🍽️ aprepitant,(prescription)

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Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV): Aprepitant is effective in preventing both acute and delayed nausea and vomiting associated with highly emetogenic chemotherapy (chemotherapy that is likely to cause severe nausea and vomiting) as well as moderately emetogenic chemotherapy.
Prevention of Postoperative Nausea and Vomiting (PONV): Aprepitant can also be used to prevent nausea and vomiting following surgery.
NK1 Receptor Antagonist: Aprepitant works by blocking the action of substance P, a neurotransmitter involved in the vomiting reflex, at the neurokinin 1 (NK1) receptor in the brain.
Multiple Dosage Forms: Aprepitant is available in oral (capsule) and intravenous (IV) formulations. The oral form is typically taken before chemotherapy or surgery, while the IV form may be administered in a healthcare setting.
Three-Day Regimen: Aprepitant is often prescribed as part of a three-day regimen, with the first dose taken prior to chemotherapy or surgery, followed by additional doses on subsequent days to provide continued protection against nausea and vomiting.
Combination Therapy: Aprepitant is frequently used in combination with other antiemetic medications, such as 5-HT3 receptor antagonists (e.g., ondansetron) and corticosteroids, to further enhance its antiemetic effects.
Well-Tolerated: Aprepitant is generally well-tolerated, with common side effects including fatigue, dizziness, constipation, diarrhea, headache, and changes in taste perception.
Drug Interactions: Aprepitant may interact with certain medications, particularly those metabolized by the cytochrome P450 enzyme system. It can increase the blood levels of drugs such as warfarin, dexamethasone, and hormonal contraceptives, potentially leading to an increased risk of side effects.
Special Populations: Aprepitant should be used with caution in patients with liver impairment, as it is primarily metabolized by the liver. Dose adjustments may be necessary in these patients.
Pregnancy and Lactation: The safety of aprepitant during pregnancy and breastfeeding has not been well-established. It should be used during pregnancy only if the potential benefits justify the potential risks to the fetus, and breastfeeding should be avoided during treatment.

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Data Contradictions — Limits of Certainity

Impacted of aprepitant,(prescription) On Probiotics

Rank	Probiotic	Impact
genus	Bifidobacterium	Reduces
species	Akkermansia muciniphila	Reduces
species	Bacteroides uniformis	Reduces
species	Bifidobacterium adolescentis	Reduces
species	Bifidobacterium longum	Reduces
species	Escherichia coli	Reduces
species	Lacticaseibacillus paracasei	Reduces
species	Parabacteroides distasonis	Reduces
subspecies	Bifidobacterium longum subsp. infantis	Reduces
subspecies	Bifidobacterium longum subsp. longum	Reduces

Bacteria Impacted by aprepitant,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

🧙?
📓 Direct Citations	👪👶 Indirect Citations	Taxonomy	Rank	Effect
0	1	Akkermansiaceae	family	Decreases
0	1	Escherichia	genus	Decreases
0	1	Dorea	genus	Decreases
0	1	Roseburia	genus	Decreases
0	1	Parabacteroides	genus	Decreases
0	1	Ruminococcus	genus	Decreases
0	1	Agathobacter	genus	Decreases
0	1	Bacteroides	genus	Decreases
0	1	Bifidobacterium	genus	Decreases
0	1	Bilophila	genus	Decreases
0	1	Clostridioides	genus	Decreases
0	1	Collinsella	genus	Decreases
0	1	Coprococcus	genus	Decreases
0	1	Lacrimispora	genus	Decreases
0	1	Mediterraneibacter	genus	Decreases
0	1	Odoribacter	genus	Decreases
0	1	Phocaeicola	genus	Decreases
0	1	Streptococcus	genus	Decreases
0	1	Veillonella	genus	Decreases
1	0	Akkermansia	genus	Decreases
0	1	Clostridium	genus	Decreases
0	1	Segatella	genus	Decreases
0	1	Enterocloster	genus	Decreases
0	1	Blautia	genus	Decreases
0	1	Thomasclavelia	genus	Decreases
0	1	Lacticaseibacillus	genus	Decreases
0	1	Escherichia coli O25:H16	no rank	Decreases
0	1	Clostridium perfringens A	no rank	Decreases
0	1	Clostridium perfringens C	no rank	Decreases
0	1	Clostridium perfringens CPE	no rank	Decreases
0	1	environmental samples	no rank	Decreases
0	1	Escherichia coli O145:H34	no rank	Decreases
0	1	Escherichia coli O16:H48	no rank	Decreases
0	1	unclassified Akkermansia	no rank	Decreases
0	1	Clostridium perfringens D	no rank	Decreases
0	1	Escherichia coli O141:H4	no rank	Decreases
0	1	Clostridium perfringens B	no rank	Decreases
0	1	Escherichia coli O139:H1	no rank	Decreases
0	1	Clostridium perfringens E	no rank	Decreases
0	1	Escherichia coli O80:H26	no rank	Decreases
0	1	Escherichia coli O158:H23	no rank	Decreases
0	1	Escherichia coli O84:H7	no rank	Decreases
0	1	Escherichia coli O2:K1:H4	no rank	Decreases
0	1	Escherichia coli O2:K1:H7	no rank	Decreases
0	1	Escherichia coli O78:H51	no rank	Decreases
0	1	Escherichia coli O18ac:H14	no rank	Decreases
0	1	Escherichia coli O85:H1	no rank	Decreases
0	1	Escherichia coli O7:H15	no rank	Decreases
0	1	Escherichia coli O68:H12	no rank	Decreases
0	1	Escherichia coli O55:H7	no rank	Decreases
0	1	Escherichia coli O1:K1:H7	no rank	Decreases
0	1	Escherichia coli O15:H12	no rank	Decreases
0	1	Escherichia coli O170:H18	no rank	Decreases
0	1	Escherichia coli O155:H21	no rank	Decreases
0	1	Escherichia coli O19:H7	no rank	Decreases
0	1	Escherichia coli O2:K1:H5	no rank	Decreases
0	1	Escherichia coli O20:H12	no rank	Decreases
0	1	Escherichia coli O111	serogroup	Decreases
0	1	Escherichia coli O121	serogroup	Decreases
0	1	Escherichia coli O155	serogroup	Decreases
0	1	Escherichia coli O177	serogroup	Decreases
0	1	Escherichia coli O26	serogroup	Decreases
0	1	Escherichia coli O3	serogroup	Decreases
0	1	Escherichia coli O5	serogroup	Decreases
0	1	Escherichia coli O86	serogroup	Decreases
0	1	Escherichia coli O91	serogroup	Decreases
0	1	Escherichia coli O103	serogroup	Decreases
0	1	Escherichia coli O78	serogroup	Decreases
0	1	Escherichia coli O43	serogroup	Decreases
0	1	Escherichia coli O119	serogroup	Decreases
0	1	Escherichia coli O157	serogroup	Decreases
0	1	Escherichia coli O145	serogroup	Decreases
0	1	Escherichia coli O1:HNT	serotype	Decreases
0	1	Escherichia coli O10:K5(L):H4	serotype	Decreases
0	1	Escherichia coli O103:H11	serotype	Decreases
0	1	Escherichia coli O103:H25	serotype	Decreases
0	1	Escherichia coli O104:H21	serotype	Decreases
0	1	Escherichia coli O111:H11	serotype	Decreases
0	1	Escherichia coli O111:H8	serotype	Decreases
0	1	Escherichia coli O112ac:H19	serotype	Decreases
0	1	Escherichia coli O114:H49	serotype	Decreases
0	1	Escherichia coli O118:H16	serotype	Decreases
0	1	Escherichia coli O121:H7	serotype	Decreases
0	1	Escherichia coli O123:H11	serotype	Decreases
0	1	Escherichia coli O127:H27	serotype	Decreases
0	1	Escherichia coli O127:H6	serotype	Decreases
0	1	Escherichia coli O128:H2	serotype	Decreases
0	1	Escherichia coli O128ac:H12	serotype	Decreases
0	1	Escherichia coli O145:H25	serotype	Decreases
0	1	Escherichia coli O145:NM	serotype	Decreases
0	1	Escherichia coli O146:H21	serotype	Decreases
0	1	Escherichia coli O153:H2	serotype	Decreases
0	1	Escherichia coli O156:H25	serotype	Decreases
0	1	Escherichia coli O157:H43	serotype	Decreases
0	1	Escherichia coli O157:NM	serotype	Decreases
0	1	Escherichia coli O165:H25	serotype	Decreases
0	1	Escherichia coli O174:H2	serotype	Decreases
0	1	Escherichia coli O174:H21	serotype	Decreases
0	1	Escherichia coli O174:H8	serotype	Decreases
0	1	Escherichia coli O176:H45	serotype	Decreases
0	1	Escherichia coli O177:NM	serotype	Decreases
0	1	Escherichia coli O26:H1	serotype	Decreases
0	1	Escherichia coli O28ac:NM	serotype	Decreases
0	1	Escherichia coli O29:H4	serotype	Decreases
0	1	Escherichia coli O32:H37	serotype	Decreases
0	1	Escherichia coli O6:H16:CFA/II	serotype	Decreases
0	1	Escherichia coli O69:H11	serotype	Decreases
0	1	Escherichia coli O78:H12	serotype	Decreases
0	1	Escherichia coli O79:H7	serotype	Decreases
0	1	Escherichia coli O81:NM	serotype	Decreases
0	1	Escherichia coli O86:H34	serotype	Decreases
0	1	Escherichia coli O91:H14	serotype	Decreases
0	1	Escherichia coli O91:NM	serotype	Decreases
0	1	Escherichia coli ONT:H33	serotype	Decreases
0	1	Escherichia coli O100:H21	serotype	Decreases
0	1	Escherichia coli O121:H19	serotype	Decreases
0	1	Escherichia coli O157:H7	serotype	Decreases
0	1	Escherichia coli O16:H6	serotype	Decreases
0	1	Escherichia coli O89m:H9	serotype	Decreases
0	1	Escherichia coli O111:H-	serotype	Decreases
0	1	Escherichia coli O113:H21	serotype	Decreases
0	1	Escherichia coli H20	serotype	Decreases
0	1	Escherichia coli O150:H6	serotype	Decreases
0	1	Escherichia coli O111:NM	serotype	Decreases
0	1	Escherichia coli O112ab:H8	serotype	Decreases
0	1	Escherichia coli O99:H6	serotype	Decreases
0	1	Escherichia coli O26:H11	serotype	Decreases
0	1	Escherichia coli O145:H28	serotype	Decreases
0	1	Escherichia coli O126:H45	serotype	Decreases
0	1	Escherichia coli O2:H6	serotype	Decreases
0	1	Escherichia coli O7:H4	serotype	Decreases
0	1	Escherichia coli O1:H42	serotype	Decreases
0	1	Escherichia coli O25:NM	serotype	Decreases
0	1	Escherichia coli O25:H1	serotype	Decreases
0	1	Escherichia coli O7:K1	serotype	Decreases
0	1	Escherichia coli O125ac:K+:H10	serotype	Decreases
0	1	Escherichia coli O6:K2:H1	serotype	Decreases
0	1	Escherichia coli O152:H23	serotype	Decreases
0	1	Escherichia coli O15:H18	serotype	Decreases
0	1	Escherichia coli O39:NM	serotype	Decreases
0	1	Escherichia coli O44:H18	serotype	Decreases
0	1	Escherichia coli O2:K2:H1	serotype	Decreases
0	1	Escherichia coli O8:H8	serotype	Decreases
0	1	Escherichia coli O89m:H10	serotype	Decreases
0	1	Escherichia coli O10:H32	serotype	Decreases
0	1	Escherichia coli O6:H16	serotype	Decreases
0	1	Escherichia coli O157:H-	serotype	Decreases
0	1	Escherichia coli O45:H2	serotype	Decreases
0	1	Escherichia coli O103:H2	serotype	Decreases
0	1	Escherichia coli O167:H26	serotype	Decreases
0	1	Escherichia coli O104:H4	serotype	Decreases
0	1	Escherichia coli O83:H1	serotype	Decreases
0	1	Escherichia coli O9:H10	serotype	Decreases
0	1	Escherichia coli O78:H4	serotype	Decreases
0	1	Escherichia coli O139:H28	serotype	Decreases
1	0	Bifidobacterium adolescentis	species	Decreases
1	0	[Ruminococcus] torques	species	Decreases
1	0	Bacteroides caccae	species	Decreases
1	0	Bacteroides fragilis	species	Decreases
1	0	Bacteroides ovatus	species	Decreases
1	0	Bacteroides uniformis	species	Decreases
1	0	Bacteroides xylanisolvens	species	Decreases
1	0	Bifidobacterium longum	species	Decreases
1	0	Blautia obeum	species	Decreases
1	0	Clostridioides difficile	species	Decreases
1	0	Clostridium perfringens	species	Decreases
1	0	Collinsella aerofaciens	species	Decreases
1	0	Coprococcus comes	species	Decreases
1	0	Dorea formicigenerans	species	Decreases
1	0	Enterocloster bolteae	species	Decreases
1	0	Mediterraneibacter gnavus	species	Decreases
1	0	Odoribacter splanchnicus	species	Decreases
1	0	Parabacteroides distasonis	species	Decreases
1	0	Parabacteroides merdae	species	Decreases
1	0	Phocaeicola vulgatus	species	Decreases
1	0	Roseburia hominis	species	Decreases
1	0	Roseburia intestinalis	species	Decreases
1	0	Ruminococcus bromii	species	Decreases
1	0	Segatella copri	species	Decreases
1	0	Veillonella parvula	species	Decreases
1	0	Bacteroides thetaiotaomicron	species	Decreases
1	0	Bilophila wadsworthia	species	Decreases
1	0	Akkermansia muciniphila	species	Decreases
1	0	Agathobacter rectalis	species	Decreases
1	0	Lacticaseibacillus paracasei	species	Decreases
0	1	Akkermansia massiliensis	species	Decreases
0	1	Candidatus Akkermansia intestinavium	species	Decreases
1	0	Escherichia coli	species	Decreases
1	0	Streptococcus parasanguinis	species	Decreases
1	0	Thomasclavelia ramosa	species	Decreases
1	0	Lacrimispora saccharolytica	species	Decreases
0	1	Akkermansia glycaniphila	species	Decreases
0	1	Bifidobacterium longum subsp. longum	subspecies	Decreases
0	1	Bifidobacterium longum subsp. infantis	subspecies	Decreases
0	1	Bifidobacterium longum subsp. suis	subspecies	Decreases
0	1	Lacticaseibacillus paracasei subsp. paracasei	subspecies	Decreases
0	1	Lacticaseibacillus paracasei subsp. tolerans	subspecies	Decreases
0	1	Bifidobacterium longum subsp. suillum	subspecies	Decreases

Impact of aprepitant,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition	Positive Impact	Negative Impact	Benefit Ratio Impact
Abdominal Aortic Aneurysm	0.8		0.8
Acne	0.6	0.9	-0.5
ADHD	5.2	0.6	7.67
Age-Related Macular Degeneration and Glaucoma	1.1	0.4	1.75
Allergic Rhinitis (Hay Fever)	3.4	2.5	0.36
Allergies	6.9	4	0.73
Allergy to milk products	2.1	1.6	0.31
Alopecia (Hair Loss)	1.6		1.6
Alzheimer's disease	6.2	7.7	-0.24
Amyotrophic lateral sclerosis (ALS) Motor Neuron	3.4	1	2.4
Ankylosing spondylitis	4.4	1.2	2.67
Anorexia Nervosa	1.6	2.9	-0.81
Antiphospholipid syndrome (APS)	1.7	0.3	4.67
Asthma	4.3	3.1	0.39
Atherosclerosis	2	2.8	-0.4
Atrial fibrillation	3.8	2.9	0.31
Autism	10.9	9.9	0.1
Autoimmune Disease	1.2	1	0.2
Barrett esophagus cancer	0.3	0.3	0
benign prostatic hyperplasia	0.6	0.3	1
Biofilm	1.6		1.6
Bipolar Disorder	2.1	1.4	0.5
Brain Trauma	0.9	1.4	-0.56
Breast Cancer	0.8	0.3	1.67
Cancer (General)	0.6	3.2	-4.33
Carcinoma	3.8	2.6	0.46
Celiac Disease	3.2	3.7	-0.16
Cerebral Palsy	1.6	1.3	0.23
Chronic Fatigue Syndrome	5	7.5	-0.5
Chronic Kidney Disease	4.9	2.7	0.81
Chronic Lyme	0.6	0.8	-0.33
Chronic Obstructive Pulmonary Disease (COPD)	1.3	1.4	-0.08
Chronic Urticaria (Hives)	1.6	1.7	-0.06
Coagulation / Micro clot triggering bacteria	1.5	1.3	0.15
Cognitive Function	3.6	1.6	1.25
Colorectal Cancer	8.4	2.4	2.5
Constipation	1.8	1.3	0.38
Coronary artery disease	2.6	2.9	-0.12
COVID-19	9.9	12.4	-0.25
Crohn's Disease	8.6	5.2	0.65
Cushing's Syndrome (hypercortisolism)		0.9	-0.9
cystic fibrosis	0.8	1.9	-1.37
d-lactic acidosis (one form of brain fog)	0.2		0.2
deep vein thrombosis	2.9	1.4	1.07
Denture Wearers Oral Shifts	0.9		0.9
Depression	11.4	10.5	0.09
Dermatomyositis	0.3	0.3	0
Eczema	2	2.1	-0.05
Endometriosis	3.1	1.9	0.63
Eosinophilic Esophagitis		0.6	-0.6
Epilepsy	3.5	2.5	0.4
erectile dysfunction	1.8	0.3	5
Fibromyalgia	2.9	2.6	0.12
Functional constipation / chronic idiopathic constipation	6.2	4.9	0.27
gallstone disease (gsd)	4	1.1	2.64
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	1.5	0.9	0.67
Generalized anxiety disorder	2.7	2.7	0
giant cell arteritis		0.2	-0.2
Glioblastoma		0.3	-0.3
Gout	2.3	1	1.3
Graves' disease	1.9	3.3	-0.74
Gulf War Syndrome	0.9	2.1	-1.33
Halitosis	0.9	0.3	2
Hashimoto's thyroiditis	3.9	1.7	1.29
Heart Failure	3.8	2	0.9
hemorrhagic stroke	1		1
Hidradenitis Suppurativa	0.9	0.3	2
High Histamine/low DAO	1.6	0.6	1.67
hypercholesterolemia (High Cholesterol)	0.7	0.5	0.4
hyperglycemia	2	1.9	0.05
Hyperlipidemia (High Blood Fats)	1.1	0.3	2.67
hypersomnia		0.7	-0.7
hypertension (High Blood Pressure	5.1	6	-0.18
Hypothyroidism	0.2	0.7	-2.5
Hypoxia	3.4	0.9	2.78
IgA nephropathy (IgAN)	1.3	4.9	-2.77
Inflammatory Bowel Disease	8	10.6	-0.32
Insomnia	1.9	2.9	-0.53
Intelligence	1.6	0.6	1.67
Intracranial aneurysms	1.2	0.9	0.33
Irritable Bowel Syndrome	8.6	5.7	0.51
ischemic stroke	3.1	1.7	0.82
Liver Cirrhosis	7.4	4.9	0.51
Long COVID	7.1	7.9	-0.11
Low bone mineral density		0.8	-0.8
Lung Cancer	1.5	1.5	0
Lymphoma	0.6		0.6
Mast Cell Issues / mastitis	0.9	0.9	0
ME/CFS with IBS	1.1	2.4	-1.18
ME/CFS without IBS	1.1	2.4	-1.18
membranous nephropathy	0.3		0.3
Menopause	2.2	0.8	1.75
Metabolic Syndrome	8.2	9	-0.1
Mood Disorders	11.6	8.1	0.43
multiple chemical sensitivity [MCS]	0.8	0.1	7
Multiple Sclerosis	6.5	6.2	0.05
Multiple system atrophy (MSA)	1.5	0.7	1.14
myasthenia gravis	0.9	0.7	0.29
neuropathic pain		3.1	-3.1
Neuropathy (all types)	0.7	2.8	-3
neuropsychiatric disorders (PANDAS, PANS)	0.8		0.8
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	5.1	5.2	-0.02
NonCeliac Gluten Sensitivity	1.5	0.6	1.5
Obesity	12.1	8	0.51
obsessive-compulsive disorder	6.3	4.7	0.34
Osteoarthritis	2.8	1.4	1
Osteoporosis	2.2	1.8	0.22
pancreatic cancer	0.6	0.3	1
Parkinson's Disease	8.9	6.5	0.37
Polycystic ovary syndrome	7.6	3.5	1.17
Postural orthostatic tachycardia syndrome	0.2	0.6	-2
Premenstrual dysphoric disorder	0.7	0.4	0.75
primary biliary cholangitis	1.2	1.4	-0.17
Primary sclerosing cholangitis	2.3	3.2	-0.39
Psoriasis	3.8	3.7	0.03
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	8.2	4.2	0.95
Rosacea	1.2	1	0.2
Schizophrenia	6.9	3	1.3
scoliosis	0.5	0.6	-0.2
Sjögren syndrome	3.2	3.3	-0.03
Sleep Apnea	1.6	1.6	0
Slow gastric motility / Gastroparesis	1.1	0.3	2.67
Small Intestinal Bacterial Overgrowth (SIBO)	1.6	0.6	1.67
Stress / posttraumatic stress disorder	2.8	2.6	0.08
Systemic Lupus Erythematosus	4.3	1.6	1.69
Tic Disorder	1.5	1.8	-0.2
Tourette syndrome	1.1	0.3	2.67
Type 1 Diabetes	5	4.2	0.19
Type 2 Diabetes	9.2	8.6	0.07
Ulcerative colitis	5.9	8.4	-0.42
Unhealthy Ageing	5.6	2.5	1.24
Vitiligo	2.2	1.8	0.22

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