	Odoribacter splanchnicus	species	Decreases
1	0	Enterocloster bolteae	species	Decreases
1	0	Blautia obeum	species	Decreases
1	0	Escherichia coli	species	Decreases
1	0	Fusobacterium nucleatum	species	Decreases
1	0	Collinsella aerofaciens	species	Decreases
0	1	Akkermansia glycaniphila	species	Increases
0	1	Akkermansia massiliensis	species	Increases
0	1	Candidatus Akkermansia intestinavium	species	Increases
0	1	Akkermansia muciniphila	species	Increases
0	1	Porphyromonas gingivalis 381	strain	Decreases
0	1	Porphyromonas gingivalis ATCC 33277	strain	Decreases
0	1	Porphyromonas gingivalis F0185	strain	Decreases
0	1	Porphyromonas gingivalis F0566	strain	Decreases
0	1	Porphyromonas gingivalis F0568	strain	Decreases
0	1	Porphyromonas gingivalis F0569	strain	Decreases
0	1	Porphyromonas gingivalis F0570	strain	Decreases
0	1	Porphyromonas gingivalis JCVI SC001	strain	Decreases
0	1	Porphyromonas gingivalis SJD11	strain	Decreases
0	1	Porphyromonas gingivalis SJD12	strain	Decreases
0	1	Porphyromonas gingivalis SJD2	strain	Decreases
0	1	Porphyromonas gingivalis SJD4	strain	Decreases
0	1	Porphyromonas gingivalis SJD5	strain	Decreases
0	1	Porphyromonas gingivalis TDC60	strain	Decreases
0	1	Porphyromonas gingivalis W4087	strain	Decreases
0	1	Porphyromonas gingivalis W50	strain	Decreases
0	1	Porphyromonas gingivalis W83	strain	Decreases
0	1	Porphyromonas gingivalis AJW4	strain	Decreases
0	1	Porphyromonas gingivalis A7A1-28	strain	Decreases
0	1	Bifidobacterium longum subsp. longum	subspecies	Decreases
0	1	Bifidobacterium longum subsp. infantis	subspecies	Decreases
0	1	Bifidobacterium longum subsp. suis	subspecies	Decreases
0	1	Lacticaseibacillus paracasei subsp. paracasei	subspecies	Decreases
0	1	Fusobacterium nucleatum subsp. nucleatum	subspecies	Decreases
0	1	Lacticaseibacillus paracasei subsp. tolerans	subspecies	Decreases
0	1	Bifidobacterium longum subsp. suillum	subspecies	Decreases

Impact of estradiol valerate,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition	Positive Impact	Negative Impact	Benefit Ratio Impact
Abdominal Aortic Aneurysm	0.8		0.8
Acne	0.6	0.9	-0.5
ADHD	4.8	0.6	7
Age-Related Macular Degeneration and Glaucoma	1.1	0.4	1.75
Allergic Rhinitis (Hay Fever)	4.4	2.3	0.91
Allergies	8.2	5.5	0.49
Allergy to milk products	1.7	2.7	-0.59
Alopecia (Hair Loss)	1.6		1.6
Alzheimer's disease	7.3	8.5	-0.16
Amyotrophic lateral sclerosis (ALS) Motor Neuron	4.3	2.3	0.87
Ankylosing spondylitis	4.1	2.1	0.95
Anorexia Nervosa	2.3	3.1	-0.35
Antiphospholipid syndrome (APS)	1.9	0.3	5.33
Asthma	6.6	2.3	1.87
Atherosclerosis	3.5	2.6	0.35
Atrial fibrillation	4.2	3.1	0.35
Autism	11.5	10.7	0.07
Autoimmune Disease	1.8	1	0.8
Barrett esophagus cancer	0.3	0.4	-0.33
benign prostatic hyperplasia	0.6	0.3	1
Biofilm	2.3		2.3
Bipolar Disorder	2.1	1.1	0.91
Brain Trauma	1	1.5	-0.5
Breast Cancer	1.3	0.3	3.33
Cancer (General)	1.4	3.5	-1.5
Carcinoma	5.2	2.6	1
Celiac Disease	3.7	3.7	0
Cerebral Palsy	1.2	1.9	-0.58
Chronic Fatigue Syndrome	4.5	7.3	-0.62
Chronic Kidney Disease	5.2	2.6	1
Chronic Lyme	0.6	0.8	-0.33
Chronic Obstructive Pulmonary Disease (COPD)	2.9	1.6	0.81
Chronic Urticaria (Hives)	2.2	1.2	0.83
Coagulation / Micro clot triggering bacteria	2.3	1.9	0.21
Cognitive Function	3.5	2.3	0.52
Colorectal Cancer	9.4	4.6	1.04
Constipation	2.1	1.9	0.11
Coronary artery disease	3.1	2.7	0.15
COVID-19	9.9	12.4	-0.25
Crohn's Disease	10.9	5.9	0.85
Cushing's Syndrome (hypercortisolism)		0.9	-0.9
cystic fibrosis	0.9	1.9	-1.11
d-lactic acidosis (one form of brain fog)	0.3		0.3
deep vein thrombosis	2.9	2.7	0.07
Denture Wearers Oral Shifts	1.7		1.7
Depression	13.3	9.6	0.39
Dermatomyositis	0.4	0.3	0.33
Eczema	2.1	3.4	-0.62
Endometriosis	3.6	1.7	1.12
Eosinophilic Esophagitis	0.3	0.7	-1.33
Epilepsy	5	2.3	1.17
erectile dysfunction	2	0.4	4
Fibromyalgia	2.8	3.6	-0.29
Functional constipation / chronic idiopathic constipation	5.9	4.9	0.2
gallstone disease (gsd)	4.3	1.1	2.91
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	1.6	0.7	1.29
Generalized anxiety disorder	3.5	3.2	0.09
giant cell arteritis		0.2	-0.2
Glioblastoma		0.4	-0.4
Gout	3.4	2	0.7
Graves' disease	1.6	3.1	-0.94
Gulf War Syndrome	2.2	1.4	0.57
Halitosis	2	0.4	4
Hashimoto's thyroiditis	4.2	2.1	1
Heart Failure	5	2.5	1
hemorrhagic stroke	1.3		1.3
Hidradenitis Suppurativa	1.6		1.6
High Histamine/low DAO	1.7	0.6	1.83
hypercholesterolemia (High Cholesterol)	1.4		1.4
hyperglycemia	2.7	1.7	0.59
Hyperlipidemia (High Blood Fats)	1.4	0.9	0.56
hypersomnia		0.8	-0.8
hypertension (High Blood Pressure	5.2	6.6	-0.27
Hypothyroidism	0.9	1.3	-0.44
Hypoxia	3.3	1.5	1.2
IgA nephropathy (IgAN)	2.5	3.4	-0.36
Inflammatory Bowel Disease	9.5	10.1	-0.06
Insomnia	3.8	2	0.9
Intelligence	1.7	0.6	1.83
Intracranial aneurysms	1.4	0.9	0.56
Irritable Bowel Syndrome	8	5.5	0.45
ischemic stroke	2.8	2.4	0.17
Liver Cirrhosis	8.9	4.5	0.98
Long COVID	7.7	7.7	0
Low bone mineral density	0.1	0.8	-7
Lung Cancer	2.1	1	1.1
Lymphoma	0.9		0.9
Mast Cell Issues / mastitis	1.7	0.9	0.89
ME/CFS with IBS	1	2.1	-1.1
ME/CFS without IBS	1.2	2.4	-1
membranous nephropathy	0.4		0.4
Menopause	2.3	0.5	3.6
Metabolic Syndrome	9.6	8.5	0.13
Mood Disorders	11.9	8.9	0.34
multiple chemical sensitivity [MCS]	1	0.7	0.43
Multiple Sclerosis	6.9	7.7	-0.12
Multiple system atrophy (MSA)		1.9	-1.9
myasthenia gravis	1	0.7	0.43
neuropathic pain	0.6	2	-2.33
Neuropathy (all types)	0.6	2.8	-3.67
neuropsychiatric disorders (PANDAS, PANS)	1		1
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	7.3	4.6	0.59
NonCeliac Gluten Sensitivity	1	1.2	-0.2
Obesity	12.2	10.2	0.2
obsessive-compulsive disorder	5.9	4.4	0.34
Osteoarthritis	3.5	1.3	1.69
Osteoporosis	2.5	1.7	0.47
pancreatic cancer	2.3	1	1.3
Parkinson's Disease	10.1	10.5	-0.04
Polycystic ovary syndrome	9.2	3.4	1.71
Postural orthostatic tachycardia syndrome	0.2	0.6	-2
Premenstrual dysphoric disorder	0.7	0.4	0.75
primary biliary cholangitis	1	1.8	-0.8
Primary sclerosing cholangitis	1.7	2.9	-0.71
Psoriasis	3.5	4	-0.14
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	8.8	5.6	0.57
Rosacea	1.2	1	0.2
Schizophrenia	7.2	3.1	1.32
scoliosis	0.6	0.6	0
Sjögren syndrome	2.5	3.3	-0.32
Sleep Apnea	1.9	1.6	0.19
Slow gastric motility / Gastroparesis	0.9	0.3	2
Small Intestinal Bacterial Overgrowth (SIBO)	1.8	0.6	2
Stress / posttraumatic stress disorder	3.8	2.7	0.41
Systemic Lupus Erythematosus	4.5	1.6	1.81
Tic Disorder	1.6	1.8	-0.13
Tourette syndrome	1	0.9	0.11
Type 1 Diabetes	4.9	5.5	-0.12
Type 2 Diabetes	10.9	8.7	0.25
Ulcerative colitis	7.3	7.7	-0.05
Unhealthy Ageing	6.3	2.4	1.63
Vitiligo	2.9	1.5	0.93

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