🍽️ diclazuril,(prescription)

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Antiprotozoal Activity: Diclazuril is a member of the triazine class of antiprotozoal drugs, which exert their therapeutic effects by interfering with the metabolism and reproduction of protozoa such as Eimeria species. Diclazuril targets the intracellular stages of the coccidian parasites, preventing their development and replication within host cells.
Treatment of Coccidiosis: Diclazuril is highly effective in the treatment of coccidial infections in animals, including poultry (chickens, turkeys), cattle, sheep, goats, pigs, and other species. It helps reduce the severity of clinical signs associated with coccidiosis, such as diarrhea, dehydration, lethargy, and poor growth or weight gain, leading to improved health and productivity in affected animals.
Prevention of Coccidiosis: In addition to its therapeutic use, diclazuril is also used for the prevention of coccidial infections in animals raised in intensive farming systems, such as commercial poultry production. Prophylactic treatment with diclazuril can help reduce the risk of coccidiosis outbreaks and minimize economic losses associated with decreased feed efficiency, poor growth rates, and increased mortality in infected animals.
Broad-Spectrum Activity: Diclazuril exhibits broad-spectrum activity against various species and strains of Eimeria parasites that commonly infect domestic animals. It is effective against both sensitive and resistant strains of coccidia, making it a valuable tool for controlling coccidial infections in livestock and poultry populations.
Ease of Administration: Diclazuril is typically administered orally to animals, either in the form of medicated feed, drinking water, or oral suspensions. It is well-absorbed from the gastrointestinal tract and rapidly distributed throughout the body, reaching therapeutic concentrations in target tissues where coccidial parasites reside.
Safety and Tolerability: Diclazuril is generally safe and well-tolerated in animals when administered at recommended dosages. Adverse effects are rare but may include mild gastrointestinal upset (e.g., vomiting, diarrhea) or allergic reactions in sensitive individuals. Proper dosing and administration practices should be followed to minimize the risk of adverse effects and ensure optimal therapeutic outcomes.
Regulatory Considerations: Diclazuril is approved for veterinary use in many countries worldwide and is available in various formulations and concentrations for use in different animal species and production systems. Veterinary oversight and prescription may be required for the use of diclazuril in some jurisdictions, particularly in commercial farming operations.

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Data Contradictions — Limits of Certainity

Impacted of diclazuril,(prescription) On Probiotics

Rank	Probiotic	Impact
species	Bacteroides uniformis	Reduces
species	Escherichia coli	Reduces
species	Lacticaseibacillus paracasei	Reduces
species	Parabacteroides distasonis	Reduces

Bacteria Impacted by diclazuril,(prescription)

We extend modifiers to include items that changes the parent and child taxa. I.e. for a species, that would be the genus that is belongs to and the strains in the species.

🧙?
📓 Direct Citations	👪👶 Indirect Citations	Taxonomy	Rank	Effect
0	1	Escherichia	genus	Decreases
0	1	Roseburia	genus	Decreases
0	1	Parabacteroides	genus	Decreases
0	1	Ruminococcus	genus	Decreases
0	1	Agathobacter	genus	Decreases
0	1	Bacteroides	genus	Decreases
0	1	Bilophila	genus	Decreases
0	1	Clostridioides	genus	Decreases
0	1	Coprococcus	genus	Decreases
0	1	Fusobacterium	genus	Decreases
0	1	Lachnospira	genus	Decreases
0	1	Lacrimispora	genus	Decreases
0	1	Mediterraneibacter	genus	Decreases
0	1	Odoribacter	genus	Decreases
0	1	Streptococcus	genus	Decreases
0	1	Clostridium	genus	Decreases
0	1	Segatella	genus	Decreases
0	1	Enterocloster	genus	Decreases
0	1	Blautia	genus	Decreases
0	1	Thomasclavelia	genus	Decreases
0	1	Lacticaseibacillus	genus	Decreases
0	2	Phocaeicola	genus	Decreases
0	1	Escherichia coli O25:H16	no rank	Decreases
0	1	Clostridium perfringens A	no rank	Decreases
0	1	Clostridium perfringens C	no rank	Decreases
0	1	Clostridium perfringens CPE	no rank	Decreases
0	1	Escherichia coli O145:H34	no rank	Decreases
0	1	Escherichia coli O16:H48	no rank	Decreases
0	1	Clostridium perfringens D	no rank	Decreases
0	1	Escherichia coli O141:H4	no rank	Decreases
0	1	Clostridium perfringens B	no rank	Decreases
0	1	Escherichia coli O139:H1	no rank	Decreases
0	1	Clostridium perfringens E	no rank	Decreases
0	1	Escherichia coli O80:H26	no rank	Decreases
0	1	Escherichia coli O158:H23	no rank	Decreases
0	1	Escherichia coli O84:H7	no rank	Decreases
0	1	Escherichia coli O2:K1:H4	no rank	Decreases
0	1	Escherichia coli O2:K1:H7	no rank	Decreases
0	1	Escherichia coli O78:H51	no rank	Decreases
0	1	Escherichia coli O18ac:H14	no rank	Decreases
0	1	Escherichia coli O85:H1	no rank	Decreases
0	1	Escherichia coli O7:H15	no rank	Decreases
0	1	Escherichia coli O68:H12	no rank	Decreases
0	1	Escherichia coli O55:H7	no rank	Decreases
0	1	Escherichia coli O1:K1:H7	no rank	Decreases
0	1	Escherichia coli O15:H12	no rank	Decreases
0	1	Escherichia coli O170:H18	no rank	Decreases
0	1	Escherichia coli O155:H21	no rank	Decreases
0	1	Escherichia coli O19:H7	no rank	Decreases
0	1	Escherichia coli O2:K1:H5	no rank	Decreases
0	1	Escherichia coli O20:H12	no rank	Decreases
0	1	Escherichia coli O111	serogroup	Decreases
0	1	Escherichia coli O121	serogroup	Decreases
0	1	Escherichia coli O155	serogroup	Decreases
0	1	Escherichia coli O177	serogroup	Decreases
0	1	Escherichia coli O26	serogroup	Decreases
0	1	Escherichia coli O3	serogroup	Decreases
0	1	Escherichia coli O5	serogroup	Decreases
0	1	Escherichia coli O86	serogroup	Decreases
0	1	Escherichia coli O91	serogroup	Decreases
0	1	Escherichia coli O103	serogroup	Decreases
0	1	Escherichia coli O78	serogroup	Decreases
0	1	Escherichia coli O43	serogroup	Decreases
0	1	Escherichia coli O119	serogroup	Decreases
0	1	Escherichia coli O157	serogroup	Decreases
0	1	Escherichia coli O145	serogroup	Decreases
0	1	Escherichia coli O1:HNT	serotype	Decreases
0	1	Escherichia coli O10:K5(L):H4	serotype	Decreases
0	1	Escherichia coli O103:H11	serotype	Decreases
0	1	Escherichia coli O103:H25	serotype	Decreases
0	1	Escherichia coli O104:H21	serotype	Decreases
0	1	Escherichia coli O111:H11	serotype	Decreases
0	1	Escherichia coli O111:H8	serotype	Decreases
0	1	Escherichia coli O112ac:H19	serotype	Decreases
0	1	Escherichia coli O114:H49	serotype	Decreases
0	1	Escherichia coli O118:H16	serotype	Decreases
0	1	Escherichia coli O121:H7	serotype	Decreases
0	1	Escherichia coli O123:H11	serotype	Decreases
0	1	Escherichia coli O127:H27	serotype	Decreases
0	1	Escherichia coli O127:H6	serotype	Decreases
0	1	Escherichia coli O128:H2	serotype	Decreases
0	1	Escherichia coli O128ac:H12	serotype	Decreases
0	1	Escherichia coli O145:H25	serotype	Decreases
0	1	Escherichia coli O145:NM	serotype	Decreases
0	1	Escherichia coli O146:H21	serotype	Decreases
0	1	Escherichia coli O153:H2	serotype	Decreases
0	1	Escherichia coli O156:H25	serotype	Decreases
0	1	Escherichia coli O157:H43	serotype	Decreases
0	1	Escherichia coli O157:NM	serotype	Decreases
0	1	Escherichia coli O165:H25	serotype	Decreases
0	1	Escherichia coli O174:H2	serotype	Decreases
0	1	Escherichia coli O174:H21	serotype	Decreases
0	1	Escherichia coli O174:H8	serotype	Decreases
0	1	Escherichia coli O176:H45	serotype	Decreases
0	1	Escherichia coli O177:NM	serotype	Decreases
0	1	Escherichia coli O26:H1	serotype	Decreases
0	1	Escherichia coli O28ac:NM	serotype	Decreases
0	1	Escherichia coli O29:H4	serotype	Decreases
0	1	Escherichia coli O32:H37	serotype	Decreases
0	1	Escherichia coli O6:H16:CFA/II	serotype	Decreases
0	1	Escherichia coli O69:H11	serotype	Decreases
0	1	Escherichia coli O78:H12	serotype	Decreases
0	1	Escherichia coli O79:H7	serotype	Decreases
0	1	Escherichia coli O81:NM	serotype	Decreases
0	1	Escherichia coli O86:H34	serotype	Decreases
0	1	Escherichia coli O91:H14	serotype	Decreases
0	1	Escherichia coli O91:NM	serotype	Decreases
0	1	Escherichia coli ONT:H33	serotype	Decreases
0	1	Escherichia coli O100:H21	serotype	Decreases
0	1	Escherichia coli O121:H19	serotype	Decreases
0	1	Escherichia coli O157:H7	serotype	Decreases
0	1	Escherichia coli O16:H6	serotype	Decreases
0	1	Escherichia coli O89m:H9	serotype	Decreases
0	1	Escherichia coli O111:H-	serotype	Decreases
0	1	Escherichia coli O113:H21	serotype	Decreases
0	1	Escherichia coli H20	serotype	Decreases
0	1	Escherichia coli O150:H6	serotype	Decreases
0	1	Escherichia coli O111:NM	serotype	Decreases
0	1	Escherichia coli O112ab:H8	serotype	Decreases
0	1	Escherichia coli O99:H6	serotype	Decreases
0	1	Escherichia coli O26:H11	serotype	Decreases
0	1	Escherichia coli O145:H28	serotype	Decreases
0	1	Escherichia coli O126:H45	serotype	Decreases
0	1	Escherichia coli O2:H6	serotype	Decreases
0	1	Escherichia coli O7:H4	serotype	Decreases
0	1	Escherichia coli O1:H42	serotype	Decreases
0	1	Escherichia coli O25:NM	serotype	Decreases
0	1	Escherichia coli O25:H1	serotype	Decreases
0	1	Escherichia coli O7:K1	serotype	Decreases
0	1	Escherichia coli O125ac:K+:H10	serotype	Decreases
0	1	Escherichia coli O6:K2:H1	serotype	Decreases
0	1	Escherichia coli O152:H23	serotype	Decreases
0	1	Escherichia coli O15:H18	serotype	Decreases
0	1	Escherichia coli O39:NM	serotype	Decreases
0	1	Escherichia coli O44:H18	serotype	Decreases
0	1	Escherichia coli O2:K2:H1	serotype	Decreases
0	1	Escherichia coli O8:H8	serotype	Decreases
0	1	Escherichia coli O89m:H10	serotype	Decreases
0	1	Escherichia coli O10:H32	serotype	Decreases
0	1	Escherichia coli O6:H16	serotype	Decreases
0	1	Escherichia coli O157:H-	serotype	Decreases
0	1	Escherichia coli O45:H2	serotype	Decreases
0	1	Escherichia coli O103:H2	serotype	Decreases
0	1	Escherichia coli O167:H26	serotype	Decreases
0	1	Escherichia coli O104:H4	serotype	Decreases
0	1	Escherichia coli O83:H1	serotype	Decreases
0	1	Escherichia coli O9:H10	serotype	Decreases
0	1	Escherichia coli O78:H4	serotype	Decreases
0	1	Escherichia coli O139:H28	serotype	Decreases
1	0	Bacteroides fragilis	species	Decreases
1	0	Bacteroides ovatus	species	Decreases
1	0	Bacteroides thetaiotaomicron	species	Decreases
1	0	Bacteroides uniformis	species	Decreases
1	0	Bilophila wadsworthia	species	Decreases
1	0	Clostridioides difficile	species	Decreases
1	0	Clostridium perfringens	species	Decreases
1	0	Coprococcus comes	species	Decreases
1	0	Enterocloster bolteae	species	Decreases
1	0	Lacticaseibacillus paracasei	species	Decreases
1	0	Mediterraneibacter gnavus	species	Decreases
1	0	Odoribacter splanchnicus	species	Decreases
1	0	Parabacteroides distasonis	species	Decreases
1	0	Parabacteroides merdae	species	Decreases
1	0	Roseburia intestinalis	species	Decreases
1	0	Ruminococcus bromii	species	Decreases
1	0	Segatella copri	species	Decreases
1	0	Streptococcus parasanguinis	species	Decreases
1	0	Thomasclavelia ramosa	species	Decreases
1	0	Escherichia coli	species	Decreases
1	0	Fusobacterium nucleatum	species	Decreases
1	0	Blautia obeum	species	Decreases
1	0	Lachnospira eligens	species	Decreases
1	0	Agathobacter rectalis	species	Decreases
1	0	[Ruminococcus] torques	species	Decreases
1	0	Lacrimispora saccharolytica	species	Decreases
2	0	Phocaeicola vulgatus	species	Decreases
1	0	Bacteroides caccae	species	Decreases
0	1	Phocaeicola vulgatus ATCC 8482	strain	Increases
0	1	Phocaeicola vulgatus 274-1D4	strain	Increases
0	1	Phocaeicola vulgatus CL09T03C04	strain	Increases
0	1	Phocaeicola vulgatus dnLKV7	strain	Increases
0	1	Phocaeicola vulgatus PC510	strain	Increases
0	1	Phocaeicola vulgatus RJ2L3	strain	Increases
0	1	Phocaeicola vulgatus str. 3775 SL(B) 10 (iv)	strain	Increases
0	1	Phocaeicola vulgatus str. 3775 SR(B) 19	strain	Increases
0	1	Phocaeicola vulgatus str. 3975 RP4	strain	Increases
0	1	Lacticaseibacillus paracasei subsp. paracasei	subspecies	Decreases
0	1	Fusobacterium nucleatum subsp. nucleatum	subspecies	Decreases
0	1	Lacticaseibacillus paracasei subsp. tolerans	subspecies	Decreases

Impact of diclazuril,(prescription) on Conditions from US National Library of Medicine

A higher number indicates impact on more bacteria associated with the condition and confidence on the impact.

We have X bacteria high and Y low reported. We find that the modifier reduces some and increases other of these two groups. We just tally: X|reduces + Y|Increase = Positive X|increases + Y|decrease = Negative.

Benefit Ratio:
Numbers above 0 have increasing positive effect.
Numbers below 0 have increasing negative effect.

Condition	Positive Impact	Negative Impact	Benefit Ratio Impact
Abdominal Aortic Aneurysm	0.9		0.9
Acne	0.6	0.4	0.5
ADHD	3.6	0.3	11
Age-Related Macular Degeneration and Glaucoma	0.5	0.4	0.25
Allergic Rhinitis (Hay Fever)	2.5	1.4	0.79
Allergies	4.7	2.3	1.04
Allergy to milk products	1.6	1.3	0.23
Alopecia (Hair Loss)	0.7		0.7
Alzheimer's disease	5.1	6.1	-0.2
Amyotrophic lateral sclerosis (ALS) Motor Neuron	2.1	0.9	1.33
Ankylosing spondylitis	3.4	1.8	0.89
Anorexia Nervosa	1.4	3.2	-1.29
Antiphospholipid syndrome (APS)	2	0.3	5.67
Asthma	3.5	1.1	2.18
Atherosclerosis	2	2.1	-0.05
Atrial fibrillation	2.9	2.6	0.12
Autism	8.1	7.4	0.09
Autoimmune Disease	0.9	0.7	0.29
Barrett esophagus cancer	0.3	0.3	0
benign prostatic hyperplasia	0.6	0.3	1
Biofilm	2.6		2.6
Bipolar Disorder	2.1	1.1	0.91
Brain Trauma	0.3	1.1	-2.67
Breast Cancer	1.4	0.3	3.67
Cancer (General)	0.6	1.3	-1.17
Carcinoma	3.4	1.4	1.43
Celiac Disease	2.7	2	0.35
Cerebral Palsy	0.8	1.3	-0.63
Chronic Fatigue Syndrome	5.1	5	0.02
Chronic Kidney Disease	3	2.1	0.43
Chronic Lyme	0.6	0.8	-0.33
Chronic Obstructive Pulmonary Disease (COPD)	2	1.7	0.18
Chronic Urticaria (Hives)	1.6	1.2	0.33
Coagulation / Micro clot triggering bacteria	1.9	1.3	0.46
Cognitive Function	2.2	1.3	0.69
Colorectal Cancer	7	1.9	2.68
Constipation	1.6	0.7	1.29
Coronary artery disease	2.6	2.5	0.04
COVID-19	6.9	8.8	-0.28
Crohn's Disease	7.5	4.2	0.79
Cushing's Syndrome (hypercortisolism)		0.4	-0.4
cystic fibrosis	1.2	1	0.2
d-lactic acidosis (one form of brain fog)	0.6		0.6
deep vein thrombosis	3.6	1.4	1.57
Denture Wearers Oral Shifts	0.8		0.8
Depression	8.6	6.4	0.34
Dermatomyositis	0.3		0.3
Eczema	2	1.1	0.82
Endometriosis	2.6	2.3	0.13
Eosinophilic Esophagitis	0.3	0.3	0
Epilepsy	3.4	1.5	1.27
erectile dysfunction	2.6		2.6
Fibromyalgia	2.5	2.3	0.09
Functional constipation / chronic idiopathic constipation	5.4	3.8	0.42
gallstone disease (gsd)	3.4	0.8	3.25
Gastroesophageal reflux disease (Gerd) including Barrett's esophagus	1.5	0.9	0.67
Generalized anxiety disorder	3	1.6	0.88
giant cell arteritis		0.2	-0.2
Glioblastoma		0.3	-0.3
Gout	1	0.8	0.25
Graves' disease	1	1.8	-0.8
Gulf War Syndrome	0.9	1.2	-0.33
Halitosis	1.4	0.3	3.67
Hashimoto's thyroiditis	2.5	1.2	1.08
Heart Failure	5.1	1.3	2.92
hemorrhagic stroke	0.7		0.7
Hidradenitis Suppurativa	1.4		1.4
High Histamine/low DAO	1.9	0.3	5.33
hypercholesterolemia (High Cholesterol)	1		1
hyperglycemia	1.2	0.9	0.33
Hyperlipidemia (High Blood Fats)	0.3		0.3
hypersomnia		0.4	-0.4
hypertension (High Blood Pressure	3.3	4	-0.21
Hypothyroidism		0.4	-0.4
Hypoxia	2.7	0.6	3.5
IgA nephropathy (IgAN)	1.6	4.1	-1.56
Inflammatory Bowel Disease	7.6	8.1	-0.07
Insomnia	1	2.1	-1.1
Intelligence	1.9	0.6	2.17
Intracranial aneurysms	1.4	0.3	3.67
Irritable Bowel Syndrome	5.7	3.9	0.46
ischemic stroke	2	1.7	0.18
Liver Cirrhosis	5.4	3	0.8
Long COVID	6.1	5.4	0.13
Low bone mineral density		1.1	-1.1
Lung Cancer	1	0.4	1.5
Lymphoma	0.6		0.6
Mast Cell Issues / mastitis	1.4	0.6	1.33
ME/CFS with IBS	1.1	1.3	-0.18
ME/CFS without IBS	1.1	0.9	0.22
membranous nephropathy	0.3		0.3
Menopause	0.9	0.5	0.8
Metabolic Syndrome	6.4	4.7	0.36
Mood Disorders	8.5	5.8	0.47
multiple chemical sensitivity [MCS]	0.3	0.1	2
Multiple Sclerosis	3.8	5.6	-0.47
Multiple system atrophy (MSA)	0.6	0.4	0.5
myasthenia gravis	0.9	0.7	0.29
neuropathic pain		2.2	-2.2
Neuropathy (all types)	0.4	2.2	-4.5
neuropsychiatric disorders (PANDAS, PANS)	1.1		1.1
Nonalcoholic Fatty Liver Disease (nafld) Nonalcoholic	5.6	2.9	0.93
NonCeliac Gluten Sensitivity	0.4	0.3	0.33
Obesity	7.6	5.7	0.33
obsessive-compulsive disorder	5.9	3.1	0.9
Osteoarthritis	3.3	0.9	2.67
Osteoporosis	1.9	0.7	1.71
pancreatic cancer	1.1	0.3	2.67
Parkinson's Disease	6.3	6.5	-0.03
Polycystic ovary syndrome	6.8	2.9	1.34
Postural orthostatic tachycardia syndrome	0.2	0.3	-0.5
Premenstrual dysphoric disorder	0.1	0.4	-3
primary biliary cholangitis	0.3	1.4	-3.67
Primary sclerosing cholangitis	2.1	2.9	-0.38
Psoriasis	2.1	3.1	-0.48
rheumatoid arthritis (RA),Spondyloarthritis (SpA)	5.8	3	0.93
Rosacea	0.7	0.7	0
Schizophrenia	4.3	2.5	0.72
scoliosis	0.8	1	-0.25
Sjögren syndrome	2.3	1.7	0.35
Sleep Apnea	1.3	1.6	-0.23
Slow gastric motility / Gastroparesis	1.1		1.1
Small Intestinal Bacterial Overgrowth (SIBO)	1.9		1.9
Stress / posttraumatic stress disorder	2.3	1.6	0.44
Systemic Lupus Erythematosus	4.3	1.8	1.39
Tic Disorder	1	0.6	0.67
Tourette syndrome	0.3	0.3	0
Type 1 Diabetes	3.7	2	0.85
Type 2 Diabetes	6.6	5.3	0.25
Ulcerative colitis	5.2	6.3	-0.21
Unhealthy Ageing	4.8	1.9	1.53
Vitiligo	2.2	1.2	0.83

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